TBK1 (TANK-binding kinase 1)-mediated regulation of autophagy in health and disease

TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy

(2020) Takashi Nozawa et al.   Nature Communications

TBK1 regulates YAP/TAZ and fibrogenic fibroblast activation

(2020) Aja Aravamudhan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The cGAS/STING/TBK1/IRF3 innate immunity pathway maintains chromosomal stability through regulation of p21 levels

(2020) Abdul Basit et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1‐Parkin independent manner

(2020) Alex P. Seabright et al.   FASEB JOURNAL

E3 ubiquitin ligase ASB8 negatively regulates interferon via regulating TBK1/IKKi homeostasis

(2020) Yanyu Guo et al.   MOLECULAR IMMUNOLOGY

The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice

(2020) Valeria Gerbino et al.   NEURON

Regulation and repurposing of nutrient sensing and autophagy in innate immunity

(2020) Julia Sanchez-Garrido et al.   Autophagy

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models

(2020) Ramanath Narayana Hegde et al.   EMBO JOURNAL

The Specific IKKε/TBK1 Inhibitor Amlexanox Suppresses Human Melanoma by the Inhibition of Autophagy, NF-κB and MAP Kinase Pathways

(2020) Moritz Möller et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

(2020) Donghyuk Shin et al.   NATURE

Blowing Hot and Cold in ALS: The Duality of TBK1

(2020) Keith Mayl et al.   NEURON

TANK‐binding kinase 1 mediates osteoclast differentiation by regulating NF‐κB, MAPK and Akt signaling pathways

(2020) Shuai Lin et al.   IMMUNOLOGY AND CELL BIOLOGY

ALS-associated TBK1 variant p.G175S is defective in phosphorylation of p62 and impacts TBK1-mediated signalling and TDP-43 autophagic degradation

(2020) A.D. Foster et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Ik2/TBK1 and Hook/Dynein, an adaptor complex for early endosome transport, are genetic modifiers of FTD-associated mutant CHMP2B toxicity in Drosophila

(2020) Yubing Lu et al.   Scientific Reports

Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by Inhibiting Type I IFN Production through Recruiting USP15 to Deubiquitinate TBK1

(2020) Li Huang et al.   Cell Reports

Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice

(2019) David Brenner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intracellular bacteria engage a STING–TBK1–MVB12b pathway to enable paracrine cGAS–STING signalling

(2019) Ramya Nandakumar et al.   Nature Microbiology

DDX19 Inhibits Type I Interferon Production by Disrupting TBK1-IKKε-IRF3 Interactions and Promoting TBK1 and IKKε Degradation

(2019) Kunli Zhang et al.   Cell Reports

Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor

(2019) Douglas W. Thomson et al.   ACS Medicinal Chemistry Letters

Structural basis of STING binding with and phosphorylation by TBK1

(2019) Conggang Zhang et al.   NATURE

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

(2019) Xiang Gui et al.   NATURE

Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy

(2019) Jose Norberto S. Vargas et al.   MOLECULAR CELL

The Cargo Receptor NDP52 Initiates Selective Autophagy by Recruiting the ULK Complex to Cytosol-Invading Bacteria

(2019) Benjamin J. Ravenhill et al.   MOLECULAR CELL

Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation

(2019) Suresh Kumar et al.   DEVELOPMENTAL CELL

Deletion of Tbk1 disrupts autophagy and reproduces behavioral and locomotor symptoms of FTD-ALS in mice

(2019) Weisong Duan et al.   Aging-US

Retinoic acid worsens ATG10-dependent autophagy impairment in TBK1-mutant hiPSC-derived motoneurons through SQSTM1/p62 accumulation

(2019) Alberto Catanese et al.   Autophagy

TANK-binding kinase 1 as a novel therapeutic target for viral diseases

(2019) Chunyuan Zhao et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1

(2019) Baoyu Zhao et al.   NATURE

Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform

(2019) Maria Zachari et al.   DEVELOPMENTAL CELL

NAC1 Potentiates Cellular Antiviral Signaling by Bridging MAVS and TBK1

(2019) Zhangchuan Xia et al.   JOURNAL OF IMMUNOLOGY

Targeting of early endosomes by autophagy facilitates EGFR recycling and signalling

(2019) Jane Fraser et al.   EMBO REPORTS

Cell phenotypic plasticity requires autophagic flux driven by YAP/TAZ mechanotransduction

(2019) Antonio Totaro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of RAB7 by TBK1/IKKε Regulates Innate Immune Signaling in Triple-Negative Breast Cancer

(2019) Jessica L. Ritter et al.   CANCER RESEARCH

TBK1‐mediated phosphorylation of LC3C and GABARAP‐L2 controls autophagosome shedding by ATG4 protease

(2019) Lina Herhaus et al.   EMBO REPORTS

Effects of ALS-associated TANK binding kinase 1 mutations on protein–protein interactions and kinase activity

(2019) Junqiang Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TBK1 Limits mTORC1 by Promoting Phosphorylation of Raptor Ser877

(2019) Ricardo J. Antonia et al.   Scientific Reports

PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis

(2019) Shireen A. Sarraf et al.   Cell Reports

Discovery of BAY-985, a Highly Selective TBK1/IKKε Inhibitor

(2019) Julien Lefranc et al.   JOURNAL OF MEDICINAL CHEMISTRY

TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis

(2019) Lele Zhu et al.   NATURE CELL BIOLOGY

TBK1 Is a Synthetic Lethal Target in Cancer with VHL Loss

(2019) Lianxin Hu et al.   Cancer Discovery

TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue

(2018) Peng Zhao et al.   CELL

Attenuation of cGAS‐STING signaling is mediated by a p62/SQSTM1‐dependent autophagy pathway activated by TBK1

(2018) Thaneas Prabakaran et al.   EMBO JOURNAL

PLA1A Participates in the Antiviral Innate Immune Response by Facilitating the Recruitment of TANK-Binding Kinase 1 to Mitochondria

(2018) Xiaoxiao Gao et al.   Journal of Innate Immunity

A brief history of autophagy from cell biology to physiology and disease

(2018) Noboru Mizushima   NATURE CELL BIOLOGY

Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses

(2018) Israel Cañadas et al.   NATURE MEDICINE

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Common and rare TBK1 variants in early-onset Alzheimer disease in a European cohort

(2018) Jan Verheijen et al.   NEUROBIOLOGY OF AGING

ALS-associated missense and nonsense TBK1 mutations can both cause loss of kinase function

(2018) Martina de Majo et al.   NEUROBIOLOGY OF AGING

The Role of Mitophagy in Innate Immunity

(2018) Ilias Gkikas et al.   Frontiers in Immunology

TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging

(2018) Daichao Xu et al.   CELL

Common Traits Spark the Mitophagy/Xenophagy Interplay

(2018) Aarti Singh et al.   Frontiers in Physiology

Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer

(2018) Joel Durand et al.   Cells

Activated kinase screening identifies the IKBKE oncogene as a positive regulator of autophagy

(2018) Margherita Leonardi et al.   Autophagy

Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy

(2018) The Duy Nguyen et al.   BLOOD

STING directly activates autophagy to tune the innate immune response

(2018) Dong Liu et al.   CELL DEATH AND DIFFERENTIATION

Human TANK-binding kinase 1 is required for early autophagy induction upon herpes simplex virus 1 infection

(2018) Liyana Ahmad et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation

(2018) Elodie Lafont et al.   NATURE CELL BIOLOGY

RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway

(2018) J.-M. Heo et al.   Science Advances

USP1–UAF1 deubiquitinase complex stabilizes TBK1 and enhances antiviral responses

(2017) Zhongxia Yu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity

(2017) Yichuan Xiao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genomic Organization of TBK1 Copy Number Variations in Glaucoma Patients

(2017) Adam P. DeLuca et al.   JOURNAL OF GLAUCOMA

Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1

(2017) Andrew P. Crew et al.   JOURNAL OF MEDICINAL CHEMISTRY

Analysis of known amyotrophic lateral sclerosis and frontotemporal dementia genes reveals a substantial genetic burden in patients manifesting both diseases not carrying theC9orf72expansion mutation

(2017) Oriol Dols-Icardo et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

The autophagy receptor ALLO-1 and the IKKE-1 kinase control clearance of paternal mitochondria in Caenorhabditis elegans

(2017) Miyuki Sato et al.   NATURE CELL BIOLOGY

Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade

(2017) Qian Zhang et al.   NATURE CELL BIOLOGY

Amyotrophic Lateral Sclerosis

(2017) Robert H. Brown et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism

(2017) Maroof Hasan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

(2017) Russell W. Jenkins et al.   Cancer Discovery

Assessment of TANK-binding kinase 1 as a therapeutic target in cancer

(2017) Victoria H. Cruz et al.   Journal of Cell Communication and Signaling

TRIM23 mediates virus-induced autophagy via activation of TBK1

(2017) Konstantin M. J. Sparrer et al.   Nature Microbiology

Recruitment of TBK1 to cytosol‐invading Salmonella induces WIPI2‐dependent antibacterial autophagy

(2016) Teresa LM Thurston et al.   EMBO JOURNAL

Therapeutic potential of targeting TBK1 in autoimmune diseases and interferonopathies

(2016) Maroof Hasan et al.   PHARMACOLOGICAL RESEARCH

Dynamic recruitment and activation of ALS-associated TBK1 with its target optineurin are required for efficient mitophagy

(2016) Andrew S. Moore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin-Dependent And Independent Signals In Selective Autophagy

(2016) Aliaksandr Khaminets et al.   TRENDS IN CELL BIOLOGY

Human TBK1: A Gatekeeper of Neuroinflammation

(2016) Liyana Ahmad et al.   TRENDS IN MOLECULAR MEDICINE

Common Molecular Pathways in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

(2016) Jochen H. Weishaupt et al.   TRENDS IN MOLECULAR MEDICINE

STING Pathway Activation Stimulates Potent Immunity against Acute Myeloid Leukemia

(2016) Emily Curran et al.   Cell Reports

Autophagy Inhibition Dysregulates TBK1 Signaling and Promotes Pancreatic Inflammation

(2016) S. Yang et al.   Cancer Immunology Research

Endosymbiosis and Eukaryotic Cell Evolution

(2015) John M. Archibald   CURRENT BIOLOGY

TBK1 inhibitors: a review of patent literature (2011 – 2014)

(2015) Tao Yu et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

TBK1 controls autophagosomal engulfment of polyubiquitinated mitochondria through p62/SQSTM1 phosphorylation

(2015) Gen Matsumoto et al.   HUMAN MOLECULAR GENETICS

The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy

(2015) Jin-Mi Heo et al.   MOLECULAR CELL

Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

(2015) Axel Freischmidt et al.   NATURE NEUROSCIENCE

Compromised autophagy and neurodegenerative diseases

(2015) Fiona M. Menzies et al.   NATURE REVIEWS NEUROSCIENCE

Emerging strategies to effectively target autophagy in cancer

(2015) V W Rebecca et al.   ONCOGENE

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

(2015) E. T. Cirulli et al.   SCIENCE

Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis

(2015) Smitha Pillai et al.   Nature Communications

TBK1 Regulates Prostate Cancer Dormancy through mTOR Inhibition

(2015) Jin Koo Kim et al.   NEOPLASIA

Targeting an IKBKE cytokine network impairs triple-negative breast cancer growth

(2014) Thanh U. Barbie et al.   JOURNAL OF CLINICAL INVESTIGATION

Evaluating TBK1 as a Therapeutic Target in Cancers with Activated IRF3

(2014) Asli Muvaffak et al.   MOLECULAR CANCER RESEARCH

Recent insights into the complexity of Tank-binding kinase 1 signaling networks: The emerging role of cellular localization in the activation and substrate specificity of TBK1

(2013) Elizabeth Helgason et al.   FEBS LETTERS

Enhanced optineurin E50K–TBK1 interaction evokes protein insolubility and initiates familial primary open-angle glaucoma

(2013) Yuriko Minegishi et al.   HUMAN MOLECULAR GENETICS

Crystal Structure and Mechanism of Activation of TANK-Binding Kinase 1

(2013) Amede Larabi et al.   Cell Reports

Inhibiting autophagy potentiates the anticancer activity of IFN1@/IFNα in chronic myeloid leukemia cells

(2012) Shan Zhu et al.   Autophagy

Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation

(2012) X. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of the ubiquitin-like domain of human TBK1

(2012) Jian Li et al.   Protein & Cell

Primary open-angle glaucoma genes

(2011) J H Fingert   EYE

Polyubiquitin Binding to Optineurin Is Required for Optimal Activation of TANK-binding Kinase 1 and Production of Interferon β

(2011) Catherine E. Gleason et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR Signaling, Function, Novel Inhibitors, and Therapeutic Targets

(2011) R. Watanabe et al.   JOURNAL OF NUCLEAR MEDICINE

Inhibition of TANK Binding Kinase 1 by Herpes Simplex Virus 1 Facilitates Productive Infection

(2011) Y. Ma et al.   JOURNAL OF VIROLOGY

Glaucoma

(2011) Harry A Quigley   LANCET

TBK1 Directly Engages Akt/PKB Survival Signaling to Support Oncogenic Transformation

(2011) Yi-Hung Ou et al.   MOLECULAR CELL

Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

(2011) P. Wild et al.   SCIENCE

Selective Autophagy in Cancer Development and Therapy

(2010) Ivan Dikic et al.   CANCER RESEARCH

The Protein Kinase IKKɛ Regulates Energy Balance in Obese Mice

(2009) Shian-Huey Chiang et al.   CELL

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

(2009) David A. Barbie et al.   NATURE

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

(2009) T. Saitoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA