Extracellular Vesicles from Airway Secretions: New Insights in Lung Diseases

Airway epithelial-targeted nanoparticles for asthma therapy

(2020) Stanislav Kan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Resident alveolar macrophage‐derived vesicular SOCS3 dampens allergic airway inflammation

(2020) Christina Draijer et al.   FASEB JOURNAL

Mechanical stretch regulates the expression of specific miRNA in extracellular vesicles released from lung epithelial cells

(2020) Tanbir Najrana et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

Small extracellular vesicles derived from human mesenchymal stromal cells prevent group 2 innate lymphoid cell-dominant allergic airway inflammation through delivery of miR-146a-5p

(2020) Shu-Bin Fang et al.   Journal of Extracellular Vesicles

Differential plasma exosomal long non-coding RNAs expression profiles and their emerging role in E-cigarette users, cigarette, waterpipe, and dual smokers

(2020) Gagandeep Kaur et al.   PLoS One

Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung

(2019) Kristopher R. Genschmer et al.   CELL

Increased Hematopoietic Extracellular RNAs and Vesicles in the Lung during Allergic Airway Responses

(2019) Heather H. Pua et al.   Cell Reports

Ticket to a bubble ride: Cargo sorting into exosomes and extracellular vesicles

(2019) Sushma Anand et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Inflammatory adipocyte-derived extracellular vesicles promote leukocyte attachment to vascular endothelial cells

(2019) Rebecca M. Wadey et al.   ATHEROSCLEROSIS

Adipose-specific knockdown of Sirt1 results in obesity and insulin resistance by promoting exosomes release

(2019) Fang Li et al.   CELL CYCLE

microRNA-328 in exosomes derived from M2 macrophages exerts a promotive effect on the progression of pulmonary fibrosis via FAM13A in a rat model

(2019) Meng-Ying Yao et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Bronchial epithelial cell extracellular vesicles ameliorate epithelial–mesenchymal transition in COPD pathogenesis by alleviating M2 macrophage polarization

(2019) Shengyang He et al.   Nanomedicine-Nanotechnology Biology and Medicine

Exosomes: A new approach to asthma pathology

(2019) José A. Cañas et al.   CLINICA CHIMICA ACTA

Appropriation of GPIbα from platelet-derived extracellular vesicles supports monocyte recruitment in systemic inflammation

(2019) Myriam Chimen et al.   HAEMATOLOGICA

Exosomes and Their Noncoding RNA Cargo Are Emerging as New Modulators for Diabetes Mellitus

(2019) Wenguang Chang et al.   Cells

Cancer-derived exosomes loaded with ultrathin palladium nanosheets for targeted bioorthogonal catalysis

(2019) María Sancho-Albero et al.   Nature Catalysis

Inflammatory role of extracellular sphingolipids in Cystic Fibrosis

(2019) Aida Zulueta et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Pulmonary delivery of Nanocomposite Microparticles (NCMPs) incorporating miR-146a for treatment of COPD

(2019) Adel Mohamed et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Exosomes: Carriers of Pro-Fibrotic Signals and Therapeutic Targets in Fibrosis

(2019) Mengyu Li et al.   CURRENT PHARMACEUTICAL DESIGN

Role of extracellular vesicles in cell-cell communication and inflammation following exposure to pulmonary toxicants

(2019) Jaclynn Andres et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Extracellular Vesicles in Lung Disease

(2018) Hiroshi Kubo   CHEST

Eosinophil-derived exosomes contribute to asthma remodelling by activating structural lung cells

(2018) J. A. Cañas et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Mesenchymal stem cell exosomes promote immunosuppression of regulatory T cells in asthma

(2018) Yu-mo Du et al.   EXPERIMENTAL CELL RESEARCH

Subpopulations of extracellular vesicles and their therapeutic potential

(2018) Cecilia Lässer et al.   MOLECULAR ASPECTS OF MEDICINE

A disintegrin and metalloprotease 10-containing exosomes derived from nasal polyps promote angiogenesis and vascular permeability

(2018) Wei Zhang et al.   Molecular Medicine Reports

Exosome-Mediated Small RNA Delivery: A Novel Therapeutic Approach for Inflammatory Lung Responses

