Molecular Changes Underlying Hypertrophic Scarring Following Burns Involve Specific Deregulations at All Wound Healing Stages (Inflammation, Proliferation and Maturation)

Deciphering the functional heterogeneity of skin fibroblasts using single‐cell RNA sequencing

(2020) Vera Vorstandlechner et al.   FASEB JOURNAL

Scars or Regeneration?—Dermal Fibroblasts as Drivers of Diverse Skin Wound Responses

(2020) Dongsheng Jiang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nintedanib inhibits keloid fibroblast functions by blocking the phosphorylation of multiple kinases and enhancing receptor internalization

(2020) Bo-ya Zhou et al.   ACTA PHARMACOLOGICA SINICA

Hypertrophic scars and keloids: Overview of the evidence and practical guide for differentiating between these abnormal scars

(2020) Grace C. Limandjaja et al.   EXPERIMENTAL DERMATOLOGY

Galectin‐1 production is elevated in hypertrophic scar

(2020) Liam D. Kirkpatrick et al.   WOUND REPAIR AND REGENERATION

Quantitative proteomic comparison of myofibroblasts derived from bone marrow and cornea

(2020) Paramananda Saikia et al.   Scientific Reports

Pancreatic Adenocarcinoma Invasiveness and the Tumor Microenvironment: From Biology to Clinical Trials

(2020) Isabel Mejia et al.   Biomedicines

The extracellular matrix as a multitasking player in disease

(2019) Achilleas D. Theocharis et al.   FEBS Journal

A Review of the Contribution of Mast Cells in Wound Healing: Involved Molecular and Cellular Mechanisms

(2019) Daniel Elieh Ali Komi et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

OVOL2 induces mesenchymal-to-epithelial transition in fibroblasts and enhances cell-state reprogramming towards epithelial lineages

(2019) Kazuhide Watanabe et al.   Scientific Reports

Keratin 6, 16 and 17—Critical Barrier Alarmin Molecules in Skin Wounds and Psoriasis

(2019) Xiaowei Zhang et al.   Cells

Understanding Keloid Pathobiology From a Quasi-Neoplastic Perspective: Less of a Scar and More of a Chronic Inflammatory Disease With Cancer-Like Tendencies

(2019) Silvian Tan et al.   Frontiers in Immunology

Re-epithelialization of adult skin wounds: Cellular mechanisms and therapeutic strategies

(2018) Patricia Rousselle et al.   ADVANCED DRUG DELIVERY REVIEWS

Stem cells, niches and scaffolds: Applications to burns and wound care

(2018) Suzanne M. Watt et al.   ADVANCED DRUG DELIVERY REVIEWS

GRHL2-Dependent Enhancer Switching Maintains a Pluripotent Stem Cell Transcriptional Subnetwork after Exit from Naive Pluripotency

(2018) Amy F. Chen et al.   Cell Stem Cell

Fibroblasts potentiate melanoma cells in vitro invasiveness induced by UV-irradiated keratinocytes

(2018) Njainday Pulo Jobe et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Wound healing

(2018) Peng-Hui Wang et al.   Journal of the Chinese Medical Association

New developments on skin fibrosis - Essential signals emanating from the extracellular matrix for the control of myofibroblasts

(2018) Jan-Niklas Schulz et al.   MATRIX BIOLOGY

Insights into the Pathophysiology of Hypertrophic Scars and Keloids

(2018) Feras M. Ghazawi et al.   Advances in Skin & Wound Care

Multiscale modeling of layer formation in epidermis

(2018) Huijing Du et al.   PLoS Computational Biology

Mechanical Forces in Cutaneous Wound Healing: Emerging Therapies to Minimize Scar Formation

(2018) Leandra A. Barnes et al.   Advances in Wound Care

Immune Regulation of Skin Wound Healing: Mechanisms and Novel Therapeutic Targets

(2018) Jacqueline Larouche et al.   Advances in Wound Care

The Role of Focal Adhesion Kinase in Keratinocyte Fibrogenic Gene Expression

(2017) Michael Januszyk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Keloid and Hypertrophic Scars Are the Result of Chronic Inflammation in the Reticular Dermis

(2017) Rei Ogawa   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Macrophage Phenotypes Regulate Scar Formation and Chronic Wound Healing

(2017) Mark Hesketh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Interleukin-6 Serum Levels Correlate With Severity of Burn Injury but Not With Gender

(2017) Stephan Hager et al.   Journal of Burn Care & Research

Efferocytosis Signaling in the Regulation of Macrophage Inflammatory Responses

(2017) Michael R. Elliott et al.   JOURNAL OF IMMUNOLOGY

How Signaling Molecules Regulate Tumor Microenvironment: Parallels to Wound Repair

(2017) Peter Gál et al.   MOLECULES

Overview of Wound Healing and Management

(2017) Dylan R. Childs et al.   SURGICAL CLINICS OF NORTH AMERICA

Mature B cells accelerate wound healing after acute and chronic diabetic skin lesions

(2017) Ruxandra F. Sîrbulescu et al.   WOUND REPAIR AND REGENERATION

Defining stem cell dynamics and migration during wound healing in mouse skin epidermis

(2017) Mariaceleste Aragona et al.   Nature Communications

SNAIL1-mediated downregulation of FOXA proteins facilitates the inactivation of transcriptional enhancer elements at key epithelial genes in colorectal cancer cells

(2017) Sabine Jägle et al.   PLoS Genetics

Restoration of the basement membrane after wounding: a hallmark of young human skin altered with aging

(2017) Gary Fisher et al.   Journal of Cell Communication and Signaling

EMT/MET at the Crossroad of Stemness, Regeneration and Oncogenesis: The Ying-Yang Equilibrium Recapitulated in Cell Spheroids

(2017) Elvira Forte et al.   Cancers

The composition of T-cell subsets are altered in the burn wound early after injury

(2017) Meenakshi Rani et al.   PLoS One

Growth factor pathways in hypertrophic scars: Molecular pathogenesis and therapeutic implications

(2016) Naqi Lian et al.   BIOMEDICINE & PHARMACOTHERAPY

Transition from inflammation to proliferation: a critical step during wound healing

(2016) Ning Xu Landén et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing

(2016) Audrey Nosbaum et al.   JOURNAL OF IMMUNOLOGY

The Response of Macrophages and Neutrophils to Hypoxia in the Context of Cancer and Other Inflammatory Diseases

(2016) Antje Egners et al.   MEDIATORS OF INFLAMMATION

Targeting Epithelial–Mesenchymal Transition (EMT) to Overcome Drug Resistance in Cancer

(2016) Bowen Du et al.   MOLECULES

Biology and Biomarkers for Wound Healing

(2016) Linsey E. Lindley et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability

(2016) D. R. Pattabiraman et al.   SCIENCE

Dendritic cells modulate burn wound healing by enhancing early proliferation

(2016) Monika Vinish et al.   WOUND REPAIR AND REGENERATION

P311 induces the transdifferentiation of epidermal stem cells to myofibroblast-like cells by stimulating transforming growth factor β1 expression

(2016) Haisheng Li et al.   Stem Cell Research & Therapy

The Burn Wound Microenvironment

(2016) Lloyd F. Rose et al.   Advances in Wound Care

Evaluation of Genetic Diversity and Development of a Core Collection of Wild Rice (Oryza rufipogon Griff.) Populations in China

(2016) Wen Liu et al.   PLoS One

Galectin-1 Accelerates Wound Healing by Regulating the Neuropilin-1/Smad3/NOX4 Pathway and ROS Production in Myofibroblasts

(2015) Yueh-Te Lin et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Epigenetic and transcriptional regulation of γδ T cell differentiation: Programming cells for responses in time and space

(2015) Nina Schmolka et al.   SEMINARS IN IMMUNOLOGY

Tumors: Wounds That Do Not Heal--Redux

(2015) H. F. Dvorak   Cancer Immunology Research

Chemokine Involvement in Fetal and Adult Wound Healing

(2015) Swathi Balaji et al.   Advances in Wound Care

Chemokines in Wound Healing and as Potential Therapeutic Targets for Reducing Cutaneous Scarring

(2015) Peter Adam Rees et al.   Advances in Wound Care

Extracellular Matrix Reorganization During Wound Healing and Its Impact on Abnormal Scarring

(2015) Meilang Xue et al.   Advances in Wound Care

Tet and TDG Mediate DNA Demethylation Essential for Mesenchymal-to-Epithelial Transition in Somatic Cell Reprogramming

(2014) Xiao Hu et al.   Cell Stem Cell

Kinome-wide Functional Analysis Highlights the Role of Cytoskeletal Remodeling in Somatic Cell Reprogramming

(2014) Kumi Sakurai et al.   Cell Stem Cell

Mammary Morphogenesis and Regeneration Require the Inhibition of EMT at Terminal End Buds by Ovol2 Transcriptional Repressor

(2014) Kazuhide Watanabe et al.   DEVELOPMENTAL CELL

Wound healing revised: A novel reepithelialization mechanism revealed by in vitro and in silico models

(2014) Kai Safferling et al.   JOURNAL OF CELL BIOLOGY

The panoply of αβT cells in the skin

(2014) Takashi Nomura et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Blockade of Mast Cell Activation Reduces Cutaneous Scar Formation

(2014) Lin Chen et al.   PLoS One

In Vivo Imaging Reveals a Pioneer Wave of Monocyte Recruitment into Mouse Skin Wounds

(2014) Mathieu P. Rodero et al.   PLoS One

Epithelialization in Wound Healing: A Comprehensive Review

(2014) Irena Pastar et al.   Advances in Wound Care

Neutrophil cell surface receptors and their intracellular signal transduction pathways

(2013) Krisztina Futosi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Through Gap Junction Communications, Co-Cultured Mast Cells and Fibroblasts Generate Fibroblast Activities Allied with Hypertrophic Scarring

(2013) Theodore T. Foley et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Transcription Factors OVOL1 and OVOL2 Induce the Mesenchymal to Epithelial Transition in Human Cancer

(2013) Hernan Roca et al.   PLoS One

Perturbed Mononuclear Phagocyte System in Severely Burned and Septic Patients

(2013) Fangming Xiu et al.   SHOCK

Role of fibronectin in normal wound healing

(2013) Ellie A Lenselink   International Wound Journal

Chemokines and Their Receptors Are Key Players in the Orchestra That Regulates Wound Healing

(2013) Manuela Martins-Green et al.   Advances in Wound Care

The Importance of Mast Cells in Dermal Scarring

(2013) Traci A. Wilgus et al.   Advances in Wound Care

The angiogenesis inhibitor vasostatin is regulated by neutrophil elastase-dependent cleavage of calreticulin in AML patients

(2012) S. Mans et al.   BLOOD

Site-specific immunophenotyping of keloid disease demonstrates immune upregulation and the presence of lymphoid aggregates

(2012) R. Bagabir et al.   BRITISH JOURNAL OF DERMATOLOGY

Wound Repair and Regeneration

(2012) J.M. Reinke et al.   EUROPEAN SURGICAL RESEARCH

Wound-associated macrophages control collagen 1α2 transcription during the early stages of skin wound healing

(2012) Mathieu P. Rodero et al.   EXPERIMENTAL DERMATOLOGY

Platelet derived growth factor-CC secreted by M2 macrophages induces alpha-smooth muscle actin expression by dermal and gingival fibroblasts

(2012) Judith E. Glim et al.   IMMUNOBIOLOGY

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular resolution of inflammation-catabasis

(2012) Alan D. Widgerow   WOUND REPAIR AND REGENERATION

Role of Endothelial-Mesenchymal Transition (EndoMT) in the Pathogenesis of Fibrotic Disorders

(2011) Sonsoles Piera-Velazquez et al.   AMERICAN JOURNAL OF PATHOLOGY

Wound Macrophages as Key Regulators of Repair

(2011) Samielle K. Brancato et al.   AMERICAN JOURNAL OF PATHOLOGY

Improving Cutaneous Scar Formation by Controlling the Mechanical Environment

(2011) Geoffrey C. Gurtner et al.   ANNALS OF SURGERY

An epidermal stem cells niche microenvironment created by engineered human amniotic membrane

(2011) Shi-zhao Ji et al.   BIOMATERIALS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice

(2011) Anca Sindrilaru et al.   JOURNAL OF CLINICAL INVESTIGATION

Mast Cells Contribute to Scar Formation during Fetal Wound Healing

(2011) Brian C. Wulff et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Unknown

(2011) Gerd Gauglitz et al.   MOLECULAR MEDICINE

Rat Mast Cells Enhance Fibroblast Proliferation and Fibroblast-Populated Collagen Lattice Contraction through Gap Junctional Intercellular Communications

(2011) Theodore T. Foley et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Blood Levels, Apoptosis, and Homing of the Endothelial Progenitor Cells After Skin Burns and Escharectomy

(2011) Carlo Foresta et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Epithelial to Mesenchymal Transition in Human Skin Wound Healing Is Induced by Tumor Necrosis Factor-α through Bone Morphogenic Protein-2

(2010) Chunli Yan et al.   AMERICAN JOURNAL OF PATHOLOGY

An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation

(2010) K. P. A. MacDonald et al.   BLOOD

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone

(2010) Jiekai Chen et al.   CELL RESEARCH

The ZEB/miR-200 feedback loop—a motor of cellular plasticity in development and cancer?

(2010) Simone Brabletz et al.   EMBO REPORTS

Epidermal T Cells and Wound Healing

(2010) W. L. Havran et al.   JOURNAL OF IMMUNOLOGY

A Wound Size–Dependent Effect of Myeloid Cell–Derived Vascular Endothelial Growth Factor on Wound Healing

(2010) Christian Stockmann et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Pathophysiology of Epithelial-Mesenchymal Transition Induced by Transforming Growth Factor-β in Normal and Malignant Mammary Epithelial Cells

(2010) Molly A. Taylor et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Burn Injury Reduces Neutrophil Directional Migration Speed in Microfluidic Devices

(2010) Kathryn L. Butler et al.   PLoS One

Impaired angiogenesis and mobilization of circulating angiogenic cells in HIF-1α heterozygous-null mice after burn wounding

(2010) Xianjie Zhang et al.   WOUND REPAIR AND REGENERATION

CD19, a Response Regulator of B Lymphocytes, Regulates Wound Healing through Hyaluronan-Induced TLR4 Signaling

(2009) Yohei Iwata et al.   AMERICAN JOURNAL OF PATHOLOGY

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Blockade of Neoangiogenesis, a New and Promising Technique to Control the Growth of Malignant Tumors and their Metastases

(2009) Daniela Grimm et al.   Current Vascular Pharmacology

Biomarkers for epithelial-mesenchymal transitions

(2009) Michael Zeisberg et al.   JOURNAL OF CLINICAL INVESTIGATION

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Fibroblasts and myofibroblasts in wound healing: Force generation and measurement

(2009) Bin Li et al.   Journal of Tissue Viability

Vascular permeability, vascular hyperpermeability and angiogenesis

(2008) Janice A. Nagy et al.   ANGIOGENESIS

γδ T-cells: Potential regulators of the post-burn inflammatory response

(2008) Martin G. Schwacha   BURNS

Thymic Selection Determines γδ T Cell Effector Fate: Antigen-Naive Cells Make Interleukin-17 and Antigen-Experienced Cells Make Interferon γ

(2008) Kirk D.C. Jensen et al.   IMMUNITY

Improved Scar in Postburn Patients Following Interferon-α2b Treatment Is Associated with Decreased Angiogenesis Mediated by Vascular Endothelial Cell Growth Factor

(2008) Jianfei Wang et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Regulation of scar formation by vascular endothelial growth factor

(2008) Traci A Wilgus et al.   LABORATORY INVESTIGATION

Immune cells in the healing skin wound: Influential players at each stage of repair

(2008) T WILGUS   PHARMACOLOGICAL RESEARCH

PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing

(2008) Stephan Barrientos et al.   WOUND REPAIR AND REGENERATION

Oxidative stress and anti-oxidative mobilization in burn injury

(2007) Arti Parihar et al.   BURNS

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark