Lipotoxicity in the Pancreatic Beta Cell: Not Just Survival and Function, but Proliferation as Well?
Published 2014 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Lipotoxicity in the Pancreatic Beta Cell: Not Just Survival and Function, but Proliferation as Well?
Authors
Keywords
Pancreatic beta cell, Islet, Lipotoxicity, Glucolipotoxicity, Lipid, Triglyceride, Free fatty acid, Nonesterified fatty acid, Growth factors, Inflammation, Metabolism, gpr40, FFAR1, Fatty acid receptor, Oxidative stress, Endoplasmic reticulum stress, Autophagy, PPAR, Cell cycle, Proliferation, Insulin secretion, Apoptosis
Journal
Current Diabetes Reports
Volume 14, Issue 6, Pages -
Publisher
Springer Nature
Online
2014-04-16
DOI
10.1007/s11892-014-0492-2
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Risk Factors for Type 2 Diabetes Mellitus Preceded by β-Cell Dysfunction, Insulin Resistance, or Both in Older Adults
- (2013) Fumiaki Imamura et al. AMERICAN JOURNAL OF EPIDEMIOLOGY
- Multiple mechanisms of GW-9508, a selective G protein-coupled receptor 40 agonist, in the regulation of glucose homeostasis and insulin sensitivity
- (2013) Horng-Yih Ou et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Overexpression of glutathione peroxidase 4 prevents β-cell dysfunction induced by prolonged elevation of lipids in vivo
- (2013) Khajag Koulajian et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Adaptive β-cell proliferation increases early in high-fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression
- (2013) Rachel E. Stamateris et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Protective effect of nicotinamide on high glucose/palmitate-induced glucolipotoxicity to INS-1 beta cells is attributed to its inhibitory activity to sirtuins
- (2013) Soo-Jin Lee et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Oleate rescues INS-1E β-cells from palmitate-induced apoptosis by preventing activation of the unfolded protein response
- (2013) Dietlind Sommerweiss et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Novel insights into pancreatic β-cell glucolipotoxicity from real-time functional analysis of mitochondrial energy metabolism in INS-1E insulinoma cells
- (2013) Jonathan Barlow et al. BIOCHEMICAL JOURNAL
- Chronic glucolipotoxic conditions in pancreatic islets impair insulin secretion due to dysregulated calcium dynamics, glucose responsiveness and mitochondrial activity
- (2013) Baggavalli P Somesh et al. BMC CELL BIOLOGY
- TAK-875, a GPR40/FFAR1 agonist, in combination with metformin prevents progression of diabetes and β-cell dysfunction in Zucker diabetic fatty rats
- (2013) R Ito et al. BRITISH JOURNAL OF PHARMACOLOGY
- Metabolic Signaling in Fuel-Induced Insulin Secretion
- (2013) Marc Prentki et al. Cell Metabolism
- Inflammation in Obesity and Diabetes: Islet Dysfunction and Therapeutic Opportunity
- (2013) Marc Y. Donath et al. Cell Metabolism
- Effects of High-Density Lipoprotein Elevation With Cholesteryl Ester Transfer Protein Inhibition on Insulin Secretion
- (2013) Andrew L. Siebel et al. CIRCULATION RESEARCH
- Killing Two Birds With One Stone, Maybe
- (2013) Sergio Fazio et al. CIRCULATION RESEARCH
- Neprilysin Deficiency Protects Against Fat-Induced Insulin Secretory Dysfunction by Maintaining Calcium Influx
- (2013) S. Zraika et al. DIABETES
- Prostaglandin E2 Receptor, EP3, Is Induced in Diabetic Islets and Negatively Regulates Glucose- and Hormone-Stimulated Insulin Secretion
- (2013) M. E. Kimple et al. DIABETES
- Npas4 Is a Novel Activity–Regulated Cytoprotective Factor in Pancreatic β-Cells
- (2013) Paul V. Sabatini et al. DIABETES
- Reevaluation of Fatty Acid Receptor 1 as a Drug Target for the Stimulation of Insulin Secretion in Humans
- (2013) R. Wagner et al. DIABETES
- β-Cell Lipotoxicity in Response to Free Fatty Acid Elevation in Prepubertal Youth
- (2013) Sara F. Michaliszyn et al. DIABETES
- NADPH oxidase inhibition prevents beta cell dysfunction induced by prolonged elevation of oleate in rodents
- (2013) K. Koulajian et al. DIABETOLOGIA
- Modulating GPR40: therapeutic promise and potential in diabetes
- (2013) Vincent Poitout et al. DRUG DISCOVERY TODAY
- FFAR1 Is Involved in Both the Acute and Chronic Effects of Palmitate on Insulin Secretion
- (2013) Hjalti Kristinsson et al. ENDOCRINOLOGY
- The C57BL/6J Niemann–Pick C1 mouse model with decreased gene dosage has impaired glucose tolerance independent of body weight
- (2013) David Jelinek et al. GENE
- Diminished Acyl-CoA Synthetase Isoform 4 Activity in INS 832/13 Cells Reduces Cellular Epoxyeicosatrienoic Acid Levels and Results in Impaired Glucose-stimulated Insulin Secretion
- (2013) Eric L. Klett et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Coordinate Changes in Histone Modifications, mRNA Levels, and Metabolite Profiles in Clonal INS-1 832/13 β-Cells Accompany Functional Adaptations to Lipotoxicity
- (2013) Siri Malmgren et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cathepsin B Contributes to Autophagy-related 7 (Atg7)-induced Nod-like Receptor 3 (NLRP3)-dependent Proinflammatory Response and Aggravates Lipotoxicity in Rat Insulinoma Cell Line
- (2013) Shali Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Alteration of Endoplasmic Reticulum Lipid Rafts Contributes to Lipotoxicity in Pancreatic β-Cells
- (2013) Ebru Boslem et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The DPP-4 Inhibitor Linagliptin Restores β-Cell Function and Survival in Human Isolated Islets Through GLP-1 Stabilization
- (2013) Payal Shah et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Metabolic Consequences of Adipose Triglyceride Lipase Deficiency in Humans: An In Vivo Study in Patients With Neutral Lipid Storage Disease With Myopathy
- (2013) Andrea Natali et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Identification of ATP Synthase As a Lipid Peroxide Protein Adduct in Pancreatic Islets From Humans With and Without Type 2 Diabetes Mellitus
- (2013) M. J. MacDonald et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Role of HDL Cholesterol and Estimates of HDL Particle Composition in Future Development of Type 2 Diabetes in the General Population: The PREVEND Study
- (2013) Ali Abbasi et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- β-Cell Lipotoxicity After an Overnight Intravenous Lipid Challenge and Free Fatty Acid Elevation in African American Versus American White Overweight/Obese Adolescents
- (2013) Kara S. Hughan et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Lipotoxicity disrupts incretin-regulated human β cell connectivity
- (2013) David J. Hodson et al. JOURNAL OF CLINICAL INVESTIGATION
- Adverse association between obesity and menopause in mice treated with bezafibrate, a pan peroxisome proliferator–activated receptor agonist
- (2013) Tatiane da Silva Faria et al. MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
- GPR40 protein levels are crucial to the regulation of stimulated hormone secretion in pancreatic islets. Lessons from spontaneous obesity-prone and non-obese type 2 diabetes in rats
- (2013) Sandra Meidute Abaraviciene et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Activation of FFA1 mediates GLP-1 secretion in mice. Evidence for allosterism at FFA1
- (2013) Yumei Xiong et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- AMPK Regulates ER Morphology and Function in Stressed Pancreatic β-Cells via Phosphorylation of DRP1
- (2013) Jakob D. Wikstrom et al. MOLECULAR ENDOCRINOLOGY
- PPAR-γ Activation Increases Insulin Secretion through the Up-regulation of the Free Fatty Acid Receptor GPR40 in Pancreatic β-Cells
- (2013) Hyo-Sup Kim et al. PLoS One
- Free Fatty Acid Induces Endoplasmic Reticulum Stress and Apoptosis of β-cells by Ca2+/Calpain-2 Pathways
- (2013) Wei Cui et al. PLoS One
- DC260126: A Small-Molecule Antagonist of GPR40 that Protects against Pancreatic β-Cells Dysfunction in db/db Mice
- (2013) Peng Sun et al. PLoS One
- A Novel Antidiabetic Drug, Fasiglifam/TAK-875, Acts as an Ago-Allosteric Modulator of FFAR1
- (2013) Chiori Yabuki et al. PLoS One
- The fatty acid receptor FFA1/GPR40 a decade later: how much do we know?
