Increased neuronal activity in motor cortex reveals prominent calcium dyshomeostasis in tauopathy mice

Chronic PD-1 Checkpoint Blockade Does Not Affect Cognition or Promote Tau Clearance in a Tauopathy Mouse Model

(2020) Yan Lin et al.   Frontiers in Aging Neuroscience

Tau antibody chimerization alters its charge and binding, thereby reducing its cellular uptake and efficacy

(2019) Erin E. Congdon et al.   EBioMedicine

In vivo imaging reveals reduced activity of neuronal circuits in a mouse tauopathy model

(2019) Petar Marinković et al.   BRAIN

Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice

(2019) Julia Gamache et al.   Nature Communications

Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease

(2018) David Baglietto-Vargas et al.   AGING CELL

Soluble tau aggregates, not large fibrils, are the toxic species that display seeding and cross-seeding behavior

(2018) Gaurav Ghag et al.   PROTEIN SCIENCE

Dynamic assessment of tau immunotherapies in the brains of live animals by two-photon imaging

(2018) Qian Wu et al.   EBioMedicine

TIA1 regulates the generation and response to toxic tau oligomers

(2018) Lulu Jiang et al.   ACTA NEUROPATHOLOGICA

Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo

(2018) Marc Aurel Busche et al.   NATURE NEUROSCIENCE

Abnormal dendritic calcium activity and synaptic depotentiation occur early in a mouse model of Alzheimer’s disease

(2017) Yang Bai et al.   Molecular Neurodegeneration

REM sleep selectively prunes and maintains new synapses in development and learning

(2017) Wei Li et al.   NATURE NEUROSCIENCE

Voltage-gated calcium flux mediatesEscherichia colimechanosensation

(2017) Giancarlo N. Bruni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Propagation of Tau aggregates

(2017) Michel Goedert et al.   Molecular Brain

High-throughput screen detects calcium signaling dysfunction in typical sporadic autism spectrum disorder

(2017) Galina Schmunk et al.   Scientific Reports

Affinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy

(2016) Erin E. Congdon et al.   Molecular Neurodegeneration

Tau pathology-mediated presynaptic dysfunction

(2016) H. Moreno et al.   NEUROSCIENCE

Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons

(2016) Keiko Imamura et al.   Scientific Reports

Branch-specific dendritic Ca2+ spikes cause persistent synaptic plasticity

(2015) Joseph Cichon et al.   NATURE

Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer's models

(2015) Marc Aurel Busche et al.   NATURE NEUROSCIENCE

Differential calcium alterations in animal models of neurodegenerative disease: Reversal by FK506

(2015) C.R. Overk et al.   NEUROSCIENCE

Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca++ dysregulation

(2015) Jochen Martin Decker et al.   Acta Neuropathologica Communications

Passive Immunization with Tau Oligomer Monoclonal Antibody Reverses Tauopathy Phenotypes without Affecting Hyperphosphorylated Neurofibrillary Tangles

(2014) D. L. Castillo-Carranza et al.   JOURNAL OF NEUROSCIENCE

Antibody Uptake into Neurons Occurs Primarily via Clathrin-dependent Fcγ Receptor Endocytosis and Is a Prerequisite for Acute Tau Protein Clearance

(2013) Erin E. Congdon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two Novel Tau Antibodies Targeting the 396/404 Region Are Primarily Taken Up by Neurons and Reduce Tau Protein Pathology

(2013) Jiaping Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau Causes Synapse Loss without Disrupting Calcium Homeostasis in the rTg4510 Model of Tauopathy

(2013) Katherine J. Kopeikina et al.   PLoS One

Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo

(2013) K. V. Kuchibhotla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Curcumin Suppresses Soluble Tau Dimers and Corrects Molecular Chaperone, Synaptic, and Behavioral Deficits in Aged Human Tau Transgenic Mice

(2012) Qiu-Lan Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

In Vivo Alterations in Calcium Buffering Capacity in Transgenic Mouse Model of Synucleinopathy

(2012) L. Reznichenko et al.   JOURNAL OF NEUROSCIENCE

Critical role of soluble amyloid-  for early hippocampal hyperactivity in a mouse model of Alzheimer's disease

(2012) M. A. Busche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Staged decline of neuronal function in vivo in an animal model of Alzheimer's disease

(2012) Christine Grienberger et al.   Nature Communications

Soluble forms of tau are toxic in Alzheimer’s disease

(2012) Katherine Kopeikina et al.   Translational Neuroscience

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

(2011) Cristian A Lasagna-Reeves et al.   Molecular Neurodegeneration

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease

(2008) M. A. Busche et al.   SCIENCE

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

(2008) Ilya Bezprozvanny et al.   TRENDS IN NEUROSCIENCES