Intracellular Ca2+ Signaling in Protozoan Parasites: An Overview with a Focus on Mitochondria

The genetic Ca2+ sensor GCaMP3 reveals multiple Ca2+ stores differentially coupled to Ca2+ entry in the human malaria parasite Plasmodium falciparum

(2020) Lucas Borges Pereira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MICU1 and MICU2 Play an Essential Role in Mitochondrial Ca2+ Uptake, Growth, and Infectivity of the Human Pathogen Trypanosoma cruzi

(2019) Mayara S. Bertolini et al.   mBio

The mitochondrial calcium uniporter complex in trypanosomes

(2018) Noelia Lander et al.   CELL BIOLOGY INTERNATIONAL

Blocking IP 3 signal transduction pathways inhibits melatonin-induced Ca 2+ signals and impairs P. falciparum development and proliferation in erythrocytes

(2018) Mateus Fila Pecenin et al.   CELL CALCIUM

VDAC1 functions in Ca 2+ homeostasis and cell life and death in health and disease

(2018) Varda Shoshan-Barmatz et al.   CELL CALCIUM

Mitochondrial and endoplasmic reticulum calcium homeostasis and cell death

(2018) Saverio Marchi et al.   CELL CALCIUM

Melatonin activate FIS1, DYN1 and DYN2 Plasmodium falciparum related-genes for mitochondria fission: mitoemerald-GFP as a tool to visualize mitochondria structure

(2018) Pedro Scarpelli et al.   JOURNAL OF PINEAL RESEARCH

PfCDPK1 is critical for malaria parasite gametogenesis and mosquito infection

(2018) Abhisheka Bansal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium-Dependent Protein Kinase 5 Is Required for Release of Egress-Specific Organelles in Plasmodium falciparum

(2018) Sabrina Absalon et al.   mBio

Membrane Proteins in Trypanosomatids Involved in Ca2+ Homeostasis and Signaling

(2018) Srinivasan Ramakrishnan et al.   Genes

Two-pore channels open up

(2018) Sandip Patel   NATURE

Intracellular calcium release channels: an update

(2017) Gaetano Santulli et al.   JOURNAL OF PHYSIOLOGY-LONDON

Tuning the ion selectivity of two-pore channels

(2017) Jiangtao Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Different Roles of Mitochondrial Calcium Uniporter Complex Subunits in Growth and Infectivity of Trypanosoma cruzi

(2017) Miguel A. Chiurillo et al.   mBio

PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum

(2017) Sudhir Kumar et al.   Nature Communications

Plasmodium falciparum GPCR-like receptor SR25 mediates extracellular K+ sensing coupled to Ca2+ signaling and stress survival

(2017) Miriam S. Moraes et al.   Scientific Reports

Polyphosphate and acidocalcisomes

(2016) N. Lander et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The origin and evolution of the acidocalcisome and its interactions with other organelles

(2016) Roberto Docampo   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Redox Nanodomains Are Induced by and Control Calcium Signaling at the ER-Mitochondrial Interface

(2016) David M. Booth et al.   MOLECULAR CELL

Calcium signalling in malaria parasites

(2016) Mathieu Brochet et al.   MOLECULAR MICROBIOLOGY

Invasion of hepatocytes byPlasmodiumsporozoites requires cGMP-dependent protein kinase and calcium dependent protein kinase 4

(2016) K. Govindasamy et al.   MOLECULAR MICROBIOLOGY

Structure and function of the mitochondrial calcium uniporter complex

(2015) Diego De Stefani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The calcium signaling toolkit of the Apicomplexan parasites Toxoplasma gondii and Plasmodium spp

(2015) Sebastian Lourido et al.   CELL CALCIUM

Calcium signaling in trypanosomatid parasites

(2015) Roberto Docampo et al.   CELL CALCIUM

The ancient roots of calcium signalling evolutionary tree

(2015) Helmut Plattner et al.   CELL CALCIUM

Conditional Degradation of Plasmodium Calcineurin Reveals Functions in Parasite Colonization of both Host and Vector

(2015) Nisha Philip et al.   Cell Host & Microbe

Structural Basis for Specific Inhibition of tRNA Synthetase by an ATP Competitive Inhibitor

(2015) Pengfei Fang et al.   CHEMISTRY & BIOLOGY

Calcium Signaling throughout theToxoplasma gondiiLytic Cycle

(2015) Lucas Borges-Pereira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Store-Operated Calcium Channels

(2015) Murali Prakriya et al.   PHYSIOLOGICAL REVIEWS

Function and dysfunction of two-pore channels

(2015) Sandip Patel   Science Signaling

Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion

(2015) Mahmood M. Alam et al.   Nature Communications

Function and dysfunction of two-pore channels

(2015) Sandip Patel   Science Signaling

Calcium storage and function in apicomplexan parasites: Figure 1

(2015) Silvia N.J. Moreno et al.   Essays in Biochemistry

Calcium dynamics ofPlasmodium bergheisporozoite motility

(2014) Allison F. Carey et al.   CELLULAR MICROBIOLOGY

Activity of melatonin against Leishmania infantum promastigotes by mitochondrial dependent pathway

(2014) Ehab Kotb Elmahallawy et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Phosphoinositide Metabolism Links cGMP-Dependent Protein Kinase G to Essential Ca2+ Signals at Key Decision Points in the Life Cycle of Malaria Parasites

(2014) Mathieu Brochet et al.   PLOS BIOLOGY

Intracellular calcium channels in protozoa

(2013) Roberto Docampo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ca2+ signalling early in evolution - all but primitive

(2013) H. Plattner et al.   JOURNAL OF CELL SCIENCE

Calcium Regulation in the Protozoan Model,Paramecium tetraurelia

(2013) Helmut Plattner   JOURNAL OF EUKARYOTIC MICROBIOLOGY

A Specific Inhibitor of PfCDPK4 Blocks Malaria Transmission: Chemical-genetic Validation

(2013) Kayode K. Ojo et al.   JOURNAL OF INFECTIOUS DISEASES

Essential regulation of cell bioenergetics in Trypanosoma brucei by the mitochondrial calcium uniporter

(2013) Guozhong Huang et al.   Nature Communications

Calcium signaling in closely related protozoan groups (Alveolata): Non-parasitic ciliates (Paramecium, Tetrahymena) vs. parasitic Apicomplexa (Plasmodium, Toxoplasma)

(2012) H. Plattner et al.   CELL CALCIUM

Characterization ofPlasmodium falciparumCalcium-dependent Protein Kinase 1 (PfCDPK1) and Its Role in Microneme Secretion during Erythrocyte Invasion

(2012) Abhisheka Bansal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondria as sensors and regulators of calcium signalling

(2012) Rosario Rizzuto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Calcium and cell death mechanisms: A perspective from the cell death community

(2011) Boris Zhivotovsky et al.   CELL CALCIUM

Acidocalcisomes

(2011) Roberto Docampo et al.   CELL CALCIUM

Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress

(2011) R. Bravo et al.   JOURNAL OF CELL SCIENCE

Functional characterization of NADP-dependent isocitrate dehydrogenase isozymes from Trypanosoma cruzi

(2011) Alejandro E. Leroux et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

Evolution of apoptosis-like programmed cell death in unicellular protozoan parasites

(2011) Szymon Kaczanowski et al.   Parasites & Vectors

Calcium-Release Channels in Paramecium. Genomic Expansion, Differential Positioning and Partial Transcriptional Elimination

(2011) Eva-Maria Ladenburger et al.   PLoS One

Identification of Intracellular and Plasma Membrane Calcium Channel Homologues in Pathogenic Parasites

(2011) David L. Prole et al.   PLoS One

Trypanosomes and the solution to a 50-year mitochondrial calcium mystery

(2011) Roberto Docampo et al.   TRENDS IN PARASITOLOGY

Voltage-Gated Calcium Channels

(2011) W. A. Catterall   Cold Spring Harbor Perspectives in Biology

The transient receptor potential family of ion channels

(2011) Bernd Nilius et al.   GENOME BIOLOGY

Melatonin and IP3-induced Ca2+Release from Intracellular Stores in the Malaria ParasitePlasmodium falciparumwithin Infected Red Blood Cells

(2010) Eduardo Alves et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melatonin triggers PKA activation in the rodent malaria parasite Plasmodium chabaudi

(2010) Marcos L. Gazarini et al.   JOURNAL OF PINEAL RESEARCH

PfCHA is a mitochondrial divalent cation/H+ antiporter in Plasmodium falciparum

(2010) Alexander Rotmann et al.   MOLECULAR MICROBIOLOGY

Targeting essential pathways in trypanosomatids gives insights into protozoan mechanisms of cell death

(2010) Despina Smirlis et al.   Parasites & Vectors

A Plant-Like Kinase in Plasmodium falciparum Regulates Parasite Egress from Erythrocytes

(2010) J. D. Dvorin et al.   SCIENCE

Calcium Oscillations

(2010) G. Dupont et al.   Cold Spring Harbor Perspectives in Biology

The Role of Transient Receptor Potential Cation Channels in Ca2+ Signaling

(2010) M. Gees et al.   Cold Spring Harbor Perspectives in Biology

Ryanodine Receptors: Structure, Expression, Molecular Details, and Function in Calcium Release

(2010) J. T. Lanner et al.   Cold Spring Harbor Perspectives in Biology

Distinct External Signals Trigger Sequential Release of Apical Organelles during Erythrocyte Invasion by Malaria Parasites

(2010) Shailja Singh et al.   PLoS Pathogens

Downregulation of Mitochondrial Porin Inhibits Cell Growth and Alters Respiratory Phenotype inTrypanosoma brucei

(2009) Ujjal K. Singha et al.   EUKARYOTIC CELL

Mitochondrial calcium overload triggers complement-dependent superoxide-mediated programmed cell death inTrypanosoma cruzi

(2008) Florencia Irigoín et al.   BIOCHEMICAL JOURNAL

Ca2+/Calmodulin-dependent Protein Kinases

(2008) M. T. Swulius et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Genome-Wide Detection of Serpentine Receptor-Like Proteins in Malaria Parasites

(2008) Luciana Madeira et al.   PLoS One

Gametogenesis in Malaria Parasites Is Mediated by the cGMP-Dependent Protein Kinase

(2008) Louisa McRobert et al.   PLOS BIOLOGY