Understanding Keloid Pathobiology From a Quasi-Neoplastic Perspective: Less of a Scar and More of a Chronic Inflammatory Disease With Cancer-Like Tendencies

TRAF4 promotes fibroblast proliferation in keloids by destabilizing p53 via interacting with the deubiquitinase USP10

(2019) Cheng-Cheng Deng et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Tumor suppressive role of miR-1224-5p in keloid proliferation, apoptosis and invasion via the TGF-β1/Smad3 signaling pathway

(2018) Xiaodong Yao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cartilage oligomeric matrix protein is a prognostic factor and biomarker of colon cancer and promotes cell proliferation by activating the Akt pathway

(2018) Ting-ting Liu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

PTEN: Tumor Suppressor and Metabolic Regulator

(2018) Chien-Yu Chen et al.   Frontiers in Endocrinology

Keloid and Hypertrophic Scars Are the Result of Chronic Inflammation in the Reticular Dermis

(2017) Rei Ogawa   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biology and Treatment of Aggressive Fibromatosis or Desmoid Tumor

(2017) Keith M. Skubitz   MAYO CLINIC PROCEEDINGS

Wnt/β-Catenin Signaling Exacerbates Keloid Cell Proliferation by Regulating Telomerase

(2016) Dongmei Yu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Hypoxia drives the transition of human dermal fibroblasts to a myofibroblast-like phenotype via the TGF-β1/Smad3 pathway

(2016) Bin Zhao et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Expression of embryonic stem cell markers in keloid-associated lymphoid tissue

(2016) Chelsea Grant et al.   JOURNAL OF CLINICAL PATHOLOGY

TSLP Is a Potential Initiator of Collagen Synthesis and an Activator of CXCR4/SDF-1 Axis in Keloid Pathogenesis

(2016) Jung U Shin et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Sorafenib exerts an anti-keloid activity by antagonizing TGF-β/Smad and MAPK/ERK signaling pathways

(2016) Wenbo Wang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Causal network analysis of head and neck keloid tissue identifies potential master regulators

(2016) Laura Garcia-Rodriguez et al.   LARYNGOSCOPE

Biological significance of genome-wide DNA methylation profiles in keloids

(2016) Lamont R. Jones et al.   LARYNGOSCOPE

Keloids: The paradigm of skin fibrosis — Pathomechanisms and treatment

(2016) Jonathan P. Andrews et al.   MATRIX BIOLOGY

Endothelial dysfunction may play a key role in keloid and hypertrophic scar pathogenesis – Keloids and hypertrophic scars may be vascular disorders

(2016) Rei Ogawa et al.   MEDICAL HYPOTHESES

Epigenetic modulators, modifiers and mediators in cancer aetiology and progression

(2016) Andrew P. Feinberg et al.   NATURE REVIEWS GENETICS

Cartilage oligomeric matrix protein contributes to the development and metastasis of breast cancer

(2016) E Englund et al.   ONCOGENE

Keloid Management

(2016) Michael E. Jones et al.   Advances in Skin & Wound Care

MiR-21-5p Links Epithelial-Mesenchymal Transition Phenotype with Stem-Like Cell Signatures via AKT Signaling in Keloid Keratinocytes

(2016) Li Yan et al.   Scientific Reports

Oxidative Damage and Nuclear Factor Erythroid 2-Related Factor 2 Protein Expression in Normal Skin and Keloid Tissue

(2015) Yoon Jin Lee et al.   Annals of Dermatology

OCT4 mediates FSH-induced epithelial–mesenchymal transition and invasion through the ERK1/2 signaling pathway in epithelial ovarian cancer

(2015) Lei Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The role of heat shock proteins in cancer

(2015) Georgios D. Lianos et al.   CANCER LETTERS

Genome-Wide Scan for Methylation Profiles in Keloids

(2015) Lamont R. Jones et al.   DISEASE MARKERS

Heat Shock Protein 90 Inhibitor Decreases Collagen Synthesis of Keloid Fibroblasts and Attenuates the Extracellular Matrix on the Keloid Spheroid Model

