Nuclear receptors, the aryl hydrocarbon receptor, and macrophage function

New Insights on the Role of Lipid Metabolism in the Metabolic Reprogramming of Macrophages

(2020) Ana Batista-Gonzalez et al.   Frontiers in Immunology

Intracellular and Intercellular Aspects of Macrophage Immunometabolism in Atherosclerosis

(2020) Ira Tabas et al.   CIRCULATION RESEARCH

Phagocytosis of Apoptotic Cells in Resolution of Inflammation

(2020) Ioannis Kourtzelis et al.   Frontiers in Immunology

Phagocytosis: Our Current Understanding of a Universal Biological Process

(2020) Eileen Uribe-Querol et al.   Frontiers in Immunology

Vitamin D Regulates MerTK-Dependent Phagocytosis in Human Myeloid Cells

(2020) Jelani Clarke et al.   JOURNAL OF IMMUNOLOGY

Anti-inflammatory functions of the glucocorticoid receptor require DNA binding

(2020) Laura Escoter-Torres et al.   NUCLEIC ACIDS RESEARCH

Polymorphisms of human glucocorticoid receptor gene in systemic lupus erythematosus: a single-centre result

(2019) Anna Bazsó et al.   CLINICAL RHEUMATOLOGY

The role of macrophages in the resolution of inflammation

(2019) Satoshi Watanabe et al.   JOURNAL OF CLINICAL INVESTIGATION

Apoptosis and Clearance of Apoptotic Cells

(2018) Shigekazu Nagata   Annual Review of Immunology

Microglial control of astrocytes in response to microbial metabolites

(2018) Veit Rothhammer et al.   NATURE

Apoptotic cell–induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans

(2018) Rahul Shinde et al.   NATURE IMMUNOLOGY

Impaired resolution of DSS-induced colitis in mice lacking the glucocorticoid receptor in myeloid cells

(2018) Garrit K. Meers et al.   PLoS One

Therapeutic Mechanisms of Glucocorticoids

(2018) Jolien Vandewalle et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements

(2018) William H. Hudson et al.   Nature Communications

Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism

(2018) Duco Steven Koenis et al.   Cell Reports

The Role of Efferocytosis in Autoimmune Diseases

(2018) Fereshte Abdolmaleki et al.   Frontiers in Immunology

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair

(2018) Shuang Zhang et al.   Cell Metabolism

The Aryl Hydrocarbon Receptor: Connecting Immunity to the Microenvironment

(2018) Rahul Shinde et al.   TRENDS IN IMMUNOLOGY

LXR Suppresses Inflammatory Gene Expression and Neutrophil Migration through cis-Repression and Cholesterol Efflux

(2018) David G. Thomas et al.   Cell Reports

A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors

(2017) Luqiao Wang et al.   Journal of Hematology & Oncology

PPAR-α Activation Mediates Innate Host Defense through Induction of TFEB and Lipid Catabolism

(2017) Yi Sak Kim et al.   JOURNAL OF IMMUNOLOGY

Structural hierarchy controlling dimerization and target DNA recognition in the AHR transcriptional complex

(2017) Seung-Hyeon Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type I Interferon in Chronic Virus Infection and Cancer

(2017) Laura M. Snell et al.   TRENDS IN IMMUNOLOGY

Macrophage Immunometabolism: Where Are We (Going)?

(2017) Jan Van den Bossche et al.   TRENDS IN IMMUNOLOGY

RORα Induces KLF4-Mediated M2 Polarization in the Liver Macrophages that Protect against Nonalcoholic Steatohepatitis

(2017) Yong-Hyun Han et al.   Cell Reports

Macrophage Metabolism As Therapeutic Target for Cancer, Atherosclerosis, and Obesity

(2017) Xenia Geeraerts et al.   Frontiers in Immunology

Phase I/II Trial of StemRegenin-1 Expanded Umbilical Cord Blood Hematopoietic Stem Cells Supports Testing as a Stand-Alone Graft

(2016) John E. Wagner et al.   Cell Stem Cell

Nuclear receptor function in skin health and disease: therapeutic opportunities in the orphan and adopted receptor classes

