Article
Immunology
Yao Feng, Xuesong Bai, Wei Li, Wenbo Cao, Xin Xu, Fan Yu, Zhaolin Fu, Qiuyue Tian, Xiaofan Guo, Tao Wang, Arman Sha, Yanfei Chen, Peng Gao, Yabing Wang, Jian Chen, Yan Ma, Fei Chen, Adam A. Dmytriw, Robert W. Regenhardt, Jie Lu, Qingfeng Ma, Bin Yang, Liqun Jiao
Summary: This study found that advanced age, increased stroke severity, poor collaterals, general anesthesia, and NLR are independent predictors for an unfavorable clinical outcome following complete reperfusion after EVT. Neuroinflammation may merit particular attention in future studies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Green & Sustainable Science & Technology
Tissa Wijeratne, Carmela Sales, Rohit Menon, Leila Karimi, Mihajlo Jakovljevic
Summary: Stroke is a major cause of adult disability and death worldwide, with the immune system playing a significant role in the pathobiological process. The neutrophil to lymphocyte ratio (NLR) has been identified as a potential biomarker with implications for diagnosis, prognosis, and therapy in acute ischemic stroke (AIS). Studies have shown that an inflammatory response involving excessive neutrophils and reduced lymphocytes is associated with worse outcomes during acute interventions and recovery trajectory in stroke, highlighting the importance of a systems biology-based approach in stroke care.
Article
Clinical Neurology
Maria X. Sanmartin, Jeffrey M. Katz, Christian Eusemann, Artem T. Boltyenkov, Kinpritma Sangha, Mehrad Bastani, Raymond Turner, Adnan H. Siddiqui, Vitor Mendes Pereira, Ferdinand K. Hui, J. Mocco, Pina C. Sanelli
Summary: This study evaluated the cost-effectiveness of remote robotic endovascular thrombectomy (RR-EVT) for acute ischemic stroke (AIS) treatment. The results showed that RR-EVT was more effective and less costly than the standard-of-care approach. Sensitivity analyses demonstrated that RR-EVT remained cost-effective under various time delays and cost assumptions. This analysis suggests that RR-EVT is a cost-effective solution to expedite EVT for AIS patients.
JOURNAL OF NEUROSURGERY
(2023)
Article
Medicine, General & Internal
Lisda Amalia, Mitha Dewi Garyani, Nushrotul Lailiyya
Summary: This study found a positive correlation between cortisol levels, NLR levels, and NIHSS scores with sleep quality disturbances in acute ischemic stroke patients.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Yuxuan Lu, Weiping Sun, Zhiyuan Shen, Wei Sun, Ran Liu, Fan Li, Junlong Shu, Liwen Tai, Guozhong Li, Huisheng Chen, Guiru Zhang, Lei Zhang, Xuwen Sun, Jinhua Qiu, Yan Wei, Haiqiang Jin, Yining Huang
Summary: Studies on the regional differences in hospital costs of acute ischemic stroke (AIS) in China are scarce. The research revealed significant disparities in hospital costs among different regions, with similar proportion size order of components but unique determinants of costs in each region.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Clinical Neurology
Artem T. Boltyenkov, Gabriela Martinez, Ankur Pandya, Jeffrey M. Katz, Jason J. Wang, Jason J. Naidich, Elizabeth Rula, Pina C. Sanelli
Summary: The study demonstrates that implementing advanced CT angiography and perfusion (CTAP) imaging strategy for acute ischemic stroke patients, while increasing costs, can improve treatment outcomes, reduce acute care costs, and result in more patients achieving good functional outcomes at 90 days.
FRONTIERS IN NEUROLOGY
(2021)
Review
Medicine, General & Internal
Rajeel Imran, Ghada A. Mohamed, Fadi Nahab
Summary: The field of acute stroke treatment has seen significant progress, particularly in understanding the pathophysiology of acute ischemic injury and neuroimaging thrombolysis therapy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Miguel A. Vences, Virgilio E. Failoc-Rojas, Diego Urrunaga-Pastor, Yamilee Hurtado-Roca
Summary: The objective of this study was to describe the clinical and demographic characteristics of patients with acute cerebral infarction treated at a national reference hospital in Peru and determine the risk factors for in-hospital complications. The study included 192 patients with acute ischemic stroke and found that at least one in-hospital complication occurred in 32.3% of the patients, with infectious complications being the most frequent. The study also identified stroke severity as a risk factor and albumin greater than 3.5 mg/dL as a protective factor for the incidence of in-hospital complications.
