Cellular senescence in the aging retina and developments of senotherapies for age-related macular degeneration

Gene Therapy for Glaucoma by Ciliary Body Aquaporin 1 Disruption Using CRISPR-Cas9

(2020) Jiahui Wu et al.   MOLECULAR THERAPY

Risk factors for progression of age‐related macular degeneration

(2020) Thomas J Heesterbeek et al.   OPHTHALMIC AND PHYSIOLOGICAL OPTICS

Dysregulated metabolic pathways in age-related macular degeneration

(2020) Meng Zhang et al.   Scientific Reports

Characterizing the Dysfunctional NK Cell: Assessing the Clinical Relevance of Exhaustion, Anergy, and Senescence

(2020) Sean J. Judge et al.   Frontiers in Cellular and Infection Microbiology

Gene therapy for neovascular age-related macular degeneration: rationale, clinical trials and future directions

(2020) Thales Antonio Cabral de Guimaraes et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

The Emerging Role of Senescence in Ocular Disease

(2020) Parameswaran G. Sreekumar et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics

(2020) Bo Yu et al.   Nature Communications

A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells

(2020) Masahiro Wakita et al.   Nature Communications

Improving retinal mitochondrial function as a treatment for age-related macular degeneration

(2020) Mara C. Ebeling et al.   Redox Biology

Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases

(2020) Ping Song et al.   Cells

T cells, aging and senescence

(2020) Luca Pangrazzi et al.   EXPERIMENTAL GERONTOLOGY

Senescence‐associated secretory phenotype promotes chronic ocular graft‐vs‐host disease in mice and humans

(2020) Mio Yamane et al.   FASEB JOURNAL

Retinal gene therapy: an eye-opener of the 21st century

(2020) Anne Louise Askou et al.   GENE THERAPY

A Senescence-Centric View of Aging: Implications for Longevity and Disease

(2020) M. Borghesan et al.   TRENDS IN CELL BIOLOGY

Bone Morphogenetic Protein (BMP)4 But Not BMP2 Disrupts the Barrier Integrity of Retinal Pigment Epithelia and Induces Their Migration: A Potential Role in Neovascular Age-Related Macular Degeneration

(2020) Ahmed S. Ibrahim et al.   Journal of Clinical Medicine

Role of Epithelial-Mesenchymal Transition in Retinal Pigment Epithelium Dysfunction

(2020) Mi Zhou et al.   Frontiers in Cell and Developmental Biology

Cell Senescence, Multiple Organelle Dysfunction and Atherosclerosis

(2020) Gisela Machado-Oliveira et al.   Cells

Reversed Senescence of Retinal Pigment Epithelial Cell by Coculture With Embryonic Stem Cell via the TGFβ and PI3K Pathways

(2020) Shoubi Wang et al.   Frontiers in Cell and Developmental Biology

Inhibition of sumoylation alleviates oxidative stress-induced retinal pigment epithelial cell senescence and represses proinflammatory gene expression.

(2019) Q. Sun et al.   CURRENT MOLECULAR MEDICINE

Whole-genome methylation profiling of the retinal pigment epithelium of individuals with age-related macular degeneration reveals differential methylation of the SKI, GTF2H4, and TNXB genes

(2019) Louise F. Porter et al.   Clinical Epigenetics

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

(2019) Jamie N. Justice et al.   EBioMedicine

T-cell senescence contributes to abnormal glucose homeostasis in humans and mice

(2019) Hyon-Seung Yi et al.   Cell Death & Disease

Is Retinal Metabolic Dysfunction at the Center of the Pathogenesis of Age-related Macular Degeneration?

(2019) Thierry Léveillard et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Astrocyte senescence: Evidence and significance

(2019) Justin Cohen et al.   AGING CELL

Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition

(2019) Branca I. Pereira et al.   Nature Communications

A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration

(2019) James T. Handa et al.   Nature Communications

Complement system and age-related macular degeneration: drugs and challenges

(2019) Jiali Wu et al.   Drug Design Development and Therapy

Cortical neurons develop a senescence-like phenotype promoted by dysfunctional autophagy

(2019) Daniel Moreno-Blas et al.   Aging-US

Outcome Measures Used in Ocular Gene Therapy Trials: A Scoping Review of Current Practice

(2019) Jasleen K. Jolly et al.   Frontiers in Pharmacology

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

(2019) LaTonya J. Hickson et al.   EBioMedicine

Pleiotropic Effects of mTOR and Autophagy During Development and Aging

(2019) Kathrin Schmeisser et al.   Frontiers in Cell and Developmental Biology

The Regulation of NFE2L2 (NRF2) Signalling and Epithelial-to-Mesenchymal Transition in Age-Related Macular Degeneration Pathology

(2019) Hyttinen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Elovanoids counteract oligomeric β-amyloid-induced gene expression and protect photoreceptors

(2019) Khanh V. Do et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA repair deficiency and senescence in concussed professional athletes involved in contact sports

(2019) Nicole Schwab et al.   Acta Neuropathologica Communications

Amitosenescence and Pseudomitosenescence: Putative New Players in the Aging Process

(2019) Diane Wengerodt et al.   Cells

Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension

(2019) Lorena Raquel Rocha et al.   AGING CELL

HTRA1, an age-related macular degeneration protease, processes extracellular matrix proteins EFEMP1 and TSP1

(2018) Michael K. Lin et al.   AGING CELL

Cellular senescence: a view throughout organismal life

(2018) Cayetano von Kobbe   CELLULAR AND MOLECULAR LIFE SCIENCES

Macrophages and lipid metabolism

(2018) Anneleen Remmerie et al.   CELLULAR IMMUNOLOGY

Strategies targeting cellular senescence

(2018) Yossi Ovadya et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms and functions of cellular senescence

(2018) Nicolás Herranz et al.   JOURNAL OF CLINICAL INVESTIGATION

The pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence

(2018) Siew-Min Ong et al.   Cell Death & Disease

Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease

(2018) Shankar J. Chinta et al.   Cell Reports

An Overview of the Role of Lipofuscin in Age-Related Neurodegeneration

(2018) Alexandra Moreno-García et al.   Frontiers in Neuroscience

Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

(2018) Tamas Fulop et al.   Frontiers in Immunology

Adjustment of the lysosomal-mitochondrial axis for control of cellular senescence

(2018) Joon Tae Park et al.   AGEING RESEARCH REVIEWS

Effects of senescent secretory phenotype acquisition on human retinal pigment epithelial stem cells

(2018) Raffaella Lazzarini et al.   Aging-US

Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

(2018) Szabolcs Felszeghy et al.   Redox Biology

Fueling Inflamm-Aging through Mitochondrial Dysfunction: Mechanisms and Molecular Targets

(2017) Anna Picca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Senescence and aging: Causes, consequences, and therapeutic avenues

(2017) Domhnall McHugh et al.   JOURNAL OF CELL BIOLOGY

Inflammatory signals from photoreceptor modulate pathological retinal angiogenesis via c-Fos

(2017) Ye Sun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intravitreous injection of AAV2-sFLT01 in patients with advanced neovascular age-related macular degeneration: a phase 1, open-label trial

(2017) Jeffrey S Heier et al.   LANCET

Targeting cellular senescence prevents age-related bone loss in mice

(2017) Joshua N Farr et al.   NATURE MEDICINE

Cellular Senescence in Age-Related Macular Degeneration: Can Autophagy and DNA Damage Response Play a Role?

(2017) Janusz Blasiak et al.   Oxidative Medicine and Cellular Longevity

The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD

(2017) Sayantan Datta et al.   PROGRESS IN RETINAL AND EYE RESEARCH

On phagocytes and macular degeneration

(2017) Xavier Guillonneau et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Telomere Dynamics in Immune Senescence and Exhaustion Triggered by Chronic Viral Infection

(2017) Marcia Bellon et al.   Viruses-Basel

The Role of Microglia in Retinal Neurodegeneration: Alzheimer's Disease, Parkinson, and Glaucoma

(2017) Ana I. Ramirez et al.   Frontiers in Aging Neuroscience

Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye

(2017) Mark A Kanow et al.   eLife

Mitochondrial contribution to lipofuscin formation

(2017) Jeannette König et al.   Redox Biology

Cellular Senescence: A Translational Perspective

(2017) James L. Kirkland et al.   EBioMedicine

Elovanoids are novel cell-specific lipid mediators necessary for neuroprotective signaling for photoreceptor cell integrity

