Clinical relevance of blood-based ctDNA analysis: mutation detection and beyond
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Title
Clinical relevance of blood-based ctDNA analysis: mutation detection and beyond
Authors
Keywords
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Journal
BRITISH JOURNAL OF CANCER
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-09-24
DOI
10.1038/s41416-020-01047-5
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Note: Only part of the references are listed.- Hypoxia differently modulates the release of mitochondrial and nuclear DNA
- (2020) Amaelle Otandault et al. BRITISH JOURNAL OF CANCER
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- (2020) Anjui Wu et al. JOURNAL OF CLINICAL INVESTIGATION
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- (2019) Xiaoji Chen et al. CLINICAL CANCER RESEARCH
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- (2019) Yaxiong Zhang et al. Molecular Cancer
- Assessment of circulating tumor DNA in pediatric solid tumors: The promise of liquid biopsies
- (2019) Samuel D. Abbou et al. PEDIATRIC BLOOD & CANCER
- Epigenetic Biomarkers in Cell-Free DNA and Applications in Liquid Biopsy
- (2019) Wanxia Gai et al. Genes
- Clinical Implications of Circulating Tumor DNA Tumor Mutational Burden (ctDNA TMB) in Non‐Small Cell Lung Cancer
- (2019) Young Kwang Chae et al. ONCOLOGIST
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- (2019) Adrienne Boire et al. NEURO-ONCOLOGY
- Liquid biopsy and minimal residual disease — latest advances and implications for cure
- (2019) Klaus Pantel et al. Nature Reviews Clinical Oncology
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- (2019) Ibiayi Dagogo-Jack et al. Journal of Thoracic Oncology
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- (2019) Wai Kei Jacky Lam et al. JOURNAL OF PATHOLOGY
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- (2019) Elin S. Gray et al. JOURNAL OF MOLECULAR DIAGNOSTICS
- Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin
- (2019) Kun Sun et al. GENOME RESEARCH
- Changes in plasma EBV-DNA and immune status in patients with nasopharyngeal carcinoma after treatment with intensity-modulated radiotherapy
- (2019) Qi Chen et al. Diagnostic Pathology
- Prediction and monitoring of relapse in stage III melanoma using circulating tumor DNA
- (2019) L Tan et al. ANNALS OF ONCOLOGY
- Pre-operative ctDNA predicts survival in high-risk stage III cutaneous melanoma patients
- (2019) J H Lee et al. ANNALS OF ONCOLOGY
- Life and death of circulating cell-free DNA
- (2019) Anatoli Kustanovich et al. CANCER BIOLOGY & THERAPY
- Early Detection of Metastatic Relapse and Monitoring of Therapeutic Efficacy by Ultra-Deep Sequencing of Plasma Cell-Free DNA in Patients With Urothelial Bladder Carcinoma
- (2019) Emil Christensen et al. JOURNAL OF CLINICAL ONCOLOGY
- Liquid biopsy of HPV DNA in cervical cancer
- (2019) Tak Hong Cheung et al. JOURNAL OF CLINICAL VIROLOGY
- Genome-wide cell-free DNA fragmentation in patients with cancer
- (2019) Stephen Cristiano et al. NATURE
- Utility of ctDNA to support patient selection for early phase clinical trials: the TARGET study
- (2019) Dominic G. Rothwell et al. NATURE MEDICINE
- Targeting DNA Methylation and EZH2 Activity to Overcome Melanoma Resistance to Immunotherapy
- (2019) Abdullah Al Emran et al. TRENDS IN IMMUNOLOGY
- Analysis of Plasma Cell-Free DNA by Ultradeep Sequencing in Patients With Stages I to III Colorectal Cancer
- (2019) Thomas Reinert et al. JAMA Oncology
- Liquid biopsy in the era of immuno-oncology: is it ready for prime-time use for cancer patients?
- (2019) P Hofman et al. ANNALS OF ONCOLOGY
- Prospective Observation: Clinical Utility of Plasma Epstein‐Barr‐Virus DNA Load in EBV‐associated Gastric Carcinoma Patients
- (2019) Miao‐Zhen Qiu et al. INTERNATIONAL JOURNAL OF CANCER
- Head and neck cancer: searching for genomic and epigenetic biomarkers in body fluids – the state of art
- (2019) Ilda Patrícia Ribeiro et al. Molecular Cytogenetics
- Tumor mutation burden and circulating tumor DNA in combined CTLA-4 and PD-1 antibody therapy in metastatic melanoma – results of a prospective biomarker study
- (2019) Andrea Forschner et al. Journal for ImmunoTherapy of Cancer
- Non-blood sources of cell-free DNA for cancer molecular profiling in clinical pathology and oncology
- (2019) Giovanni Ponti et al. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
- Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers
- (2019) Aparna R. Parikh et al. NATURE MEDICINE
- Salivary HPV DNA informs locoregional disease status in advanced HPV-associated oropharyngeal cancer
- (2019) Glenn J. Hanna et al. ORAL ONCOLOGY
- DNA analysis of low- and high-density fractions defines heterogeneous subpopulations of small extracellular vesicles based on their DNA cargo and topology
- (2019) Elisa Lázaro-Ibáñez et al. Journal of Extracellular Vesicles
- Toward the Early Detection of Cancer by Decoding the Epigenetic and Environmental Fingerprints of Cell-Free DNA
- (2019) Ymke van der Pol et al. CANCER CELL
- Multicenter Evaluation of Circulating Cell-Free DNA Extraction and Downstream Analyses for the Development of Standardized (Pre)analytical Work Flows
- (2019) Rita Lampignano et al. CLINICAL CHEMISTRY
- High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants
- (2019) Pedram Razavi et al. NATURE MEDICINE
- Inference of transcription factor binding from cell-free DNA enables tumor subtype prediction and early detection
- (2019) Peter Ulz et al. Nature Communications
- Liquid biopsy tracking during sequential chemo-radiotherapy identifies distinct prognostic phenotypes in nasopharyngeal carcinoma
- (2019) Jiawei Lv et al. Nature Communications
- Salivary Biomarkers for Oral Squamous Cell Carcinoma Diagnosis and Follow-Up: Current Status and Perspectives
- (2019) Marta Cristaldi et al. Frontiers in Physiology
- Validation of a Plasma-Based Comprehensive Cancer Genotyping Assay Utilizing Orthogonal Tissue- and Plasma-Based Methodologies
- (2018) Justin I. Odegaard et al. CLINICAL CANCER RESEARCH
- Liquid Profiling of Circulating Tumor DNA in Plasma of Melanoma Patients for Companion Diagnostics and Monitoring of BRAF Inhibitor Therapy
- (2018) Verena Haselmann et al. CLINICAL CHEMISTRY
- Liver- and Colon-Specific DNA Methylation Markers in Plasma for Investigation of Colorectal Cancers With or Without Liver Metastases
- (2018) Wanxia Gai et al. CLINICAL CHEMISTRY
- Circulating human papillomavirus DNA as a surveillance tool in head and neck squamous cell carcinoma: A systematic review and meta-analysis
- (2018) K.K. Jensen et al. CLINICAL OTOLARYNGOLOGY
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- (2018) Jelena Belic et al. INTERNATIONAL JOURNAL OF CANCER
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- (2018) Jason D. Merker et al. JOURNAL OF CLINICAL ONCOLOGY
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- (2018) Christopher Douville et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sequencing-based counting and size profiling of plasma Epstein–Barr virus DNA enhance population screening of nasopharyngeal carcinoma
- (2018) W. K. Jacky Lam et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Detection and localization of surgically resectable cancers with a multi-analyte blood test
- (2018) Joshua D. Cohen et al. SCIENCE
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- (2018) Philip Burnham et al. Nature Communications
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- (2018) Hai Zemmour et al. Nature Communications
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- (2018) Havell Markus et al. Scientific Reports
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- (2018) Qiu-Yan Chen et al. Cancer Research and Treatment
- Dynamic changes in plasma Epstein-Barr virus DNA load during treatment have prognostic value in nasopharyngeal carcinoma: a retrospective study
- (2018) Sha-Sha He et al. Cancer Medicine
- Epstein–Barr Virus and Cancer
- (2018) Paul J. Farrell Annual Review of Pathology-Mechanisms of Disease
- Ultra-Sensitive Mutation Detection and Genome-Wide DNA Copy Number Reconstruction by Error-Corrected Circulating Tumor DNA Sequencing
