Does microRNA Perturbation Control the Mechanisms Linking Obesity and Diabetes? Implications for Cardiovascular Risk

Blood Co-Circulating Extracellular microRNAs and Immune Cell Subsets Associate with Type 1 Diabetes Severity

(2020) Silvia Garavelli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Obesity, unfavourable lifestyle and genetic risk of type 2 diabetes: a case-cohort study

(2020) Theresia M. Schnurr et al.   DIABETOLOGIA

Circulating MicroRNA-15a Associates With Retinal Damage in Patients With Early Stage Type 2 Diabetes

(2020) Elena Sangalli et al.   Frontiers in Endocrinology

Plasma circulating miR-23~27~24 clusters correlate with the immunometabolic derangement and predict C-peptide loss in children with type 1 diabetes

(2020) Silvia Garavelli et al.   DIABETOLOGIA

Effect of diabetes on exosomal miRNA profile in patients with obesity

(2020) Hyoshik Kim et al.   BMJ Open Diabetes Research & Care

Reduced delivery of epididymal adipocyte-derived exosomal resistin is essential for melatonin ameliorating hepatic steatosis in mice

(2019) Bohan Rong et al.   JOURNAL OF PINEAL RESEARCH

Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic disease

(2019) Marah C. Runtsch et al.   PLoS Genetics

Circulating microRNA-21 is an early predictor of ROS-mediated damage in subjects with high risk of developing diabetes and in drug-naïve T2D

(2019) Lucia La Sala et al.   Cardiovascular Diabetology

MicroRNA-31 Regulates Immunosuppression in Ang II (Angiotensin II)–induced Hypertension by Targeting Ppp6C (Protein Phosphatase 6c)

(2019) Xiangxiao Li et al.   HYPERTENSION

miR-431-5p Knockdown Protects Against Angiotensin II–Induced Hypertension and Vascular Injury

(2019) Ku-Geng Huo et al.   HYPERTENSION

Association of circulating miR-155 expression level and inflammatory markers with white coat hypertension

(2019) Yu-qing Huang et al.   JOURNAL OF HUMAN HYPERTENSION

The link between diabetes and atherosclerosis

(2019) Lucia La Sala et al.   European Journal of Preventive Cardiology

miR-10b and miR-223-3p in serum microvesicles signal progression from prediabetes to type 2 diabetes

(2019) M. Parrizas et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

PTRF acts as an adipokine contributing to adipocyte dysfunctionality and ectopic lipid deposition

(2018) Sergio Perez-Diaz et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue

(2018) David A. Hill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adipocyte-Derived Exosomal MiR-27a Induces Insulin Resistance in Skeletal Muscle Through Repression of PPARγ

(2018) Yang Yu et al.   Theranostics

Adipose tissue derived-factors impaired pancreatic β-cell function in diabetes

(2018) Sandra A. Rebuffat et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Glucose-sensing microRNA-21 disrupts ROS homeostasis and impairs antioxidant responses in cellular glucose variability

(2018) Lucia La Sala et al.   Cardiovascular Diabetology

Lymphocyte-Derived Exosomal MicroRNAs Promote Pancreatic β Cell Death and May Contribute to Type 1 Diabetes Development

(2018) Claudiane Guay et al.   Cell Metabolism

Exosomes and diabetes

(2018) Carlos Castaño et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

In Vitro and in Vivo RNA Inhibition by CD9-HuR Functionalized Exosomes Encapsulated with miRNA or CRISPR/dCas9

(2018) Zhelong Li et al.   NANO LETTERS

Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice

(2018) Carlos Castaño et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adipogenic miR-27a in adipose tissue upregulates macrophage activation via inhibiting PPARγ of insulin resistance induced by high-fat diet-associated obesity

(2017) Fan Yao et al.   EXPERIMENTAL CELL RESEARCH

Global Burden of Hypertension and Systolic Blood Pressure of at Least 110 to 115 mm Hg, 1990-2015

(2017) Mohammad H. Forouzanfar et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Tissue-specific exosome biomarkers for noninvasively monitoring immunologic rejection of transplanted tissue