- (2013) Arturo D. Mancini et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- β-cell metabolic alterations under chronic nutrient overload in rat and human islets
- (2013) Stephanie Vernier et al. Islets
- Treatment with CNX-011-67, a novel GPR40 agonist, delays onset and progression of diabetes and improves beta cell preservation and function in male ZDF rats
- (2013) Nagesh Gowda et al. BMC Pharmacology & Toxicology
- A role for aberrant protein palmitoylation in FFA-induced ER stress and β-cell death
- (2012) Aaron C. Baldwin et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Endoplasmic Reticulum Stress and Type 2 Diabetes
- (2012) Sung Hoon Back et al. Annual Review of Biochemistry
- Upregulation of phagocyte-like NADPH oxidase by cytokines in pancreatic beta-cells: Attenuation of oxidative and nitrosative stress by 2-bromopalmitate
- (2012) Abiy M. Mohammed et al. BIOCHEMICAL PHARMACOLOGY
- Relationship between blood lipid profiles and pancreatic islet β cell function in Chinese men and women with normal glucose tolerance: a cross-sectional study
- (2012) Tianpeng Zheng et al. BMC PUBLIC HEALTH
- Changes in food intake, metabolic parameters and insulin resistance are induced by an isoenergetic, medium-chain fatty acid diet and are associated with modifications in insulin signalling in isolated rat pancreatic islets
- (2012) A. C. Marçal et al. BRITISH JOURNAL OF NUTRITION
- Statin Use and the Risk of Incident Diabetes Mellitus: A Review of the Literature
- (2012) Jillian D. Colbert et al. CANADIAN JOURNAL OF CARDIOLOGY
- Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation
- (2012) Kosei Eguchi et al. Cell Metabolism
- Long-term in vitro treatment of INS-1 rat pancreatic β-cells by unsaturated free fatty acids protects cells against gluco- and lipotoxicities via activation of GPR40 receptors
- (2012) Ya Tuo et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- HDLs Protect Pancreatic β-Cells Against ER Stress by Restoring Protein Folding and Trafficking
- (2012) Jannick Pétremand et al. DIABETES
- Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress-Mitochondrial Dialog Triggering Lipotoxic Rodent and Human -Cell Apoptosis
- (2012) D. A. Cunha et al. DIABETES
- Free Fatty Acids Block Glucose-Induced -Cell Proliferation in Mice by Inducing Cell Cycle Inhibitors p16 and p18
- (2012) J. Pascoe et al. DIABETES
- Pancreatic Steatosis and Its Relationship to -Cell Dysfunction in Humans: Racial and ethnic variations
- (2012) L. S. Szczepaniak et al. DIABETES CARE
- Long-term high density lipoprotein infusion ameliorates metabolic phenotypes of diabetic db/db mice
- (2012) Qichun Zhang et al. DIABETES-METABOLISM RESEARCH AND REVIEWS
- Banting Memorial Lecture 2012Reversing the twin cycles of Type 2 diabetes
- (2012) R. Taylor DIABETIC MEDICINE
- Identification of direct forkhead box O1 targets involved in palmitate-induced apoptosis in clonal insulin-secreting cells using chromatin immunoprecipitation coupled to DNA selection and ligation
- (2012) H. Y. Lin et al. DIABETOLOGIA
- Lactogens protect rodent and human beta cells against glucolipotoxicity-induced cell death through Janus kinase‐2 (JAK2)/signal transducer and activator of transcription-5 (STAT5) signalling
- (2012) N. Guthalu Kondegowda et al. DIABETOLOGIA
- Pharmacological reduction of NEFA restores the efficacy of incretin-based therapies through GLP-1 receptor signalling in the beta cell in mouse models of diabetes
- (2012) Z. F. Kang et al. DIABETOLOGIA
- Aberrant activation of liver X receptors impairs pancreatic beta cell function through upregulation of sterol regulatory element-binding protein 1c in mouse islets and rodent cell lines
- (2012) Z. X. Meng et al. DIABETOLOGIA
- G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1
- (2012) M. Ferdaoussi et al. DIABETOLOGIA
- Mild Endoplasmic Reticulum Stress Augments the Proinflammatory Effect of IL-1β in Pancreatic Rat β-Cells via the IRE1α/XBP1s Pathway
- (2012) Michela Miani et al. ENDOCRINOLOGY
- Susceptibility to Fatty Acid-Induced β-Cell Dysfunction Is Enhanced in Prediabetic Diabetes-Prone BioBreeding Rats: A Potential Link Between β-Cell Lipotoxicity and Islet Inflammation
- (2012) Christine Tang et al. ENDOCRINOLOGY
- Overexpression of peroxisome proliferator-activated receptor α in pancreatic β-cells improves glucose tolerance in diet-induced obese mice
- (2012) K-Lynn N. Hogh et al. EXPERIMENTAL PHYSIOLOGY
- Quantitative imaging of electron transfer flavoprotein autofluorescence reveals the dynamics of lipid partitioning in living pancreatic islets
- (2012) Alan K. Lam et al. Integrative Biology
- Cellular Inhibitor of Apoptosis Protein-1 (cIAP1) Plays a Critical Role in β-Cell Survival under Endoplasmic Reticulum Stress
- (2012) Yanfei Qi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Higher Fasting Plasma Free Fatty Acid Levels Are Associated with Lower Insulin Secretion in Children and Adults and a Higher Incidence of Type 2 Diabetes
- (2012) Burak Salgin et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Exendin-4 inhibits glucolipotoxic ER stress in pancreatic β cells via regulation of SREBP1c and C/EBPβ transcription factors
- (2012) Yoon Sin Oh et al. JOURNAL OF ENDOCRINOLOGY
- GLP1-derived nonapeptide GLP1(28–36)amide protects pancreatic β-cells from glucolipotoxicity
- (2012) Zhengu Liu et al. JOURNAL OF ENDOCRINOLOGY
- Repression of sterol regulatory element-binding protein 1-c is involved in the protective effects of exendin-4 in pancreatic β-cell line
- (2012) Seok-Woo Hong et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction
- (2012) Jessica R. Weaver et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Associations of ATP-Binding Cassette Transporter A1 and G1 With Insulin Secretion in Human Insulinomas
- (2012) Huali Zhou et al. PANCREAS
- The human glucagon-like peptide-1 analogue liraglutide regulates pancreatic beta-cell proliferation and apoptosis via an AMPK/mTOR/P70S6K signaling pathway
- (2012) Xin-Yu Miao et al. PEPTIDES
- Improved Preservation of Residual Beta Cell Function by Atorvastatin in Patients with Recent Onset Type 1 Diabetes and High CRP Levels (DIATOR Trial)
- (2012) Alexander Strom et al. PLoS One
- Palmitate Activates Autophagy in INS-1E β-Cells and in Isolated Rat and Human Pancreatic Islets
- (2012) Luisa Martino et al. PLoS One
- Lipopolysaccharides Impair Insulin Gene Expression in Isolated Islets of Langerhans via Toll-Like Receptor-4 and NF-κB Signalling
- (2012) Julie Amyot et al. PLoS One
- Endoplasmic Reticulum Redox State Is Not Perturbed by Pharmacological or Pathological Endoplasmic Reticulum Stress in Live Pancreatic β-Cells
- (2012) Irmgard Schuiki et al. PLoS One
- Roles of ceramide and sphingolipids in pancreatic β-cell function and dysfunction
- (2012) Ebru Boslem et al. Islets
- Early peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell mass
- (2011) Yurena Vivas et al. BMC Medical Genomics
- Autophagy deficiency in beta cells leads to compromised unfolded protein response and progression from obesity to diabetes in mice
- (2011) W. Quan et al. DIABETOLOGIA
- Ubiquitin C-terminal hydrolase L1 is required for pancreatic beta cell survival and function in lipotoxic conditions
- (2011) K. Y. Chu et al. DIABETOLOGIA
- The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes
- (2011) M. Shimoda et al. DIABETOLOGIA
- Stimulation of Lipogenesis as Well as Fatty Acid Oxidation Protects against Palmitate-Induced INS-1 β-Cell Death
- (2011) Sung-E. Choi et al. ENDOCRINOLOGY
- Macrophage migration inhibitory factor deficiency protects pancreatic islets from palmitic acid-induced apoptosis
- (2011) Tamara Saksida et al. IMMUNOLOGY AND CELL BIOLOGY
- Fatty Acids Suppress Autophagic Turnover in β-Cells
- (2011) Guy Las et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inhibition of GPR40 protects MIN6 β cells from palmitate-induced ER stress and apoptosis
- (2011) Jinwei Wu et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Exogenous Insulin Enhances Glucose-Stimulated Insulin Response in Healthy Humans Independent of Changes in Free Fatty Acids
- (2011) Ximena Lopez et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents β cell failure in rodent models of type 2 diabetes
- (2011) Joseph P. Tiano et al. JOURNAL OF CLINICAL INVESTIGATION
- Glucagon-like peptide–1 and candesartan additively improve glucolipotoxicity in pancreatic β-cells
- (2011) Hong-Wei Wang et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Glycerolipid/free fatty acid cycle and islet β-cell function in health, obesity and diabetes
- (2011) Marc Prentki et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport
- (2011) Kazuaki Ohtsubo et al. NATURE MEDICINE
- UPR in palmitate-treated pancreatic beta-cells is not affected by altering oxidation of the fatty acid
- (2011) Ernest Sargsyan et al. Nutrition & Metabolism
- Regulation of insulin secretion and reactive oxygen species production by free fatty acids in pancreatic islets
- (2011) Maria Fernanda Graciano et al. Islets
- Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass
- (2010) G. Fontés et al. DIABETOLOGIA
- Novel Proapoptotic Effect of Hepatocyte Growth Factor: Synergy with Palmitate to Cause Pancreatic β-Cell Apoptosis
- (2010) José A. González-Pertusa et al. ENDOCRINOLOGY
- Regulation of pancreatic islet gene expression in mouse islets by pregnancy
- (2010) B T Layden et al. JOURNAL OF ENDOCRINOLOGY
- Islet beta cell failure in the 60% pancreatectomised obese hyperlipidaemic Zucker fatty rat: severe dysfunction with altered glycerolipid metabolism without steatosis or a falling beta cell mass
- (2009) V. Delghingaro-Augusto et al. DIABETOLOGIA
- Glycerolipid Metabolism and Signaling in Health and Disease
- (2008) Marc Prentki et al. ENDOCRINE REVIEWS
- Glucolipotoxicity: Fuel Excess and β-Cell Dysfunction
- (2008) Vincent Poitout et al. ENDOCRINE REVIEWS
- Beneficial effects of lipids and prolactin on insulin secretion and β-cell proliferation: a role for lipids in the adaptation of islets to pregnancy
- (2008) T Clark Brelje et al. JOURNAL OF ENDOCRINOLOGY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now