Neurobiology of BDNF in fear memory, sensitivity to stress, and stress-related disorders

Functional rs6265 polymorphism in the brain-derived neurotrophic factor gene confers protection against neurocognitive dysfunction in posttraumatic stress disorder among Chinese patients with hepatocellular carcinoma

(2019) Jun-Cheng Guo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Pathway specific activation of ventral hippocampal cells projecting to the prelimbic cortex diminishes fear renewal

(2019) J.H. Vasquez et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Sex-specific spatial memory deficits in mice with a conditional TrkB deletion on parvalbumin interneurons

(2019) Adrienne Mary Grech et al.   BEHAVIOURAL BRAIN RESEARCH

Differential BDNF methylation in combat exposed veterans and the association with exercise

(2019) Joanne Voisey et al.   GENE

Understanding the Molecular Mechanisms Underpinning Gene by Environment Interactions in Psychiatric Disorders: The FKBP5 Model

(2018) Natalie Matosin et al.   BIOLOGICAL PSYCHIATRY

Distinct Proteomic, Transcriptomic, and Epigenetic Stress Responses in Dorsal and Ventral Hippocampus

(2018) Amalia Floriou-Servou et al.   BIOLOGICAL PSYCHIATRY

Prefrontal cortical parvalbumin and somatostatin expression and cell density increase during adolescence and are modified by BDNF and sex

(2018) X. Du et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Excitatory connections between the prelimbic and infralimbic medial prefrontal cortex show a role for the prelimbic cortex in fear extinction

(2018) Roger Marek et al.   NATURE NEUROSCIENCE

The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior

(2018) Joanna I. Giza et al.   NEURON

The Effects of a BDNF Val66Met Polymorphism on Posttraumatic Stress Disorder: A Meta-Analysis

(2018) Kaitlin E. Bountress et al.   NEUROPSYCHOBIOLOGY

Correlations of Four Genetic Single Nucleotide Polymorphisms in Brain-Derived Neurotrophic Factor with Posttraumatic Stress Disorder

(2018) Jun-Cheng Guo et al.   Psychiatry Investigation

The BDNF Val66Met polymorphism moderates the relationship between Posttraumatic Stress Disorder and fear extinction learning

(2018) Kim L. Felmingham et al.   PSYCHONEUROENDOCRINOLOGY

Brain-Derived Neurotrophic Factor (BDNF): Novel Insights into Regulation and Genetic Variation

(2018) Michael Notaras et al.   NEUROSCIENTIST

Genetic Variants of the Brain-Derived Neurotrophic Factor and Metabolic Indices in Veterans With Posttraumatic Stress Disorder

(2018) Lucija Tudor et al.   Frontiers in Psychiatry

BDNF Val66Met polymorphism and posttraumatic stress symptoms in U.S. military veterans: Protective effect of physical exercise

(2018) Barbara L. Pitts et al.   PSYCHONEUROENDOCRINOLOGY

Brain-derived neurotrophic factor haploinsufficiency impairs high-frequency cortical oscillations in mice

(2017) Nigel C. Jones et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

A cross species study of heterogeneity in fear extinction learning in relation to FKBP5 variation and expression: Implications for the acute treatment of posttraumatic stress disorder

(2017) Isaac R. Galatzer-Levy et al.   NEUROPHARMACOLOGY

The Val66Met brain-derived neurotrophic factor gene variant interacts with early pain exposure to predict cortisol dysregulation in 7-year-old children born very preterm: Implications for cognition

(2017) C.M.Y. Chau et al.   NEUROSCIENCE

Estradiol and raloxifene modulate hippocampal gamma oscillations during a spatial memory task

(2017) Anna Schroeder et al.   PSYCHONEUROENDOCRINOLOGY

The BDNF Val66Met polymorphism regulates glucocorticoid-induced corticohippocampal remodeling and behavioral despair

(2017) M Notaras et al.   Translational Psychiatry

Utilization of machine learning for prediction of post-traumatic stress: a re-examination of cortisol in the prediction and pathways to non-remitting PTSD

(2017) I R Galatzer-Levy et al.   Translational Psychiatry

Exercise alters mouse sperm small noncoding RNAs and induces a transgenerational modification of male offspring conditioned fear and anxiety

(2017) A K Short et al.   Translational Psychiatry

Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation

(2016) Rachel Yehuda et al.   BIOLOGICAL PSYCHIATRY

Effects of theBDNFVal66Met Polymorphism on Gray Matter Volume in Typically Developing Children and Adolescents

(2016) Teruo Hashimoto et al.   CEREBRAL CORTEX

BDNF Val66Met genotype and neuroticism predict life stress: A longitudinal study from childhood to adulthood

(2016) Kelli Lehto et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

BDNF – a key transducer of antidepressant effects

(2016) Carl Björkholm et al.   NEUROPHARMACOLOGY

Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF)

(2016) Sumangali Kailainathan et al.   PHARMACOLOGICAL RESEARCH

Neurobiological actions by three distinct subtypes of brain-derived neurotrophic factor: Multi-ligand model of growth factor signaling

(2016) Toshiyuki Mizui et al.   PHARMACOLOGICAL RESEARCH

BDNF val66met genotype shows distinct associations with the acoustic startle reflex and the cortisol stress response in young adults and children

(2016) Diana Armbruster et al.   PSYCHONEUROENDOCRINOLOGY

Reduced severity of posttraumatic stress disorder associated with Val allele of Val66Met polymorphism at brain-derived neurotrophic factor gene among Chinese adolescents after Wenchuan earthquake

(2016) Rong Hui Li et al.   PSYCHOPHYSIOLOGY

BDNF pro-peptide regulates dendritic spines via caspase-3

(2016) J Guo et al.   Cell Death & Disease

A Case-Control Study and Meta-Analysis RevealBDNFVal66Met Is a Possible Risk Factor for PTSD

(2016) Dagmar Bruenig et al.   NEURAL PLASTICITY

Germ Cell Origins of Posttraumatic Stress Disorder Risk: The Transgenerational Impact of Parental Stress Experience

(2015) Ali B. Rodgers et al.   BIOLOGICAL PSYCHIATRY

Requirement for BDNF in the Reconsolidation of Fear Extinction

(2015) A. Radiske et al.   JOURNAL OF NEUROSCIENCE

BDNF Val66Met genotype determines hippocampus-dependent behavior via sensitivity to glucocorticoid signaling

(2015) M Notaras et al.   MOLECULAR PSYCHIATRY

The BDNF gene Val66Met polymorphism as a modifier of psychiatric disorder susceptibility: progress and controversy

(2015) M Notaras et al.   MOLECULAR PSYCHIATRY

7,8-Dihydroxyflavone as a pro-neurotrophic treatment for neurodevelopmental disorders

(2015) X. Du et al.   NEUROCHEMISTRY INTERNATIONAL

Dexamethasone Treatment Leads to Enhanced Fear Extinction and Dynamic Fkbp5 Regulation in Amygdala

(2015) Takehito Sawamura et al.   NEUROPSYCHOPHARMACOLOGY

A role for the BDNF gene Val66Met polymorphism in schizophrenia? A comprehensive review

(2015) Michael Notaras et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The Pfam protein families database: towards a more sustainable future

(2015) Robert D. Finn et al.   NUCLEIC ACIDS RESEARCH

BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met

(2015) Toshiyuki Mizui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Obesity Associated with an Intronic SNP in the Brain-Derived Neurotrophic Factor Locus

(2015) Zongyang Mou et al.   Cell Reports

Analyzing the influence of BDNF heterozygosity on spatial memory response to 17β-estradiol

(2015) Y W C Wu et al.   Translational Psychiatry

Brain-derived neurotropic factor polymorphisms, traumatic stress, mild traumatic brain injury, and combat exposure contribute to postdeployment traumatic stress

(2015) Michael N. Dretsch et al.   Brain and Behavior

Early Life Stress Effects on Glucocorticoid—BDNF Interplay in the Hippocampus

(2015) Nikolaos P. Daskalakis et al.   Frontiers in Molecular Neuroscience

Mice lacking TrkB in parvalbumin-positive cells exhibit sexually dimorphic behavioral phenotypes

(2014) Elizabeth K. Lucas et al.   BEHAVIOURAL BRAIN RESEARCH

Corticosterone treatment during adolescence induces down-regulation of reelin and NMDA receptor subunit GLUN2C expression only in male mice: implications for schizophrenia