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- Clinical potential of circulating tumour DNA in patients receiving anticancer immunotherapy
- (2018) Luc Cabel et al. Nature Reviews Clinical Oncology
- Longitudinal Liquid Biopsy and Mathematical Modeling of Clonal Evolution Forecast Time to Treatment Failure in the PROSPECT-C Phase II Colorectal Cancer Clinical Trial
- (2018) Khurum H. Khan et al. Cancer Discovery
- Measurement of Plasma Cell-Free Mitochondrial Tumor DNA Improves Detection of Glioblastoma in Patient-Derived Orthotopic Xenograft Models
- (2018) Richard Mair et al. CANCER RESEARCH
- Clinical validity of HPV circulating tumor DNA in advanced anal carcinoma: an ancillary study to the Epitopes-HPV02 trial
- (2018) Alice Bernard-Tessier et al. CLINICAL CANCER RESEARCH
- Detection of cell‐free DNA fragmentation and copy number alterations in cerebrospinal fluid from glioma patients
- (2018) Florent Mouliere et al. EMBO Molecular Medicine
- Does Size Matter? Comparison of Extraction Yields for Different-Sized DNA Fragments by Seven Different Routine and Four New Circulating Cell-Free Extraction Methods
- (2018) Linda Cook et al. JOURNAL OF CLINICAL MICROBIOLOGY
- Sensitive tumour detection and classification using plasma cell-free DNA methylomes
- (2018) Shu Yi Shen et al. NATURE
- Current and future perspectives of liquid biopsies in genomics-driven oncology
- (2018) Ellen Heitzer et al. NATURE REVIEWS GENETICS
- Enhanced detection of circulating tumor DNA by fragment size analysis
- (2018) Florent Mouliere et al. Science Translational Medicine
- Donor-specific Cell-Free DNA as a Biomarker in Solid Organ Transplantation. A Systematic Review
- (2018) Simon R. Knight et al. TRANSPLANTATION
- New insights into structural features and optimal detection of circulating tumor DNA determined by single-strand DNA analysis
- (2018) Cynthia Sanchez et al. npj Genomic Medicine
- Viral-Cellular DNA Junctions as Molecular Markers for Assessing Intra-Tumor Heterogeneity in Cervical Cancer and for the Detection of Circulating Tumor DNA
- (2017) Katrin Carow et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution
- (2017) Christopher Abbosh et al. NATURE
- Circulating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma
- (2017) Rui-hua Xu et al. NATURE MATERIALS
- Analysis of Plasma Epstein–Barr Virus DNA to Screen for Nasopharyngeal Cancer
- (2017) K.C. Allen Chan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Human papillomavirus DNA detection in plasma and cervical samples of women with a recent history of low grade or precancerous cervical dysplasia
- (2017) Clementina Elvezia Cocuzza et al. PLoS One
- Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors
- (2017) Viktor A. Adalsteinsson et al. Nature Communications
- Genomic Landscape of Cell-Free DNA in Patients with Colorectal Cancer
- (2017) John H. Strickler et al. Cancer Discovery
- Detection of ubiquitous and heterogeneous mutations in cell-free DNA from patients with early-stage non-small-cell lung cancer
- (2016) M. Jamal-Hanjani et al. ANNALS OF ONCOLOGY
- Distinct subclonal tumour responses to therapy revealed by circulating cell-free DNA
- (2016) G. Gremel et al. ANNALS OF ONCOLOGY
- Characterization of the cell-free DNA released by cultured cancer cells
- (2016) Abel Jacobus Bronkhorst et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Nanopore sequencing detects structural variants in cancer
- (2016) Alexis L. Norris et al. CANCER BIOLOGY & THERAPY
- Cell-free DNA Comprises an In Vivo Nucleosome Footprint that Informs Its Tissues-Of-Origin
- (2016) Matthew W. Snyder et al. CELL
- Methylated circulating tumor DNA in blood: power in cancer prognosis and response
- (2016) Kristina Warton et al. ENDOCRINE-RELATED CANCER
- Nucleosome mapping in plasma DNA predicts cancer gene expression
- (2016) Muhammed Murtaza et al. NATURE GENETICS
- Inferring expressed genes by whole-genome sequencing of plasma DNA
- (2016) Peter Ulz et al. NATURE GENETICS
- Epigenetic modulators, modifiers and mediators in cancer aetiology and progression
- (2016) Andrew P. Feinberg et al. NATURE REVIEWS GENETICS
- Assessment of the total cfDNA and HPV16/18 detection in plasma samples of head and neck squamous cell carcinoma patients
- (2016) Agnieszka M. Mazurek et al. ORAL ONCOLOGY
- Identification of tissue-specific cell death using methylation patterns of circulating DNA
- (2016) Roni Lehmann-Werman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Profiling genome-wide DNA methylation
- (2016) Wai-Shin Yong et al. Epigenetics & Chromatin
- Fragment Length of Circulating Tumor DNA
- (2016) Hunter R. Underhill et al. PLoS Genetics
- Exploratory Analysis of TP53 Mutations in Circulating Tumour DNA as Biomarkers of Treatment Response for Patients with Relapsed High-Grade Serous Ovarian Carcinoma: A Retrospective Study
- (2016) Christine A. Parkinson et al. PLOS MEDICINE
- High level of chromosomal instability in circulating tumor cells of ROS1-rearranged non-small-cell lung cancer
- (2015) E. Pailler et al. ANNALS OF ONCOLOGY
- Non-random fragmentation patterns in circulating cell-free DNA reflect epigenetic regulation
- (2015) Maxim Ivanov et al. BMC GENOMICS
- PIK3CA mutations in serum DNA are predictive of recurrence in primary breast cancer patients
- (2015) Chiya Oshiro et al. BREAST CANCER RESEARCH AND TREATMENT
- Circulating human papillomavirus DNA as a marker for disease extent and recurrence among patients with oropharyngeal cancer
- (2015) Kristina R. Dahlstrom et al. CANCER
- Integrative analysis of 111 reference human epigenomes
- (2015) Anshul Kundaje et al. NATURE
- Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments
- (2015) Kun Sun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients
- (2015) Peiyong Jiang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas
- (2015) Yuxuan Wang et al. Science Translational Medicine
- Detection of Clonal and Subclonal Copy-Number Variants in Cell-Free DNA from Patients with Breast Cancer Using a Massively Multiplexed PCR Methodology
- (2015) Eser Kirkizlar et al. Translational Oncology
- Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer
- (2015) Muhammed Murtaza et al. Nature Communications
- Plasma Epstein–Barr viral DNA load at midpoint of radiotherapy course predicts outcome in advanced-stage nasopharyngeal carcinoma
- (2014) S. F. Leung et al. ANNALS OF ONCOLOGY
- Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: a proof-of-principle
- (2014) L. De Mattos-Arruda et al. ANNALS OF ONCOLOGY
- Comparison of KRAS mutation analysis of primary tumors and matched circulating cell-free DNA in plasmas of patients with colorectal cancer
- (2014) Yung-Bin Kuo et al. CLINICA CHIMICA ACTA
- Clinical validation of the detection of KRAS and BRAF mutations from circulating tumor DNA
- (2014) Alain R Thierry et al. NATURE MEDICINE
- Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies
- (2014) C. Bettegowda et al. Science Translational Medicine
- Saliva and Plasma Quantitative Polymerase Chain Reaction–Based Detection and Surveillance of Human Papillomavirus–Related Head and Neck Cancer
- (2014) Sun M. Ahn et al. JAMA Otolaryngology-Head & Neck Surgery
- Computational tools for copy number variation (CNV) detection using next-generation sequencing data: features and perspectives
- (2013) Min Zhao et al. BMC BIOINFORMATICS
- Noninvasive Prenatal Methylomic Analysis by Genomewide Bisulfite Sequencing of Maternal Plasma DNA
- (2013) F. M. F. Lun et al. CLINICAL CHEMISTRY
- Tumor-associated copy number changes in the circulation of patients with prostate cancer identified through whole-genome sequencing
- (2013) Ellen Heitzer et al. Genome Medicine
- Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing
- (2012) K. C. A. Chan et al. CLINICAL CHEMISTRY
- Genome-wide nucleosome positioning during embryonic stem cell development
- (2012) Vladimir B Teif et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Human Papillomavirus Mutational Insertion: Specific Marker of Circulating Tumor DNA in Cervical Cancer Patients
- (2012) Maura Campitelli et al. PLoS One
- Noninvasive Identification and Monitoring of Cancer Mutations by Targeted Deep Sequencing of Plasma DNA
- (2012) T. Forshew et al. Science Translational Medicine
- Detection of Chromosomal Alterations in the Circulation of Cancer Patients with Whole-Genome Sequencing
- (2012) R. J. Leary et al. Science Translational Medicine
- Quantitation of Human Papillomavirus DNA in Plasma of Oropharyngeal Carcinoma Patients
- (2011) Hongbin Cao et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Determinants of nucleosome organization in primary human cells
- (2011) Anton Valouev et al. NATURE
- High Fragmentation Characterizes Tumour-Derived Circulating DNA
- (2011) Florent Mouliere et al. PLoS One
- Maternal Plasma DNA Sequencing Reveals the Genome-Wide Genetic and Mutational Profile of the Fetus
- (2010) Y. M. D. Lo et al. Science Translational Medicine
- Circulating tumour cells in cancer patients: challenges and perspectives
- (2010) Klaus Pantel et al. TRENDS IN MOLECULAR MEDICINE
- Nucleosome destabilization in the epigenetic regulation of gene expression
- (2007) Steven Henikoff NATURE REVIEWS GENETICS
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