(2017) Bokkyoo Jun et al.   Scientific Reports

Identification of new genes associated to senescent and tumorigenic phenotypes in mesenchymal stem cells

(2017) Joana Cristina Medeiros Tavares Marques et al.   Scientific Reports

NKG2D ligands mediate immunosurveillance of senescent cells

(2016) Adi Sagiv et al.   Aging-US

Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence

(2016) Haoran Tai et al.   Autophagy

Autophagy regulates death of retinal pigment epithelium cells in age-related macular degeneration

(2016) Kai Kaarniranta et al.   CELL BIOLOGY AND TOXICOLOGY

Lysosomes: Regulators of autophagy in the retinal pigmented epithelium

(2016) Debasish Sinha et al.   EXPERIMENTAL EYE RESEARCH

Structural and molecular changes in the aging choroid: implications for age-related macular degeneration

(2016) K R Chirco et al.   EYE

Measuring IL-6 and sIL-6R in serum from patients treated with tocilizumab and/or siltuximab following CAR T cell therapy

(2016) Fang Chen et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Interleukin-33 regulates tissue remodelling and inhibits angiogenesis in the eye

(2016) Sofia Theodoropoulou et al.   JOURNAL OF PATHOLOGY

NOTCH1 mediates a switch between two distinct secretomes during senescence

(2016) Matthew Hoare et al.   NATURE CELL BIOLOGY

PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease

(2016) Kuti Baruch et al.   NATURE MEDICINE

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo

(2016) Lluc Mosteiro et al.   SCIENCE

Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy

(2016) M. Oubaha et al.   Science Translational Medicine

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

(2016) Reut Yosef et al.   Nature Communications

Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration

(2016) Toshihide Kurihara et al.   eLife

Public Attitudes About Eye and Vision Health

(2016) Adrienne W. Scott et al.   JAMA Ophthalmology

Oxidative stress-induced premature senescence dysregulates VEGF and CFH expression in retinal pigment epithelial cells: Implications for Age-related Macular Degeneration

(2016) Mariela C. Marazita et al.   Redox Biology

Impairing autophagy in retinal pigment epithelium leads to inflammasome activation and enhanced macrophage-mediated angiogenesis

(2016) Jian Liu et al.   Scientific Reports

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Leukocyte telomere length is associated with advanced age-related macular degeneration in the Han Chinese population

(2015) Xiaoling Weng et al.   EXPERIMENTAL GERONTOLOGY

Activated adult microglia influence retinal progenitor cell proliferation and differentiation toward recoverin-expressing neuron-like cells in a co-culture model

(2015) Yunhe Xu et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Parainflammation, chronic inflammation, and age-related macular degeneration

(2015) M. Chen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Genomic regulation of senescence and innate immunity signaling in the retinal pigment epithelium

(2015) Edward Chaum et al.   MAMMALIAN GENOME

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

(2015) Nicolás Herranz et al.   NATURE CELL BIOLOGY

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

(2015) Lars G Fritsche et al.   NATURE GENETICS

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging

(2014) Dorian V. Ziegler et al.   AGING CELL

Cellular senescence and aging: the role of B-MYB

(2014) Sophia N. Mowla et al.   AGING CELL

Immune Responses in Age-Related Macular Degeneration and a Possible Long-term Therapeutic Strategy for Prevention

(2014) Robert B. Nussenblatt et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Serum cytokines as biomarkers for age-related macular degeneration

(2014) Khaled Nassar et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Immunosenescence in monocytes, macrophages, and dendritic cells: Lessons learned from the lung and heart

(2014) Phyllis-Jean Linton et al.   IMMUNOLOGY LETTERS

Siltuximab for multicentric Castleman's disease: a randomised, double-blind, placebo-controlled trial

(2014) Frits van Rhee et al.   LANCET ONCOLOGY

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Evaluation of premature senescence and senescence biomarkers in carcinoma cells and xenograft mice exposed to single or fractionated irradiation

(2014) BONG CHO KIM et al.   ONCOLOGY REPORTS

Current Treatment Limitations in Age-Related Macular Degeneration and Future Approaches Based on Cell Therapy and Tissue Engineering

(2014) P. Fernández-Robredo et al.   Journal of Ophthalmology

Humanin and Age-Related Diseases: A New Link?

(2014) Zhenwei Gong et al.   Frontiers in Endocrinology

Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration

(2013) Kai Kaarniranta et al.   Autophagy

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

Rat retinal transcriptome: Effects of aging and AMD-like retinopathy

(2013) Oyuna S. Kozhevnikova et al.   CELL CYCLE

Impaired Cholesterol Efflux in Senescent Macrophages Promotes Age-Related Macular Degeneration

(2013) Abdoulaye Sene et al.   Cell Metabolism

HtrA1 is induced by oxidative stress and enhances cell senescence through p38 MAPK pathway

(2013) Supanji et al.   EXPERIMENTAL EYE RESEARCH

The Th17/Treg balance is disturbed during aging

(2013) Vanessa Schmitt et al.   EXPERIMENTAL GERONTOLOGY

Cathepsin B: a potential prognostic marker for inflammatory breast cancer

(2013) Mohamed A Nouh et al.   Journal of Translational Medicine

The Ubiquitin–Proteasome System in Retinal Health and Disease

(2013) Laura Campello et al.   MOLECULAR NEUROBIOLOGY

Gene expression changes in aging retinal microglia: relationship to microglial support functions and regulation of activation

(2013) Wenxin Ma et al.   NEUROBIOLOGY OF AGING

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

(2013) Stephan A. Grupp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-related Macular Degeneration Is Associated with Increased Proportion of CD56+ T Cells in Peripheral Blood

(2013) Carsten Faber et al.   OPHTHALMOLOGY

Myeloid Cells Expressing VEGF and Arginase-1 Following Uptake of Damaged Retinal Pigment Epithelium Suggests Potential Mechanism That Drives the Onset of Choroidal Angiogenesis in Mice

(2013) Jian Liu et al.   PLoS One

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

(2012) Diana Jurk et al.   AGING CELL

RPE cell senescence: A key contributor to age-related macular degeneration

(2012) Michael R. Kozlowski   MEDICAL HYPOTHESES

A2E accumulation influences retinal microglial activation and complement regulation

(2012) Wenxin Ma et al.   NEUROBIOLOGY OF AGING

The Neuronal Organization of the Retina

(2012) Richard H. Masland   NEURON

The Age-related Eye Disease Study 2 (AREDS2)

(2012) Emily Y. Chew et al.   OPHTHALMOLOGY

Interleukin-1 Receptor-Associated Kinase-3 Is a Key Inhibitor of Inflammation in Obesity and Metabolic Syndrome

(2012) Maarten Hulsmans et al.   PLoS One

Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)

(2011) Antero Salminen et al.   CELLULAR SIGNALLING

Transcriptional regulation of bone morphogenetic protein 4 by tumor necrosis factor and its relationship with age-related macular degeneration

(2011) Jing Xu et al.   FASEB JOURNAL

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice

(2011) A. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of cellular senescence signature on ageing research

(2010) Ewa Sikora et al.   AGEING RESEARCH REVIEWS

Age-related alterations in the dynamic behavior of microglia

(2010) Mausam R. Damani et al.   AGING CELL

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Mitochondrial energy metabolism and ageing

(2010) Ivana Bratic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice

(2010) Chen Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

A Major Role for Bim in Regulatory T Cell Homeostasis

(2010) C. A. Chougnet et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial Turnover and Aging of Long-Lived Postmitotic Cells: The Mitochondrial–Lysosomal Axis Theory of Aging

(2009) Alexei Terman et al.   ANTIOXIDANTS & REDOX SIGNALING

BMP4 Mediates Oxidative Stress-induced Retinal Pigment Epithelial Cell Senescence and Is Overexpressed in Age-related Macular Degeneration

(2009) DanHong Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA damage and repair in age-related macular degeneration

(2009) Jacek P. Szaflik et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Immune cells in the human choroid

(2008) M-K Ezzat et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Vascular endothelial growth factor in eye disease

(2008) J.S. Penn et al.   PROGRESS IN RETINAL AND EYE RESEARCH