(2018) Duo Zhang et al.   MOLECULAR THERAPY

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Increased Extracellular Vesicles Mediate WNT-5A Signaling in Idiopathic Pulmonary Fibrosis

(2018) Aina Martin-Medina et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Intercellular Communication between Airway Epithelial Cells is Mediated by Exosome-Like Vesicles

(2018) Richa Gupta et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Activated Human Lung Fibroblasts Produce Extracellular Vesicles with Anti-Fibrotic Prostaglandins

(2018) Shannon H Lacy et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Extracellular vesicles: translational challenges and opportunities

(2018) Hannah Clemmens et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Understanding Asthma Phenotypes, Endotypes, and Mechanisms of Disease

(2018) Merin E. Kuruvilla et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Sputum exosomes: promising biomarkers for idiopathic pulmonary fibrosis

(2018) Makon-Sébastien Njock et al.   THORAX

Unique Lipid Signatures of Extracellular Vesicles from the Airways of Asthmatics

(2018) Kenneth P. Hough et al.   Scientific Reports

Stability of Circulating Exosomal miRNAs in Healthy Subjects

(2018) David Sanz-Rubio et al.   Scientific Reports

Air Pollution and Noncommunicable Diseases

(2018) Dean E. Schraufnagel et al.   CHEST

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Circulating Extracellular Vesicles in Human Disease

(2018)   NEW ENGLAND JOURNAL OF MEDICINE

Vesiclepedia 2019: a compendium of RNA, proteins, lipids and metabolites in extracellular vesicles

(2018) Mohashin Pathan et al.   NUCLEIC ACIDS RESEARCH

Mesenchymal stem cell-derived extracellular vesicles affect disease outcomes via transfer of microRNAs

(2018) Guanguan Qiu et al.   Stem Cell Research & Therapy

Altered cargo proteins of human plasma endothelial cell–derived exosomes in atherosclerotic cerebrovascular disease

(2017) Edward J. Goetzl et al.   FASEB JOURNAL

Smoker extracellular vesicles influence status of human bronchial epithelial cells

(2017) Amélie Héliot et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

RNA-containing exosomes in induced sputum of asthmatic patients

(2017) Sara Sánchez-Vidaurre et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Exosomes from eosinophils autoregulate and promote eosinophil functions

(2017) José Antonio Cañas et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Alternatives to induced sputum for identifying inflammatory subtypes of asthma

(2017) Jodie L. Simpson et al.   RESPIROLOGY

The role of exosomes in cancer metastasis

(2017) Teresa Bernadette Steinbichler et al.   SEMINARS IN CANCER BIOLOGY

Thy-1 dependent uptake of mesenchymal stem cell-derived extracellular vesicles blocks myofibroblastic differentiation

(2017) Tzu-Pin Shentu et al.   Scientific Reports

Extracellular Vesicle MicroRNA Transfer in Lung Diseases

(2017) Jie Chen et al.   Frontiers in Physiology

Methodology for Sputum Induction and Laboratory Processing

(2017) Julien Guiot et al.   Jove-Journal of Visualized Experiments

Functional Roles for Exosomal MicroRNAs in the Tumour Microenvironment

(2017) Emma Bell et al.   Computational and Structural Biotechnology Journal

microRNA profiling in lung tissue and bronchoalveolar lavage of cigarette smoke-exposed mice and in COPD patients: a translational approach

(2017) Griet Conickx et al.   Scientific Reports

Emergence of Biomolecular Pathways to Define Novel Asthma Phenotypes. Type-2 Immunity and Beyond

(2016) Sally E. Wenzel   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Toll-Like Receptor 4 Engagement Mediates Prolyl Endopeptidase Release from Airway Epithelia via Exosomes

(2016) Tomasz Szul et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Upper airway and systemic inflammation in obstructive sleep apnoea

(2016) Eugenio Vicente et al.   EUROPEAN RESPIRATORY JOURNAL

Therapeutic and diagnostic applications of extracellular vesicles

(2016) Stephan Stremersch et al.   JOURNAL OF CONTROLLED RELEASE

Evaluation of optimal extracellular vesicle small RNA isolation and qRT-PCR normalisation for serum and urine

(2016) Rachel E. Crossland et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Exosomes in the nose induce immune cell trafficking and harbour an altered protein cargo in chronic airway inflammation

(2016) Cecilia Lässer et al.   Journal of Translational Medicine

MicroRNA–21 as a novel biomarker in diagnosis and response to therapy in asthmatic children

(2016) Rabab M. Elbehidy et al.   MOLECULAR IMMUNOLOGY

Hyaluronan and TLR4 promote surfactant-protein-C-positive alveolar progenitor cell renewal and prevent severe pulmonary fibrosis in mice

(2016) Jiurong Liang et al.   NATURE MEDICINE

Nasal lavage, blood or sputum: Which is best for phenotyping asthma?

(2016) Camyla F. de Farias et al.   RESPIROLOGY

Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response

(2016) Jan Rossaint et al.   Nature Communications

Epithelial cell-derived microvesicles activate macrophages and promote inflammation via microvesicle-containing microRNAs

(2016) Heedoo Lee et al.   Scientific Reports

Exosomes Mediate LTB4 Release during Neutrophil Chemotaxis

(2016) Ritankar Majumdar et al.   PLOS BIOLOGY

Microparticles in sputum of COPD patients: a potential biomarker of the disease?

(2016) Chiara Porro et al.   International Journal of Chronic Obstructive Pulmonary Disease

Structural and functional characterization of endothelial microparticles released by cigarette smoke

(2016) Karina A. Serban et al.   Scientific Reports

Dendritic cell-derived exosomes carry the major cat allergen Fel d 1 and induce an allergic immune response

(2015) H. Vallhov et al.   ALLERGY

Emerging molecular phenotypes of asthma

(2015) Anuradha Ray et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Global and regional trends in COPD mortality, 1990–2010

(2015) Peter G.J. Burney et al.   EUROPEAN RESPIRATORY JOURNAL

Global incidence and mortality of idiopathic pulmonary fibrosis: a systematic review

(2015) John Hutchinson et al.   EUROPEAN RESPIRATORY JOURNAL

Exosome secretion by eosinophils: A possible role in asthma pathogenesis

(2015) Carla Mazzeo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling

(2015) Emilie Bourdonnay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Methods of isolating extracellular vesicles impact down-stream analyses of their cargoes

(2015) Douglas D. Taylor et al.   METHODS

Accelerated ageing of the lung in COPD: new concepts

(2015) Nicolas Mercado et al.   THORAX

Ectosomes and exosomes: shedding the confusion between extracellular vesicles

(2015) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY

Lung epithelial cell-derived extracellular vesicles activate macrophage-mediated inflammatory responses via ROCK1 pathway

(2015) H-G Moon et al.   Cell Death & Disease

A novel mechanism of generating extracellular vesicles during apoptosis via a beads-on-a-string membrane structure

(2015) Georgia K. Atkin-Smith et al.   Nature Communications

Systemic Administration of Human Bone Marrow-Derived Mesenchymal Stromal Cell Extracellular Vesicles AmelioratesAspergillusHyphal Extract-Induced Allergic Airway Inflammation in Immunocompetent Mice

(2015) Fernanda F. Cruz et al.   Stem Cells Translational Medicine

Emerging Roles of Exosomes in Normal and Pathological Conditions: New Insights for Diagnosis and Therapeutic Applications

(2015) Julieta De Toro et al.   Frontiers in Immunology

CCN1 secretion and cleavage regulate the lung epithelial cell functions after cigarette smoke

(2014) Hyung-Geun Moon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Biogenesis and secretion of exosomes

(2014) Joanna Kowal et al.   CURRENT OPINION IN CELL BIOLOGY

Evaluation of IL-8 Nasal Lavage Levels and the Effects of Nasal Involvement on Disease Severity in Patients with Stable Chronic Obstructive Pulmonary Disease

(2014) Hacer Celik et al.   INFLAMMATION

Rapid shedding of proinflammatory microparticles by human mononuclear cells exposed to cigarette smoke is dependent on Ca2+ mobilization

(2014) Cinzia Cordazzo et al.   INFLAMMATION RESEARCH

Diagnostic utility of bronchoalveolar lavage

(2014) Sistla Radha et al.   Journal of Cytology

Isolation of biologically-active exosomes from human plasma

(2014) Laurent Muller et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Extracellular vesicles from blood plasma: determination of their morphology, size, phenotype and concentration

(2014) N. Arraud et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Procoagulant, Tissue Factor-Bearing Microparticles in Bronchoalveolar Lavage of Interstitial Lung Disease Patients: An Observational Study

(2014) Federica Novelli et al.   PLoS One

Active Trafficking of Alpha 1 Antitrypsin across the Lung Endothelium

(2014) Angelia D. Lockett et al.   PLoS One

Novel Proteolytic Microvesicles Released from Human Macrophages after Exposure to Tobacco Smoke

(2013) Chun-Jun Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of Lung Pericytes and Resident Fibroblasts in the Pathogenesis of Pulmonary Fibrosis

(2013) Chi Hung et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cellular and Molecular Mechanisms of Chronic Obstructive Pulmonary Disease

(2013) Peter J. Barnes   CLINICS IN CHEST MEDICINE

Cellular and molecular mechanisms of goblet cell metaplasia in the respiratory airways

(2013) Olivier Boucherat et al.   EXPERIMENTAL LUNG RESEARCH

Altered microRNA profiles in bronchoalveolar lavage fluid exosomes in asthmatic patients

(2013) Bettina Levänen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Proinflammatory role of epithelial cell–derived exosomes in allergic airway inflammation

(2013) Ankur Kulshreshtha et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Distribution of sputum cellular phenotype in a large asthma cohort: predicting factors for eosinophilic vs neutrophilic inflammation

(2013) Florence N Schleich et al.   BMC Pulmonary Medicine

An Official American Thoracic Society Clinical Practice Guideline: The Clinical Utility of Bronchoalveolar Lavage Cellular Analysis in Interstitial Lung Disease

(2012) Keith C. Meyer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Airway Smooth Muscle in Asthma

(2012) Judith L. Black et al.   CLINICS IN CHEST MEDICINE

Tissue factor–bearing exosome secretion from human mechanically stimulated bronchial epithelial cells in vitro and in vivo

(2012) Jin-Ah Park et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TGF- 1-Containing Exosomes from Injured Epithelial Cells Activate Fibroblasts to Initiate Tissue Regenerative Responses and Fibrosis

(2012) F. T. Borges et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Circulating Endothelial Microparticles as a Measure of Early Lung Destruction in Cigarette Smokers

(2011) Cynthia Gordon et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

RNA-containing Exosomes in Human Nasal Secretions

(2011) Cecilia Lässer et al.   American Journal of Rhinology & Allergy

Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

(2011) Bence György et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages

(2011) Cecilia Lässer et al.   Journal of Translational Medicine

Small-Airway Obstruction and Emphysema in Chronic Obstructive Pulmonary Disease

(2011) John E. McDonough et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pharyngeal Lavage Lymphocytosis in Patients with Obstructive Sleep Apnea: A Preliminary Observation

(2011) Hans-Peter Hauber et al.   PLoS One

Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition

(2011) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical Course and Prediction of Survival in Idiopathic Pulmonary Fibrosis

(2010) Brett Ley et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cigarette smoking reprograms apical junctional complex molecular architecture in the human airway epithelium in vivo

(2010) Renat Shaykhiev et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression

(2010) Fei Liu et al.   JOURNAL OF CELL BIOLOGY

miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis

(2010) Gang Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense

(2009) Mehmet Kesimer et al.   FASEB JOURNAL

TH17-associated cytokines (IL-17A and IL-17F) in severe asthma

(2009) Wisam Al-Ramli et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

MicroRNA-21 Is Up-Regulated in Allergic Airway Inflammation and Regulates IL-12p35 Expression

(2009) T. X. Lu et al.   JOURNAL OF IMMUNOLOGY

Sputum IL-5 Concentration Is Associated with a Sputum Eosinophilia and Attenuated by Corticosteroid Therapy in COPD

(2009) M. Bafadhel et al.   RESPIRATION