EMT/MET at the Crossroad of Stemness, Regeneration and Oncogenesis: The Ying-Yang Equilibrium Recapitulated in Cell Spheroids

Beta2-adrenergic signaling affects the phenotype of human cardiac progenitor cells through EMT modulation

(2018) Francesca Pagano et al.   PHARMACOLOGICAL RESEARCH

Role of Rac1 Pathway in Epithelial-to-Mesenchymal Transition and Cancer Stem-like Cell Phenotypes in Gastric Adenocarcinoma

(2017) Changhwan Yoon et al.   MOLECULAR CANCER RESEARCH

Normal and cancerous mammary stem cells evade interferon-induced constraint through the miR-199a–LCOR axis

(2017) Toni Celià-Terrassa et al.   NATURE CELL BIOLOGY

Increase in the radioresistance of normal skin fibroblasts but not tumor cells by mechanical injury

(2017) Zelin Chen et al.   Cell Death & Disease

Stem Cell Spheroids and Ex Vivo Niche Modeling: Rationalization and Scaling-Up

(2017) Isotta Chimenti et al.   Journal of Cardiovascular Translational Research

Tissue transglutaminase induces Epithelial-Mesenchymal-Transition and the acquisition of stem cell like characteristics in colorectal cancer cells

(2017) Oluseyi Ayinde et al.   Oncotarget

Multicellular Spheroids as a Model for Hypoxia-induced EMT

(2016) CASEY LEE et al.   ANTICANCER RESEARCH

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

Wound repair: a showcase for cell plasticity and migration

(2016) Tanya J Shaw et al.   CURRENT OPINION IN CELL BIOLOGY

Inflammatory cytokines prime adipose tissue mesenchymal stem cells to enhance malignancy of MCF-7 breast cancer cells via transforming growth factor-β1

(2016) Drenka Trivanović et al.   IUBMB LIFE

Mesenchymal stem cells promote pancreatic adenocarcinoma cells invasion by transforming growth factor-β1 induced epithelial-mesenchymal transition

(2016) Hai-Sen Zhou et al.   Oncotarget

NF-kappaΒ-inducing kinase regulates stem cell phenotype in breast cancer

(2016) Karla Vazquez-Santillan et al.   Scientific Reports

Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity

(2016) Evelyne Beerling et al.   Cell Reports

Filling the Gaps between the In Vivo and In Vitro Microenvironment: Engineering of Spheroids for Stem Cell Technology

(2016) Carmine Gentile   Current Stem Cell Research & Therapy

Human Lung Spheroids as In Vitro Niches of Lung Progenitor Cells with Distinctive Paracrine and Plasticity Properties

(2016) Isotta Chimenti et al.   Stem Cells Translational Medicine

Spheroid Culture of Mesenchymal Stem Cells

(2016) Zoe Cesarz et al.   Stem Cells International

New Insights into the Crossroads between EMT and Stemness in the Context of Cancer

(2016) Isabel Fabregat et al.   Journal of Clinical Medicine

TGFβ signaling regulates epithelial–mesenchymal plasticity in ovarian cancer ascites-derived spheroids

(2015) Samah Rafehi et al.   ENDOCRINE-RELATED CANCER

PTEN deletion potentiates invasion of colorectal cancer spheroidal cells through 3D Matrigel

(2015) Siddarth Chandrasekaran et al.   Integrative Biology

microRNA-181a enhances cell proliferation in acute lymphoblastic leukemia by targeting EGR1

(2015) Lorena Verduci et al.   LEUKEMIA RESEARCH

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

(2015) Xiaofeng Zheng et al.   NATURE

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

(2015) Kari R. Fischer et al.   NATURE

Distinct EMT programs control normal mammary stem cells and tumour-initiating cells

(2015) Xin Ye et al.   NATURE

Interleukin-6 and pro inflammatory status in the breast tumor microenvironment

(2015) Alessandro Sanguinetti et al.   World Journal of Surgical Oncology

A NOX2/Egr-1/Fyn pathway delineates new targets for TKI-resistant malignancies

(2015) Mary E. Irwin et al.   Oncotarget

Spontaneously-forming spheroids as an in vitro cancer cell model for anticancer drug screening

