USP1–UAF1 deubiquitinase complex stabilizes TBK1 and enhances antiviral responses

USP38 Inhibits Type I Interferon Signaling by Editing TBK1 Ubiquitination through NLRP4 Signalosome

(2016) Meng Lin et al.   MOLECULAR CELL

Mint3 potentiates TLR3/4- and RIG-I–induced IFN-β expression and antiviral immune responses

(2016) Wanwan Huai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

USP1 Regulates Cellular Senescence by Controlling Genomic Integrity

(2016) Müge Ogrunc et al.   Cell Reports

Viral RNA detection by RIG-I-like receptors

(2015) Mitsutoshi Yoneyama et al.   CURRENT OPINION IN IMMUNOLOGY

Ubiquitin in the activation and attenuation of innate antiviral immunity

(2015) Steven M. Heaton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

(2015) Axel Freischmidt et al.   NATURE NEUROSCIENCE

Dynamic control of type I IFN signalling by an integrated network of negative regulators

(2015) Rebecca A. Porritt et al.   TRENDS IN IMMUNOLOGY

Interferons and viruses: an evolutionary arms race of molecular interactions

(2015) Hans-Heinrich Hoffmann et al.   TRENDS IN IMMUNOLOGY

The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling

(2014) Xin Cai et al.   MOLECULAR CELL

A selective USP1–UAF1 inhibitor links deubiquitination to DNA damage responses

(2014) Qin Liang et al.   Nature Chemical Biology

Negative regulation of TBK1-mediated antiviral immunity

(2013) Wei Zhao   FEBS LETTERS

Inactivation ofUaf1Causes Defective Homologous Recombination and Early Embryonic Lethality in Mice

(2013) Eunmi Park et al.   MOLECULAR AND CELLULAR BIOLOGY

TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1

(2012) Meng Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4

(2012) Jun Cui et al.   NATURE IMMUNOLOGY

The yin and yang of viruses and interferons

(2012) Ben X. Wang et al.   TRENDS IN IMMUNOLOGY

USP1 Deubiquitinates ID Proteins to Preserve a Mesenchymal Stem Cell Program in Osteosarcoma

(2011) Samuel A. Williams et al.   CELL

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

Synoviocyte innate immune responses: TANK-binding kinase-1 as a potential therapeutic target in rheumatoid arthritis

(2011) D. Hammaker et al.   RHEUMATOLOGY

New developments in the induction and antiviral effectors of type I interferon

(2010) Su-Yang Liu et al.   CURRENT OPINION IN IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Emerging roles for the non-canonical IKKs in cancer

(2010) R R Shen et al.   ONCOGENE

Defining the Human Deubiquitinating Enzyme Interaction Landscape

(2009) Mathew E. Sowa et al.   CELL

Inactivation of Murine Usp1 Results in Genomic Instability and a Fanconi Anemia Phenotype

(2009) Jung Min Kim et al.   DEVELOPMENTAL CELL

UAF1 Is a Subunit of Multiple Deubiquitinating Enzyme Complexes

(2008) Martin A. Cohn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY