Molecular Biology of Atherosclerotic Ischemic Strokes

MicroRNA-384-5p Promotes Endothelial Progenitor Cell Proliferation and Angiogenesis in Cerebral Ischemic Stroke through the Delta-Likeligand 4-Mediated Notch Signaling Pathway

(2020) Jia Fan et al.   CEREBROVASCULAR DISEASES

Dectin-1/Syk signaling triggers neuroinflammation after ischemic stroke in mice

(2020) Xin-Chun Ye et al.   Journal of Neuroinflammation

Adipocyte fatty acid-binding protein exacerbates cerebral ischaemia injury by disrupting the blood–brain barrier

(2020) Boya Liao et al.   EUROPEAN HEART JOURNAL

DKK3 (Dikkopf-3) Transdifferentiates Fibroblasts Into Functional Endothelial Cells—Brief Report

(2019) Ting Chen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

HLA and killer cell immunoglobulin-like receptor (KIRs) genotyping in patients with acute ischemic stroke

(2019) Antonino Tuttolomondo et al.   Journal of Neuroinflammation

Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/TXNIP complex in cerebral ischemia reperfusion injury

(2018) Yanghao Hou et al.   BEHAVIOURAL BRAIN RESEARCH

Interferon regulatory factor 4/5 signaling impacts on microglial activation after ischemic stroke in mice

(2018) Abdullah Al Mamun et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Immune responses in stroke: how the immune system contributes to damage and healing after stroke and how this knowledge could be translated to better cures?

(2018) Aditya Rayasam et al.   IMMUNOLOGY

Clinical use of lentiviral vectors

(2018) Michael C. Milone et al.   LEUKEMIA

Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery

(2018) Minako Ito et al.   NATURE

MicroRNA-137 protects neurons against ischemia/reperfusion injury through regulation of the Notch signaling pathway

(2017) Fangkun Shi et al.   EXPERIMENTAL CELL RESEARCH

Depletion of microglia exacerbates postischemic inflammation and brain injury

(2017) Wei-Na Jin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Diagnostic Value of Serum miRNA-221-3p, miRNA-382-5p, and miRNA-4271 in Ischemic Stroke

(2017) Yaru Wang et al.   Journal of Stroke & Cerebrovascular Diseases

Dickkopf‐3 Ablation Attenuates the Development of Atherosclerosis in ApoE‐Deficient Mice

(2017) Wen‐Lin Cheng et al.   Journal of the American Heart Association

The Diagnostic Value of Serum miRNA-221-3p, miRNA-382-5p, and miRNA-4271 in Ischemic Stroke

(2017) Yaru Wang et al.   Journal of Stroke & Cerebrovascular Diseases

Targeting resolution of neuroinflammation after ischemic stroke with a lipoxin A4 analog: Protective mechanisms and long-term effects on neurological recovery

(2017) Kimberly E. Hawkins et al.   Brain and Behavior

Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan

(2016) Andrea J. Wolf et al.   CELL

NLRP3 inflammasome: a promising target in ischemic stroke

(2016) Li Gao et al.   INFLAMMATION RESEARCH

Neutrophil-to-Lymphocyte Ratio Predicts Length of Stay and Acute Hospital Cost in Patients with Acute Ischemic Stroke

(2016) Lingling Zhao et al.   Journal of Stroke & Cerebrovascular Diseases

Loss of Fatty Acid Binding Protein 4/aP2 Reduces Macrophage Inflammation Through Activation of SIRT3

(2016) Hongliang Xu et al.   MOLECULAR ENDOCRINOLOGY

Inflammation and Stroke: An Overview

(2016) Josef Anrather et al.   Neurotherapeutics

ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis Ischemia/Reperfusion Injury

(2016) Letteria Minutoli et al.   Oxidative Medicine and Cellular Longevity

Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke

(2016) Xiao-Yi Xiong et al.   PROGRESS IN NEUROBIOLOGY

Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke

(2016) Gergely Szalay et al.   Nature Communications

MKEY, a Peptide Inhibitor of CXCL4‐CCL5 Heterodimer Formation, Protects Against Stroke in Mice