(2015) Maria A. Theodoraki et al.   Oncotarget

Coupling the modules of EMT and stemness: A tunable ‘stemness window’ model

(2015) Mohit Kumar Jolly et al.   Oncotarget

Adult Lung Spheroid Cells Contain Progenitor Cells and Mediate Regeneration in Rodents With Bleomycin-Induced Pulmonary Fibrosis

(2015) Eric Henry et al.   Stem Cells Translational Medicine

Acquisition of epithelial–mesenchymal transition and cancer stem-like phenotypes within chitosan-hyaluronan membrane-derived 3D tumor spheroids

(2014) Yen-Jang Huang et al.   BIOMATERIALS

Substrate-dependent gene regulation of self-assembled human MSC spheroids on chitosan membranes

(2014) Hsi-Yi Yeh et al.   BMC GENOMICS

The Role of Snail in EMT and Tumorigenesis

(2014) Yifan Wang et al.   CURRENT CANCER DRUG TARGETS

Sub-circuits of a gene regulatory network control a developmental epithelial-mesenchymal transition

(2014) L. R. Saunders et al.   DEVELOPMENT

Identification and characterization of a novel expandable adult stem/progenitor cell population in the human exocrine pancreas

(2014) M. A. Puglisi et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells

(2014) Wei-Lun Hwang et al.   NATURE CELL BIOLOGY

Personalized In Vitro Cancer Modeling — Fantasy or Reality?

(2014) Richard Bartlett et al.   Translational Oncology

Induction of pluripotency in human somatic cells via a transient state resembling primitive streak-like mesendoderm

(2014) Kazutoshi Takahashi et al.   Nature Communications

Influence of Egr-1 in Cardiac Tissue-Derived Mesenchymal Stem Cells in Response to Glucose Variations

(2014) Daniela Bastianelli et al.   Biomed Research International

Drug Resistance in Cancer: An Overview

(2014) Genevieve Housman et al.   Cancers

Generation of multicellular tumor spheroids of breast cancer cells: How to go three-dimensional

(2013) Anika Nagelkerke et al.   ANALYTICAL BIOCHEMISTRY

TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer

(2013) Neil E. Bhola et al.   JOURNAL OF CLINICAL INVESTIGATION

Lin28 Induces Epithelial-to-Mesenchymal Transition and Stemness via Downregulation of Let-7a in Breast Cancer Cells

(2013) Yujie Liu et al.   PLoS One

Spheroid culture as a tool for creating 3D complex tissues

(2013) Eelco Fennema et al.   TRENDS IN BIOTECHNOLOGY

An EMT spectrum defines an anoikis-resistant and spheroidogenic intermediate mesenchymal state that is sensitive to e-cadherin restoration by a src-kinase inhibitor, saracatinib (AZD0530)

(2013) R Y-J Huang et al.   Cell Death & Disease

Regenerative activity of the lung after epithelial injury

(2012) Andrew E. Vaughan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

EMT and MET in Metastasis: Where Are the Cancer Stem Cells?

(2012) Thomas Brabletz   CANCER CELL

Early growth response 1 regulates glucose deprivation-induced necrosis

(2012) HYUN MIN JEON et al.   ONCOLOGY REPORTS

TGFβ-Dependent Epithelial-to-Mesenchymal Transition Is Required to Generate Cardiospheres from Human Adult Heart Biopsies

(2012) Elvira Forte et al.   STEM CELLS AND DEVELOPMENT

Functional Impairment of Human Resident Cardiac Stem Cells by the Cardiotoxic Antineoplastic Agent Trastuzumab

(2012) Andreas S. Barth et al.   Stem Cells Translational Medicine

Spontaneous spheroid budding from monolayers: a potential contribution to ovarian cancer dissemination

(2012) J. C. Pease et al.   Biology Open

Spheroid formation of mesenchymal stem cells on chitosan and chitosan-hyaluronan membranes

(2011) Guo-Shiang Huang et al.   BIOMATERIALS

Tracking the intermediate stages of epithelial-mesenchymal transition in epithelial stem cells and cancer

(2011) Nicole Vincent Jordan et al.   CELL CYCLE

MAP3K4/CBP-Regulated H2B Acetylation Controls Epithelial-Mesenchymal Transition in Trophoblast Stem Cells

(2011) Amy N. Abell et al.   Cell Stem Cell

Eyes Wide Open: A Critical Review of Sphere-Formation as an Assay for Stem Cells

(2011) Erika Pastrana et al.   Cell Stem Cell

The histone deacetylase 4/SP1/microrna-200a regulatory network contributes to aberrant histone acetylation in hepatocellular carcinoma

(2011) Ji-hang Yuan et al.   HEPATOLOGY

p53 regulates epithelial–mesenchymal transition and stem cell properties through modulating miRNAs

(2011) Chun-Ju Chang et al.   NATURE CELL BIOLOGY

Gamma-secretase inhibitors target tumor-initiating cells in a mouse model of ERBB2 breast cancer

(2011) M Kondratyev et al.   ONCOGENE

Early Growth Response-1 Induces and Enhances Vascular Endothelial Growth Factor-A Expression in Lung Cancer Cells

(2010) Hiroaki Shimoyamada et al.   AMERICAN JOURNAL OF PATHOLOGY

MicroRNA miR-183 Functions as an Oncogene by Targeting the Transcription Factor EGR1 and Promoting Tumor Cell Migration

(2010) A. L. Sarver et al.   CANCER RESEARCH

Double-Negative Feedback Loop between Reprogramming Factor LIN28 and microRNA let-7 Regulates Aldehyde Dehydrogenase 1-Positive Cancer Stem Cells

(2010) X. Yang et al.   CANCER RESEARCH

A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts

(2010) Ronghui Li et al.   Cell Stem Cell

Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche

(2010) Ahmed Mohyeldin et al.   Cell Stem Cell

Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells

(2010) Y. Li et al.   CLINICAL CANCER RESEARCH

Multicellular tumor spheroids: An underestimated tool is catching up again

(2010) Franziska Hirschhaeuser et al.   JOURNAL OF BIOTECHNOLOGY

Cardiospheres Recapitulate a Niche-Like Microenvironment Rich in Stemness and Cell-Matrix Interactions, Rationalizing Their Enhanced Functional Potency for Myocardial Repair

(2010) Tao-Sheng Li et al.   STEM CELLS

Constitutive activation of BMP signalling abrogates experimental metastasis of OVCA429 cells via reduced cell adhesion

(2010) Trevor G Shepherd et al.   Journal of Ovarian Research

Downregulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells

(2009) Yohei Shimono et al.   CELL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition

(2009) Erica L. McCoy et al.   JOURNAL OF CLINICAL INVESTIGATION

Kidney-Derived Stromal Cells Modulate Dendritic and T Cell Responses

(2009) Y. Huang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Direct cell reprogramming is a stochastic process amenable to acceleration

(2009) Jacob Hanna et al.   NATURE

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

(2009) Ulrich Wellner et al.   NATURE CELL BIOLOGY

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Hmga2 Promotes Neural Stem Cell Self-Renewal in Young but Not Old Mice by Reducing p16Ink4a and p19Arf Expression

(2008) Jinsuke Nishino et al.   CELL

Epithelial-mesenchymal transition (EMT) is not sufficient for spontaneous murine breast cancer metastasis

(2008) Yuanmei Lou et al.   DEVELOPMENTAL DYNAMICS

PTEN regulation by Akt–EGR1–ARF–PTEN axis

(2008) Jianxiu Yu et al.   EMBO JOURNAL

Identification of an adult stem/progenitor cell-like population in the human thyroid

(2008) Alessandra Fierabracci et al.   JOURNAL OF ENDOCRINOLOGY

Erk5 Controls Slug Expression and Keratinocyte Activation during Wound Healing

(2008) Valerie Arnoux et al.   MOLECULAR BIOLOGY OF THE CELL

The transcription factor Egr1 regulates the HIF-1α gene during hypoxia

(2008) Sabina Sperandio et al.   MOLECULAR CARCINOGENESIS

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

(2008) Philip A. Gregory et al.   NATURE CELL BIOLOGY

Development of a three-dimensional culture model of prostatic epithelial cells and its use for the study of epithelial-mesenchymal transition and inhibition of PI3K pathway in prostate cancer

(2008) Jian Hong Chu et al.   PROSTATE