Article
Clinical Neurology
Andy Y. Wang, Lester Y. Leung, Eric J. Puttock, Patrick H. Luetmer, David F. Kallmes, Jason Nelson, Sunyang Fu, Chengyi Zheng, Hongfang Liu, Wansu Chen, David M. Kent
Summary: This study examined the association between incidentally discovered white matter disease (WMD) severity and covert brain infarction (CBI) location with the risk of subsequent symptomatic stroke. The results showed that increasing WMD severity is associated with an increased incidence rate of future stroke, while the location of CBI does not have a significant association with the risk.
CEREBROVASCULAR DISEASES
(2023)
Review
Immunology
Xuelun Zou, Leiyun Wang, Linxiao Xiao, Sai Wang, Le Zhang
Summary: This article discusses the connection between gut microbiota and cerebrovascular diseases and investigates the involvement of gut microbes in the occurrence and development of CeVD. The study also evaluates the effectiveness of various therapies for CeVD.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Chao Zhou, Wei Rao, Xinhua Zhou, Dan He, Zhen Li, Nyambayar Dashtsoodol, Yue Ren
Summary: This study examined the frequencies and cell numbers of peripheral blood T lymphocyte subpopulations in patients with cerebral ischemia. The results showed significantly reduced cell numbers of iNKT cells, NKTL cells, and gamma delta T cells in these patients. Particularly, the reduction of iNKT cells appeared to be associated with disease severity and recovery.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Jonah Gordon, Gavin Lockard, Molly Monsour, Adam Alayli, Cesario Borlongan
Summary: This review examines the potential effects and challenges of combining stem cell therapy and Nrf2 targeting treatment in stroke patients, emphasizing the need for further research on upstream and downstream pathways in optimizing Nrf2 treatments.
Article
Emergency Medicine
Hannah M. Higgins, Lucia Chen, Brandy C. Ravare, Kerri A. Jeppson, Heather T. Bina, Paco S. Herson, Andrew A. Monte, Sharon N. Poisson, Layne Dylla
Summary: This study found that there was no difference in the frequency of patient presentation with classic stroke symptoms based on biological sex alone, nor a significant difference in the distribution of infarcts between males and females. However, an infarct involving the anterior circulation was associated with a classic presentation.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Clinical Neurology
Rania Abdelkhaleq, Youngran Kim, Swapnil Khose, Peter Kan, Sergio Salazar-Marioni, Luca Giancardo, Sunil A. Sheth
Summary: In patients with large-vessel occlusion (LVO) acute ischemic stroke (AIS), determining infarct size is crucial for identifying candidates for endovascular stroke therapy (EVT). This study aimed to compare three methods of measuring infarct core at presentation, including an automated method using machine learning. Results showed that methods using NCHCT-ASPECTS and analyzing CTA source images with a machine learning model were equivalent to CTP in predicting final infarct volume (FIV) in LVO AIS patients who achieved reperfusion.
NEUROSURGICAL FOCUS
(2021)
Article
Rheumatology
Niv Ben-Shabat, Omer Gendelman, Lior Fisher, Uria Shani, Yonatan Shneor Patt, Abdulla Watad, Vita Skuja, Dennis McGonagle, Howard Amital
Summary: This study aimed to evaluate the incidence and risk of stroke in FMF patients. The findings suggest that FMF patients are at higher risk for stroke, regardless of known complications.
Article
Clinical Neurology
Carolin Beuker, Jeanette Koeppe, Jannik Feld, Christian Lennart Meyer, Patrik Droege, Thomas Ruhnke, Christian Guenster, Heinz Wiendl, Holger Reinecke, Jens Minnerup
Summary: A retrospective cohort study found that age is strongly associated with long-term outcomes after mechanical thrombectomy for stroke patients. Patients aged 80 and above had higher mortality, disability, and worse living conditions compared to younger patients.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Clinical Neurology
David J. Seiffge, Thomas Meinel, Jan Christoph Purrucker, Johannes Kaesmacher, Urs Fischer, Duncan Wilson, Teddy Y. Wu
Summary: This review discusses the primary therapeutic option for stroke prevention in atrial fibrillation patients, Direct Oral Anticoagulants (DOACs); it evaluates different approaches to patient selection, including time since last DOAC intake, drug-specific coagulation assays, and the use of reversal agents; precision medicine using a tailored approach seems to be a reasonable choice based on clinicoradiological information, anticoagulant activity, and the use of specific reversal agents only if necessary.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Clinical Neurology
Gian Marco De Marchis, David J. Seiffge, Sabine Schaedelin, Duncan Wilson, Valeria Caso, Monica Acciarresi, Georgios Tsivgoulis, Masatoshi Koga, Sohei Yoshimura, Kazunori Toyoda, Manuel Cappellari, Bruno Bonetti, Kosmas Macha, Bernd Kallmuenzer, Carlo W. Cereda, Philippe Lyrer, Leo H. Bonati, Maurizio Paciaroni, Stefan T. Engelter, David J. Werring
Summary: This study compared the optimal timing of starting direct oral anticoagulants (DOACs) after acute ischemic stroke (AIS) related to atrial fibrillation (AF) and found no significant difference in the risk of recurrent AIS and intracranial hemorrhage between early versus late DOAC-start groups. The sevenfold higher risk of recurrent AIS than intracranial hemorrhage suggests that an early DOAC-start might be reasonable, supporting enrollment into randomized trials comparing an early versus late DOAC-start.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Aravind Ganesh, Bijoy K. Menon, Zarina A. Assis, Andrew M. Demchuk, Fahad S. Al-Ajlan, Mohammed A. Al-Mekhlafi, Jeremy L. Rempel, Ashfaq Shuaib, Blaise W. Baxter, Thomas Devlin, John Thornton, David Williams, Alexandre Y. Poppe, Daniel Roy, Timo Krings, Leanne K. Casaubon, Nima Kashani, Michael D. Hill, Mayank Goyal
Summary: This study found that discrepancies between functional outcomes and post-treatment infarct volume in stroke patients may be influenced by factors such as age, comorbidities, and post-stroke complications, highlighting the importance of high-quality post-thrombectomy stroke care.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Cardiac & Cardiovascular Systems
Mervyn Jun Rui Lim, Yilong Zheng, Rodney Yu-Hang Soh, Qi Xuan Joel Foo, Andie Hartanto Djohan, Vincent Nga Diong Weng, Jamie Sin-Ying Ho, Tseng Tsai Yeo, Hui-Wen Sim, Tiong-Cheng Yeo, Huay-Cheem Tan, Mark Yan-Yee Chan, Joshua Ping-Yun Loh, Ching-Hui Sia
Summary: This study aimed to investigate the occurrence, risk factors, and association with cardiovascular outcomes of symptomatic intracerebral hemorrhage (ICH) after non-emergency percutaneous coronary intervention (PCI). The results showed that age, chronic kidney disease, and prior coronary artery bypass graft surgery were associated with an increased risk of ICH after PCI. Furthermore, ICH after PCI was associated with a higher risk of all-cause mortality and acute ischemic stroke or transient ischemic attack.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Clinical Neurology
Amit Kumar, Ganesh Chauhan, Shriram Sharma, Surekha Dabla, P. N. Sylaja, Neera Chaudhary, Salil Gupta, Chandra Sekhar Agrawal, Kuljeet Singh Anand, Achal Kumar Srivastava, Deepti Vibha, Ram Sagar, Ritesh Raj, Ankita Maheshwari, Subbiah Vivekanandhan, Bhavna Kaul, Samudrala Raghavan, Sankar Prasad Gorthi, Dheeraj Mohania, Samander Kaushik, Rohtas Kanwar Yadav, Anjali Hazarika, Pankaj Sharma, Kameshwar Prasad
Summary: The GWAS study in an Indian population identified novel loci for stroke and replicated previously known loci. The study showed that modifiable risk factors such as hypertension, smoking, and alcohol consumption have the highest effect on stroke.
Article
Immunology
Jiejie Li, Jinxi Lin, Yuesong Pan, Mengxing Wang, Xia Meng, Hao Li, Yilong Wang, Xingquan Zhao, Haiqiang Qin, Liping Liu, Yongjun Wang
Summary: The study found that IL-6 and YKL-40 were independently associated with recurrent stroke and poor functional outcome, and improved risk classification of clinical risk algorithms.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Clinical Neurology
Jun Zhang, Johnathan Abou-Fadel, Mellisa Renteria, Ofek Belkin, Bixia Chen, Yuan Zhu, Philipp Dammann, Daniele Rigamonti
Summary: This paper reviews the possible coexistence of PIK3CA and CCM mutations/phenotypes in CCM lesions and attempts to conceptualise their relationships and differences. The study suggests that the activation of the PIK3CA pathway may be a possible universal regulator of vascular morphogenesis, but conflicting data exist among different groups and studies.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Review
Immunology
Hua Zhu, Siping Hu, Yuntao Li, Yao Sun, Xiaoxing Xiong, Xinyao Hu, Junjing Chen, Sheng Qiu
Summary: Ischemic stroke caused by cerebral artery occlusion is a major cause of chronic disability globally. Interleukins (ILs) play a bidirectional role in ischemic stroke by regulating the activation, multiplication, and differentiation of immune cells, as well as the inflammatory reaction. Interactions between different ILs in different immune cells also impact the outcome of ischemic stroke. This overview discusses the role of various ILs in ischemic stroke.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Wang Jing, Xie Tuxiu, Long Xiaobing, Jiang Guijun, Kang Lulu, Jiang Jie, Ye Lu, Zhan Liying, Xiong Xiaoxing, Lyu Jingjun
Summary: This study revealed the involvement of lncRNA GAS5/miR-137 in the astrocyte-microglia communication during CA/CPR, inhibiting PI3K/Akt signaling activation through regulation of INPP4B. The findings suggest a potential therapeutic target for improving outcomes in CA/CPR patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Cheng Xu, Xiaowei Liu, Xiaoxin Fang, Lei Yu, Hui Chong Lau, Danlei Li, Xiaoman Liu, Haili Li, Justin Ren, Baohui Xu, Jianjun Jiang, Lijiang Tang, Xiaofeng Chen
Summary: This study utilizes single-cell RNA sequencing technology to reveal the cellular composition and heterogeneity of smooth muscle cells (SMCs) in experimental aortic dissection (AD). The study identified 15 cell clusters and 9 cell types, showing significant changes in the relative numbers of SMCs and identifying 7 core differentially expressed genes (DEGs) in SMCs. The study also found that SMCs can differentiate into 8 different subtypes.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, General & Internal
Hua Zhu, Xinyao Hu, Shi Feng, Yuntao Li, Yonggang Zhang, Sheng Qiu, Ran Chen, Yingze Ye, Lijuan Gu, Zhihong Jian, Ximing Xu, Xiaoxing Xiong
Summary: The study reveals that APOL4 expression is associated with tumor grade and immune infiltration in glioma, suggesting its potential as a new biomarker for therapeutic and prognostic evaluations, as well as predicting the efficacy of immunotherapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Takahiro Shoji, Jia Guo, Yingbin Ge, Yankui Li, Gang Li, Toru Ikezoe, Wei Wang, Xiaoya Zheng, Sihai Zhao, Naoki Fujimura, Jianhua Huang, Baohui Xu, Ronald L. Dalman
Summary: This study assessed the influence of type I interferon receptor deficiency on the formation and progression of experimental abdominal aortic aneurysms. The results showed that IFNAR1 deficiency can limit the progression of experimental AAA and suggest an important role for IFNAR1 in AAA pathogenesis.
Article
Neurosciences
Hua Zhu, Yonggang Zhang, Shi Feng, Yina Li, Yingze Ye, Zhihong Jian, Xiaoxing Xiong, Lijuan Gu
Summary: This study conducted a bibliometric analysis to assess the current state of research on NLRP3 in ischemic stroke worldwide over the past 12 years. It identified important results, major research areas, and emerging trends. The study found that research on NLRP3 in ischemic stroke has rapidly developed, with China and Zhejiang University being the most productive.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biotechnology & Applied Microbiology
Ziyu Wang, Fenglian Xu, Xueyan Zhao, Yi Zhang, Xi Wang, Zhirui Zhang, Lele Zixin Yang, Joshua Sam Badshah, Baohui Xu, Rong Xie, Weirong Fang
Summary: In this study, exosomes derived from mouse astrocytes were sequenced to investigate the differentially expressed microRNAs following oxygen glucose deprivation/re-oxygenation injury, which mimics ischemic stroke. A total of 176 microRNAs, including known and novel microRNAs, were found to be differentially expressed in astrocyte-derived exosomes. These alterations in microRNAs are associated with a broad range of physiological functions, such as signaling transduction, neuroprotection, and stress responses. Further investigation of these differentially expressed microRNAs in human diseases, especially ischemic stroke, is warranted.
Article
Cardiac & Cardiovascular Systems
Yankui Li, Xiaoya Zheng, Jia Guo, Makoto Samura, Yingbin Ge, Sihai Zhao, Gang Li, Xiaofeng Chen, Takahiro Shoji, Toru Ikezoe, Masaaki Miyata, Baohui Xu, Ronald L. L. Dalman
Summary: Diabetes attenuates abdominal aortic aneurysms (AAAs), and this is mainly due to the accumulation of advanced glycation end-products (AGEs) that reduce extracellular matrix (ECM) degradation. Inhibiting AGE formation or disrupting AGE-ECM cross-linking enhances the development of AAAs in diabetes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Pharmacology & Pharmacy
Yu Liu, Shuai Liu, Jiani Zhao, Kemin Wu, Baohui Xu, Wei Wang
Summary: This study investigated the relationship between plasma renin level/activity and AAA development, and found a positive correlation. Animal experiments revealed that direct-acting vasodilators promoted AAA progression and aggravated aortic degeneration. Therefore, caution should be exercised when using direct-acting vasodilators in the treatment of AAA.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jia Guo, Jinyun Shi, Min Qin, Yan Wang, Zhidong Li, Takahiro Shoji, Toru Ikezoe, Yingbin Ge, Baohui Xu
Summary: This study showed that using disulfiram, a small molecule inhibitor to gasdermin D, can effectively reduce the formation and progression of abdominal aortic aneurysms (AAA) induced by angiotensin II. Gasdermin D inhibition by disulfiram also resulted in reduced systemic levels of IL-1 beta and IL-1 beta secretion from activated macrophages. These findings suggest the translational potential of pharmacological gasdermin D inhibition in limiting clinical AAA progression.
Article
Cardiac & Cardiovascular Systems
Weilai Fu, Haole Liu, Panpan Wei, Congcong Xia, Qingqing Yu, Kangli Tian, Yankui Li, Enqi Liu, Baohui Xu, Masaaki Miyata, Rong Wang, Sihai Zhao
Summary: PIAS3 deficiency can alleviate the development of abdominal aortic aneurysms by reducing elastin degradation, smooth muscle cell loss, leukocyte accumulation, and angiogenesis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Neurosciences
Yonggang Zhang, Peng Ye, Hua Zhu, Lijuan Gu, Yuntao Li, Shi Feng, Zhi Zeng, Qianxue Chen, Benhong Zhou, Xiaoxing Xiong
Summary: This study investigated the potential effects of Neutral polysaccharide from Gastrodia elata (NPGE) on cerebral ischemia-reperfusion injury (CIRI) neuropathology. The results showed that NPGE treatment could alleviate neurological deficits, reduce infarct volume, and promote cell survival. Mechanistically, NPGE could regulate the expression of various signaling molecules, alleviating neuroinflammation and ferroptosis.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Immunology
Cheng Xu, Xiaowei Liu, Lei Yu, Xiaoxin Fang, Lei Yao, HuiChong Lau, Punit Vyas, Luke Pryke, Baohui Xu, Lijiang Tang, Jianjun Jiang, Xiaofeng Chen
Summary: In this study, it was found that CD147 monoclonal antibody effectively suppresses Ang II-induced AAA formation in apoE-/- mice by reducing aortic expansion, elastic lamina degradation, and inflammatory cells accumulation. Protein-protein interaction analysis revealed that Ptk6, Itch, Casp3, and Oas1a were the hub differentially expressed proteins, which were mainly involved in collagen fibril organization, extracellular matrix organization, and muscle contraction. Therefore, CD147 monoclonal antibody may be a promising target for the treatment of abdominal aortic aneurysm.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jia Guo, Zeyu Xu, Rachel C. Gunderson, Baohui Xu, Sara A. Michie
Summary: In this study, the researchers found that ICAM-1 is expressed on the sinus endothelia of lymph nodes, but not on the lymphatic vessels of peripheral tissues. Memory CD4(+) T cells migrated to lymph nodes from peripheral tissues more efficiently than from blood vessels. ICAM-1 deficiency significantly inhibited the migration of lymphocytes from peripheral tissues into lymph nodes, and the absence of ICAM-1 or LFA-1 reduced the number of memory T cells in lymph nodes.
Article
Biochemistry & Molecular Biology
Meng Li, Panpan Wei, Kexin Li, Haole Liu, Naqash Alam, Haiwen Hou, Jie Deng, Baohui Xu, Enqi Liu, Sihai Zhao, Yankui Li
Summary: This study provides the first evidence of the occurrence of intimal hyperplasia (IH) in an elastase-induced mouse AAA model. The study investigates the incidence and histological characteristics of IH in aneurysmal mice, shedding light on the understanding and optimization of this model for AAA-related research.
ANIMAL MODELS AND EXPERIMENTAL MEDICINE
(2023)