(2014) Laetitia Buret et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Prefrontal Oscillations during Recall of Conditioned and Extinguished Fear in Humans

(2014) E. M. Mueller et al.   JOURNAL OF NEUROSCIENCE

Hippocampal–Prefrontal BDNF and Memory for Fear Extinction

(2014) Luis E Rosas-Vidal et al.   NEUROPSYCHOPHARMACOLOGY

UniProt: a hub for protein information

(2014)   NUCLEIC ACIDS RESEARCH

Moderate treadmill exercise rescues anxiety and depression-like behavior as well as memory impairment in a rat model of posttraumatic stress disorder

(2014) Gaurav Patki et al.   PHYSIOLOGY & BEHAVIOR

Sex differences in the adolescent developmental trajectory of parvalbumin interneurons in the hippocampus: A role for estradiol

(2014) YeeWen Candace Wu et al.   PSYCHONEUROENDOCRINOLOGY

The Brain-Derived Neurotrophic Factor Val66Met Polymorphism Predicts Response to Exposure Therapy in Posttraumatic Stress Disorder

(2013) Kim L. Felmingham et al.   BIOLOGICAL PSYCHIATRY

Brain-Derived Neurotrophic Factor Signaling Rewrites the Glucocorticoid Transcriptome via Glucocorticoid Receptor Phosphorylation

(2013) W. M. Lambert et al.   MOLECULAR AND CELLULAR BIOLOGY

PTSD risk is associated with BDNF Val66Met and BDNF overexpression

(2013) L Zhang et al.   MOLECULAR PSYCHIATRY

BDNF-TrkB signaling through Erk1/2MAPK phosphorylation mediates the enhancement of fear memory induced by glucocorticoids

(2013) J-M Revest et al.   MOLECULAR PSYCHIATRY

Prefrontal parvalbumin interneurons shape neuronal activity to drive fear expression

(2013) Julien Courtin et al.   NATURE

Impaired fear extinction learning in adult heterozygous BDNF knock-out mice

(2013) Laura Psotta et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Differential regulation of BDNF, synaptic plasticity and sprouting in the hippocampal mossy fiber pathway of male and female rats

(2013) Helen E. Scharfman et al.   NEUROPHARMACOLOGY

Steroid hormones and BDNF

(2013) N. Pluchino et al.   NEUROSCIENCE

Neurogenic and Neurotrophic Effects of BDNF Peptides in Mouse Hippocampal Primary Neuronal Cell Cultures

(2013) Maria del Carmen Cardenas-Aguayo et al.   PLoS One

Role of activity-dependent BDNF expression in hippocampal-prefrontal cortical regulation of behavioral perseverance

(2013) K. Sakata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction

(2013) Agustin Anastasia et al.   Nature Communications

Variant Brain-Derived Neurotrophic Factor (Valine66Methionine) Polymorphism Contributes to Developmental and Estrous Stage-Specific Expression of Anxiety-Like Behavior in Female Mice

(2012) Kevin G. Bath et al.   BIOLOGICAL PSYCHIATRY

Long-lasting regulation of hippocampal Bdnf gene transcription after contextual fear conditioning

(2012) K. Mizuno et al.   GENES BRAIN AND BEHAVIOR

Modulatory Effects of Sex Steroid Hormones on Brain-Derived Neurotrophic Factor-Tyrosine Kinase B Expression during Adolescent Development in C57Bl/6 Mice

(2012) R. A. Hill et al.   JOURNAL OF NEUROENDOCRINOLOGY

Variant Brain-Derived Neurotrophic Factor Val66Met Polymorphism Alters Vulnerability to Stress and Response to Antidepressants

(2012) H. Yu et al.   JOURNAL OF NEUROSCIENCE

The BDNF Val66Met Polymorphism Impairs Synaptic Transmission and Plasticity in the Infralimbic Medial Prefrontal Cortex

(2012) S. S. Pattwell et al.   JOURNAL OF NEUROSCIENCE

Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions

(2012) Torsten Klengel et al.   NATURE NEUROSCIENCE

Long-term behavioral and NMDA receptor effects of young-adult corticosterone treatment in BDNF heterozygous mice

(2012) Maren Klug et al.   NEUROBIOLOGY OF DISEASE

Progesterone, brain-derived neurotrophic factor and neuroprotection

(2012) M. Singh et al.   NEUROSCIENCE

Sex and stress hormone influences on the expression and activity of brain-derived neurotrophic factor

(2012) D.L. Carbone et al.   NEUROSCIENCE

Are BDNF and glucocorticoid activities calibrated?

(2012) F. Jeanneteau et al.   NEUROSCIENCE

Brain-derived neurotrophic factor and glucocorticoids: Reciprocal influence on the central nervous system

(2012) T. Numakawa et al.   NEUROSCIENCE

Vagal Nerve Stimulation Rapidly Activates Brain-Derived Neurotrophic Factor Receptor TrkB in Rat Brain

(2012) Havan Furmaga et al.   PLoS One

BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus

(2012) F. D. Jeanneteau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex-dependent and region-specific changes in TrkB signaling in BDNF heterozygous mice

(2011) Rachel A. Hill et al.   BRAIN RESEARCH

Childhood abuse, the BDNF-Val66Met polymorphism and adult psychotic-like experiences

(2011) Silvia Alemany et al.   BRITISH JOURNAL OF PSYCHIATRY

Estrogen synthesis in the hippocampus

(2011) Lars Fester et al.   CELL AND TISSUE RESEARCH

Steroid up-regulation of FKBP51 and its role in hormone signaling

(2011) Tiina Jääskeläinen et al.   CURRENT OPINION IN PHARMACOLOGY

Glucocorticoid suppresses BDNF-stimulated MAPK/ERK pathway via inhibiting interaction of Shp2 with TrkB

(2011) Emi Kumamaru et al.   FEBS LETTERS

Candidate-Gene Approach in Posttraumatic Stress Disorder After Urban Violence: Association Analysis of the Genes Encoding Serotonin Transporter, Dopamine Transporter, and BDNF

(2011) Nina Leão Marques Valente et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Distribution of Phosphorylated TrkB Receptor in the Mouse Hippocampal Formation Depends on Sex and Estrous Cycle Stage

(2011) J. L. Spencer-Segal et al.   JOURNAL OF NEUROSCIENCE

Estradiol acts via estrogen receptors alpha and beta on pathways important for synaptic plasticity in the mouse hippocampal formation

(2011) J.L. Spencer-Segal et al.   NEUROSCIENCE

Fear Erasure in Mice Requires Synergy Between Antidepressant Drugs and Extinction Training

(2011) N. N. Karpova et al.   SCIENCE

FKBP51 and FKBP52 in signaling and disease

(2011) Cheryl L. Storer et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The association between brain-derived neurotrophic factor Val66Met variants and psychotic symptoms in posttraumatic stress disorder

(2011) Nela Pivac et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents

(2010) Stephen M. Massa et al.   JOURNAL OF CLINICAL INVESTIGATION

Progesterone inhibits estrogen-mediated neuroprotection against excitotoxicity by down-regulating estrogen receptor-β

(2010) Claudia Aguirre et al.   JOURNAL OF NEUROCHEMISTRY

The BDNF Val66Met Polymorphism Impairs NMDA Receptor-Dependent Synaptic Plasticity in the Hippocampus

(2010) I. Ninan et al.   JOURNAL OF NEUROSCIENCE

The exclusive induction of extinction is gated by BDNF

(2010) A. Kirtley et al.   LEARNING & MEMORY

Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures?

(2010) Michael S. Fanselow et al.   NEURON

Interaction of FKBP5 with Childhood Adversity on Risk for Post-Traumatic Stress Disorder

(2010) Pingxing Xie et al.   NEUROPSYCHOPHARMACOLOGY

BDNF variant Val66Met interacts with estrous cycle in the control of hippocampal function

(2010) J. L. Spencer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prelimbic cortical BDNF is required for memory of learned fear but not extinction or innate fear

(2010) D. C. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The BDNF Val66Met polymorphism affects HPA-axis reactivity to acute stress

(2010) Nina Alexander et al.   PSYCHONEUROENDOCRINOLOGY

Induction of Fear Extinction with Hippocampal-Infralimbic BDNF

(2010) J. Peters et al.   SCIENCE

A Genetic Variant BDNF Polymorphism Alters Extinction Learning in Both Mouse and Human