(2015) Won Jai Lee et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Concise Review: NANOG in Cancer Stem Cells and Tumor Development: An Update and Outstanding Questions

(2015) Collene R. Jeter et al.   STEM CELLS

Epithelial-mesenchymal transition in keloid tissues and TGF-β1-induced hair follicle outer root sheath keratinocytes

(2015) Li Yan et al.   WOUND REPAIR AND REGENERATION

Intralesional 5-Fluorouracil in Keloid Treatment: A Systematic Review

(2015) E Bijlard et al.   ACTA DERMATO-VENEREOLOGICA

Periostin Is a Key Niche Component for Wound Metastasis of Melanoma

(2015) Keitaro Fukuda et al.   PLoS One

The IL-6/JAK/Stat3 Feed-Forward Loop Drives Tumorigenesis and Metastasis

(2015) Qing Chang et al.   NEOPLASIA

Dermatofibrosarcoma Protuberans on the Chest with a Variety of Clinical Features Masquerading as a Keloid: Is the Disease Really Protuberant?

(2014) Kumiko Kimura et al.   Annals of Dermatology

Clinical and epidemiological analysis of keloids in Chinese patients

(2014) Wen-sheng Lu et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Elastin peptides regulate HT-1080 fibrosarcoma cell migration and invasion through an Hsp90-dependent mechanism

(2014) M Donet et al.   BRITISH JOURNAL OF CANCER

PDGF receptor signaling networks in normal and cancer cells

(2014) Jean-Baptiste Demoulin et al.   CYTOKINE & GROWTH FACTOR REVIEWS

New Insights on Keloids, Hypertrophic Scars, and Striae

(2014) Sara Ud-Din et al.   DERMATOLOGIC CLINICS

Osteopontin expression in healing wounds of horses and in human keloids

(2014) V. Miragliotta et al.   EQUINE VETERINARY JOURNAL

MicroRNA control of epithelial-mesenchymal transition in cancer stem cells

(2014) Jin Hao et al.   INTERNATIONAL JOURNAL OF CANCER

Increased periostin expression affects the proliferation, collagen synthesis, migration and invasion of keloid fibroblasts under hypoxic conditions

(2014) ZHE ZHANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

c-Jun promotes cell migration and drives expression of the motility factor ENPP2 in soft tissue sarcomas

(2014) Stefano Sioletic et al.   JOURNAL OF PATHOLOGY

Role of osteopontin in the pathophysiology of cancer

(2014) Lalita A. Shevde et al.   MATRIX BIOLOGY

Upregulated periostin promotes angiogenesis in keloids through activation of the ERK 1/2 and focal adhesion kinase pathways, as well as the upregulated expression of VEGF and angiopoietin-1

(2014) ZHE ZHANG et al.   Molecular Medicine Reports

SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma

(2014) Soufiane Boumahdi et al.   NATURE

High-Dose-Rate Brachytherapy for the Treatment of Recalcitrant Keloids

(2014) Michiel C. E. van Leeuwen et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

MicroRNA-21 Affects Proliferation and Apoptosis by Regulating Expression of PTEN in Human Keloid Fibroblasts

(2014) Ying Liu et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Oxidative Stress Induces Persistent Telomeric DNA Damage Responsible for Nuclear Morphology Change in Mammalian Cells

(2014) Elisa Coluzzi et al.   PLoS One

A diagnosis of giant cell-rich tumour of bone is supported by p63 immunohistochemistry, when more than 50 % of cells is stained

(2014) André Maues De Paula et al.   VIRCHOWS ARCHIV

Skin equivalent tensional force alters keloid fibroblast behavior and phenotype

(2014) Edna Suarez et al.   WOUND REPAIR AND REGENERATION

Immunohistochemical Evaluation of COX-1 and COX-2 Expression in Keloid and Hypertrophic Scar

(2013) Asmaa G. Abdou et al.   AMERICAN JOURNAL OF DERMATOPATHOLOGY

Identification of steroid sensitive responders versus non-responders in the treatment of keloid disease

(2013) Sara Ud-Din et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Identification and Characterization of Wnt Signaling Pathway in Keloid Pathogenesis

(2013) Shinichi Igota et al.   International Journal of Medical Sciences

Periostin Mediates the Increased Pro-Angiogenic Activity of Gastric Cancer Cells under Hypoxic Conditions

(2013) Feng Qiu et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Fibrosing connective tissue disorders of the skin: Molecular similarities and distinctions

(2013) Johanna Canady et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Change Is in the Air: The Hypoxic Induction of Phenotype Switching in Melanoma

(2013) Michael P. O'Connell et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

CXCR4 in Epidermal Keratinocytes: Crosstalk within the Skin

(2013) Wendy B. Bollag et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Enhanced deposition of cartilage oligomeric matrix protein is a common feature in fibrotic skin pathologies

(2013) Pallavi Agarwal et al.   MATRIX BIOLOGY

De-Regulated MicroRNAs in Pediatric Cancer Stem Cells Target Pathways Involved in Cell Proliferation, Cell Cycle and Development

(2013) Patricia C. Sanchez-Diaz et al.   PLoS One

Site-Specific Keloid Fibroblasts Alter the Behaviour of Normal Skin and Normal Scar Fibroblasts through Paracrine Signalling

(2013) Kevin J. Ashcroft et al.   PLoS One

Keloid-derived keratinocytes exhibit an abnormal gene expression profile consistent with a distinct causal role in keloid pathology

(2013) Jennifer M. Hahn et al.   WOUND REPAIR AND REGENERATION

Tissue Engineering for In Vitro Analysis of Matrix Metalloproteinases in the Pathogenesis of Keloid Lesions

(2013) Hanwei Li et al.   JAMA Facial Plastic Surgery

Keloidal Dermatofibroma

(2012) Jean Kanitakis   AMERICAN JOURNAL OF DERMATOPATHOLOGY

Keloid Disease Can Be Inhibited by Antagonizing Excessive mTOR Signaling With a Novel Dual TORC1/2 Inhibitor

(2012) Farhatullah Syed et al.   AMERICAN JOURNAL OF PATHOLOGY

Identification of fibrocytes from mesenchymal stem cells in keloid tissue: a potential source of abnormal fibroblasts in keloid scarring

(2012) S. A. Iqbal et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Photodynamic therapy: an innovative approach to the treatment of keloid disease evaluated using subjective and objective non-invasive tools

(2012) Sara Ud-Din et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Site-specific immunophenotyping of keloid disease demonstrates immune upregulation and the presence of lymphoid aggregates

(2012) R. Bagabir et al.   BRITISH JOURNAL OF DERMATOLOGY

Bcl-2 family members: Essential players in skin cancer

(2012) Kris Nys et al.   CANCER LETTERS

Effects of hypoxia and HIFs on cancer metabolism

(2012) Vera Mucaj et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Effect of metformin on the proliferation, migration, and MMP-2 and -9 expression of human umbilical vein endothelial cells

(2012) NILUFAR ESFAHANIAN et al.   Molecular Medicine Reports

Notch signaling pathway in keloid disease: Enhanced fibroblast activity in a Jagged-1 peptide-dependent manner in lesional vs. extralesional fibroblasts

(2012) Farhatullah Syed et al.   WOUND REPAIR AND REGENERATION

Are keloid and hypertrophic scar different forms of the same disorder? A fibroproliferative skin disorder hypothesis based on keloid findings

(2012) Chenyu Huang et al.   International Wound Journal

Dermatofibrosarcoma protuberans: Our experience of 59 cases

(2012) ALESSIO STIVALA et al.   Oncology Letters

miRNA Expression Profiles in Keloid Tissue and Corresponding Normal Skin Tissue

(2011) Ying Liu et al.   AESTHETIC PLASTIC SURGERY

Identification and Characterization of Cartilage Oligomeric Matrix Protein as a Novel Pathogenic Factor in Keloids

(2011) Shigeki Inui et al.   AMERICAN JOURNAL OF PATHOLOGY

Cancer Stem Cell Niche: The Place to Be

(2011) T. Borovski et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Multiphoton microscopy study of the morphological and quantity changes of collagen and elastic fiber components in keloid disease

(2011) Jianxin Chen et al.   JOURNAL OF BIOMEDICAL OPTICS

Histone Deacetylase 2 Is Upregulated in Normal and Keloid Scars

(2011) Edmund J. Fitzgerald O'Connor et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Sox2 maintains self renewal of tumor-initiating cells in osteosarcomas

(2011) U Basu-Roy et al.   ONCOGENE

Regulation and function of miRNA-21 in health and disease

(2011) Regalla Kumarswamy et al.   RNA Biology

Influence of the Human Leukocyte Antigen Complex on the Development of Cutaneous Fibrosis: An Immunogenetic Perspective

(2010) A Bayat et al.   ACTA DERMATO-VENEREOLOGICA

Genetics of keloid scarring

(2010) Barbara Shih et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Comparative proteomic analysis between normal skin and keloid scar

(2010) C.T. Ong et al.   BRITISH JOURNAL OF DERMATOLOGY

Fibroblasts from the growing margin of keloid scars produce higher levels of collagen I and III compared with intralesional and extralesional sites: clinical implications for lesional site-directed therapy

(2010) F. Syed et al.   BRITISH JOURNAL OF DERMATOLOGY

Differential distribution of haematopoietic and nonhaematopoietic progenitor cells in intralesional and extralesional keloid: do keloid scars provide a niche for nonhaematopoietic mesenchymal stem cells?

(2010) S.A. Iqbal et al.   BRITISH JOURNAL OF DERMATOLOGY

TWIST activation by hypoxia inducible factor-1 (HIF-1): Implications in metastasis and development

(2010) Muh-Hwa Yang et al.   CELL CYCLE

Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition

(2010) Melissa G. Mendez et al.   FASEB JOURNAL

Periostin promotes ovarian cancer angiogenesis and metastasis

(2010) Min Zhu et al.   GYNECOLOGIC ONCOLOGY

ILK expression in human basal cell carcinoma correlates with epithelial-mesenchymal transition markers and tumour invasion

(2010) Sofia Papanikolaou et al.   HISTOPATHOLOGY

Epigenetically Altered Wound Healing in Keloid Fibroblasts

(2010) Shirley B. Russell et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

ERK2 but Not ERK1 Induces Epithelial-to-Mesenchymal Transformation via DEF Motif-Dependent Signaling Events

(2010) Sejeong Shin et al.   MOLECULAR CELL

Spatiotemporal expression of periostin during skin development and incisional wound healing: lessons for human fibrotic scar formation

(2010) Hong-Ming Zhou et al.   Journal of Cell Communication and Signaling

Elastic fiber assembly is disrupted by excessive accumulation of chondroitin sulfate in the human dermal fibrotic disease, keloid

(2009) Mika Ikeda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Telomere shortening may be associated with human keloids

(2009) Bruna De Felice et al.   BMC Medical Genetics

Advances and Challenges in Basic and Translational Research on Clusterin

(2009) I. P. Trougakos et al.   CANCER RESEARCH

Epigenetics in cancer

(2009) S. Sharma et al.   CARCINOGENESIS

Matrix metalloproteinase-2 and -9 activities in human keloids, hypertrophic and atrophic scars: a pilot study

(2009) S. Tanriverdi-Akhisaroglu et al.   CELL BIOCHEMISTRY AND FUNCTION

Keloids Show Regional Distribution of Proliferative and Degenerate Connective Tissue Elements

(2009) Shamin Bux et al.   CELLS TISSUES ORGANS

The multifaceted role of periostin in tumorigenesis

(2009) Kai Ruan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Exploring the role of stem cells in cutaneous wound healing

(2009) Katherine Lau et al.   EXPERIMENTAL DERMATOLOGY

Keloids: Current concepts of pathogenesis (Review)

(2009) Bran   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Biomarkers for epithelial-mesenchymal transitions

(2009) Michael Zeisberg et al.   JOURNAL OF CLINICAL INVESTIGATION

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Matrix metalloproteinases and tissue inhibitors of metalloproteinases in patients with different types of scars and keloids

(2009) Dietmar Ulrich et al.   Journal of Plastic Reconstructive and Aesthetic Surgery

Angiogenesis in cutaneous disease: Part II

(2009) Vivian Laquer et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Guidelines for practical use of MAL-PDT in non-melanoma skin cancer

(2009) E Christensen et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Differential apoptosis markers in human keloids and hypertrophic scars fibroblasts

(2009) Bruna De Felice et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Effect of estradiol, progesterone and testosterone on apoptosis- and proliferation-induced MAPK signaling in human umbilical vein endothelial cells

(2009) Powazniak   Molecular Medicine Reports

Cooperation between GLI and JUN enhances transcription of JUN and selected GLI target genes

(2009) S Laner-Plamberger et al.   ONCOGENE

Patterns of MMP-2 and MMP-9 expression in human cancer cell lines

(2009) Niedzwiecki   ONCOLOGY REPORTS

Tumor-Like Stem Cells Derived from Human Keloid Are Governed by the Inflammatory Niche Driven by IL-17/IL-6 Axis

(2009) Qunzhou Zhang et al.   PLoS One

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Differences in collagen architecture between keloid, hypertrophic scar, normotrophic scar, and normal skin: An objective histopathological analysis

(2009) Pauline D. H. M. Verhaegen et al.   WOUND REPAIR AND REGENERATION

Fibulin-5, an integrin-binding matricellular protein: its function in development and disease

(2009) Hiromi Yanagisawa et al.   Journal of Cell Communication and Signaling

Fibulin-5 initiates epithelial-mesenchymal transition (EMT) and enhances EMT induced by TGF-  in mammary epithelial cells via a MMP-dependent mechanism

(2008) Y.-H. Lee et al.   CARCINOGENESIS

Efficacy of recombinant adenovirus-mediated double suicide gene therapy in human keloid fibroblasts

(2008) B. Xu et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

Ectopic SOX9 Mediates Extracellular Matrix Deposition Characteristic of Organ Fibrosis

(2008) Karen Piper Hanley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cadherin switching

(2008) M. J. Wheelock et al.   JOURNAL OF CELL SCIENCE

RAGE signaling sustains inflammation and promotes tumor development

(2008) Christoffer Gebhardt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Wound repair and regeneration

(2008) Geoffrey C. Gurtner et al.   NATURE

Notch tumor suppressor function

(2008) G P Dotto   ONCOGENE

Dual roles of Nrf2 in cancer

(2008) A LAU et al.   PHARMACOLOGICAL RESEARCH

Scars: A Review of Emerging and Currently Available Therapies

(2008) Richard G. Reish et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Isolation and Characterization of Multipotent Human Keloid-Derived Mesenchymal-Like Stem Cells

(2008) Jai-Hee Moon et al.   STEM CELLS AND DEVELOPMENT

Human Skin Keloid Fibroblasts Display Bioenergetics of Cancer Cells

(2007) Annette S. Vincent et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Levels of evidence for the treatment of keloid disease

(2007) P. Durani et al.   Journal of Plastic Reconstructive and Aesthetic Surgery