Hypoxia-driven paracrine osteopontin/integrin αvβ3 signaling promotes pancreatic cancer cell epithelial-mesenchymal transition and cancer stem cell-like properties by modulating forkhead box protein M1

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The FOXO3-FOXM1 axis: A key cancer drug target and a modulator of cancer drug resistance

(2018) Shang Yao et al.   SEMINARS IN CANCER BIOLOGY

Early detection of pancreatic cancer: Where are we now and where are we going?

(2017) Bin Zhou et al.   INTERNATIONAL JOURNAL OF CANCER

Osteopontin at the Crossroads of Inflammation and Tumor Progression

(2017) Luigi Mario Castello et al.   MEDIATORS OF INFLAMMATION

Long noncoding RNA NORAD, a novel competing endogenous RNA, enhances the hypoxia-induced epithelial-mesenchymal transition to promote metastasis in pancreatic cancer

(2017) Hongzhe Li et al.   Molecular Cancer

The epithelial to mesenchymal transition (EMT) and cancer stem cells: implication for treatment resistance in pancreatic cancer

(2017) Pingting Zhou et al.   Molecular Cancer

Effect of NR5A2 inhibition on pancreatic cancer stem cell (CSC) properties and epithelial-mesenchymal transition (EMT) markers

(2017) Zhaofan Luo et al.   MOLECULAR CARCINOGENESIS

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

(2017) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

Pancreatic stellate cell: Pandora's box for pancreatic disease biology

(2017) Ratnakar R Bynigeri et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Gemcitabine treatment promotes pancreatic cancer stemness through the Nox/ROS/NF-κB/STAT3 signaling cascade

(2016) Zhengle Zhang et al.   CANCER LETTERS

HGF/Met and FOXM1 form a positive feedback loop and render pancreatic cancer cells resistance to Met inhibition and aggressive phenotypes

(2016) J Cui et al.   ONCOGENE

Curcumin inhibits hypoxia-induced epithelial-mesenchymal transition in pancreatic cancer cells via suppression of the hedgehog signaling pathway

(2016) LEI CAO et al.   ONCOLOGY REPORTS

Prognostic Value of FOXM1 in Patients with Malignant Solid Tumor: A Meta-Analysis and System Review

(2015) Jun Dai et al.   DISEASE MARKERS

Hypoxia-inducible MiR-182 promotes angiogenesis by targeting RASA1 in hepatocellular carcinoma

(2015) Chengli Du et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Resveratrol inhibits hypoxia-driven ROS-induced invasive and migratory ability of pancreatic cancer cells via suppression of the Hedgehog signaling pathway

(2015) WEI LI et al.   ONCOLOGY REPORTS

The epithelial to mesenchymal transition in pancreatic cancer: A systematic review

(2015) Mircea Beuran et al.   PANCREATOLOGY

Pancreatic stellate cells: A dynamic player of the intercellular communication in pancreatic cancer

(2015) Atsushi Masamune et al.   Clinics and Research in Hepatology and Gastroenterology

Pancreatic Adenocarcinoma

(2015) David P. Ryan et al.   NEW ENGLAND JOURNAL OF MEDICINE

FOXM1 confers to epithelial-mesenchymal transition, stemness and chemoresistance in epithelial ovarian carcinoma cells

(2015) Wen-Tai Chiu et al.   Oncotarget

α-Mangostin inhibits hypoxia-driven ROS-induced PSC activation and pancreatic cancer cell invasion

(2014) Jianjun Lei et al.   CANCER LETTERS

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

(2014) L. Rahib et al.   CANCER RESEARCH

Sonic Hedgehog Paracrine Signaling Activates Stromal Cells to Promote Perineural Invasion in Pancreatic Cancer

(2014) X. Li et al.   CLINICAL CANCER RESEARCH

OPN Induces FoxM1 Expression and Localization through ERK 1/2, AKT, and p38 Signaling Pathway in HEC-1A Cells

(2014) Yunpeng Xie et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biology and Clinical Applications of Pancreatic Cancer Stem Cells

(2013) Ethan V. Abel et al.   GASTROENTEROLOGY

The roles of FOXM1 in pancreatic stem cells and carcinogenesis

(2013) Ming Quan et al.   Molecular Cancer

Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner

(2013) Jianjun Lei et al.   Molecular Cancer

RGD-conjugated albumin nanoparticles as a novel delivery vehicle in pancreatic cancer therapy

(2012) Shunrong Ji et al.   CANCER BIOLOGY & THERAPY

Persistent activation of pancreatic stellate cells creates a microenvironment favorable for the malignant behavior of pancreatic ductal adenocarcinoma

(2012) Dong Tang et al.   INTERNATIONAL JOURNAL OF CANCER

Multiple faces of FoxM1 transcription factor

(2011) Tanya V. Kalin et al.   CELL CYCLE

Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin αVβ3 engagement and PI3K/pAkt/NFκB signaling

(2011) Raquel Urtasun et al.   HEPATOLOGY

Over-expression of FoxM1 leads to epithelial-mesenchymal transition and cancer stem cell phenotype in pancreatic cancer cells

(2011) Bin Bao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Cancer cells in epithelial-to-mesenchymal transition and tumor-propagating–cancer stem cells: distinct, overlapping or same populations

(2011) S Floor et al.   ONCOGENE

Tumour necrosis is a postoperative prognostic marker for pancreatic cancer patients with a high interobserver reproducibility in histological evaluation

(2010) N Hiraoka et al.   BRITISH JOURNAL OF CANCER

Involvement of Osteopontin in the Matrix-Degrading and Proangiogenic Changes Mediated by Nicotine in Pancreatic Cancer Cells

(2010) Melissa Lazar et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Osteopontin increases migration and MMP-9 up-regulation via αvβ3 integrin, FAK, ERK, and NF-κB-dependent pathway in human chondrosarcoma cells

(2009) Ying-Ju Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cancer-Associated Stromal Fibroblasts Promote Pancreatic Tumor Progression

(2008) R. F. Hwang et al.   CANCER RESEARCH

Pancreatic Cancer Stem Cells

(2008) Cheong J. Lee et al.   JOURNAL OF CLINICAL ONCOLOGY