(2017) Prashanth Vallabhajosyula et al.   JOURNAL OF CLINICAL INVESTIGATION

Adipose-derived circulating miRNAs regulate gene expression in other tissues

(2017) Thomas Thomou et al.   NATURE

Mesenchymal stem cells as natural biofactories for exosomes carrying miR-124a in the treatment of gliomas

(2017) Frederick M Lang et al.   NEURO-ONCOLOGY

miRNA‑145 is associated with spontaneous hypertension by targeting SLC7A1

(2017) Yong Wang et al.   Experimental and Therapeutic Medicine

A unique plasma microRNA profile defines type 2 diabetes progression

(2017) Paola de Candia et al.   PLoS One

MicroRNA-185 regulates expression of lipid metabolism genes and improves insulin sensitivity in mice with non-alcoholic fatty liver disease

(2017) Xiao-Chen Wang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

MicroRNA-192* impairs adipocyte triglyceride storage

(2016) Raghavendra Mysore et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Oscillating glucose induces microRNA-185 and impairs an efficient antioxidant response in human endothelial cells

(2016) Lucia La Sala et al.   Cardiovascular Diabetology

Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk

(2016) Jennifer H. Stern et al.   Cell Metabolism

Circulating MicroRNA-122 Is Associated With the Risk of New-Onset Metabolic Syndrome and Type 2 Diabetes

(2016) Peter Willeit et al.   DIABETES

Exosome-like vesicles released from lipid-induced insulin-resistant muscles modulate gene expression and proliferation of beta recipient cells in mice

(2016) Audrey Jalabert et al.   DIABETOLOGIA

Circulating microRNAs are deregulated in overweight/obese children: preliminary results of the I.Family study

(2016) Giuseppe Iacomino et al.   Genes and Nutrition

Differential microRNA Profiles Predict Diabetic Nephropathy Progression in Taiwan

(2016) Hung-Yu Chien et al.   International Journal of Medical Sciences

Association of Changes in Abdominal Fat Quantity and Quality With Incident Cardiovascular Disease Risk Factors

(2016) Jane J. Lee et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Visceral Adipose MicroRNA 223 Is Upregulated in Human and Murine Obesity and Modulates the Inflammatory Phenotype of Macrophages

(2016) Jeffrey A. Deiuliis et al.   PLoS One

Adipocyte-derived microvesicles from obese mice induce M1 macrophage phenotype through secreted miR-155

(2016) Yaqin Zhang et al.   Journal of Molecular Cell Biology

Circulating microRNAs are deregulated in overweight/obese children: preliminary results of the I.Family study

(2016) Giuseppe Iacomino et al.   Genes and Nutrition

Pancreas-enriched miRNAs are altered in the circulation of subjects with diabetes: a pilot cross-sectional study

(2016) Attila A. Seyhan et al.   Scientific Reports

Obesity and Atherosclerosis: Mechanistic Insights

(2015) Fina Lovren et al.   CANADIAN JOURNAL OF CARDIOLOGY

Hypertension: Renin-Angiotensin-Aldosterone System Alterations

(2015) L. te Riet et al.   CIRCULATION RESEARCH

The microRNA-29 Family Dictates the Balance Between Homeostatic and Pathological Glucose Handling in Diabetes and Obesity

(2015) James Dooley et al.   DIABETES

MicroRNA-193b Controls Adiponectin Production in Human White Adipose Tissue

(2015) Yasmina Belarbi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Circulating miR-192 and miR-193b Are Markers of Prediabetes and Are Modulated by an Exercise Intervention

(2015) Marcelina Párrizas et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Interaction between microRNA expression and classical risk factors in the risk of coronary heart disease

(2015) Xiao-Qing Ding et al.   Scientific Reports

GLP-1 reduces metalloproteinase-9 induced by both hyperglycemia and hypoglycemia in type 1 diabetes. The possible role of oxidative stress

(2015) Antonio Ceriello et al.   Therapeutics and Clinical Risk Management

Oscillating glucose and constant high glucose induce endoglin expression in endothelial cells: the role of oxidative stress

(2014) Lucia La Sala et al.   ACTA DIABETOLOGICA

2. Classification and Diagnosis of Diabetes

(2014)   DIABETES CARE

Role of islet microRNAs in diabetes: which model for which question?

