Islet biology, the CDKN2A/B locus and type 2 diabetes risk

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Association study of the miRNA-binding site polymorphisms of CDKN2A/B genes with gestational diabetes mellitus susceptibility

(2015) Xiaojing Wang et al.   ACTA DIABETOLOGICA

Aging-Dependent Demethylation of Regulatory Elements Correlates with Chromatin State and Improved β Cell Function

(2015) Dana Avrahami et al.   Cell Metabolism

Loss-of-Function Mutations in the Cell-Cycle Control GeneCDKN2AImpact on Glucose Homeostasis in Humans

(2015) Aparna Pal et al.   DIABETES

Association Analysis of 29,956 Individuals Confirms That a Low-Frequency Variant atCCND2Halves the Risk of Type 2 Diabetes by Enhancing Insulin Secretion

(2015) Hanieh Yaghootkar et al.   DIABETES

Bisphenol-A Treatment During Pregnancy in Mice: A New Window of Susceptibility for the Development of Diabetes in Mothers Later in Life

(2015) Paloma Alonso-Magdalena et al.   ENDOCRINOLOGY

Diabetes susceptibility in Mayas: Evidence for the involvement of polymorphisms in HHEX, HNF4α, KCNJ11, PPARγ, CDKN2A/2B, SLC30A8, CDC123/CAMK1D, TCF7L2, ABCA1 and SLC16A11 genes

(2015) J.C. Lara-Riegos et al.   GENE

CDK4 is an essential insulin effector in adipocytes

(2015) Sylviane Lagarrigue et al.   JOURNAL OF CLINICAL INVESTIGATION

Epigenetic linkage of aging, cancer and nutrition

(2015) M. Daniel et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Long non-coding RNA ANRIL is upregulated in hepatocellular carcinoma and regulates cell apoptosis by epigenetic silencing of KLF2

(2015) Ming-de Huang et al.   Journal of Hematology & Oncology

Functional genomics of the CDKN2A/B locus in cardiovascular and metabolic disease: what have we learned from GWASs?

(2015) Sarah Anissa Hannou et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

TOX and CDKN2A/B Gene Polymorphisms Are Associated with Type 2 Diabetes in Han Chinese

(2015) Fengjiang Wei et al.   Scientific Reports

CDKN2B expression and subcutaneous adipose tissue expandability: Possible influence of the 9p21 atherosclerosis locus

(2014) Per-Arne Svensson et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Interaction of type 2 diabetes mellitus with Chromosome 9p21 rs10757274 polymorphism on the risk of myocardial infarction: a case–control study in Chinese population

(2014) Liu-wei Zhang et al.   BMC Cardiovascular Disorders

Genetic polymorphisms in the 9p21 region associated with risk of multiple cancers

(2014) W.-Q. Li et al.   CARCINOGENESIS

Fine Mapping of Type 2 Diabetes Susceptibility Loci

(2014) Andrew P. Morris   Current Diabetes Reports

Lipotoxicity in the Pancreatic Beta Cell: Not Just Survival and Function, but Proliferation as Well?

(2014) Rohit B. Sharma et al.   Current Diabetes Reports

Differential Transcriptome Analysis of Diabetes-Resistant and -Sensitive Mouse Islets Reveals Significant Overlap With Human Diabetes Susceptibility Genes

(2014) O. Kluth et al.   DIABETES

Reduced Ki67 Staining in the Postmortem State Calls Into Question Past Conclusions About the Lack of Turnover of Adult Human β-Cells

(2014) Brooke A. Sullivan et al.   DIABETES

Cdkn2a/p16Ink4a Regulates Fasting-Induced Hepatic Gluconeogenesis Through the PKA-CREB-PGC1  Pathway

(2014) K. Bantubungi et al.   DIABETES

Gender-dependent associations of CDKN2A/2B, KCNJ11, POLI, SLC30A8, and TCF7L2 variants with type 2 diabetes in (North African) Tunisian Arabs

(2014) Amira Turki et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Genetic variants for type 2 diabetes and new-onset cancer in Chinese with type 2 diabetes

(2014) R.C.W. Ma et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Dorothy Hodgkin Lecture 2014Understanding genes identified by genome-wide association studies for Type 2 diabetes

