Domesticated and optimized mitochondria: Mitochondrial modifications based on energetic status and cellular stress

Astrocytes rescue neuronal health after cisplatin treatment through mitochondrial transfer

(2020) Krystal English et al.   Acta Neuropathologica Communications

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

(2019) Rumani Singh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms of Ferroptosis and Relations With Regulated Cell Death: A Review

(2019) Pengxu Lei et al.   Frontiers in Physiology

Parkin controls brown adipose tissue plasticity in response to adaptive thermogenesis

(2019) Montserrat Cairó et al.   EMBO REPORTS

Receptor-Interacting Serine/Threonine-Protein Kinase 3 (RIPK3)–Mixed Lineage Kinase Domain-Like Protein (MLKL)–Mediated Necroptosis Contributes to Ischemia-Reperfusion Injury of Steatotic Livers

(2019) Hong-Min Ni et al.   AMERICAN JOURNAL OF PATHOLOGY

Prophylactic treatment of hyperbaric oxygen treatment mitigates inflammatory response via mitochondria transfer

(2019) Trenton Lippert et al.   CNS Neuroscience & Therapeutics

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

(2019) Corey Rogers et al.   Nature Communications

Mitochondria transfer via tunneling nanotubes is an important mechanism by which CD133+ scattered tubular cells eliminate hypoxic tubular cell injury

(2019) Xiangyu Zou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondria as multifaceted regulators of cell death

(2019) Florian J. Bock et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endoplasmic reticulum mediates mitochondrial transfer within the osteocyte dendritic network

(2019) Junjie Gao et al.   Science Advances

Molecular insights on cytochrome c and nucleotide regulation of apoptosome function and its implication in cancer

(2019) Neelu Yadav et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Crucial players in glycolysis: Cancer progress

(2019) Zaka Abbaszadeh et al.   GENE

Variation and asymmetry in host-symbiont dependence in a microbial symbiosis

(2018) Ewan J. A. Minter et al.   BMC EVOLUTIONARY BIOLOGY

New insights into apoptosome structure and function

(2018) Loretta Dorstyn et al.   CELL DEATH AND DIFFERENTIATION

The Science and Translation of Lactate Shuttle Theory

(2018) George A. Brooks   Cell Metabolism

Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism

(2018) Gary Yellen   JOURNAL OF CELL BIOLOGY

Miro1 Enhances Mitochondria Transfer from Multipotent Mesenchymal Stem Cells (MMSC) to Neural Cells and Improves the Efficacy of Cell Recovery

(2018) Valentina Babenko et al.   MOLECULES

RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis

(2018) Zhentao Yang et al.   NATURE CELL BIOLOGY

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lactate in the brain: from metabolic end-product to signalling molecule

(2018) Pierre J. Magistretti et al.   NATURE REVIEWS NEUROSCIENCE

The role of the Fas/FasL signaling pathway in environmental toxicant-induced testicular cell apoptosis: An update

(2018) Mei Wang et al.   Systems Biology in Reproductive Medicine

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

(2018) Zhenyu Zhong et al.   NATURE

Mitochondria as a therapeutic target for common pathologies

(2018) Michael P. Murphy et al.   NATURE REVIEWS DRUG DISCOVERY

Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases

(2018) Junying Yuan et al.   NATURE REVIEWS NEUROSCIENCE

FADD at the Crossroads between Cancer and Inflammation

(2018) Sara Mouasni et al.   TRENDS IN IMMUNOLOGY

Connexin 43-Mediated Mitochondrial Transfer of iPSC-MSCs Alleviates Asthma Inflammation

(2018) Yin Yao et al.   Stem Cell Reports

mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1

(2017) Masahiro Morita et al.   MOLECULAR CELL

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Mitochondrial diseases: the contribution of organelle stress responses to pathology

(2017) Anu Suomalainen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy

(2017) Rhianna C. Laker et al.   Nature Communications

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

Neuronal Mitophagy in Neurodegenerative Diseases

(2017) Marta Martinez-Vicente   Frontiers in Molecular Neuroscience

Antioxidant effect of exercise: Exploring the role of the mitochondrial complex I superassembly

(2017) J.R. Huertas et al.   Redox Biology

Mitochondrial Biogenesis as a Pharmacological Target: A New Approach to Acute and Chronic Diseases

(2016) Ryan M. Whitaker et al.   Annual Review of Pharmacology and Toxicology

Supramolecular Organization of Respiratory Complexes

(2016) José Antonio Enríquez   Annual Review of Physiology

Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance

(2016) Svetlana Altshuler-Keylin et al.   Cell Metabolism

Transitions in individuality through symbiosis

(2016) Sylvie Estrela et al.   CURRENT OPINION IN MICROBIOLOGY

AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours

(2016) Fiona A. Ross et al.   FEBS Journal

Neonatal anoxia leads to time dependent progression of mitochondrial linked apoptosis in rat cortex and associated long term sensorimotor deficits

(2016) Puneet K. Samaiya et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Bioenergetics and redox adaptations of astrocytes to neuronal activity

(2016) Juan P. Bolaños   JOURNAL OF NEUROCHEMISTRY

Mechanism of super-assembly of respiratory complexes III and IV

(2016) Sara Cogliati et al.   NATURE

Transfer of mitochondria from astrocytes to neurons after stroke

(2016) Kazuhide Hayakawa et al.   NATURE

Complex I assembly into supercomplexes determines differential mitochondrial ROS production in neurons and astrocytes

(2016) Irene Lopez-Fabuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS

(2016) Yasushi Ito et al.   SCIENCE

Mitochondrial Transfer via Tunneling Nanotubes is an Important Mechanism by Which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the In Vitro and In Vivo Models of ARDS

(2016) Megan V. Jackson et al.   STEM CELLS

The CoQH2/CoQ Ratio Serves as a Sensor of Respiratory Chain Efficiency

(2016) Adela Guarás et al.   Cell Reports

Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury

(2016) Weilin Zhang et al.   eLife

Functional asymmetry and electron flow in the bovine respirasome

(2016) Joana S Sousa et al.   eLife

Hypoxia Activation of Mitophagy and Its Role in Disease Pathogenesis

(2015) Hao Wu et al.   ANTIOXIDANTS & REDOX SIGNALING

Impaired mitochondrial oxidative phosphorylation and supercomplex assembly in rectus abdominis muscle of diabetic obese individuals

(2015) Ghadi Antoun et al.   DIABETOLOGIA

Hemichannel-mediated release of lactate

(2015) Anastassios Karagiannis et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Channel-Mediated Lactate Release by K+-Stimulated Astrocytes

(2015) T. Sotelo-Hitschfeld et al.   JOURNAL OF NEUROSCIENCE

Bone marrow-derived mesenchymal stem cells rescue injured H9c2 cells via transferring intact mitochondria through tunneling nanotubes in an in vitro simulated ischemia/reperfusion model

(2015) HUI HAN et al.   Molecular Medicine Reports

Cancer across the tree of life: cooperation and cheating in multicellularity

(2015) C. A. Aktipis et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Black Queen evolution: the role of leakiness in structuring microbial communities

(2015) J. Jeffrey Morris   TRENDS IN GENETICS

BAX channel activity mediates lysosomal disruption linked to Parkinson disease

(2014) Jordi Bové et al.   Autophagy

Editorial (Thematic Issue: Mitochondrial Biogenesis: Pharmacological Approaches)

(2014) Teresa Valero   CURRENT PHARMACEUTICAL DESIGN

Mitochondrial bioenergetics and neuronal survival modelled in primary neuronal culture and isolated nerve terminals

(2014) David G. Nicholls et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Mesenchymal stem cells rescue injured endothelial cells in an in vitro ischemia–reperfusion model via tunneling nanotube like structure-mediated mitochondrial transfer

(2014) Kaiming Liu et al.   MICROVASCULAR RESEARCH

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Variants of mitochondrial autophagy: Types 1 and 2 mitophagy and micromitophagy (Type 3)

(2014) John J. Lemasters   Redox Biology

Mitochondrial Respiratory Supercomplex Association Limits Production of Reactive Oxygen Species from Complex I

(2013) Evelina Maranzana et al.   ANTIOXIDANTS & REDOX SIGNALING

The function of the respiratory supercomplexes: The plasticity model

(2013) Rebeca Acin-Perez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Crosstalk between apoptosis, necrosis and autophagy

(2013) Vassiliki Nikoletopoulou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Turn up the power - pharmacological activation of mitochondrial biogenesis in mouse models

(2013) J C Komen et al.   BRITISH JOURNAL OF PHARMACOLOGY

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

Rheb Regulates Mitophagy Induced by Mitochondrial Energetic Status

(2013) Su Melser et al.   Cell Metabolism

Loss of iron triggers PINK1/Parkin-independent mitophagy

(2013) George F G Allen et al.   EMBO REPORTS

Lysosomal cell death at a glance

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Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis

(2013) Shin H Kang et al.   NATURE NEUROSCIENCE

Caspase-8 Binding to Cardiolipin in Giant Unilamellar Vesicles Provides a Functional Docking Platform for Bid

(2013) Olivier Jalmar et al.   PLoS One

Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain

(2013) E. Lapuente-Brun et al.   SCIENCE

Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells

(2013) J. Suzuki et al.   SCIENCE

Clearing the Dead: Apoptotic Cell Sensing, Recognition, Engulfment, and Digestion