(2014) Claudiane Guay et al.   DIABETOLOGIA

Exosomes participate in the alteration of muscle homeostasis during lipid-induced insulin resistance in mice

(2014) Hala Aswad et al.   DIABETOLOGIA

Microvesicle-Shuttled miR-130b Reduces Fat Deposition in Recipient Primary Cultured Porcine Adipocytes by Inhibiting PPAR-γ Expression

(2014) Shifeng Pan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

MicroRNA-146a and -21 cooperate to regulate vascular smooth muscle cell proliferation via modulation of the Notch signaling pathway

(2014) JIAN CAO et al.   Molecular Medicine Reports

An emerging role for the miR-26 family in cardiovascular disease

(2014) Basak Icli et al.   TRENDS IN CARDIOVASCULAR MEDICINE

The Origins and Drivers of Insulin Resistance

(2013) Andrew M.F. Johnson et al.   CELL

Vitamin C Further Improves the Protective Effect of Glucagon-Like Peptide-1 on Acute Hypoglycemia-Induced Oxidative Stress, Inflammation, and Endothelial Dysfunction in Type 1 Diabetes

(2013) A. Ceriello et al.   DIABETES CARE

Circulating miR-130b mediates metabolic crosstalk between fat and muscle in overweight/obesity

(2013) Yu-cheng Wang et al.   DIABETOLOGIA

Downregulation of Sfrp5 promotes beta cell proliferation during obesity in the rat

(2013) Sandra A. Rebuffat et al.   DIABETOLOGIA

Identification of particular groups of microRNAs that positively or negatively impact on beta cell function in obese models of type 2 diabetes

(2013) Valeria Nesca et al.   DIABETOLOGIA

MicroRNAs: potential mediators and biomarkers of diabetic complications

(2013) Mitsuo Kato et al.   FREE RADICAL BIOLOGY AND MEDICINE

Identification of miR-185 as a regulator of de novo cholesterol biosynthesis and low density lipoprotein uptake

(2013) Muhua Yang et al.   JOURNAL OF LIPID RESEARCH

Circulating microRNAs as novel biomarkers for diabetes mellitus

(2013) Claudiane Guay et al.   Nature Reviews Endocrinology

Serum Circulating microRNA Profiling for Identification of Potential Type 2 Diabetes and Obesity Biomarkers

(2013) Nuria Pescador et al.   PLoS One

A Role for miR-145 in Pulmonary Arterial Hypertension

(2012) Paola Caruso et al.   CIRCULATION RESEARCH

CXCL10 contributes to p38-mediated apoptosis in primary T lymphocytes in vitro

(2012) Abubaker M.E. Sidahmed et al.   CYTOKINE

MicroRNA-7 Regulates the mTOR Pathway and Proliferation in Adult Pancreatic  -Cells

(2012) Y. Wang et al.   DIABETES

Evidence That Hyperglycemia After Recovery From Hypoglycemia Worsens Endothelial Function and Increases Oxidative Stress and Inflammation in Healthy Control Subjects and Subjects With Type 1 Diabetes

(2012) A. Ceriello et al.   DIABETES

Essential Role of MicroRNA-155 in Regulating Endothelium-Dependent Vasorelaxation by Targeting Endothelial Nitric Oxide Synthase

(2012) Hai-Xiang Sun et al.   HYPERTENSION

Circulating miRNA Profiles in Patients with Metabolic Syndrome

(2012) Dwi Setyowati Karolina et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs

(2012) Eduard Hergenreider et al.   NATURE CELL BIOLOGY

MicroRNA-21 Promotes Fibrosis of the Kidney by Silencing Metabolic Pathways

(2012) B. N. Chau et al.   Science Translational Medicine

Ectopic Fat Depots and Cardiovascular Disease

(2011) Kathryn A. Britton et al.   CIRCULATION

Gene Expression Profiling Reveals Renin mRNA Overexpression in Human Hypertensive Kidneys and a Role for MicroRNAs

(2011) Francine Z. Marques et al.   HYPERTENSION

MicroRNA-21 Orchestrates High Glucose-induced Signals to TOR Complex 1, Resulting in Renal Cell Pathology in Diabetes

(2011) Nirmalya Dey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-29a and miR-29b Contribute to Pancreatic  -Cell-Specific Silencing of Monocarboxylate Transporter 1 (Mct1)

(2011) T. J. Pullen et al.   MOLECULAR AND CELLULAR BIOLOGY

MicroRNAs 103 and 107 regulate insulin sensitivity

(2011) Mirko Trajkovski et al.   NATURE

Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism

(2011) Sabine D. Jordan et al.   NATURE CELL BIOLOGY

MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins

(2011) Kasey C. Vickers et al.   NATURE CELL BIOLOGY

Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity

(2011) Pernille Keller et al.   BMC Endocrine Disorders

Differences in islet-enriched miRNAs in healthy and glucose intolerant human subjects

(2010) Caroline Bolmeson et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Circulating MicroRNAs in Patients With Coronary Artery Disease

(2010) Stephan Fichtlscherer et al.   CIRCULATION RESEARCH

Involvement of MicroRNAs in the Cytotoxic Effects Exerted by Proinflammatory Cytokines on Pancreatic  -Cells

(2010) E. Roggli et al.   DIABETES

Up-Regulated Pancreatic Tissue MicroRNA-375 Associates With Human Type 2 Diabetes Through β-Cell Deficit and Islet Amyloid Deposition

(2010) Hailu Zhao et al.   PANCREAS

Structure and activity of putative intronic miRNA promoters

(2010) A. M. Monteys et al.   RNA

MicroRNA hsa-miR-138 Inhibits Adipogenic Differentiation of Human Adipose Tissue-Derived Mesenchymal Stem Cells Through Adenovirus EID-1

(2010) Zhuo Yang et al.   STEM CELLS AND DEVELOPMENT

Immune and Inflammatory Mechanisms of Atherosclerosis

(2009) Elena Galkina et al.   Annual Review of Immunology

MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue

(2009) Sashwati Roy et al.   CARDIOVASCULAR RESEARCH

MicroRNAs Induced During Adipogenesis that Accelerate Fat Cell Development Are Downregulated in Obesity

(2009) H. Xie et al.   DIABETES

Adipose Tissue Exosome-Like Vesicles Mediate Activation of Macrophage-Induced Insulin Resistance

(2009) Z.-b. Deng et al.   DIABETES

A role ofmiR-27in the regulation of adipogenesis

(2009) Qun Lin et al.   FEBS Journal

Obesity and genetics regulate microRNAs in islets, liver, and adipose of diabetic mice

(2009) Enpeng Zhao et al.   MAMMALIAN GENOME

Adipose tissue as an endocrine organ

(2009) Sandra Galic et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

MicroRNAlet-7Regulates 3T3-L1 Adipogenesis

(2009) Tingwan Sun et al.   MOLECULAR ENDOCRINOLOGY

Epigenetics: Definition, Mechanisms and Clinical Perspective

(2009) Cathérine Dupont et al.   SEMINARS IN REPRODUCTIVE MEDICINE

Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases

(2008) Xi Chen et al.   CELL RESEARCH

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

Mechanistic insights into the link between a polymorphism of the 3′UTR of theSLC7A1gene and hypertension

(2008) Zhiyong Yang et al.   HUMAN MUTATION

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

(2008) Thomas Thum et al.   NATURE

Oxidative Stress in Severely Obese Persons Is Greater in Those With Insulin Resistance

(2008) Francisco J. Tinahones et al.   Obesity

The microRNA miR-8 is a conserved negative regulator of Wnt signaling

(2008) J. A. Kennell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130

(2008) Q. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA