Liquid biopsy enters the clinic — implementation issues and future challenges

Harmonizing cell-free DNA Collection and Processing Practices through Evidence-based Guidance

(2020) Sarah R. Greytak et al.   CLINICAL CANCER RESEARCH

Minimum Technical Data Elements for Liquid Biopsy Data Submitted to Public Databases

(2020) Phillip G. Febbo et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pan-cancer analysis of whole genomes

(2020)   NATURE

Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution

(2020) Saioa López et al.   NATURE GENETICS

Antitumor activity of crizotinib in lung cancers harboring a MET exon 14 alteration

(2020) Alexander Drilon et al.   NATURE MEDICINE

Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis

(2020) Richard Y. Ebright et al.   SCIENCE

Spectrum of driver mutations and clinical impact of circulating tumor DNA analysis in non–small cell lung cancer: Analysis of over 8000 cases

(2020) Philip C. Mack et al.   CANCER

Liquid Biopsy-Based Biomarkers of Treatment Response and Resistance

(2020) Elaine Kilgour et al.   CANCER CELL

The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution

(2020) Orit Rozenblatt-Rosen et al.   CELL

Integrating genomic features for non-invasive early lung cancer detection

(2020) Jacob J. Chabon et al.   NATURE

A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer

(2020) Alex H. Wagner et al.   NATURE GENETICS

Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring

(2020) Asaf Zviran et al.   NATURE MEDICINE

Deciphering cancer clues from blood

(2020) Ning Ma et al.   SCIENCE

Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention

(2020) Anne Marie Lennon et al.   SCIENCE

Integrative Analysis and Machine Learning based Characterization of Single Circulating Tumor Cells

(2020) Arvind Iyer et al.   Journal of Clinical Medicine

Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA

(2020) M.C. Liu et al.   ANNALS OF ONCOLOGY

Plasma or Serum: Which Is Preferable for Mutation Detection in Liquid Biopsy?

(2020) Fabio Pittella-Silva et al.   CLINICAL CHEMISTRY

Assessment of Pre-Analytical Sample Handling Conditions for Comprehensive Liquid Biopsy Analysis

(2020) Teresa Gerber et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Association of Circulating Tumor DNA and Circulating Tumor Cells After Neoadjuvant Chemotherapy With Disease Recurrence in Patients With Triple-Negative Breast Cancer

(2020) Milan Radovich et al.   JAMA Oncology

Shallow Whole-Genome Sequencing from Plasma Identifies FGFR1 Amplified Breast Cancers and Predicts Overall Survival

(2020) Chantal Bourrier et al.   Cancers

Clinical relevance of blood-based ctDNA analysis: mutation detection and beyond

(2020) Laura Keller et al.   BRITISH JOURNAL OF CANCER

Genome-wide study of the effect of blood collection tubes on the cell-free DNA methylome

(2020) Ruben Van Paemel et al.   Epigenetics

Circulating tumour DNA analysis to direct therapy in advanced breast cancer (plasmaMATCH): a multicentre, multicohort, phase 2a, platform trial

(2020) Nicholas C Turner et al.   LANCET ONCOLOGY

Inherited causes of clonal haematopoiesis in 97,691 whole genomes

(2020) Alexander G. Bick et al.   NATURE

Clinical utility of circulating tumor DNA sequencing in advanced gastrointestinal cancer: SCRUM-Japan GI-SCREEN and GOZILA studies

(2020) Yoshiaki Nakamura et al.   NATURE MEDICINE

Clonal Hematopoiesis in Liquid Biopsy: From Biological Noise to Valuable Clinical Implications

(2020) Hiu Ting Chan et al.   Cancers

Association of Clonal Hematopoiesis in DNA Repair Genes With Prostate Cancer Plasma Cell-free DNA Testing Interference

(2020) Kendal Jensen et al.   JAMA Oncology

The FNIH Biomarkers Consortium: Past Accomplishments and New Strategic Direction

(2019) Joseph P. Menetski et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Tumor mutational load predicts survival after immunotherapy across multiple cancer types

(2019) Robert M. Samstein et al.   NATURE GENETICS

Darolutamide in Nonmetastatic, Castration-Resistant Prostate Cancer

(2019) Karim Fizazi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Liquid biopsy and minimal residual disease — latest advances and implications for cure

(2019) Klaus Pantel et al.   Nature Reviews Clinical Oncology

Prospective Multicenter Validation of Androgen Receptor Splice Variant 7 and Hormone Therapy Resistance in High-Risk Castration-Resistant Prostate Cancer: The PROPHECY Study

(2019) Andrew J. Armstrong et al.   JOURNAL OF CLINICAL ONCOLOGY

Guidelines for the Preanalytical Conditions for Analyzing Circulating Cell-Free DNA

(2019) Romain Meddeb et al.   CLINICAL CHEMISTRY

Circulating tumor DNA in HER2 amplified breast cancer: a translational research substudy of the NeoALTTO phase 3 trial

(2019) Françoise Rothé et al.   CLINICAL CANCER RESEARCH

Ultra-deep next-generation sequencing of plasma cell-free DNA in patients with advanced lung cancers: results from the Actionable Genome Consortium

(2019) B T Li et al.   ANNALS OF ONCOLOGY

Clinical Utility of Comprehensive Cell-free DNA Analysis to Identify Genomic Biomarkers in Patients with Newly Diagnosed Metastatic Non–small Cell Lung Cancer

(2019) Natasha B. Leighl et al.   CLINICAL CANCER RESEARCH

Personalized detection of circulating tumor DNA antedates breast cancer metastatic recurrence

(2019) R. Charles Coombes et al.   CLINICAL CANCER RESEARCH

Genome-wide cell-free DNA fragmentation in patients with cancer

(2019) Stephen Cristiano et al.   NATURE

Genomic characterization of metastatic breast cancers

(2019) François Bertucci et al.   NATURE

Utility of ctDNA to support patient selection for early phase clinical trials: the TARGET study

(2019) Dominic G. Rothwell et al.   NATURE MEDICINE

Alpelisib for PIK3CA-Mutated, Hormone Receptor–Positive Advanced Breast Cancer

(2019) Fabrice André et al.   NEW ENGLAND JOURNAL OF MEDICINE

High efficiency error suppression for accurate detection of low-frequency variants

(2019) Ting Ting Wang et al.   NUCLEIC ACIDS RESEARCH

Circulating Tumor Cells and Circulating Tumor DNA Detection in Potentially Resectable Metastatic Colorectal Cancer: A Prospective Ancillary Study to the Unicancer Prodige-14 Trial

(2019) Bidard et al.   Cells

Liquid biopsy in the era of immuno-oncology: is it ready for prime-time use for cancer patients?

(2019) P Hofman et al.   ANNALS OF ONCOLOGY

Liquid biopsy in pancreatic ductal adenocarcinoma: current status of circulating tumor cells and circulating tumor DNA

(2019) Jee‐Soo Lee et al.   Molecular Oncology

Assessment of Molecular Relapse Detection in Early-Stage Breast Cancer

(2019) Isaac Garcia-Murillas et al.   JAMA Oncology

A comparison of EGFR mutation status in tissue and plasma cell-free DNA detected by ADx-ARMS in advanced lung adenocarcinoma patients

(2019) Hanyan Xu et al.   Translational Lung Cancer Research

Machine learning enables detection of early-stage colorectal cancer by whole-genome sequencing of plasma cell-free DNA

(2019) Nathan Wan et al.   BMC CANCER

Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers

(2019) Aparna R. Parikh et al.   NATURE MEDICINE

THE PRE-ANALYTICAL PHASE OF THE LIQUID BIOPSY

(2019) Francesca Salvianti et al.   New Biotechnology

Personalized circulating tumor DNA analysis to detect residual disease after neoadjuvant therapy in breast cancer

(2019) Bradon R. McDonald et al.   Science Translational Medicine

Multicenter Evaluation of Circulating Cell-Free DNA Extraction and Downstream Analyses for the Development of Standardized (Pre)analytical Work Flows

(2019) Rita Lampignano et al.   CLINICAL CHEMISTRY

Randomized Phase II Study of Paclitaxel plus Alisertib versus Paclitaxel plus Placebo as Second-Line Therapy for SCLC: Primary and Correlative Biomarker Analyses

(2019) Taofeek K. Owonikoko et al.   Journal of Thoracic Oncology

High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants

(2019) Pedram Razavi et al.   NATURE MEDICINE

Adaptive mutability of colorectal cancers in response to targeted therapies

(2019) Mariangela Russo et al.   SCIENCE

Inference of transcription factor binding from cell-free DNA enables tumor subtype prediction and early detection

(2019) Peter Ulz et al.   Nature Communications

Cell-free Circulating Tumor DNA Variant Allele Frequency Associates with Survival in Metastatic Cancer

(2019) Seyed Pairawan et al.   CLINICAL CANCER RESEARCH

Clonal hematopoiesis as a model for premalignant changes during aging

(2019) David P. Steensma et al.   EXPERIMENTAL HEMATOLOGY

Independent prognostic value of ultra-sensitive quantification of tumor pre-treatment T790M subclones in EGFR mutated non-small cell lung cancer (NSCLC) treated by first/second generation TKI, depends on variant allele frequency (VAF): Results of the French cooperative thoracic intergroup (IFCT) biomarkers France project

(2019) Michèle Beau-Faller et al.   LUNG CANCER

RAS mutation analysis in circulating tumor DNA from patients with metastatic colorectal cancer: the AGEO RASANC prospective multicenter study

(2018) J B Bachet et al.   ANNALS OF ONCOLOGY

Trastuzumab versus observation for HER2 nonamplified early breast cancer with circulating tumor cells (EORTC 90091-10093, BIG 1-12, Treat CTC): a randomized phase II trial

(2018) M Ignatiadis et al.   ANNALS OF ONCOLOGY

Blinatumomab for minimal residual disease in adults with B-cell precursor acute lymphoblastic leukemia

(2018) Nicola Gökbuget et al.   BLOOD

Future of Liquid Biopsies With Growing Technological and Bioinformatics Studies

(2018) Naveen Ramalingam et al.   CANCER JOURNAL

Next-Generation Machine Learning for Biological Networks

(2018) Diogo M. Camacho et al.   CELL

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

(2018) Katherine A. Hoadley et al.   CELL

The Landscape of Actionable Genomic Alterations in Cell-Free Circulating Tumor DNA from 21,807 Advanced Cancer Patients

(2018) Oliver A. Zill et al.   CLINICAL CANCER RESEARCH

False positive plasma genotyping due to clonal hematopoiesis

(2018) Yuebi Hu et al.   CLINICAL CANCER RESEARCH

Circulating Tumor Cell Number as a Response Measure of Prolonged Survival for Metastatic Castration-Resistant Prostate Cancer: A Comparison With Prostate-Specific Antigen Across Five Randomized Phase III Clinical Trials

(2018) Glenn Heller et al.   JOURNAL OF CLINICAL ONCOLOGY

Circulating Tumor DNA Analysis in Patients With Cancer: American Society of Clinical Oncology and College of American Pathologists Joint Review

(2018) Jason D. Merker et al.   JOURNAL OF CLINICAL ONCOLOGY

Analytical Validation of a Hybrid Capture–Based Next-Generation Sequencing Clinical Assay for Genomic Profiling of Cell-Free Circulating Tumor DNA

(2018) Travis A. Clark et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Circulating Tumor Cells in Breast Cancer Patients Treated by Neoadjuvant Chemotherapy: A Meta-analysis

(2018) François-Clément Bidard et al.   JNCI-Journal of the National Cancer Institute

The emerging clinical relevance of genomics in cancer medicine

(2018) Michael F. Berger et al.   Nature Reviews Clinical Oncology

Enzalutamide in Men with Nonmetastatic, Castration-Resistant Prostate Cancer

(2018) Maha Hussain et al.   NEW ENGLAND JOURNAL OF MEDICINE

Apalutamide Treatment and Metastasis-free Survival in Prostate Cancer

(2018) Matthew R. Smith et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ghost cytometry

(2018) Sadao Ota et al.   SCIENCE

Detection and localization of surgically resectable cancers with a multi-analyte blood test

(2018) Joshua D. Cohen et al.   SCIENCE

Circulating Tumor Cells in Breast Cancer Patients Treated by Neoadjuvant Chemotherapy: A Meta-analysis

(2018) François-Clément Bidard et al.   JNCI-Journal of the National Cancer Institute

Assessment of the Validity of Nuclear-Localized Androgen Receptor Splice Variant 7 in Circulating Tumor Cells as a Predictive Biomarker for Castration-Resistant Prostate Cancer

(2018) Howard I. Scher et al.   JAMA Oncology

Patient-Paired Sample Congruence Between 2 Commercial Liquid Biopsy Tests

(2018) Gonzalo Torga et al.   JAMA Oncology

A framework to rank genomic alterations as targets for cancer precision medicine: the ESMO Scale for Clinical Actionability of molecular Targets (ESCAT)

(2018) J Mateo et al.   ANNALS OF ONCOLOGY

How to Agree on a CTC: Evaluating the Consensus in Circulating Tumor Cell Scoring

(2018) Leonie L. Zeune et al.   CYTOMETRY PART A

OUP accepted manuscript

(2018)   JNCI-Journal of the National Cancer Institute

OUP accepted manuscript

(2018)   JNCI-Journal of the National Cancer Institute

Clinical potential of circulating tumour DNA in patients receiving anticancer immunotherapy

(2018) Luc Cabel et al.   Nature Reviews Clinical Oncology

The genetic landscape and clonal evolution of breast cancer resistance to palbociclib plus fulvestrant in the PALOMA-3 trial

(2018) Ben O'Leary et al.   Cancer Discovery

Prostate cancer screening with prostate-specific antigen (PSA) test: a systematic review and meta-analysis

(2018) Dragan Ilic et al.   BMJ-British Medical Journal

Association of Circulating Tumor Cells With Late Recurrence of Estrogen Receptor–Positive Breast Cancer

(2018) Joseph Sparano et al.   JAMA Oncology

Diagnostic leukapheresis for CTC analysis in breast cancer patients: CTC frequency, clinical experiences and recommendations for standardized reporting

(2018) Tanja N. Fehm et al.   CYTOMETRY PART A

Does Size Matter? Comparison of Extraction Yields for Different-Sized DNA Fragments by Seven Different Routine and Four New Circulating Cell-Free Extraction Methods

(2018) Linda Cook et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Sensitive tumour detection and classification using plasma cell-free DNA methylomes

(2018) Shu Yi Shen et al.   NATURE

High-performance medicine: the convergence of human and artificial intelligence

(2018) Eric J. Topol   NATURE MEDICINE

Current and future perspectives of liquid biopsies in genomics-driven oncology

(2018) Ellen Heitzer et al.   NATURE REVIEWS GENETICS

Trastuzumab Emtansine for Residual Invasive HER2-Positive Breast Cancer

(2018) Gunter von Minckwitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Enhanced detection of circulating tumor DNA by fragment size analysis

(2018) Florent Mouliere et al.   Science Translational Medicine

Clinical Implications of Plasma-Based Genotyping With the Delivery of Personalized Therapy in Metastatic Non–Small Cell Lung Cancer

(2018) Charu Aggarwal et al.   JAMA Oncology

Total-Body PET: Maximizing Sensitivity to Create New Opportunities for Clinical Research and Patient Care

(2017) Simon R. Cherry et al.   JOURNAL OF NUCLEAR MEDICINE

Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

(2017) Christopher Abbosh et al.   NATURE

Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

(2017) Ahmet Zehir et al.   NATURE MEDICINE

Disseminated breast tumour cells: biological and clinical meaning

(2017) Klaus Pantel et al.   Nature Reviews Clinical Oncology

Integrating liquid biopsies into the management of cancer

(2017) Giulia Siravegna et al.   Nature Reviews Clinical Oncology

20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years

(2017) Hongchao Pan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Osimertinib or Platinum–Pemetrexed in EGFR T790M–Positive Lung Cancer

(2017) Tony S. Mok et al.   NEW ENGLAND JOURNAL OF MEDICINE

DNA methylation markers for diagnosis and prognosis of common cancers

(2017) Xiaoke Hao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct detection of early-stage cancers using circulating tumor DNA

(2017) Jillian Phallen et al.   Science Translational Medicine

Effectiveness of circulating tumor DNA for detection of KRAS gene mutations in colorectal cancer patients: a meta-analysis

(2017) Yi-xin Hao et al.   OncoTargets and Therapy

Whole blood stabilization for the microfluidic isolation and molecular characterization of circulating tumor cells

(2017) Keith H. K. Wong et al.   Nature Communications

Effectiveness of Breast Cancer Screening: Systematic Review and Meta-analysis to Update the 2009 U.S. Preventive Services Task Force Recommendation

(2016) Heidi D. Nelson et al.   ANNALS OF INTERNAL MEDICINE

The Effect of Preservative and Temperature on the Analysis of Circulating Tumor DNA

(2016) Sonya Parpart-Li et al.   CLINICAL CANCER RESEARCH

Frequent detection of PIK3CA mutations in single circulating tumor cells of patients suffering from HER2-negative metastatic breast cancer

(2016) Christin Gasch et al.   Molecular Oncology

Integrated digital error suppression for improved detection of circulating tumor DNA

(2016) Aaron M Newman et al.   NATURE BIOTECHNOLOGY

Association of AR-V7 on Circulating Tumor Cells as a Treatment-Specific Biomarker With Outcomes and Survival in Castration-Resistant Prostate Cancer

(2016) Howard I. Scher et al.   JAMA Oncology

Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

(2015) D. P. Steensma et al.   BLOOD

Circulating Tumor Cells and Circulating Tumor DNA: Challenges and Opportunities on the Path to Clinical Utility

(2015) M. Ignatiadis et al.   CLINICAL CANCER RESEARCH

Serial monitoring of circulating tumor DNA in patients with primary breast cancer for detection of occult metastatic disease

(2015) Eleonor Olsson et al.   EMBO Molecular Medicine

Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT)

(2015) Donavan T. Cheng et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Challenges in circulating tumor cell detection by the CellSearch system

(2015) Kiki C. Andree et al.   Molecular Oncology

Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer

(2015) Isaac Garcia-Murillas et al.   Science Translational Medicine

Plasma circulating tumor DNA as an alternative to metastatic biopsies for mutational analysis in breast cancer

(2014) F. Rothé et al.   ANNALS OF ONCOLOGY

Coexistence of EGFR with KRAS, or BRAF, or PIK3CA somatic mutations in lung cancer: a comprehensive mutation profiling from 5125 Chinese cohorts

(2014) S Li et al.   BRITISH JOURNAL OF CANCER

Noninvasive Detection of Response and Resistance in EGFR-Mutant Lung Cancer Using Quantitative Next-Generation Genotyping of Cell-Free Plasma DNA

(2014) G. R. Oxnard et al.   CLINICAL CANCER RESEARCH

PIK3CA Mutational Status in Circulating Tumor Cells Can Change During Disease Recurrence or Progression in Patients with Breast Cancer

(2014) A. Markou et al.   CLINICAL CANCER RESEARCH

Circulating Tumor Cells and Response to Chemotherapy in Metastatic Breast Cancer: SWOG S0500

(2014) Jeffrey B. Smerage et al.   JOURNAL OF CLINICAL ONCOLOGY

Clinical Outcome With Correlation to Disseminated Tumor Cell (DTC) Status After DTC-Guided Secondary Adjuvant Treatment With Docetaxel in Early Breast Cancer

(2014) Bjørn Naume et al.   JOURNAL OF CLINICAL ONCOLOGY

Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis

(2014) Patricia Cortazar et al.   LANCET

Clinical validity of circulating tumour cells in patients with metastatic breast cancer: a pooled analysis of individual patient data

(2014) François-Clément Bidard et al.   LANCET ONCOLOGY

Comparative genomic hybridisation array and DNA sequencing to direct treatment of metastatic breast cancer: a multicentre, prospective trial (SAFIR01/UNICANCER)

(2014) Fabrice André et al.   LANCET ONCOLOGY

Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer

(2014) Cassandra L Hodgkinson et al.   NATURE MEDICINE

AR-V7 and Resistance to Enzalutamide and Abiraterone in Prostate Cancer

(2014) Emmanuel S. Antonarakis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility

(2014) M. Yu et al.   SCIENCE

Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

(2014) C. Bettegowda et al.   Science Translational Medicine

Mutational heterogeneity in cancer and the search for new cancer-associated genes

(2013) Michael S. Lawrence et al.   NATURE

Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

(2013) Muhammed Murtaza et al.   NATURE

Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing

(2013) Garrett M Frampton et al.   NATURE BIOTECHNOLOGY

Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer

(2013) Sarah-Jane Dawson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Tumor-associated copy number changes in the circulation of patients with prostate cancer identified through whole-genome sequencing

(2013) Ellen Heitzer et al.   Genome Medicine

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

(2012) Sandra Misale et al.   NATURE

The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers

(2012) Luis A. Diaz Jr et al.   NATURE

Evolution of the cancer genome

(2012) Lucy R. Yates et al.   NATURE REVIEWS GENETICS

Single Cell Profiling of Circulating Tumor Cells: Transcriptional Heterogeneity and Diversity from Breast Cancer Cell Lines

(2012) Ashley A. Powell et al.   PLoS One

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Tumour evolution inferred by single-cell sequencing

(2011) Nicholas Navin et al.   NATURE

Neoadjuvant chemotherapy with trastuzumab followed by adjuvant trastuzumab versus neoadjuvant chemotherapy alone, in patients with HER2-positive locally advanced breast cancer (the NOAH trial): a randomised controlled superiority trial with a parallel HER2-negative cohort

(2010) Luca Gianni et al.   LANCET

KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer

(2010) Wendy De Roock et al.   LANCET ONCOLOGY

International network of cancer genome projects

(2010) Thomas J. Hudson (Chairperson) et al.   NATURE

Circulating tumour cells in cancer patients: challenges and perspectives

(2010) Klaus Pantel et al.   TRENDS IN MOLECULAR MEDICINE

Prognostic significance of circulating tumor cells in patients with metastatic colorectal cancer

(2009) S. J. Cohen et al.   ANNALS OF ONCOLOGY

The Evaluation of Genomic Applications in Practice and Prevention (EGAPP) initiative: methods of the EGAPP Working Group

(2009) Steven M Teutsch et al.   GENETICS IN MEDICINE

Prognostic Value of the Molecular Detection of Circulating Tumor Cells Using a Multimarker Reverse Transcription-PCR Assay for Cytokeratin 19, Mammaglobin A, and HER2 in Early Breast Cancer

(2008) M. Ignatiadis et al.   CLINICAL CANCER RESEARCH

New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)

(2008) E.A. Eisenhauer et al.   EUROPEAN JOURNAL OF CANCER

Circulating mutant DNA to assess tumor dynamics

(2008) Frank Diehl et al.   NATURE MEDICINE