Review
Pharmacology & Pharmacy
T. Marc Eastin, Justin A. Dye, Promod Pillai, Miguel A. Lopez-Gonzalez, Lei Huang, John H. Zhang, Warren W. Boling
Summary: Stroke is a significant cause of death and disability worldwide, with post-stroke cognitive impairment causing a decline in the quality of life. Currently, only pharmacological and mechanical thrombolysis interventions are advised for revascularization. However, these treatments are limited to the acute phase of stroke. Advances in neuroimaging and interventional devices have expanded the potential revascularization window, with delayed revascularization showing positive outcomes beyond the recommended therapeutic window. This review discusses the understanding of ischemic stroke, the latest revascularization doctrine, and evidence from clinical studies on effective delayed revascularization.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Donghua Mi, Zixiao Li, Hongqiu Gu, Yingyu Jiang, Xingquan Zhao, Yilong Wang, Yongjun Wang
Summary: This study aimed to examine the association between stress-induced hyperglycemia and the occurrence of in-hospital death in patients with diabetes and acute ischemic stroke. The results showed that hyperglycemia in stroke patients with diabetes mellitus is associated with a higher risk of in-hospital death.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Clinical Neurology
Adeel S. S. Zubair, Kevin N. N. Sheth
Summary: Stroke is a major cause of illness and death worldwide, and hemorrhagic transformation is a serious complication of ischemic stroke. Current treatments for acute ischemic stroke, such as endovascular thrombectomy and thrombolytic therapy, increase the risk of hemorrhagic conversion. The timely diagnosis and management of patients with hemorrhagic conversion are crucial for patient outcomes. This review aims to discuss the pathophysiology, risk factors, imaging considerations, and treatment of hemorrhagic conversion in acute ischemic stroke.
Article
Clinical Neurology
Nikolaos Mouchtouris, Fadi Al Saiegh, Breanna Valcarcel, Carrie E. Andrews, Evan Fitchett, David Nauheim, David Moskal, Nabeel Herial, Pascal Jabbour, Stavropoula Tjoumakaris, Ashwini D. Sharan, Robert H. Rosenwasser, M. Reid Gooch
Summary: The study identified hypertension, length of hospital stay, and hemorrhagic conversion as predictors of 30-day readmission in stroke patients after mechanical thrombectomy. Infection was the most common cause of readmission within 30 days, followed by cardiac and cerebrovascular diagnoses. These results are important in identifying patients requiring increased surveillance to reduce complications and unplanned readmissions.
JOURNAL OF NEUROSURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Yunyun Xiong, Ajay K. Wakhloo, Marc Fisher
Summary: The treatment of acute ischemic stroke is advancing with intravenous thrombolysis, mechanical thrombectomy, and cytoprotection being investigated. Later treatment with alteplase and the use of tenecteplase are beneficial alternatives to alteplase. Cytoprotection as an adjunct to reperfusion has shown no efficacy in prior clinical trials, but may have potential benefits.
CIRCULATION RESEARCH
(2022)
Article
Neuroimaging
Maria X. Sanmartin, Jeffrey M. Katz, Jason Wang, Ajay Malhotra, Kinpritma Sangha, Mehrad Bastani, Gabriela Martinez, Pina C. Sanelli
Summary: This study demonstrates that endovascular thrombectomy (EVT) treatment is cost-effective in acute ischemic stroke (AIS) patients with large established infarcts (ASPECTS 3-5), compared to standard care (SC).
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2022)
Article
Clinical Neurology
Chi Phuong Nguyen, Maarten M. H. Lahr, Durk-Jouke van der Zee, Henk van Voorst, Yvo B. W. E. M. Roos, Maarten Uyttenboogaart, Erik Buskens, CONTRAST Consortium
Summary: This study evaluated the cost-effectiveness of 0.25 mg/kg tenecteplase versus 0.9 mg/kg alteplase for intravenous thrombolysis in AIS patients. The results showed that tenecteplase was cost-effective for all AIS patients, including those with large vessel occlusion (LVO).
EUROPEAN STROKE JOURNAL
(2023)