Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease

Stop Alzheimer’s before it starts

(2017) Eric McDade et al.   NATURE

Synaptic Impairment in Alzheimer’s Disease: A Dysregulated Symphony

(2017) Stefania Forner et al.   TRENDS IN NEUROSCIENCES

Estrogen and Hippocampal Plasticity in Rodent Models

(2017) Michael R. Foy et al.   JOURNAL OF ALZHEIMERS DISEASE

Defective actin dynamics in dendritic spines: cause or consequence of age-induced cognitive decline?

(2016) Till Georg Alexander Mack et al.   BIOLOGICAL CHEMISTRY

Amyloid-β-Induced Dysregulation of AMPA Receptor Trafficking

(2016) Sumasri Guntupalli et al.   NEURAL PLASTICITY

Amyloid-β dimers in the absence of plaque pathology impair learning and synaptic plasticity

(2015) Andreas Müller-Schiffmann et al.   BRAIN

Short-term modern life-like stress exacerbates Aβ-pathology and synapse loss in 3xTg-AD mice

(2015) David Baglietto-Vargas et al.   JOURNAL OF NEUROCHEMISTRY

Alterations in synaptic plasticity coincide with deficits in spatial working memory in presymptomatic 3xTg-AD mice

(2015) Jason K. Clark et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus

(2015) G. Aleph Prieto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau Oligomers: The Toxic Player at Synapses in Alzheimer’s Disease

(2015) Marcos J. Guerrero-Muñoz et al.   Frontiers in Cellular Neuroscience

Phosphorylation of the AMPA receptor GluA1 subunit regulates memory load capacity

(2014) Laura Olivito et al.   Brain Structure & Function

Impaired Src signaling and post-synaptic actin polymerization in Alzheimer's disease mice hippocampus — Linking NMDA receptors and the reelin pathway

(2014) Sandra I. Mota et al.   EXPERIMENTAL NEUROLOGY

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease

(2014) Shichun Tu et al.   Molecular Neurodegeneration

Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease

(2014) Meredith A. Chabrier et al.   NEUROBIOLOGY OF DISEASE

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

(2014) Tara L. Spires-Jones et al.   NEURON

PAK Inactivation Impairs Social Recognition in 3xTg-AD Mice without Increasing Brain Deposition of Tau and A 

(2013) D. Arsenault et al.   JOURNAL OF NEUROSCIENCE

Immunotherapy for Alzheimer’s disease: hoops and hurdles

(2013) Cynthia A Lemere   Molecular Neurodegeneration

Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition

(2013) David Baglietto-Vargas et al.   NEUROBIOLOGY OF DISEASE

Animal Models of Alzheimer Disease

(2013) F. M. LaFerla et al.   Cold Spring Harbor Perspectives in Medicine

Early Presynaptic and Postsynaptic Calcium Signaling Abnormalities Mask Underlying Synaptic Depression in Presymptomatic Alzheimer's Disease Mice

(2012) S. Chakroborty et al.   JOURNAL OF NEUROSCIENCE

The  -Secretase-Derived C-Terminal Fragment of  APP, C99, But Not A , Is a Key Contributor to Early Intraneuronal Lesions in Triple-Transgenic Mouse Hippocampus

(2012) I. Lauritzen et al.   JOURNAL OF NEUROSCIENCE

Loss of functional GABAA receptors in the Alzheimer diseased brain

(2012) A. Limon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus

(2011) Raquel Sanchez-Varo et al.   ACTA NEUROPATHOLOGICA

Dendritic spine pathology in neuropsychiatric disorders

(2011) Peter Penzes et al.   NATURE NEUROSCIENCE

Structural Modulation of Dendritic Spines during Synaptic Plasticity

(2011) Dale A. Fortin et al.   NEUROSCIENTIST

Sex differences in β-amyloid accumulation in 3xTg-AD mice: Role of neonatal sex steroid hormone exposure

(2010) Jenna C. Carroll et al.   BRAIN RESEARCH

Hippocampal atrophy patterns in mild cognitive impairment and Alzheimer's disease

(2010) Susanne G. Mueller et al.   HUMAN BRAIN MAPPING

Actin in dendritic spines: connecting dynamics to function

(2010) Pirta Hotulainen et al.   JOURNAL OF CELL BIOLOGY

Multiple Events Lead to Dendritic Spine Loss in Triple Transgenic Alzheimer's Disease Mice

(2010) Tobias Bittner et al.   PLoS One

CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease

(2010) A. Caccamo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

(2010) H. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPA receptor trafficking pathways and links to dendritic spine morphogenesis

(2010) Jonathan G. Hanley   Cell Adhesion & Migration

Activity of the AMPA receptor regulates drebrin stabilization in dendritic spine morphogenesis

(2009) H. Takahashi et al.   JOURNAL OF CELL SCIENCE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy

(2008) Lorenzo A. Cingolani et al.   NATURE REVIEWS NEUROSCIENCE