(2014) G. A. Rutter   DIABETIC MEDICINE

Disease-associated polymorphisms in 9p21 are not associated with extreme longevity

(2014) Ada Congrains et al.   Geriatrics & Gerontology International

Long Noncoding RNA ANRIL Promotes Non-Small Cell Lung Cancer Cell Proliferation and Inhibits Apoptosis by Silencing KLF2 and P21 Expression

(2014) F.-q. Nie et al.   MOLECULAR CANCER THERAPEUTICS

Cyclin D1–Cdk4 controls glucose metabolism independently of cell cycle progression

(2014) Yoonjin Lee et al.   NATURE

Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes

(2014) Valgerdur Steinthorsdottir et al.   NATURE GENETICS

Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants

(2014) Lorenzo Pasquali et al.   NATURE GENETICS

Deletions of RDINK4/ARF Enhancer in Gastrinomas and Nonfunctioning Pancreatic Neuroendocrine Tumors

(2014) Ming J. Poi et al.   PANCREAS

Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism

(2014) J. Fadista et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Ink4a/Arf Locus in Beta Cell Mass Expansion under Physiological and Pathological Conditions

(2014) Elisabet Salas et al.   Journal of Diabetes Research

PTEN controls β-cell regeneration in aged mice by regulating cell cycle inhibitor p16ink4a

(2013) Ni Zeng et al.   AGING CELL

Adaptive β-cell proliferation increases early in high-fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression

(2013) Rachel E. Stamateris et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Evidence that P12, a specific variant of P16INK4A, plays a suppressive role in human pancreatic carcinogenesis

(2013) Ming J. Poi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effects of Common Genetic Variants Associated With Type 2 Diabetes and Glycemic Traits on α- and β-Cell Function and Insulin Action in Humans

(2013) Anna Jonsson et al.   DIABETES

Human Pancreatic  -Cell G1/S Molecule Cell Cycle Atlas

(2013) N. M. Fiaschi-Taesch et al.   DIABETES

Cytoplasmic-Nuclear Trafficking of G1/S Cell Cycle Molecules and Adult Human  -Cell Replication: A Revised Model of Human  -Cell G1/S Control

(2013) N. M. Fiaschi-Taesch et al.   DIABETES

Systemic Regulation of the Age-Related Decline of Pancreatic β-Cell Replication

(2013) Seth J. Salpeter et al.   DIABETES

Genetic Modifiers of Cystic Fibrosis-Related Diabetes

(2013) S. M. Blackman et al.   DIABETES

Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity

(2013) Antigone S. Dimas et al.   DIABETES

Adult-onset deletion of Pten increases islet mass and beta cell proliferation in mice

(2013) Kai-Ting Yang et al.   DIABETOLOGIA

Glucose regulation of a cell cycle gene module is selectively lost in mouse pancreatic islets during ageing

(2013) A. Moreno-Asso et al.   DIABETOLOGIA

Search for genetic determinants of sulfonylurea efficacy in type 2 diabetic patients from China

(2013) Qian Ren et al.   DIABETOLOGIA

TCF7L2 in mouse pancreatic beta cells plays a crucial role in glucose homeostasis by regulating beta cell mass

(2013) Iseki Takamoto et al.   DIABETOLOGIA

Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets

(2013) T. A. Dayeh et al.   DIABETOLOGIA

Trans-ethnic fine mapping identifies a novel independent locus at the 3′ end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population

(2013) Jane Z. Kuo et al.   DIABETOLOGIA

The relationship between five widely-evaluated variants in CDKN2A/B and CDKAL1 genes and the risk of type 2 diabetes: A meta-analysis

(2013) Feng Peng et al.   GENE

Senescence in pancreatic carcinogenesis: from signalling to chromatin remodelling and epigenetics

(2013) Shiv K Singh et al.   GUT

The large non-coding RNA ANRIL, which is associated with atherosclerosis, periodontitis and several forms of cancer, regulates ADIPOR1, VAMP3 and C11ORF10

(2013) Gregor Bochenek et al.   HUMAN MOLECULAR GENETICS

ANRIL: Molecular Mechanisms and Implications in Human Health

(2013) Ada Congrains et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Clinical and Genetic Risk Factors for Type 2 Diabetes at Early or Late Post Partum After Gestational Diabetes Mellitus

(2013) Soo Heon Kwak et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The role of aging upon β cell turnover

(2013) Jake A. Kushner   JOURNAL OF CLINICAL INVESTIGATION

Combined modulation of polycomb and trithorax genes rejuvenates β cell replication

(2013) Josie X. Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

CDKN2Bexpression in adipose tissue of familial combined hyperlipidemia patients

(2013) Stuart D. Horswell et al.   JOURNAL OF LIPID RESEARCH

Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes

(2013) Jalal Taneera et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants

(2013) S. C. J. Parker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of β-cell replication by a synthetic HNF4α antagonist

(2013) Seung-Hee Lee et al.   STEM CELLS

Age-associated changes of islet endocrine cells and the effects of body mass index in Japanese

(2013) Hiroki Mizukami et al.   Journal of Diabetes Investigation

Alu Elements in ANRIL Non-Coding RNA at Chromosome 9p21 Modulate Atherogenic Cell Functions through Trans-Regulation of Gene Networks

(2013) Lesca M. Holdt et al.   PLoS Genetics

Re-thinking cell cycle regulators: the cross-talk with metabolism

(2013) Lluis Fajas   Frontiers in Oncology

Increased dosage ofInk4/Arfprotects against glucose intolerance and insulin resistance associated with aging

(2012) Herminia González-Navarro et al.   AGING CELL

Review: a meta-analysis of GWAS and age-associated diseases

(2012) William R. Jeck et al.   AGING CELL

Common genetic variants on chromosome 9p21 are associated with myocardial infarction and type 2 diabetes in an Italian population

(2012) Francesca Gori et al.   BMC Medical Genetics

Association between 9p21 genetic variants and mortality risk in a prospective cohort of patients with type 2 diabetes (ZODIAC-15)

(2012) Gijs WD Landman et al.   Cardiovascular Diabetology

Molecular Profiling of Pancreatic Neuroendocrine Tumors in Sporadic and Von Hippel-Lindau Patients

(2012) D. Speisky et al.   CLINICAL CANCER RESEARCH

Contribution of Common Genetic Variation to the Risk of Type 2 Diabetes in the Mexican Mestizo Population

(2012) M. A. Gamboa-Melendez et al.   DIABETES

ChREBP Mediates Glucose-Stimulated Pancreatic  -Cell Proliferation

(2012) M. R. Metukuri et al.   DIABETES

Free Fatty Acids Block Glucose-Induced  -Cell Proliferation in Mice by Inducing Cell Cycle Inhibitors p16 and p18

(2012) J. Pascoe et al.   DIABETES

A Genome-Wide Association Study IdentifiesGRK5andRASGRP1as Type 2 Diabetes Loci in Chinese Hans

(2012) Huaixing Li et al.   DIABETES

European genetic variants associated with type 2 diabetes in North African Arabs

(2012) S. Cauchi et al.   DIABETES & METABOLISM

 -Cell Mass and Turnover in Humans: Effects of obesity and aging

(2012) Y. Saisho et al.   DIABETES CARE

Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skeletal muscle of healthy young men

(2012) S. C. Jacobsen et al.   DIABETOLOGIA

SNP in the genome-wide association study hotspot on chromosome 9p21 confers susceptibility to diabetic nephropathy in type 1 diabetes

(2012) E. Fagerholm et al.   DIABETOLOGIA

Analysis of common type 2 diabetes mellitus genetic risk factors in new-onset diabetes after transplantation in kidney transplant patients medicated with tacrolimus

(2012) Mateusz Kurzawski et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Bmi1 Is Required for Regeneration of the Exocrine Pancreas in Mice

(2012) Akihisa Fukuda et al.   GASTROENTEROLOGY

Pancreatic Beta Cells in Very Old Mice Retain Capacity for Compensatory Proliferation

(2012) Miri Stolovich-Rain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formation of a Human β-Cell Population within Pancreatic Islets Is Set Early in Life

(2012) Brigid E. Gregg et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography

(2012) Kikuko Hotta et al.   JOURNAL OF HUMAN GENETICS

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

(2012)   NATURE GENETICS

Activation of Protein Kinase C-  in Pancreatic  -Cells In Vivo Improves Glucose Tolerance and Induces  -Cell Expansion via mTOR Activation

(2011) S. Velazquez-Garcia et al.   DIABETES

Replication of 13 genome-wide association (GWA)-validated risk variants for type 2 diabetes in Pakistani populations

(2011) S. D. Rees et al.   DIABETOLOGIA

Downregulation of the tumour suppressor p16INK4A contributes to the polarisation of human macrophages toward an adipose tissue macrophage (ATM)-like phenotype

(2011) L. Fuentes et al.   DIABETOLOGIA

Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B

(2011) M. L. Hribal et al.   DIABETOLOGIA

Systemic and acute administration of parathyroid hormone-related peptide(1–36) stimulates endogenous beta cell proliferation while preserving function in adult mice

(2011) K. Williams et al.   DIABETOLOGIA

Association analysis of 31 common polymorphisms with type 2 diabetes and its related traits in Indian sib pairs

(2011) V. Gupta et al.   DIABETOLOGIA

Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas

(2011) E. J. Parra et al.   DIABETOLOGIA

Glucose Regulates Cyclin D2 Expression in Quiescent and Replicating Pancreatic β-Cells Through Glycolysis and Calcium Channels

(2011) Seth J. Salpeter et al.   ENDOCRINOLOGY

Common genetic variants associated with open-angle glaucoma

(2011) Wishal D. Ramdas et al.   HUMAN MOLECULAR GENETICS

9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response

(2011) Olivier Harismendy et al.   NATURE

E2F transcription factor-1 regulates oxidative metabolism

(2011) Emilie Blanchet et al.   NATURE CELL BIOLOGY

Comparing strategies to fine-map the association of common SNPs at chromosome 9p21 with type 2 diabetes and myocardial infarction

(2011) Jessica Shea et al.   NATURE GENETICS

Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1

(2011) Kathryn P Burdon et al.   NATURE GENETICS

p16Ink4a overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors

(2011) C Romagosa et al.   ONCOGENE

Hyperglycemia-Induced Proliferation of Adult Human Beta Cells Engrafted Into Spontaneously Diabetic Immunodeficient NOD-Rag1null IL2rγnull Ins2Akita Mice

(2011) Philip diIorio et al.   PANCREAS

Correction: Identifying and Characterizing Nodes Important to Community Structure Using the Spectrum of the Graph

(2011) Yang Wang et al.   PLoS One

Clinical translation of genetic predictors for type 2 diabetes

(2011) Amit R Majithia et al.   Current Opinion in Endocrinology Diabetes and Obesity

Cell cycle control of β-cell replication in the prenatal and postnatal human pancreas

(2010) Christina U. Köhler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in Type 2 Diabetes in a Chinese population

(2010) Xueyao Han et al.   BMC Medical Genetics

Glycemia Determines the Effect of Type 2 Diabetes Risk Genes on Insulin Secretion

(2010) M. Heni et al.   DIABETES

Decreased IRS Signaling Impairs  -Cell Cycle Progression and Survival in Transgenic Mice Overexpressing S6K in  -Cells

(2010) L. Elghazi et al.   DIABETES

Cyclin D2 Is Essential for the Compensatory  -Cell Hyperplastic Response to Insulin Resistance in Rodents

(2010) S. Georgia et al.   DIABETES

Induction of Human β-Cell Proliferation and Engraftment Using a Single G1/S Regulatory Molecule, cdk6

(2010) Nathalie M. Fiaschi-Taesch et al.   DIABETES

Impact of Common Variants ofPPARG,KCNJ11,TCF7L2,SLC30A8,HHEX,CDKN2A,IGF2BP2, andCDKAL1on the Risk of Type 2 Diabetes in 5,164 Indians

(2010) Ganesh Chauhan et al.   DIABETES

Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass

(2010) G. Fontés et al.   DIABETOLOGIA

Glucose stimulates human beta cell replication in vivo in islets transplanted into NOD–severe combined immunodeficiency (SCID) mice

(2010) H. E. Levitt et al.   DIABETOLOGIA

Expression analysis of loci associated with type 2 diabetes in human tissues

(2010) C. Cotsapas et al.   DIABETOLOGIA

Epigenetic regulation of theINK4b-ARF-INK4alocus

(2010) Nikolay Popov et al.   Epigenetics

ANRIL, a long, noncoding RNA, is an unexpected major hotspot in GWAS

(2010) Eric Pasmant et al.   FASEB JOURNAL

Significant Human β-Cell Turnover Is Limited to the First Three Decades of Life as Determined byin VivoThymidine Analog Incorporation and Radiocarbon Dating

(2010) S. Perl et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Replication of recently described type 2 diabetes gene variants in a South Indian population

(2010) Manickam Chidambaram et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Molecular Interplay of the Noncoding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4a

(2010) Kyoko L. Yap et al.   MOLECULAR CELL

Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice

(2010) Axel Visel et al.   NATURE

A genome-wide association study identifies genetic variants in the CDKN2BAS locus associated with endometriosis in Japanese

(2010) Satoko Uno et al.   NATURE GENETICS

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

(2010) Benjamin F Voight et al.   NATURE GENETICS

Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15 INK4B tumor suppressor gene

(2010) Y Kotake et al.   ONCOGENE

Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression

(2010) Michael S. Cunnington et al.   PLoS Genetics

Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke

(2009) Andreas Gschwendtner et al.   ANNALS OF NEUROLOGY

Functional Analysis of the Chromosome 9p21.3 Coronary Artery Disease Risk Locus

(2009) Olga Jarinova et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Disproportionate Hyperproinsulinemia, β-Cell Restricted Prohormone Convertase 2 Deficiency, and Cell Cycle Inhibitors Expression by Human Islets Transplanted into Athymic Nude Mice: Insights into Nonimmune-Mediated Mechanisms of Delayed Islet Graft Failure

(2009) Alberto M. Davalli et al.   CELL TRANSPLANTATION

p38MAPK Controls Expression of Multiple Cell Cycle Inhibitors and Islet Proliferation with Advancing Age

(2009) Esther Sook Miin Wong et al.   DEVELOPMENTAL CELL

Age-Dependent Decline in  -Cell Proliferation Restricts the Capacity of  -Cell Regeneration in Mice

(2009) S.-I. Tschen et al.   DIABETES

Combined Risk Allele Score of Eight Type 2 Diabetes Genes Is Associated With Reduced First-Phase Glucose-Stimulated Insulin Secretion During Hyperglycemic Clamps

(2009) L. M. 't Hart et al.   DIABETES

Interrogating Type 2 Diabetes Genome-Wide Association Data Using a Biological Pathway-Based Approach

(2009) J. R.B. Perry et al.   DIABETES

Previously Associated Type 2 Diabetes Variants May Interact With Physical Activity to Modify the Risk of Impaired Glucose Regulation and Type 2 Diabetes: A Study of 16,003 Swedish Adults

(2009) E. C. Brito et al.   DIABETES

Confirmation of Multiple Risk Loci and Genetic Impacts by a Genome-Wide Association Study of Type 2 Diabetes in the Japanese Population

(2009) F. Takeuchi et al.   DIABETES

Adaptive  -Cell Proliferation Is Severely Restricted With Advanced Age

(2009) M. M. Rankin et al.   DIABETES

Survey of the Human Pancreatic  -Cell G1/S Proteome Reveals a Potential Therapeutic Role for Cdk-6 and Cyclin D1 in Enhancing Human  -Cell Replication and Function In Vivo

(2009) N. Fiaschi-Taesch et al.   DIABETES

No association of multiple type 2 diabetes loci with type 1 diabetes

(2009) S. M. Raj et al.   DIABETOLOGIA

Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes

(2009) N. Pulizzi et al.   DIABETOLOGIA

Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study

(2009) S.-M. Ruchat et al.   DIABETOLOGIA

Poor maternal nutrition followed by accelerated postnatal growth leads to telomere shortening and increased markers of cell senescence in rat islets

(2009) J. L. Tarry-Adkins et al.   FASEB JOURNAL

Bmi-1 regulates the Ink4a/Arf locus to control pancreatic  -cell proliferation

(2009) S. Dhawan et al.   GENES & DEVELOPMENT

Polycomb protein Ezh2 regulates pancreatic  -cell Ink4a/Arf expression and regeneration in diabetes mellitus

(2009) H. Chen et al.   GENES & DEVELOPMENT

mTORC1 Activation Regulates β-Cell Mass and Proliferation by Modulation of Cyclin D2 Synthesis and Stability

(2009) Norman Balcazar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Inhibitory Effect of Recent Type 2 Diabetes Risk Loci on Insulin Secretion Is Modulated by Insulin Sensitivity

(2009) Axel Haupt et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Polymorphisms Identified through Genome-Wide Association Studies and Their Associations with Type 2 Diabetes in Chinese, Malays, and Asian-Indians in Singapore

(2009) Jonathan T. Tan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cyclin D2 Protein Stability Is Regulated in Pancreatic β-Cells

(2009) Lu Mei He et al.   MOLECULAR ENDOCRINOLOGY

The CDK4–pRB–E2F1 pathway controls insulin secretion

(2009) Jean-Sébastien Annicotte et al.   NATURE CELL BIOLOGY

Chromosome 9p21.3 genotype is associated with vascular dementia and Alzheimer's disease

(2009) Enzo Emanuele et al.   NEUROBIOLOGY OF AGING

Spectral Karyotypic and Comparative Genomic Analysis of the Endocrine Pancreatic Tumor Cell Line BON-1

(2009) Juan R. Lopez et al.   NEUROENDOCRINOLOGY

Polycomb Mediated Epigenetic Silencing and Replication Timing at the INK4a/ARF Locus during Senescence

(2009) Hanane Agherbi et al.   PLoS One

Relationship between CAD Risk Genotype in the Chromosome 9p21 Locus and Gene Expression. Identification of Eight New ANRIL Splice Variants

(2009) Lasse Folkersen et al.   PLoS One

Bmi1 lineage tracing identifies a self-renewing pancreatic acinar cell subpopulation capable of maintaining pancreatic organ homeostasis

(2009) E. Sangiorgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of Common Type 2 Diabetes Risk Gene Variants and Posttransplantation Diabetes Mellitus in Renal Allograft Recipients in Korea

(2009) Eun Seok Kang et al.   TRANSPLANTATION

Identification of a Shared Genetic Susceptibility Locus for Coronary Heart Disease and Periodontitis

(2009) Arne S. Schaefer et al.   PLoS Genetics

New gene variants alter type 2 diabetes risk predominantly through reduced beta-cell function

(2008) John RB Perry et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Replication Study of Candidate Genes Associated With Type 2 Diabetes Based On Genome-Wide Screening

(2008) Y. Tabara et al.   DIABETES

Extension of Type 2 Diabetes Genome-Wide Association Scan Results in the Diabetes Prevention Program

(2008) A. F. Moore et al.   DIABETES

Lessons From the First Comprehensive Molecular Characterization of Cell Cycle Control in Rodent Insulinoma Cell Lines

(2008) I. Cozar-Castellano et al.   DIABETES

Association Analysis of Type 2 Diabetes Loci in Type 1 Diabetes

(2008) H.-Q. Qu et al.   DIABETES

Predicting Type 2 Diabetes Based on Polymorphisms From Genome-Wide Association Studies: A Population-Based Study

(2008) M. van Hoek et al.   DIABETES

Implication of Genetic Variants Near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in Type 2 Diabetes and Obesity in 6,719 Asians

(2008) M. C.Y. Ng et al.   DIABETES

 -Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of  -Cell Mass in Humans

(2008) J. J. Meier et al.   DIABETES

Strong association of common variants in the CDKN2A/CDKN2B region with type 2 diabetes in French Europids

(2008) K. Duesing et al.   DIABETOLOGIA

Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion

(2008) K. Kirchhoff et al.   DIABETOLOGIA

Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps

(2008) M. J. Groenewoud et al.   DIABETOLOGIA

Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population

(2008) Y. M. Cho et al.   DIABETOLOGIA

Common Type 2 Diabetes Risk Gene Variants Associate with Gestational Diabetes

(2008) Jeannet Lauenborg et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population

(2008) Yong-Ho Lee et al.   JOURNAL OF HUMAN GENETICS

Whole Genome Analyses Suggest Ischemic Stroke and Heart Disease Share an Association With Polymorphisms on Chromosome 9p21

(2008) Mar Matarin et al.   STROKE