(2013) A. Hochreiter-Hufford et al.   Cold Spring Harbor Perspectives in Biology

Apoptotic cells can induce non-autonomous apoptosis through the TNF pathway

(2013) Ainhoa Pérez-Garijo et al.   eLife

Inhibition of complex I regulates the mitochondrial permeability transition through a phosphate-sensitive inhibitory site masked by cyclophilin D

(2012) Bo Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Identification of a Protein Mediating Respiratory Supercomplex Stability

(2012) Yu-Chan Chen et al.   Cell Metabolism

Rcf1 Mediates Cytochrome Oxidase Assembly and Respirasome Formation, Revealing Heterogeneity of the Enzyme Complex

(2012) Milena Vukotic et al.   Cell Metabolism

Non-apoptotic functions of apoptosis-regulatory proteins

(2012) Lorenzo Galluzzi et al.   EMBO REPORTS

Updated Energy Budgets for Neural Computation in the Neocortex and Cerebellum

(2012) Clare Howarth et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Rcf1 and Rcf2, Members of the Hypoxia-Induced Gene 1 Protein Family, Are Critical Components of the Mitochondrial Cytochrome bc1-Cytochrome c Oxidase Supercomplex

(2012) V. Strogolova et al.   MOLECULAR AND CELLULAR BIOLOGY

The mitochondrial transporter family SLC25: Identification, properties and physiopathology

(2012) Ferdinando Palmieri   MOLECULAR ASPECTS OF MEDICINE

Mitochondrial transfer from bone-marrow–derived stromal cells to pulmonary alveoli protects against acute lung injury

(2012) Mohammad Naimul Islam et al.   NATURE MEDICINE

Mitochondria: master regulators of danger signalling

(2012) Lorenzo Galluzzi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Interleukin-11 Links Oxidative Stress and Compensatory Proliferation

(2012) T. Nishina et al.   Science Signaling

Transcriptional integration of mitochondrial biogenesis

(2012) Richard C. Scarpulla et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mitochondrial pharmacology

(2012) Robin A.J. Smith et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

Mitotic catastrophe: a mechanism for avoiding genomic instability

(2011) Ilio Vitale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PGC-1α is required for AICAR-induced expression of GLUT4 and mitochondrial proteins in mouse skeletal muscle

(2010) Lotte Leick et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Calpain-mediated Hsp70.1 cleavage in hippocampal CA1 neuronal death

(2010) Shunya Sahara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Selective Autophagy in Cancer Development and Therapy

(2010) Ivan Dikic et al.   CANCER RESEARCH

Apoptosis Threshold Set by Noxa and Mcl-1 after T Cell Activation Regulates Competitive Selection of High-Affinity Clones

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Predominant Enhancement of Glucose Uptake in Astrocytes versus Neurons during Activation of the Somatosensory Cortex

(2010) J. Chuquet et al.   JOURNAL OF NEUROSCIENCE

NAD+ Depletion Is Necessary and Sufficient forPoly(ADP-Ribose) Polymerase-1-Mediated Neuronal Death

(2010) C. C. Alano et al.   JOURNAL OF NEUROSCIENCE

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Differential roles of phospholipases A2 in neuronal death and neurogenesis: Implications for Alzheimer disease

(2010) Evelin L. Schaeffer et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Regulation of autophagy by ROS: physiology and pathology

(2010) Ruth Scherz-Shouval et al.   TRENDS IN BIOCHEMICAL SCIENCES

Supercomplexes of the mitochondrial electron transport chain decline in the aging rat heart

(2009) Luis A. Gómez et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The role of Dpp and Wg in compensatory proliferation and in the formation of hyperplastic overgrowths caused by apoptotic cells in the Drosophila wing disc

(2009) A. Perez-Garijo et al.   DEVELOPMENT

Cell-cell and intracellular lactate shuttles

(2009) George A. Brooks   JOURNAL OF PHYSIOLOGY-LONDON

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Cell Death

(2009) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hepatocyte Necrosis Induced by Oxidative Stress and IL-1α Release Mediate Carcinogen-Induced Compensatory Proliferation and Liver Tumorigenesis

(2008) Toshiharu Sakurai et al.   CANCER CELL

Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation

(2008) Mariana G. Rosca et al.   CARDIOVASCULAR RESEARCH

AMPK and PPARδ Agonists Are Exercise Mimetics

(2008) Vihang A. Narkar et al.   CELL

Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt

(2008) Marcella Fulco et al.   DEVELOPMENTAL CELL

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lack of Cytochromecin Mouse Fibroblasts Disrupts Assembly/Stability of Respiratory Complexes I and IV

(2008) Uma D. Vempati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Respiratory Active Mitochondrial Supercomplexes

(2008) Rebeca Acín-Pérez et al.   MOLECULAR CELL

Oxygen sensors in context

(2007) Jeremy P.T. Ward   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS