A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The NCI-MATCH trial and precision medicine in gynecologic cancers

(2018) Lisa Barroilhet et al.   GYNECOLOGIC ONCOLOGY

Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations

(2018) David Tamborero et al.   Genome Medicine

A framework to rank genomic alterations as targets for cancer precision medicine: the ESMO Scale for Clinical Actionability of molecular Targets (ESCAT)

(2018) J Mateo et al.   ANNALS OF ONCOLOGY

ClinGen Allele Registry links information about genetic variants

(2018) Piotr Pawliczek et al.   HUMAN MUTATION

Standards and Guidelines for the Interpretation and Reporting of Sequence Variants in Cancer

(2017) Marilyn M. Li et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer

(2017) Malachi Griffith et al.   NATURE GENETICS

Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

(2017) Ahmet Zehir et al.   NATURE MEDICINE

Sharing Clinical and Genomic Data on Cancer — The Need for Global Solutions

(2017)   NEW ENGLAND JOURNAL OF MEDICINE

The EBI search engine: EBI search as a service—making biological data accessible for all

(2017) Young M. Park et al.   NUCLEIC ACIDS RESEARCH

AACR Project GENIE: Powering Precision Medicine through an International Consortium

(2017)   Cancer Discovery

Circulating tumor DNA identified by targeted sequencing in advanced-stage non-small cell lung cancer patients

(2016) Song Xu et al.   CANCER LETTERS

Facilitating a culture of responsible and effective sharing of cancer genome data

(2016) Lillian L Siu et al.   NATURE MEDICINE

DoCM: a database of curated mutations in cancer

(2016) Benjamin J Ainscough et al.   NATURE METHODS

The Monarch Initiative: an integrative data and analytic platform connecting phenotypes to genotypes across species

(2016) Christopher J. Mungall et al.   NUCLEIC ACIDS RESEARCH

COSMIC: somatic cancer genetics at high-resolution

(2016) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Molecular profiling of advanced solid tumors and patient outcomes with genotype-matched clinical trials: the Princess Margaret IMPACT/COMPACT trial

(2016) Tracy L. Stockley et al.   Genome Medicine

Somatic cancer variant curation and harmonization through consensus minimum variant level data

(2016) Deborah I. Ritter et al.   Genome Medicine

Targeting HER2 aberrations as actionable drivers in lung cancers: phase II trial of the pan-HER tyrosine kinase inhibitor dacomitinib in patients with HER2-mutant or amplified tumors

(2015) M. G. Kris et al.   ANNALS OF ONCOLOGY

Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology

(2015) Sue Richards et al.   GENETICS IN MEDICINE

Cancer Driver Log (CanDL)

(2015) Senthilkumar Damodaran et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

ClinGen — The Clinical Genome Resource

(2015) Heidi L. Rehm et al.   NEW ENGLAND JOURNAL OF MEDICINE

ChEMBL web services: streamlining access to drug discovery data and utilities

(2015) Mark Davies et al.   NUCLEIC ACIDS RESEARCH

PubChem Substance and Compound databases

(2015) Sunghwan Kim et al.   NUCLEIC ACIDS RESEARCH

ClinVar: public archive of interpretations of clinically relevant variants

(2015) Melissa J. Landrum et al.   NUCLEIC ACIDS RESEARCH

All the World's a Stage: Facilitating Discovery Science and Improved Cancer Care through the Global Alliance for Genomics and Health

(2015) M. Lawler et al.   Cancer Discovery

Database of Genomic Biomarkers for Cancer Drugs and Clinical Targetability in Solid Tumors

(2015) Rodrigo Dienstmann et al.   Cancer Discovery

UpSet: Visualization of Intersecting Sets

(2014) Alexander Lex et al.   IEEE TRANSACTIONS ON VISUALIZATION AND COMPUTER GRAPHICS

Disease Ontology 2015 update: an expanded and updated database of human diseases for linking biomedical knowledge through disease data

(2014) Warren A. Kibbe et al.   NUCLEIC ACIDS RESEARCH

Standardized description of scientific evidence using the Evidence Ontology (ECO)

(2014) M. C. Chibucos et al.   Database-The Journal of Biological Databases and Curation

DNA-Mutation Inventory to Refine and Enhance Cancer Treatment (DIRECT): A Catalog of Clinically Relevant Cancer Mutations to Enable Genome-Directed Anticancer Therapy

(2013) P. Yeh et al.   CLINICAL CANCER RESEARCH

Pharmacogenomics Knowledge for Personalized Medicine

(2012) M Whirl-Carrillo et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Activating HER2 Mutations in HER2 Gene Amplification Negative Breast Cancer

(2012) Ron Bose et al.   Cancer Discovery