(2010) F. Soliman et al.   SCIENCE

Status of Glucocorticoid Alterations in Post-traumatic Stress Disorder

(2009) Rachel Yehuda   Annals of the New York Academy of Sciences

Relapse of Successfully Treated Anxiety and Fear: Theoretical Issues and Recommendations for Clinical Practice

(2009) Mark J. Boschen et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

Gene Expression Patterns Associated with Posttraumatic Stress Disorder Following Exposure to the World Trade Center Attacks

(2009) Rachel Yehuda et al.   BIOLOGICAL PSYCHIATRY

Progesterone reverses 17β-estradiol-mediated neuroprotection and BDNF induction in cultured hippocampal slices

(2009) Claudia C. Aguirre et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Cholesterol-promoted synaptogenesis requires the conversion of cholesterol to estradiol in the hippocampus

(2009) Lars Fester et al.   HIPPOCAMPUS

Interaction between genetic polymorphisms and stressful life events in first episode depression

(2009) Jens Drachmann Bukh et al.   JOURNAL OF AFFECTIVE DISORDERS

Population genetic study of the brain-derived neurotrophic factor (BDNF) gene

(2009) T L Petryshen et al.   MOLECULAR PSYCHIATRY

Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety

(2009) J M Gatt et al.   MOLECULAR PSYCHIATRY

Neuronal release of proBDNF

(2009) Jianmin Yang et al.   NATURE NEUROSCIENCE

TrkB signalling pathways in LTP and learning

(2009) Liliana Minichiello   NATURE REVIEWS NEUROSCIENCE

Effects of stress throughout the lifespan on the brain, behaviour and cognition

(2009) Sonia J. Lupien et al.   NATURE REVIEWS NEUROSCIENCE

Dendritic trafficking of BDNF mRNA is mediated by translin and blocked by the G196A (Val66Met) mutation

(2009) C. Chiaruttini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical role of promoter IV-driven BDNF transcription in GABAergic transmission and synaptic plasticity in the prefrontal cortex

(2009) K. Sakata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucocorticoid receptor interaction with TrkB promotes BDNF-triggered PLC-  signaling for glutamate release via a glutamate transporter

(2009) T. Numakawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estradiol and the relationship between dendritic spines, NR2B containing NMDA receptors, and the magnitude of long-term potentiation at hippocampal CA3–CA1 synapses

(2009) Caroline C. Smith et al.   PSYCHONEUROENDOCRINOLOGY

The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders

(2009) Elisabeth B. Binder   PSYCHONEUROENDOCRINOLOGY

Combined neonatal stress and young‐adult glucocorticoid stimulation in rats reduce BDNF expression in hippocampus: Effects on learning and memory

(2008) Kwok Ho Christopher Choy et al.   HIPPOCAMPUS

Association of FKBP5 Polymorphisms and Childhood Abuse With Risk of Posttraumatic Stress Disorder Symptoms in Adults

(2008) Elisabeth B. Binder   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Aromatase in the Brain: Not Just for Reproduction Anymore

(2008) L. M. Garcia-Segura   JOURNAL OF NEUROENDOCRINOLOGY

Epigenetic Regulation of bdnf Gene Transcription in the Consolidation of Fear Memory

(2008) F. D. Lubin et al.   JOURNAL OF NEUROSCIENCE

Estrogen synthesis in the brain—Role in synaptic plasticity and memory

(2008) Yasushi Hojo et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF

(2008) Tomoya Matsumoto et al.   NATURE NEUROSCIENCE

A History of Corticosterone Exposure Regulates Fear Extinction and Cortical NR2B, GluR2/3 and BDNF

(2008) Shannon L Gourley et al.   NEUROPSYCHOPHARMACOLOGY

Activation of Trk neurotrophin receptors by glucocorticoids provides a neuroprotective effect

(2008) F. Jeanneteau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BDNF Val66Met polymorphism is associated with HPA axis reactivity to psychological stress characterized by genotype and gender interactions

(2008) Idan Shalev et al.   PSYCHONEUROENDOCRINOLOGY

Glucocorticoid Prevents Brain-Derived Neurotrophic Factor-Mediated Maturation of Synaptic Function in Developing Hippocampal Neurons through Reduction in the Activity of Mitogen-Activated Protein Kinase

(2007) Emi Kumamaru et al.   MOLECULAR ENDOCRINOLOGY