(2016) Yifang Fan et al.   Journal of the American Heart Association

Neutrophil-to-Lymphocyte Ratio Predicts Length of Stay and Acute Hospital Cost in Patients with Acute Ischemic Stroke

(2016) Lingling Zhao et al.   Journal of Stroke & Cerebrovascular Diseases

An APOC3 3′UTR variant associated with plasma triglycerides levels and coronary heart disease by creating a functional miR-4271 binding site

(2016) Sen-Lin Hu et al.   Scientific Reports

Effects of Persistent Atrial Fibrillation on Serum Galectin-3 Levels

(2015) Kadri Murat Gurses et al.   AMERICAN JOURNAL OF CARDIOLOGY

MicroRNA-19b/221/222 induces endothelial cell dysfunction via suppression of PGC-1α in the progression of atherosclerosis

(2015) Yunxing Xue et al.   ATHEROSCLEROSIS

Dickkopf-3 (DKK-3) obstructs VEGFR-2/Akt/mTOR signaling cascade by interacting of β2-microglobulin (β2M) in ovarian tumorigenesis

(2015) Boh-Ram Kim et al.   CELLULAR SIGNALLING

miR-98 and let-7g* Protect the Blood-Brain Barrier Under Neuroinflammatory Conditions

(2015) Slava Rom et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Functional differences between microglia and monocytes after ischemic stroke

(2015) Rodney M. Ritzel et al.   Journal of Neuroinflammation

Endothelial CD36 Contributes to Postischemic Brain Injury by Promoting Neutrophil Activation via CSF3

(2015) L. Garcia-Bonilla et al.   JOURNAL OF NEUROSCIENCE

Neuronal Interleukin-4 as a Modulator of Microglial Pathways and Ischemic Brain Damage

(2015) X. Zhao et al.   JOURNAL OF NEUROSCIENCE

Peripheral Frequency of CD4+ CD28− Cells in Acute Ischemic Stroke

(2015) Antonino Tuttolomondo et al.   MEDICINE

Early Upregulation of NLRP3 in the Brain of Neonatal Mice Exposed to Hypoxia-Ischemia: No Early Neuroprotective Effects of NLRP3 Deficiency

(2015) Martin Bogale Ystgaard et al.   Neonatology

Inhibition of p53 attenuates ischemic stress-induced activation of astrocytes

(2015) Kee-Chan Ahn et al.   NEUROREPORT

Upregulation of NLRP3 Inflammasome in the Tears and Ocular Surface of Dry Eye Patients

(2015) Liangliang Niu et al.   PLoS One

Involvement of p38 MAPK in reactive astrogliosis induced by ischemic stroke

(2014) Gourav Roy Choudhury et al.   BRAIN RESEARCH

Association of Serum Levels of Adipocyte Fatty Acid-Binding Protein and High-Sensitivity C Reactive Protein with Severity of Acute Ischemic Stroke

(2014) Xiang-lei Huang   CELL BIOCHEMISTRY AND BIOPHYSICS

Comparison of miR-124-3p and miR-16 for early diagnosis of hemorrhagic and ischemic stroke

(2014) Ling Yan Leung et al.   CLINICA CHIMICA ACTA

Innate Inflammatory Responses in Stroke: Mechanisms and Potential Therapeutic Targets

(2014) J.Y. Kim et al.   CURRENT MEDICINAL CHEMISTRY

Effects of Immediate Blood Pressure Reduction on Death and Major Disability in Patients With Acute Ischemic Stroke

(2014) Jiang He et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

NLRP3 Deficiency Ameliorates Neurovascular Damage in Experimental Ischemic Stroke

(2014) Fan Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Inflammatory Chemokine CCL5 and Cancer Progression

(2014) Donatella Aldinucci et al.   MEDIATORS OF INFLAMMATION

Cell-specific therapy on target

(2014) Daniel T. W. Clarke et al.   Nature Nanotechnology

Microglial and macrophage polarization—new prospects for brain repair

(2014) Xiaoming Hu et al.   Nature Reviews Neurology

The dual role of astrocyte activation and reactive gliosis

(2014) Milos Pekny et al.   NEUROSCIENCE LETTERS

Circulating miR-9* and miR-384-5p as Potential Indicators for Trimethyltin-induced Neurotoxicity

(2014) Keiko Ogata et al.   TOXICOLOGIC PATHOLOGY

The impact of microglial activation on blood-brain barrier in brain diseases

(2014) Anna Carolina Carvalho da Fonseca et al.   Frontiers in Cellular Neuroscience

Dll4-containing exosomes induce capillary sprout retraction in a 3D microenvironment

(2014) Soheila Sharghi-Namini et al.   Scientific Reports

The pH-Responsive PacC Transcription Factor of Aspergillus fumigatus Governs Epithelial Entry and Tissue Invasion during Pulmonary Aspergillosis

(2014) Margherita Bertuzzi et al.   PLoS Pathogens

MicroRNA-384-5p regulates ischemia-induced cardioprotection by targeting phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta (PI3K p110δ)

(2013) Yanyan Bao et al.   APOPTOSIS

Circulating miR-30a, miR-126 and let-7b as biomarker for ischemic stroke in humans

(2013) Guangwen Long et al.   BMC Neurology

The Acute-Phase Protein PTX3 is an Essential Mediator of Glial Scar Formation and Resolution of Brain Edema after Ischemic Injury

(2013) Beatriz Rodriguez-Grande et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Methanol extract of Evodia lepta displays Syk/Src-targeted anti-inflammatory activity

(2013) Ju Young Yoon et al.   JOURNAL OF ETHNOPHARMACOLOGY

In vitro and in vivo anti-inflammatory effect of Rhodomyrtus tomentosa methanol extract

(2013) Deok Jeong et al.   JOURNAL OF ETHNOPHARMACOLOGY

Changes in matrix metalloproteinase-9 levels during progression of atrial fibrillation

(2013) Mingjiang Li et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Boosting Regulatory T Cells Limits Neuroinflammation in Permanent Cortical Stroke

(2013) A. Liesz et al.   JOURNAL OF NEUROSCIENCE

Downregulation of miR-181b in mouse brain following ischemic stroke induces neuroprotection against ischemic injury through targeting heat shock protein A5 and ubiquitin carboxyl-terminal hydrolase isozyme L1

(2013) Zhifeng Peng et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Interferon-Regulatory Factors Determine Macrophage Phenotype Polarization

(2013) Roman Günthner et al.   MEDIATORS OF INFLAMMATION

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

High pro-BNP levels predict the occurrence of atrial fibrillation after cryptogenic stroke

(2013) M. Rodriguez-Yanez et al.   NEUROLOGY

Neuroprotection by astrocytes in brain ischemia: Importance of microRNAs

(2013) Yi-Bing Ouyang et al.   NEUROSCIENCE LETTERS

Inhibition of Glycogen Synthase Kinase 3β Promotes Tight Junction Stability in Brain Endothelial Cells by Half-Life Extension of Occludin and Claudin-5

(2013) Servio H. Ramirez et al.   PLoS One

Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke

(2012) M. Gelderblom et al.   BLOOD

Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome

(2012) Christine M. Oslowski et al.   Cell Metabolism

Inflammation in Ischemic Stroke Subtypes

(2012) Antonino Tuttolomondo et al.   CURRENT PHARMACEUTICAL DESIGN

Dectin-1 is inducible and plays a crucial role in Aspergillus-induced innate immune responses in human bronchial epithelial cells

(2012) W.-K. Sun et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Quantitative Expression of C-Type Lectin Receptors in Humans and Mice

(2012) Maciej Lech et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Src/NF-κB-targeted inhibition of LPS-induced macrophage activation and dextran sodium sulphate-induced colitis by Archidendron clypearia methanol extract

(2012) Woo Seok Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Matrix Metalloproteinase-2-Mediated Occludin Degradation and Caveolin-1-Mediated Claudin-5 Redistribution Contribute to Blood-Brain Barrier Damage in Early Ischemic Stroke Stage

(2012) J. Liu et al.   JOURNAL OF NEUROSCIENCE

Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome

(2012) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain

(2012) Takashi Shichita et al.   NATURE MEDICINE

Neuroinflammation by Cytotoxic T-Lymphocytes Impairs Retrograde Axonal Transport in an Oligodendrocyte Mutant Mouse

(2012) Chi Wang Ip et al.   PLoS One

The role of pro-inflammatory cytokines in the neuroinflammation and neurogenesis of schizophrenia

(2012) Kyoung-Sae Na et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

(2012) Xiaoming Hu et al.   STROKE

Adiponectin and adipocyte fatty acid binding protein in the pathogenesis of cardiovascular disease

(2011) Aimin Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke

(2011) Arthur Liesz et al.   BRAIN

The ability of an ethanol extract of Cinnamomum cassia to inhibit Src and spleen tyrosine kinase activity contributes to its anti-inflammatory action

(2011) Tao Yu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Reduction of neutrophil activity decreases early microvascular injury after subarachnoid haemorrhage

(2011) Victor Friedrich et al.   Journal of Neuroinflammation

Role of microRNAs in endothelial inflammation and senescence

(2011) Bing Qin et al.   MOLECULAR BIOLOGY REPORTS

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Neuroprotection by Interleukin-6 Is Mediated by Signal Transducer and Activator of Transcription 3 and Antioxidative Signaling in Ischemic Stroke

(2011) Joo Eun Jung et al.   STROKE

Cyanobacterial Microcystis aeruginosa Lipopolysaccharide Elicits Release of Superoxide Anion, Thromboxane B2, Cytokines, Chemokines, and Matrix Metalloproteinase-9 by Rat Microglia

(2011) Alejandro M. S. Mayer et al.   TOXICOLOGICAL SCIENCES

Regulation by glycogen synthase kinase-3 of inflammation and T cells in CNS diseases

(2011) Eléonore Beurel   Frontiers in Molecular Neuroscience

Inhibition of Glycogen Synthase Kinase 3β (GSK3β) Decreases Inflammatory Responses in Brain Endothelial Cells

(2010) Servio H. Ramirez et al.   AMERICAN JOURNAL OF PATHOLOGY

Spleen tyrosine kinase inhibition prevents tissue damage after ischemia-reperfusion

(2010) Omer Nuri Pamuk et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

The role of the CXC chemokines platelet factor-4 (CXCL4/PF-4) and its variant (CXCL4L1/PF-4var) in inflammation, angiogenesis and cancer

(2010) Jo Vandercappellen et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Astrocyte targeted overexpression of Hsp72 or SOD2 reduces neuronal vulnerability to forebrain ischemia

(2010) Lijun Xu et al.   GLIA

(1,3)- -Glucans Activate Both Dectin-1 and NLRP3 Inflammasome in Human Macrophages

(2010) P. Kankkunen et al.   JOURNAL OF IMMUNOLOGY

Exacerbated brain damage, edema and inflammation in type-2 diabetic mice subjected to focal ischemia

(2010) Kudret Tureyen et al.   JOURNAL OF NEUROCHEMISTRY

Protection by pyruvate against glutamate neurotoxicity is mediated by astrocytes through a glutathione-dependent mechanism

(2010) Yifeng Miao et al.   MOLECULAR BIOLOGY REPORTS

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Aspergillus fumigatus Stimulates the NLRP3 Inflammasome through a Pathway Requiring ROS Production and the Syk Tyrosine Kinase

(2010) Najwane Saïd-Sadier et al.   PLoS One

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

(2010) K. Schroder et al.   SCIENCE

CC and CXC chemokines are pivotal mediators of cerebral injury in ischaemic stroke

(2010) Giorgio Luciano Viviani et al.   THROMBOSIS AND HAEMOSTASIS

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

The Notch Ligands Dll4 and Jagged1 Have Opposing Effects on Angiogenesis

(2009) Rui Benedito et al.   CELL

Lipopolysaccharide-Activated Microglia Induce Dysfunction of the Blood–Brain Barrier in Rat Microvascular Endothelial Cells Co-Cultured with Microglia

(2009) Noriko Sumi et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Interleukin-17-Producing γδ T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals

(2009) Bruno Martin et al.   IMMUNITY

Plasma levels of inflammatory and thrombotic/fibrinolytic markers in acute ischemic strokes: Relationship with TOAST subtype, outcome and infarct site

(2009) Antonino Tuttolomondo et al.   JOURNAL OF NEUROIMMUNOLOGY

Identification of a dendritic cell receptor that couples sensing of necrosis to immunity

(2009) David Sancho et al.   NATURE

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

(2009) Olaf Gross et al.   NATURE

Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice

(2009) Rory R Koenen et al.   NATURE MEDICINE

Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury

(2009) Takashi Shichita et al.   NATURE MEDICINE

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

(2009) Arthur Liesz et al.   NATURE MEDICINE

microRNA: Emerging therapeutic targets in acute ischemic diseases

(2009) Pasquale Fasanaro et al.   PHARMACOLOGY & THERAPEUTICS

Immuno-inflammatory activation in acute cardio-embolic strokes in comparison with other subtypes of ischaemic stroke

(2009) Domenico Di Raimondo et al.   THROMBOSIS AND HAEMOSTASIS

Brain Natriuretic Peptide as a Surrogate Marker for Cardioembolic Stroke with Paroxysmal Atrial Fibrillation

(2008) Takayuki Naya et al.   CEREBROVASCULAR DISEASES

Inflammatory Cytokines in Acute Ischemic Stroke

(2008) Antonino Tuttolomondo et al.   CURRENT PHARMACEUTICAL DESIGN

The NLR Gene Family: A Standard Nomenclature

(2008) Jenny P.-Y. Ting et al.   IMMUNITY

Dkk3, downregulated in cervical cancer, functions as a negative regulator of β-catenin

(2008) Eun-Ju Lee et al.   INTERNATIONAL JOURNAL OF CANCER

CLEC9A Is a Novel Activation C-type Lectin-like Receptor Expressed on BDCA3+Dendritic Cells and a Subset of Monocytes

(2008) Cristal Huysamen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of the Inflammasome Complex Reduces the Inflammatory Response after Thromboembolic Stroke in Mice

(2008) Denise P Abulafia et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The impact of inflammation on the pathogenesis and prognosis of ischemic stroke

(2008) Taizen Nakase et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Strategies to advance translational research into brain barriers

(2008) Edward Neuwelt et al.   LANCET NEUROLOGY

Mincle is an ITAM-coupled activating receptor that senses damaged cells

(2008) Sho Yamasaki et al.   NATURE IMMUNOLOGY

Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets

(2008) Masato Furuhashi et al.   NATURE REVIEWS DRUG DISCOVERY

REIC/Dkk-3 induces cell death in human malignant glioma

(2008) Yoshifumi Mizobuchi et al.   NEURO-ONCOLOGY

Harms and benefits of lymphocyte subpopulations in patients with acute stroke

(2008) X. Urra et al.   NEUROSCIENCE

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE

Blood Cell-Derived RANTES Mediates Cerebral Microvascular Dysfunction, Inflammation, and Tissue Injury After Focal Ischemia–Reperfusion

(2008) Satoshi Terao et al.   STROKE