Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration

Inflammaging: disturbed interplay between autophagy and inflammasomes

(2016) Antero Salminen et al.   Aging-US

Gene transfer of master autophagy regulator TFEB results in clearance of toxic protein and correction of hepatic disease in alpha-1-anti-trypsin deficiency

(2013) Nunzia Pastore et al.   EMBO Molecular Medicine

Rapamycin slows aging in mice

(2012) John E. Wilkinson et al.   AGING CELL

Chloroquine enhances the chemotherapeutic activity of 5-fluorouracil in a colon cancer cell line via cell cycle alteration

(2012) Jung-Hye Choi et al.   APMIS

Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy

(2012) Paola Maycotte et al.   Autophagy

Sequestosome 1/p62: across diseases

(2012) Thangiah Geetha et al.   BIOMARKERS

In search of new targets for retinal neuroprotection: is there a role for autophagy?

(2012) Rossella Russo et al.   CURRENT OPINION IN PHARMACOLOGY

Autophagy regulating kinases as potential therapeutic targets for age-related macular degeneration

(2012) Kai Kaarniranta et al.   Future Medicinal Chemistry

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells—Implications for age-related macular degeneration (AMD)

(2012) Anu Kauppinen et al.   IMMUNOLOGY LETTERS

How does the macula protect itself from oxidative stress?

(2012) James T. Handa   MOLECULAR ASPECTS OF MEDICINE

Nutritional modulation of age-related macular degeneration

(2012) Karen A. Weikel et al.   MOLECULAR ASPECTS OF MEDICINE

Consequences of oxidative stress in age-related macular degeneration

(2012) Stuart G. Jarrett et al.   MOLECULAR ASPECTS OF MEDICINE

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

(2012) Sarah L Doyle et al.   NATURE MEDICINE

Mechanisms of Age-Related Macular Degeneration

(2012) Jayakrishna Ambati et al.   NEURON

Genetics of Immunological and Inflammatory Components in Age-related Macular Degeneration

(2012) Jingsheng Tuo et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

Efflux Protein Expression in Human Stem Cell-Derived Retinal Pigment Epithelial Cells

(2012) Kati Juuti-Uusitalo et al.   PLoS One

The 5HT1a Receptor Agonist 8-Oh DPAT Induces Protection from Lipofuscin Accumulation and Oxidative Stress in the Retinal Pigment Epithelium

(2012) Prajitha Thampi et al.   PLoS One

Acidic Nanoparticles Are Trafficked to Lysosomes and Restore an Acidic Lysosomal pH and Degradative Function to Compromised ARPE-19 Cells

(2012) Gabriel C. Baltazar et al.   PLoS One

Novel roles for α-crystallins in retinal function and disease

(2012) Ram Kannan et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Chloroquine enhances the cytotoxicity of topotecan by inhibiting autophagy in lung cancer cells

(2012) Yao Wang et al.   Chinese Journal of Cancer

Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration

(2011) Kati Kinnunen et al.   ACTA OPHTHALMOLOGICA

Chloroquine and Hydroxychloroquine Toxicity

(2011) Nicholas M. Hickley   ARCHIVES OF OPHTHALMOLOGY

Retinal Toxicity Associated With Hydroxychloroquine and Chloroquine

(2011) Michel Michaelides   ARCHIVES OF OPHTHALMOLOGY

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Autophagy promotes survival of retinal ganglion cells after optic nerve axotomy in mice

(2011) N Rodríguez-Muela et al.   CELL DEATH AND DIFFERENTIATION

Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

(2011) James Harris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutation in the  A3/A1-crystallin gene impairs phagosome degradation in the retinal pigmented epithelium of the rat

(2011) J. S. Zigler et al.   JOURNAL OF CELL SCIENCE

The Role of Autophagy in Cancer: Therapeutic Implications

(2011) Z. J. Yang et al.   MOLECULAR CANCER THERAPEUTICS

CCR3 and Choroidal Neovascularization

(2011) Yiwen Li et al.   PLoS One

Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease

(2011) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

Chloroquine treatment of ARPE-19 cells leads to lysosome dilation and intracellular lipid accumulation: possible implications of lysosomal dysfunction in macular degeneration

(2011) Patrick M Chen et al.   Cell and Bioscience

The inhibition of autophagy potentiates anti-angiogenic effects of sulforaphane by inducing apoptosis

(2010) Takeshi Nishikawa et al.   ANGIOGENESIS

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis

(2010) Nora B Caberoy et al.   EMBO JOURNAL

Lipofuscin-bound iron is a major intracellular source of oxidants: Role in senescent cells

(2010) Annika Höhn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Influence of Hsp90 and HDAC Inhibition and Tubulin Acetylation on Perinuclear Protein Aggregation in Human Retinal Pigment Epithelial Cells

(2010) Tuomas Ryhänen et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice

(2010) Chen Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

The molecular genetic basis of age-related macular degeneration: an overview

(2010) Saritha Katta et al.   JOURNAL OF GENETICS

Nerve cells immunoreactive for p62 in select hypothalamic and brainstem nuclei of controls and Parkinson’s disease cases

(2010) Heiko Braak et al.   JOURNAL OF NEURAL TRANSMISSION

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Phagocytosis of Retinal Rod and Cone Photoreceptors

(2010) Brian M. Kevany et al.   PHYSIOLOGY

Mechanisms of acute axonal degeneration in the optic nerve in vivo

(2010) J. Knoferle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The late stage of autophagy: cellular events and molecular regulation

(2010) Jingjing Tong et al.   Protein & Cell

Heat shock proteins as gatekeepers of proteolytic pathways—Implications for age-related macular degeneration (AMD)

(2009) Kai Kaarniranta et al.   AGEING RESEARCH REVIEWS

Mitochondrial Turnover and Aging of Long-Lived Postmitotic Cells: The Mitochondrial–Lysosomal Axis Theory of Aging

(2009) Alexei Terman et al.   ANTIOXIDANTS & REDOX SIGNALING

Serum Cystatin C Level, Kidney Disease Markers, and Incidence of Age-Related Macular Degeneration

(2009) Ronald Klein   ARCHIVES OF OPHTHALMOLOGY

ARPE-19 retinal pigment epitheliaL CELLS are highly resistant to oxidative stress and exercise strict control over their lysosomal redox-active iron

(2009) Tino Kurz et al.   Autophagy

Autophagy, exosomes and drusen formation in age-related macular degeneration

(2009) Ai Ling Wang et al.   Autophagy

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells

(2009) Griselda Herrero-Martín et al.   EMBO JOURNAL

Is there more to aging than mitochondrial DNA and reactive oxygen species?

(2009) Mikhail F. Alexeyev   FEBS Journal

The proteasomal system

(2009) Tobias Jung et al.   MOLECULAR ASPECTS OF MEDICINE

Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates

(2009) Viktor I. Korolchuk et al.   MOLECULAR CELL

Autophagy and Exosomes in the Aged Retinal Pigment Epithelium: Possible Relevance to Drusen Formation and Age-Related Macular Degeneration

(2009) Ai Ling Wang et al.   PLoS One

Cystatin C in macular and neuronal degenerations: Implications for mechanism(s) of age-related macular degeneration

(2009) Luminita Paraoan et al.   VISION RESEARCH

Lysosomes and oxidative stress in aging and apoptosis

(2008) Tino Kurz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The autophagic machinery is necessary for removal of cell corpses from the developing retinal neuroepithelium

(2008) M A Mellén et al.   CELL DEATH AND DIFFERENTIATION

Alterations of activity and intracellular distribution of the 20S proteasome in ageing retinal pigment epithelial cells

(2008) Yue Li et al.   EXPERIMENTAL GERONTOLOGY

Rapamycin reduces VEGF expression in retinal pigment epithelium (RPE) and inhibits RPE-induced sprouting angiogenesis in vitro

(2008) A. Stahl et al.   FEBS LETTERS

α2 but Not α1 AMP-activated Protein Kinase Mediates Oxidative Stress-induced Inhibition of Retinal Pigment Epithelium Cell Phagocytosis of Photoreceptor Outer Segments

(2008) Suofu Qin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative Inactivation of the Proteasome in Retinal Pigment Epithelial Cells

(2008) Alexandre F. Fernandes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Age Lipid A2E and Mitochondrial Dysfunction Synergistically Impair Phagocytosis by Retinal Pigment Epithelial Cells

(2008) Cristofol Vives-Bauza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells

(2008) Tuomas Ryhänen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Activation of autophagy in retinal ganglion cells

(2008) Seok Hwan Kim et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Phagosome maturation: going through the acid test

(2008) Jason M. Kinchen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lack of αvβ5 Integrin Receptor or Its Ligand MFG-E8: Distinct Effects on Retinal Function

(2008) Emeline F. Nandrot et al.   OPHTHALMIC RESEARCH