Inhibition of hypoxic response decreases stemness and reduces tumorigenic signaling due to impaired assembly of HIF1 transcription complex in pancreatic cancer

The ever-expanding role of HIF in tumour and stromal biology

(2016) Edward L. LaGory et al.   NATURE CELL BIOLOGY

Microenvironment mediated alterations to metabolic pathways confer increased chemo-resistance in CD133+ tumor initiating cells

(2016) Alice Nomura et al.   Oncotarget

Hypoxia-induced chemoresistance in cancer cells: The role of not only HIF-1

(2015) Helena Doktorova et al.   BIOMEDICAL PAPERS-OLOMOUC

Impaired Synthesis of Stromal Components in Response to Minnelide Improves Vascular Function, Drug Delivery, and Survival in Pancreatic Cancer

(2015) S. Banerjee et al.   CLINICAL CANCER RESEARCH

Hypoxia-induced cell stemness leads to drug resistance and poor prognosis in lung adenocarcinoma

(2015) Mingchuan Zhao et al.   LUNG CANCER

A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models

(2015) Chrysi Xintaropoulou et al.   Oncotarget

HIF-1α and GLUT1 Gene Expression is Associated with Chemoresistance of Acute Myeloid Leukemia

(2014) Kui Song et al.   Asian Pacific Journal of Cancer Prevention

Hypoxia promotes stem-like properties of laryngeal cancer cell lines by increasing the CD133+ stem cell fraction

(2014) CHUN-PING WU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Involvement of HIF-1α activation in the doxorubicin resistance of human osteosarcoma cells

(2014) LAURA RONCUZZI et al.   ONCOLOGY REPORTS

Hypoxia-Inducible Factors Modulate the Stemness and Malignancy of Colon Cancer Cells by Playing Opposite Roles in Canonical Wnt Signaling

(2014) Paula Santoyo-Ramos et al.   PLoS One

BAY 87–2243, a novel inhibitor of hypoxia-induced gene activation, improves local tumor control after fractionated irradiation in a schedule-dependent manner in head and neck human xenografts

(2014) Linda Helbig et al.   Radiation Oncology

The stromal compartments in pancreatic cancer: Are there any therapeutic targets?

(2013) Serena Lunardi et al.   CANCER LETTERS

Transcriptional regulation by hypoxia inducible factors

(2013) Veronica L. Dengler et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Triptolide-induced Cell Death in Pancreatic Cancer Is Mediated byO-GlcNAc Modification of Transcription Factor Sp1

(2013) Sulagna Banerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I

(2013) Peter Ellinghaus et al.   Cancer Medicine

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

(2012) Michael A Jacobetz et al.   GUT

Cooperativity of Stress-Responsive Transcription Factors in Core Hypoxia-Inducible Factor Binding Regions

(2012) Diego Villar et al.   PLoS One

A Preclinical Evaluation of Minnelide as a Therapeutic Agent Against Pancreatic Cancer

(2012) R. Chugh et al.   Science Translational Medicine

Triptolide (TPL) Inhibits Global Transcription by Inducing Proteasome-Dependent Degradation of RNA Polymerase II (Pol II)

(2011) Ying Wang et al.   PLoS One

Global Patterns of Cancer Incidence and Mortality Rates and Trends

(2010) A. Jemal et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Stabilization of Hypoxia-inducible Factor-1α Protein in Hypoxia Occurs Independently of Mitochondrial Reactive Oxygen Species Production

(2010) Yee Liu Chua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heat Shock Protein 70 Inhibits Apoptosis in Cancer Cells Through Simultaneous and Independent Mechanisms

(2009) Vikas Dudeja et al.   GASTROENTEROLOGY

Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts

(2009) David R. Mole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIF-1α Modulates Energy Metabolism in Cancer Cells by Inducing Over-Expression of Specific Glycolytic Isoforms

(2009) Alvaro Marin-Hernandez et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death

(2009) D A Tennant et al.   ONCOGENE