(2016) Kelvin Yin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The life cycle of phagosomes: formation, maturation, and resolution

(2016) Roni Levin et al.   IMMUNOLOGICAL REVIEWS

Retinoid acid receptor-related orphan receptor alpha (RORα) regulates macrophage M2 polarization via activation of AMPKα

(2016) Lei Xiao et al.   MOLECULAR IMMUNOLOGY

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

(2016) Bruno Lamas et al.   NATURE MEDICINE

Defects in lysosomal maturation facilitate the activation of innate sensors in systemic lupus erythematosus

(2016) Andrew J. Monteith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The neuron-derived orphan receptor 1 (NOR1) is induced upon human alternative macrophage polarization and stimulates the expression of markers of the M2 phenotype

(2015) F. De Paoli et al.   ATHEROSCLEROSIS

Treatment in vitro with PPARα and PPARγ ligands drives M1-to-M2 polarization of macrophages from T. cruzi-infected mice

(2015) Federico Penas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Glucocorticoids enhance prolonged clearance of apoptotic cells by upregulating liver X receptor, peroxisome proliferator-activated receptor-δ and UCP2

(2015) Éva Garabuczi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Orphan Nuclear Receptor ERRα Controls Macrophage Metabolic Signaling and A20 Expression to Negatively Regulate TLR-Induced Inflammation

(2015) Jae-Min Yuk et al.   IMMUNITY

Apoptotic cell responses in the splenic marginal zone: a paradigm for immunologic reactions to apoptotic antigens with implications for autoimmunity

(2015) Tracy L. McGaha et al.   IMMUNOLOGICAL REVIEWS

Nuclear Receptor Nr4a2 Promotes Alternative Polarization of Macrophages and Confers Protection in Sepsis

(2015) Sahil Mahajan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transcription factor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation

(2015) Iftach Shaked et al.   NATURE IMMUNOLOGY

The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity

(2015) Buvana Ravishankar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vitamin D receptor TaqI and ApaI polymorphisms: A comparative study in patients with Behçet’s disease and Rheumatoid arthritis in Tunisian population

(2014) Kalthoum Tizaoui et al.   CELLULAR IMMUNOLOGY

TRα Protects Against Atherosclerosis in Male Mice: Identification of a Novel Anti-Inflammatory Property for TRα in Mice

(2014) Cyrielle Billon et al.   ENDOCRINOLOGY

Effects of Liver X Receptor Agonist Treatment on Pulmonary Inflammation and Host Defense

(2014) K. Smoak et al.   JOURNAL OF IMMUNOLOGY

The Nuclear Receptor Nr4a1 Mediates Anti-Inflammatory Effects of Apoptotic Cells

(2014) N. Ipseiz et al.   JOURNAL OF IMMUNOLOGY

Aryl hydrocarbon receptor control of a disease tolerance defence pathway

(2014) Alban Bessede et al.   NATURE

Nutrient-sensing nuclear receptors coordinate autophagy

(2014) Jae Man Lee et al.   NATURE

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

(2014) Stanley Ching-Cheng Huang et al.   NATURE IMMUNOLOGY

Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages

(2014) Christoph Schneider et al.   NATURE IMMUNOLOGY

Vitamin D receptor gene polymorphisms in Iranian Azary patients with Behçet’s disease

(2014) S Kolahi et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Immunosuppression via adenosine receptor activation by adenosine monophosphate released from apoptotic cells

(2014) Hiroshi Yamaguchi et al.   eLife

Milk fat globule-EGF factor 8 mediates the enhancement of apoptotic cell clearance by glucocorticoids

(2013) K Lauber et al.   CELL DEATH AND DIFFERENTIATION

The Relationship between Metabolism and the Autophagy Machinery during the Innate Immune Response

(2013) Jennifer Martinez et al.   Cell Metabolism

Metabolic Pathways in Immune Cell Activation and Quiescence

(2013) Erika L. Pearce et al.   IMMUNITY

HumanIL10Gene Repression by Rev-erbα AmelioratesMycobacterium tuberculosisClearance

(2013) Vemika Chandra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The nuclear receptor LXRα controls the functional specialization of splenic macrophages

(2013) Noelia A-Gonzalez et al.   NATURE IMMUNOLOGY

Elevated levels of PPAR-gamma in the cerebrospinal fluid of patients with multiple sclerosis

(2013) Levente Szalardy et al.   NEUROSCIENCE LETTERS

PPARα and PPARγ regulate the nucleoside transporter hENT1

(2012) Trinidad D. Montero et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase

(2012) B. Ravishankar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bone Marrow–Specific Deficiency of Nuclear Receptor Nur77 Enhances Atherosclerosis

(2011) Anouk A.J. Hamers et al.   CIRCULATION RESEARCH

Associations of vitamin D receptor gene polymorphisms FokI and BsmI with susceptibility to rheumatoid arthritis and Behçet's disease in Tunisians

(2011) Emna Fakhfakh Karray et al.   JOINT BONE SPINE

Glucocorticoids Sensitize the Innate Immune System through Regulation of the NLRP3 Inflammasome

(2011) John M. Busillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

(2011) Christiane A. Opitz et al.   NATURE

Equilibrative Nucleoside Transporter 3 Deficiency Perturbs Lysosome Function and Macrophage Homeostasis

(2011) C.-L. Hsu et al.   SCIENCE

Negative regulation by nuclear receptors: a plethora of mechanisms

(2011) Guilherme M. Santos et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Glucocorticoids promote survival of anti-inflammatory macrophages via stimulation of adenosine receptor A3

(2010) K. Barczyk et al.   BLOOD

Autoimmune Kidney Disease and Impaired Engulfment of Apoptotic Cells in Mice with Macrophage Peroxisome Proliferator-Activated Receptor   or Retinoid X Receptor   Deficiency

(2010) T. Roszer et al.   JOURNAL OF IMMUNOLOGY

An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis

(2010) F. J. Quintana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical Features Associated with Glucocorticoid Receptor Polymorphisms

(2009) Laura Manenschijn et al.   Annals of the New York Academy of Sciences

An anatomical view on macrophages in tolerance

(2009) Fredrik Wermeling et al.   AUTOIMMUNITY REVIEWS

Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR

(2009) Noelia A-Gonzalez et al.   IMMUNITY

Differential Transcriptional Expression of PPARα, PPARγ1, and PPARγ2 in the Peritoneal Macrophages and T-cell Subsets of Non-obese Diabetic Mice

(2009) Nik-Soriani Yaacob et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses

(2009) Akihiro Kimura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Glucocorticoids Induce Protein S-Dependent Phagocytosis of Apoptotic Neutrophils by Human Macrophages

(2009) A. McColl et al.   JOURNAL OF IMMUNOLOGY

PPAR-δ senses and orchestrates clearance of apoptotic cells to promote tolerance

(2009) Lata Mukundan et al.   NATURE MEDICINE

Adipocyte-Derived Th2 Cytokines and Myeloid PPARδ Regulate Macrophage Polarization and Insulin Sensitivity

(2008) Kihwa Kang et al.   Cell Metabolism

Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

(2008) Justin I. Odegaard et al.   Cell Metabolism

The Nuclear Receptor Rev-erbα Is a Liver X Receptor (LXR) Target Gene Driving a Negative Feedback Loop on Select LXR-Induced Pathways in Human Macrophages

(2008) Coralie Fontaine et al.   MOLECULAR ENDOCRINOLOGY

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

(2008) Marc Veldhoen et al.   NATURE

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

(2008) Francisco J. Quintana et al.   NATURE

Association of the PPARγ gene polymorphism Pro12Ala with delayed onset of multiple sclerosis

(2008) Luisa Klotz et al.   NEUROSCIENCE LETTERS

Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells

(2008) A. Kimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phagosome maturation during the removal of apoptotic cells: receptors lead the way

(2008) Zheng Zhou et al.   TRENDS IN CELL BIOLOGY

Increased Expression of the Orphan Nuclear Receptor NURR1 in Psoriasis and Modulation following TNF-α Inhibition

(2007) Marina O'Kane et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY