Scars or Regeneration?—Dermal Fibroblasts as Drivers of Diverse Skin Wound Responses

Cadherin-11–mediated adhesion of macrophages to myofibroblasts establishes a profibrotic niche of active TGF-β

(2019) Monika Lodyga et al.   Science Signaling

In Vivo Models for the Study of Fibrosis

(2019) Jagannath Padmanabhan et al.   Advances in Wound Care

Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds

(2019) Christian F. Guerrero-Juarez et al.   Nature Communications

Wound healing and fibrosis: current stem cell therapies

(2019) Ruth Ellen Jones et al.   TRANSFUSION

STAT 3 Signaling Pathway is Implicated in Keloid Pathogenesis by Preliminary Transcriptome and Open Chromatin Analyses

(2019) Yun‐Shain Lee et al.   EXPERIMENTAL DERMATOLOGY

Comparative regenerative biology of spiny (Acomys cahirinus) and laboratory (Mus musculus) mouse skin

(2019) Ting-Xin Jiang et al.   EXPERIMENTAL DERMATOLOGY

Epidermal growth factor receptor (EGFR) paracrine upregulation in idiopathic pulmonary fibrosis (IPF) fibroblasts is blocked by nintedanib

(2019) Gali Epstein Shochet et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Differentiated fibrocytes assume a functional mesenchymal phenotype with regenerative potential

(2019) Changying Ling et al.   Science Advances

TGF ‐β1‐Induced Connexin43 Promotes Scar Formation via the Erk/ MMP ‐1/Collagen III Pathway

(2019) Xiaoyan Li et al.   JOURNAL OF ORAL REHABILITATION

The Prrx1 limb enhancer marks an adult subpopulation of injury-responsive dermal fibroblasts

(2019) Joshua D. Currie et al.   Biology Open

Activation of mTORC1 in fibroblasts accelerates wound healing and induces fibrosis in mice

(2019) Xiao Hu et al.   WOUND REPAIR AND REGENERATION

PAI1 mediates fibroblast–mast cell interactions in skin fibrosis

(2018) Neha Pincha et al.   JOURNAL OF CLINICAL INVESTIGATION

Msx2 Supports Epidermal Competency during Wound-Induced Hair Follicle Neogenesis

(2018) Michael W. Hughes et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Wound Regeneration Deficit in Rats Correlates with Low Morphogenetic Potential and Distinct Transcriptome Profile of Epidermis

(2018) Christian F. Guerrero-Juarez et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations

(2018) Christina Philippeos et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Two succeeding fibroblastic lineages drive dermal development and the transition from regeneration to scarring

(2018) Dongsheng Jiang et al.   NATURE CELL BIOLOGY

Nanopillar force measurements reveal actin-cap-mediated YAP mechanotransduction

(2018) Jau-Ye Shiu et al.   NATURE CELL BIOLOGY

Denervation-activated STAT3–IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis

(2018) Luca Madaro et al.   NATURE CELL BIOLOGY

Direct conversion of injury-site myeloid cells to fibroblast-like cells of granulation tissue

(2018) Mithun Sinha et al.   Nature Communications

Macrophages, Wound Healing, and Fibrosis: Recent Insights

(2018) Kate S. Smigiel et al.   Current Rheumatology Reports

Tensile forces drive a reversible fibroblast-to-myofibroblast transition during tissue growth in engineered clefts

(2018) Philip Kollmannsberger et al.   Science Advances

Lineage identity and location within the dermis determine the function of papillary and reticular fibroblasts in human skin

(2018) Ana Korosec et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Transcriptional signature primes human oral mucosa for rapid wound healing

(2018) Ramiro Iglesias-Bartolome et al.   Science Translational Medicine

Gap junction protein Connexin-43 is a direct transcriptional regulator of N-cadherin in vivo

(2018) Maria Kotini et al.   Nature Communications

Aging Suppresses Skin-Derived Circulating SDF1 to Promote Full-Thickness Tissue Regeneration

(2018) Mailyn A. Nishiguchi et al.   Cell Reports

Identity Noise and Adipogenic Traits Characterize Dermal Fibroblast Aging

(2018) Marion Claudia Salzer et al.   CELL

Insights into the regeneration of skin from Acomys , the spiny mouse

(2018) Malcolm Maden et al.   EXPERIMENTAL DERMATOLOGY

Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair

(2018) Brett A. Shook et al.   SCIENCE

Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing

(2018) Chae Ho Lim et al.   Nature Communications

Macrophage Phenotypes Regulate Scar Formation and Chronic Wound Healing

(2017) Mark Hesketh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis

(2017) Soung-Hoon Lee et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Targeting of cadherin-11 decreases skin fibrosis in the tight skin-1 mouse model

(2017) Mesias Pedroza et al.   PLoS One

Unifying mechanism for different fibrotic diseases

(2017) Gerlinde Wernig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation and metabolism in tissue repair and regeneration

(2017) Sabine A. Eming et al.   SCIENCE

Regeneration of fat cells from myofibroblasts during wound healing

(2017) Maksim V. Plikus et al.   SCIENCE

Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF

(2017) Xusheng Wang et al.   Nature Communications

Macrophages are necessary for epimorphic regeneration in African spiny mice

(2017) Jennifer Simkin et al.   eLife

Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing

(2016) Emanuel Rognoni et al.   DEVELOPMENT

Skin Wound Healing: An Update on the Current Knowledge and Concepts

(2016) Heiko Sorg et al.   EUROPEAN SURGICAL RESEARCH

Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer

(2016) Qing Chen et al.   NATURE

Dipeptidyl Peptidase-4, Wound Healing, Scarring, and Fibrosis

(2016) Michael S. Hu et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages

(2016) Beate M. Lichtenberger et al.   Nature Communications

Cellular forces and matrix assembly coordinate fibrous tissue repair

(2016) Mahmut Selman Sakar et al.   Nature Communications

The Role of Connexins in Wound Healing and Repair: Novel Therapeutic Approaches

(2016) Pui Wong et al.   Frontiers in Physiology

The role of myofibroblasts in wound healing

(2016) B. Hinz   Current Research in Translational Medicine

Maturation of the Human Scar: An Observational Study

(2016) Jeremy S. Bond et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

(2015) Fei Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration

(2015) Amanda M. Nelson et al.   Cell Stem Cell

Inhibition of Wnt/β-catenin pathway promotes regenerative repair of cutaneous and cartilage injury

(2015) Dikshya Bastakoty et al.   FASEB JOURNAL

Epidermal growth factor improves the migration and contractility of aged fibroblasts cultured on 3D collagen matrices

(2015) DAEHWAN KIM et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Adhesion to fibronectin regulates Hippo signaling via the FAK–Src–PI3K pathway

(2015) Nam-Gyun Kim et al.   JOURNAL OF CELL BIOLOGY

Connexin 43 deficiency accelerates skin wound healing and extracellular matrix remodeling in mice

(2015) Bruno Cogliati et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Identification and isolation of a dermal lineage with intrinsic fibrogenic potential

(2015) Y. Rinkevich et al.   SCIENCE

The α v β 1 integrin plays a critical in vivo role in tissue fibrosis

(2015) Nilgun I. Reed et al.   Science Translational Medicine

CDH2 and CDH11 act as regulators of stem cell fate decisions

(2015) Stella Alimperti et al.   Stem Cell Research

Extracellular Matrix Reorganization During Wound Healing and Its Impact on Abnormal Scarring

(2015) Meilang Xue et al.   Advances in Wound Care

Delineating the roles of neutrophils and macrophages in zebrafish regeneration models

(2014) Maria-Cristina Keightley et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

Transforming Growth Factor-β1 (TGF-β1)-stimulated Fibroblast to Myofibroblast Differentiation Is Mediated by Hyaluronan (HA)-facilitated Epidermal Growth Factor Receptor (EGFR) and CD44 Co-localization in Lipid Rafts

(2013) Adam C. Midgley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct fibroblast lineages determine dermal architecture in skin development and repair

(2013) Ryan R. Driskell et al.   NATURE

Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding

(2013) Denise Gay et al.   NATURE MEDICINE

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

(2013) Neil C Henderson et al.   NATURE MEDICINE

Identification of Cadherin 11 as a Mediator of Dermal Fibrosis and Possible Role in Systemic Sclerosis

(2013) Minghua Wu et al.   Arthritis & Rheumatology

Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis

(2012) B. Zhao et al.   GENES & DEVELOPMENT

Prostaglandin D2 Inhibits Wound-Induced Hair Follicle Neogenesis through the Receptor, Gpr44

(2012) Amanda M. Nelson et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration

(2012) Peggy S. Myung et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Skin shedding and tissue regeneration in African spiny mice (Acomys)

(2012) Ashley W. Seifert et al.   NATURE

Lineage tracing and genetic ablation of ADAM12+ perivascular cells identify a major source of profibrotic cells during acute tissue injury

(2012) Sophie Dulauroy et al.   NATURE MEDICINE

Connexins in wound healing; perspectives in diabetic patients

(2011) David L. Becker et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

β-catenin signaling

(2011) Anna P. Lam et al.   CURRENT OPINION IN RHEUMATOLOGY

Hippo pathway regulation by cell morphology and stress fibers

(2011) K.-I. Wada et al.   DEVELOPMENT

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling

(2011) Victor W Wong et al.   NATURE MEDICINE

A Positive Role of Cadherin in Wnt/β-Catenin Signalling during Epithelial-Mesenchymal Transition

(2011) Sara Howard et al.   PLoS One

Increased expression of fibroblast activation protein-alpha in keloid fibroblasts: implications for development of a novel treatment option

(2010) Kirstin Dienus et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Surgical Approaches to Create Murine Models of Human Wound Healing

(2010) Victor W. Wong et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Scarless Fetal Wound Healing: A Basic Science Review

(2010) Barrett J. Larson et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Interplay of Cadherin-Mediated Cell Adhesion and Canonical Wnt Signaling

(2009) J. Heuberger et al.   Cold Spring Harbor Perspectives in Biology

Wound repair and regeneration

(2008) Geoffrey C. Gurtner et al.   NATURE

Inhibitors of Dipeptidyl Peptidase IV-Like Activity Mediate Antifibrotic Effects in Normal and Keloid-Derived Skin Fibroblasts

(2007) Anja Thielitz et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY