The Response of Macrophages and Neutrophils to Hypoxia in the Context of Cancer and Other Inflammatory Diseases

Role of Intestinal HIF-2α in Health and Disease

(2016) Sadeesh K. Ramakrishnan et al.   Annual Review of Physiology

Macrophage polarization in pathology

(2015) Antonio Sica et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Oxygen Sensing and Homeostasis

(2015) Nanduri R. Prabhakar et al.   PHYSIOLOGY

Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A

(2015) Nadine Rohwer et al.   Oncotarget

Targeting hypoxia-inducible factor-1α (HIF-1α) in combination with antiangiogenic therapy: A phase I trial of bortezomib plus bevacizumab

(2015) Gerald S. Falchook et al.   Oncotarget

Toll-like Receptor 3 Regulates Angiogenesis and Apoptosis in Prostate Cancer Cell Lines through Hypoxia-Inducible Factor 1α

(2015) Alessio Paone et al.   NEOPLASIA

2-Methoxyestradiol synergizes with sorafenib to suppress hepatocellular carcinoma by simultaneously dysregulating hypoxia-inducible factor-1 and -2

(2014) Li Ma et al.   CANCER LETTERS

Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation

(2014) Eric L. Campbell et al.   IMMUNITY

HIF Transcription Factors, Inflammation, and Immunity

(2014) Asis Palazon et al.   IMMUNITY

The Tumor Microenvironment Shapes Lineage, Transcriptional, and Functional Diversity of Infiltrating Myeloid Cells

(2014) K. G. Elpek et al.   Cancer Immunology Research

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

Hypoxia-inducible factor 2  regulates key neutrophil functions in humans, mice, and zebrafish

(2013) A. A. R. Thompson et al.   BLOOD

Hypoxia-mediated sorafenib resistance can be overcome by EF24 through Von Hippel-Lindau tumor suppressor-dependent HIF-1α inhibition in hepatocellular carcinoma

(2013) Yingjian Liang et al.   HEPATOLOGY

Weekly EZN-2208 (PEGylated SN-38) in combination with bevacizumab in patients with refractory solid tumors

(2013) Woondong Jeong et al.   INVESTIGATIONAL NEW DRUGS

Hypoxia-inducible factor pathway and diseases of the vascular wall

(2013) Chung S. Lim et al.   JOURNAL OF VASCULAR SURGERY

Tumor stroma: a complexity dictated by the hypoxic tumor microenvironment

(2013) A Casazza et al.   ONCOGENE

Tumor-associated neutrophils: friend or foe?

(2012) Z. G. Fridlender et al.   CARCINOGENESIS

NF-κB as a Target for Modulating Inflammatory Responses

(2012) Chiara Gasparini et al.   CURRENT PHARMACEUTICAL DESIGN

Hypoxia—a key regulator of angiogenesis and inflammation in rheumatoid arthritis

(2012) Sofia Konisti et al.   Nature Reviews Rheumatology

Tumor-Associated Neutrophils: New Targets for Cancer Therapy

(2011) A. D. Gregory et al.   CANCER RESEARCH

IGF-1 induced HIF-1α-TLR9 cross talk regulates inflammatory responses in glioma

(2011) Sanchari Sinha et al.   CELLULAR SIGNALLING

Intrarectal administration of oxygenated perfluorodecalin promotes healing of murine colitis by targeting inflammatory hypoxia

(2011) Pieter Hindryckx et al.   LABORATORY INVESTIGATION

Tumor-infiltrating neutrophils in pancreatic neoplasia

(2011) Michelle D Reid et al.   MODERN PATHOLOGY

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypoxia-inducible Factor 1 as one of the “Signaling Drivers” of Toll-like Receptor-Dependent and Allergic Inflammation

(2010) Vadim V. Sumbayev et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Opposing roles for HIF-1  and HIF-2  in the regulation of angiogenesis by mononuclear phagocytes

(2010) T. D. Eubank et al.   BLOOD

Knockout of HIF-1  in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses

(2010) C. Werno et al.   CARCINOGENESIS

Differential activation and antagonistic function of HIF-  isoforms in macrophages are essential for NO homeostasis

(2010) N. Takeda et al.   GENES & DEVELOPMENT

Osteopontin is up-regulated and associated with neutrophil and macrophage infiltration in glioblastoma

(2010) Nadia A. Atai et al.   IMMUNOLOGY

Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation

(2010) Hongxia Z. Imtiyaz et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia Selectively Inhibits Respiratory Burst Activity and Killing of Staphylococcus aureus in Human Neutrophils

(2010) N. N. McGovern et al.   JOURNAL OF IMMUNOLOGY

Inflammation, HIF-1, and the Epigenetics That Follows

(2010) Claudio Brigati et al.   MEDIATORS OF INFLAMMATION

Neutrophil elastase–mediated degradation of IRS-1 accelerates lung tumor growth

(2010) A McGarry Houghton et al.   NATURE MEDICINE

Neutrophil function in inflammation and inflammatory diseases

(2010) H. L. Wright et al.   RHEUMATOLOGY

Macrophages: Master Regulators of Inflammation and Fibrosis

(2010) Thomas Wynn et al.   SEMINARS IN LIVER DISEASE

Cigarette Smoke Impairs Clearance of Apoptotic Cells through Oxidant-dependent Activation of RhoA

(2009) Tiffany R. Richens et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Cytokine Network in Chronic Obstructive Pulmonary Disease

(2009) Peter J. Barnes   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Tumor-associated macrophages: Effectors of angiogenesis and tumor progression

(2009) Seth B. Coffelt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia

(2009) H.-Y. Fang et al.   BLOOD

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

The involvement of hypoxia-inducible factor 1 alpha in Toll-like receptor 7/8-mediated inflammatory response

(2009) Sally A Nicholas et al.   CELL RESEARCH

HIF-1 Inhibitors for Cancer Therapy: From Gene Expression to Drug Discovery

(2009) G. Semenza   CURRENT PHARMACEUTICAL DESIGN

Hypoxic stress up-regulates the expression of Toll-like receptor 4 in macrophages via hypoxia-inducible factor

(2009) So Young Kim et al.   IMMUNOLOGY

Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation

(2009) B. Kruger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peripheral Blood Neutrophils as Independent Immunologic Predictor of Response and Long-Term Survival upon Immunotherapy in Metastatic Renal-Cell Carcinoma

(2008) Jens Atzpodien et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Biology of HIF-1α

(2008) A Weidemann et al.   CELL DEATH AND DIFFERENTIATION

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE

Nitric oxide, apoptosis and macrophage polarization during tumor progression

(2008) Andreas Weigert et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Aerobic metabolism underlies complexity and capacity

(2007) Lauren G. Koch et al.   JOURNAL OF PHYSIOLOGY-LONDON