Article
Multidisciplinary Sciences
Zahra Kavian, Saman Sargazi, Mahdi Majidpour, Mohammad Sarhadi, Ramin Saravani, Mansour Shahraki, Shekoufeh Mirinejad, Milad Heidari Nia, Maryam Piri
Summary: This study investigated the association between SLC11A1 gene polymorphisms and Type 2 Diabetes Mellitus (T2DM). The results showed that rs3731864 G/A and rs17235416 + TGTG/- TGTG had a negative association with T2DM and provided protection against the disease, while rs3731865 G/C was associated with an increased risk of T2DM. Additionally, SLC11A1-rs3731864 G/A was significantly associated with triglyceride levels in T2DM patients.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Zaihan Zhu, Yanfen Zhang, Ruocen Bai, Ru Yang, Zhongyan Shan, Chunyan Ma, Jun Yang, Dandan Sun
Summary: This study found that miRNA polymorphisms involved in the insulin signaling pathways and the interaction effects of SNP-SNP, SNP-environmental factors were related to T2DM susceptibility in a Chinese population.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Health Care Sciences & Services
Charity Masilela, Brendon Pearce, Joven Jebio Ongole, Oladele Vincent Adeniyi, Mongi Benjeddou
Summary: This study examined the association of specific gene polymorphisms with the glycaemic response to metformin and sulphonylureas in South African adults with type 2 diabetes. Certain genotypes were found to be significantly associated with uncontrolled diabetes, while others were associated with controlled diabetes. An interaction between two gene polymorphisms was observed, indicating a potential influence on treatment response.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Genetics & Heredity
Di Wang, Liangshu Liu, Chengyu Zhang, Wensheng Lu, Feifei Wu, Xiaofeng He
Summary: This study conducted a meta-analysis to investigate the association between endothelial nitric oxide synthase (eNOS) polymorphisms and the risk of type 2 diabetes mellitus (T2DM). The results showed that the eNOS 4b/a and T786C polymorphisms were significantly associated with an increased risk of T2DM, while the eNOS G894T polymorphism was significantly associated with a decreased risk of T2DM. However, sensitivity analysis suggested that the association for the eNOS G894T polymorphism may be unreliable.
FRONTIERS IN GENETICS
(2022)
Article
Endocrinology & Metabolism
Jamie R. J. Inshaw, Carlo Sidore, Francesco Cucca, M. Irina Stefana, Daniel J. M. Crouch, Mark I. McCarthy, Anubha Mahajan, John A. Todd
Summary: This study identified genetic regions associated with both type 1 and type 2 diabetes, with four association signals co-localising between the two diseases in opposite directions, suggesting a complex genetic relationship between them.
Article
Cardiac & Cardiovascular Systems
Meng-Meng Wang, Chen-Fei Lu, Shi-Qi Yan, Bao-Zhu Wang, Gulinazi Yesitayi, Yong-Liang Tian, Xiang-Ma, Yi-Tong Ma
Summary: This study found that the rs2483205 CT + TT and CT genotypes, as well as the rs2495477 GA + GG genotype in the PCSK9 gene, were associated with an increased risk of type 2 diabetes in the Uygur population in Xinjiang.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Peixian Chen, Yumin Cao, Shenren Chen, Zhike Liu, Shiyi Chen, Yali Guo
Summary: This study evaluated the effects of genetic variations in organic cation transporter genes on the response to metformin treatment in diabetic patients. The results showed significant associations between variations in SLC47A1 and SLC47A2 genes and metformin efficacy, suggesting that these variations could be predictors of insulin resistance.
Article
Multidisciplinary Sciences
Sana Rafaqat, Jaida Manzoor, Rimsha Akhter, Zain Ishaque, Asifa Kamal, Faiza Saleem, Rasheeda Bashir
Summary: This study found a strong genetic association between PTPN22 gene polymorphisms rs2476601 and rs1310182 and type 1 diabetes in Pakistani children.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Nutrition & Dietetics
Xiaoting Lu, Rongzhu Huang, Shuyi Li, Aiping Fang, Yuming Chen, Si Chen, Fan Wang, Xinlei Lin, Zhaoyan Liu, Huilian Zhu
Summary: The study found that higher serum betaine levels, mutations in MTHFR G1793A and A1298C genes, as well as their combined effects, are associated with a lower risk of type 2 diabetes.
Article
Endocrinology & Metabolism
Sameh Sarray, Meriem Dallel, Laila Ben Lamine, Deeba Jairajpuri, Nejla Sellami, Amira Turki, Zainab Malalla, Roland Brock, Mohamed Ghorbel, Touhami Mahjoub
Summary: The study revealed a consistent association of the rs243865 and rs243866 genotypes with protection against T2D susceptibility.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2021)
Article
Immunology
Minghang Pei, Xinshu Liu, Peizeng Yang, Chan Zhao, Fei Gao, Yi Qu, Anyi Liang, Junyan Xiao, Meifen Zhang
Summary: IL33/ST2 gene polymorphisms are associated with the development of BDU, with specific alleles showing significant differences in BD patients with different clinical features, indicating the important role of IL33/ST2 in the pathogenesis of BDU.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Health Care Sciences & Services
Malek Zihlif, Amer Imraish, Baeth Al-Rawashdeh, Aya Qteish, Raihan Husami, Rawand Husami, Farah Tahboub, Yazun Jarrar, Su-Jun Lee
Summary: This study found a statistically significant association between multiple ADAM33 genetic polymorphisms and IgE levels, particularly showing a significant relationship between V4 polymorphism and IgE levels in both adults and children. Such findings add to the growing evidence that the ADAM33 gene has a major impact on IgE levels among asthmatic patients of Jordanian origin.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medical Laboratory Technology
Yuqi Wang, Ling Li, Ping Li
Summary: The association between gestational diabetes mellitus (GDM) and single nucleotide polymorphisms (SNPs) has been widely studied. SNPs can provide insights into the pathogenesis of GDM, help predict the risk of GDM, and guide the management of GDM patients. This review focuses on recent studies investigating the association between SNPs and GDM, identifying several SNPs that have been associated with GDM. However, further research is needed to explore the role of SNPs in the prediction, diagnosis, treatment, and prognosis of GDM in diverse ethnic populations.
CLINICA CHIMICA ACTA
(2023)
Article
Chemistry, Multidisciplinary
Arvindkumar H. Chaurasiya, Ajinkya A. Khilari, Rubina Kazi, Meera R. Jaiswal, Gouri M. Bhoite, Meghana K. Padwal, Abdulrahaman A. Momin, Dhanasekaran Shanmugam, Mahesh J. Kulkarni
Summary: The study used nanopore sequencing to genotype RAGE polymorphisms and found 33 polymorphisms, including two previously unreported mutations. Five single nucleotide polymorphisms were associated with an increased risk for type 2 diabetes. These findings provide insights into the role of RAGE in diabetes progression and its complications.
Article
Endocrinology & Metabolism
Jiahao Zhu, Huanling Zhao, Dingwan Chen, Lap Ah Tse, Sanjay Kinra, Yingjun Li
Summary: This study found significant genetic correlations between T2D, glycemic traits, and pulmonary function, with Mendelian randomization analyses suggesting a bidirectional causal association between T2D and pulmonary function.
FRONTIERS IN ENDOCRINOLOGY
(2021)
