MICU1 and MICU2 Play an Essential Role in Mitochondrial Ca2+ Uptake, Growth, and Infectivity of the Human Pathogen Trypanosoma cruzi

The conserved aspartate ring of MCU mediates MICU1 binding and regulation in the mitochondrial calcium uniporter complex

(2019) Charles B Phillips et al.   eLife

The MCU complex in cell death

(2018) Elisa Penna et al.   CELL CALCIUM

Cryo-EM structure of a mitochondrial calcium uniporter

(2018) Jiho Yoo et al.   SCIENCE

An Intracellular Ammonium Transporter Is Necessary for Replication, Differentiation, and Resistance to Starvation and Osmotic Stress in Trypanosoma cruzi

(2018) Teresa Cruz-Bustos et al.   mSphere

Calcium-sensitive pyruvate dehydrogenase phosphatase is required for energy metabolism, growth, differentiation, and infectivity of Trypanosoma cruzi

(2018) Noelia Lander et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

X-ray and cryo-EM structures of the mitochondrial calcium uniporter

(2018) Chao Fan et al.   NATURE

Cryo-EM structure of a fungal mitochondrial calcium uniporter

(2018) Nam X. Nguyen et al.   NATURE

Cryo-EM structures of fungal and metazoan mitochondrial calcium uniporters

(2018) Rozbeh Baradaran et al.   NATURE

The machineries, regulation and cellular functions of mitochondrial calcium

(2018) Carlotta Giorgi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Mitochondrial Ca2+ Uniporter Complex (MCUC) of Trypanosoma brucei Is a Hetero-oligomer That Contains Novel Subunits Essential for Ca2+ Uptake

(2018) Guozhong Huang et al.   mBio

MICU1 Interacts with the D-Ring of the MCU Pore to Control Its Ca2+ Flux and Sensitivity to Ru360

(2018) Melanie Paillard et al.   MOLECULAR CELL

RNA targeting with CRISPR–Cas13

(2017) Omar O. Abudayyeh et al.   NATURE

Cardiovascular homeostasis dependence on MICU2, a regulatory subunit of the mitochondrial calcium uniporter

(2017) Alexander G. Bick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Different Roles of Mitochondrial Calcium Uniporter Complex Subunits in Growth and Infectivity of Trypanosoma cruzi

(2017) Miguel A. Chiurillo et al.   mBio

MICU2 Restricts Spatial Crosstalk between InsP 3 R and MCU Channels by Regulating Threshold and Gain of MICU1-Mediated Inhibition and Activation of MCU

(2017) Riley Payne et al.   Cell Reports

Tissue-Specific Mitochondrial Decoding of Cytoplasmic Ca 2+ Signals Is Controlled by the Stoichiometry of MICU1/2 and MCU

(2017) Melanie Paillard et al.   Cell Reports

Functional roles of MICU1 and MICU2 in mitochondrial Ca 2+ uptake

(2016) Jessica Matesanz-Isabel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets

(2016) Sudhir Kumar et al.   MOLECULAR BIOLOGY AND EVOLUTION

MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium Overload

(2016) Julia C. Liu et al.   Cell Reports

EMRE Is a Matrix Ca 2+ Sensor that Governs Gatekeeping of the Mitochondrial Ca 2+ Uniporter

(2016) Horia Vais et al.   Cell Reports

Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex

(2016) Ming-Feng Tsai et al.   eLife

Expression and preliminary characterization of human MICU2

(2016) Dan Li et al.   Biology Open

The Ca2+-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca2+ Uptake

(2015) Carmelina Petrungaro et al.   Cell Metabolism

Tissue and sex specificities in Ca2+handling by isolated mitochondria in conditions avoiding the permeability transition

(2015) Hanan Chweih et al.   EXPERIMENTAL PHYSIOLOGY

CRISPR/Cas9-Induced Disruption of Paraflagellar Rod Protein 1 and 2 Genes in Trypanosoma cruzi Reveals Their Role in Flagellar Attachment

(2015) Noelia Lander et al.   mBio

MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter

(2014) K. J. Kamer et al.   EMBO REPORTS

Mitochondrial calcium transport in trypanosomes

(2014) Roberto Docampo et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Evolution of parasitism in kinetoplastid flagellates

(2014) Julius Lukeš et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

MICU1 and MICU2 Finely Tune the Mitochondrial Ca2+ Uniporter by Exerting Opposite Effects on MCU Activity

(2014) Maria Patron et al.   MOLECULAR CELL

MICU1 Controls Both the Threshold and Cooperative Activation of the Mitochondrial Ca2+ Uniporter

(2013) György Csordás et al.   Cell Metabolism

Paratrypanosoma Is a Novel Early-Branching Trypanosomatid

(2013) Pavel Flegontov et al.   CURRENT BIOLOGY

The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit

(2013) Anna Raffaello et al.   EMBO JOURNAL

Trypanosoma bruceiVacuolar Transporter Chaperone 4 (TbVtc4) Is an Acidocalcisome Polyphosphate Kinase Required forin VivoInfection

(2013) Noelia Lander et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling

(2013) Molly Plovanich et al.   PLoS One

EMRE Is an Essential Component of the Mitochondrial Calcium Uniporter Complex

(2013) Y. Sancak et al.   SCIENCE

Essential regulation of cell bioenergetics in Trypanosoma brucei by the mitochondrial calcium uniporter

(2013) Guozhong Huang et al.   Nature Communications

MICU1 Is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca2+ Uptake that Regulates Cell Survival

(2012) Karthik Mallilankaraman et al.   CELL

A role of autophagy in Trypanosoma brucei cell death

(2012) Feng-Jun Li et al.   CELLULAR MICROBIOLOGY

MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

(2012) Karthik Mallilankaraman et al.   NATURE CELL BIOLOGY

Evolutionary Diversity of the Mitochondrial Calcium Uniporter

(2012) A. G. Bick et al.   SCIENCE

The higher susceptibility of congenital analbuminemic rats to Ca2+-induced mitochondrial permeability transition is associated with the increased expression of cyclophilin D and nitrosothiol depletion

(2011) Tiago R. Figueira et al.   MOLECULAR GENETICS AND METABOLISM

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

Trypanosomes and the solution to a 50-year mitochondrial calcium mystery

(2011) Roberto Docampo et al.   TRENDS IN PARASITOLOGY

The fateful encounter of mitochondria with calcium: How did it happen?

(2010) Ernesto Carafoli   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

MICU1 encodes a mitochondrial EF hand protein required for Ca2+ uptake

(2010) Fabiana Perocchi et al.   NATURE

Localization and Developmental Regulation of a Dispersed Gene Family 1 Protein in Trypanosoma cruzi

(2009) N. Lander et al.   INFECTION AND IMMUNITY

TriTrypDB: a functional genomic resource for the Trypanosomatidae

(2009) Martin Aslett et al.   NUCLEIC ACIDS RESEARCH