Article
Toxicology
Hattaya Benya-aphikul, Varisa Pongrakhananon, Paninee Chetprayoon, Thongchai Sooksawate, Ratchanee Rodsiri
Summary: Prenatal exposure to methamphetamine disrupts synaptogenesis and impairs learning and memory, with alterations in the BDNF-TrkB signaling pathway. This disruption leads to long-lasting memory impairment in adolescent and adult mice.
TOXICOLOGY LETTERS
(2021)
Article
Cell Biology
Lanxia Meng, Li Zou, Min Xiong, Jiehui Chen, Xingyu Zhang, Ting Yu, Yiming Li, Congcong Liu, Guiqin Chen, Zhihao Wang, Keqiang Ye, Zhentao Zhang
Summary: This study reveals a novel mechanism of synaptic dysfunction in Alzheimer's disease, where the synaptic protein synapsin I is cleaved into fragments by the enzyme AEP, leading to synaptic dysfunction.
Article
Neurosciences
Alex Xiong Gao, Tracy Chen-Xi Xia, Lish Sheng-Ying Lin, Tina Ting-Xia Dong, Karl Wah-Keung Tsim
Summary: We aimed to investigate the neurotrophic activities of apigenin (4',5,7-trihydroxyflavone) through its interaction with brain-derived neurotrophic factor (BDNF) and the activation of tyrosine kinase receptor B (Trk B receptor). Our results showed that apigenin and BDNF synergistically enhanced the survival and neurite outgrowth of cultured neurons. Apigenin also potentiated the neurogenesis induced by BDNF and protected against amyloid-beta-induced cytotoxicity and mitochondrial dysfunction. These effects were mediated by the phosphorylation of Trk B receptor. In conclusion, apigenin can enhance the neurotrophic effects of BDNF and may have therapeutic potential in neurodegenerative diseases and depression.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Psychiatry
Adam Pavlinek, Rugile Matuleviciute, Laura Sichlinger, Lucia Dutan Polit, Nikolaos Armeniakos, Anthony Christopher Vernon, Deepak Prakash Srivastava
Summary: Maternal immune activation during gestation is linked to increased risk for psychiatric disorders with neurodevelopmental origin. Animal and human cellular models suggest that inflammatory cytokines play a critical role in the impact of maternal infection on offspring brain and behavior development. However, the specific cytokines necessary for these effects and their impact on specific cell types are still unclear.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Yuanyuan Li, Amanda Tran, Lori Graham, John Brock, Mark H. Tuszynski, Paul Lu
Summary: Providing trophic gradients caudal to the spinal cord injury can enhance and guide the growth of neural stem cell axons, improving neural relay formation and functional outcomes.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Neurosciences
Tatiana A. Gudasheva, Polina Yu Povarnina, Tatiana A. Antipova, Sergey Kruglov, Ilya O. Logvinov, Dmitry M. Nikiforov, Sergey B. Seredenin
Summary: The dimeric dipeptide BDNF mimetic GSB-106 demonstrated neuroprotective effects in an ischemic stroke rat model by promoting neurogenesis and synaptogenesis, suggesting its potential for neuroregeneration within a clinically relevant time window of 24 hours.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2021)
Article
Pharmacology & Pharmacy
Yaping Sun, Nengjuan Li
Summary: This study investigated the efficacy and mechanism of action of Rhodiola rosea L. on diabetic gastroparesis (DGP) based on Synapsin-I. The results showed that Rhodiola rosea L. extract exerted a protective effect on DGP by enhancing synaptic plasticity via upregulation of expression of synapsin-I. This study provides an experimental basis for the potential clinical application of Rhodiola rosea L. extract in the management of diabetic peripheral neuropathy.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2023)
Review
Cell Biology
Rui O. Costa, Luis F. Martins, Emanuel Tahiri, Carlos B. Duarte
Summary: The neurotrophin BDNF plays multiple roles in the nervous system, including in neuronal development, synaptic potentiation, and neuronal survival. Its effects are mediated by the activation of TrkB receptors and involve the regulation of local protein synthesis. This local protein synthesis is crucial for neuronal development and synaptic plasticity.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2022)
Review
Behavioral Sciences
Xi-Yi Hu, Yu-Long Wu, Chao-Hui Cheng, Xiao-Xi Liu, Lan Zhou
Summary: The meta-analysis suggests that the BDNF rs6265 G > A polymorphism is associated with PTSD susceptibility, with an increased risk of A allele mutations. Subgroup analysis showed similar situations in Asian populations and other groups.
BRAIN AND BEHAVIOR
(2021)
Review
Neurosciences
Ning Sun, Wen-Qiang Cui, Xiao-Man Min, Guang-Ming Zhang, Jia-Zheng Liu, Hong-Yun Wu
Summary: Post-stroke depression is a common complication that significantly affects the recovery and quality of life of stroke patients. The treatment for post-stroke depression remains challenging due to its complex mechanisms. This review discusses the role of hippocampal synaptic plasticity in post-stroke depression, summarizing recent research and analyzing possible molecular mechanisms. Understanding the correlation between hippocampal mechanisms and post-stroke depression can enhance the treatment of this condition.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Matthew J. Van Hook
Summary: Brain-derived neurotrophic factor (BDNF) plays a critical role in regulating neural development and plasticity. This study reveals that BDNF modulates the retinogeniculate pathway by affecting both presynaptic and postsynaptic mechanisms, enhancing neuronal responses and synaptic vesicle release in the visual system.
JOURNAL OF NEUROPHYSIOLOGY
(2022)
Article
Cell Biology
Yacong He, Shuang Chen, Bun Tsoi, Shuhua Qi, Bing Gu, Zhenxing Wang, Cheng Peng, Jiangang Shen
Summary: The study found that by inducing the BDNF signaling pathway, AOM can promote adult hippocampal neurogenesis and improve cognitive impairments after stroke. P-CA is identified as the most effective compound in AOM, with the ability to activate the BDNF/TrkB/AKT signaling pathway and promote NSC proliferation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Gwyneth W. Y. Wu, Owen M. Wolkowitz, Victor I. Reus, Jee In Kang, Mathea Elnar, Reuben Sarwal, Janine D. Flory, Duna Abu-Amara, Rasha Hammamieh, Aarti Gautam, Francis J. Doyle Iii, Rachel Yehuda, Charles R. Marmar, Marti Jett, Synthia H. Mellon
Summary: Research on the correlation between blood levels of brain-derived neurotrophic factor (BDNF) and post-traumatic stress disorder (PTSD) has yielded conflicting results. This study found that combat veterans with PTSD had significantly higher serum BDNF levels compared to those without PTSD, both in cross-sectional and longitudinal analysis. However, serum BDNF levels did not correlate with PTSD symptom severity within the PTSD group at different time points.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Harpreet Kaur, Deepaneeta Sarmah, Pabbala Veeresh, Aishika Datta, Kiran Kalia, Anupom Borah, Dileep R. Yavagal, Pallab Bhattacharya
Summary: The study demonstrates that intrarterially administered mesenchymal stem cells post ischemic stroke provide neuroprotection and can modulate ER stress-induced apoptosis via the BDNF/TrkB signaling pathway.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Genetics & Heredity
Juncheng Guo, Yijun Yang, Xiangling Jiang, Min Guo, Xiang Li, Ping Huang, Zhuo Liu
Summary: The study explored the correlations of BDNF promoter methylation and SNP with PTSD in Li and Han nationalities in Hainan province. The study found differences in PTSD incidence between the two nationalities, with lower BDNF levels in Li nationality PTSD patients and higher BDNF promoter methylation. The G-712A genotype and BDNF promoter methylation were identified as independent risk factors for PTSD.
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)