Journal
CELL CALCIUM
Volume 57, Issue 3, Pages 194-202Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2014.10.015
Keywords
Calcium; Acidocalcisome; Acidic store; Trypanosoma; Leishmania; Inositol 1,4,5-trisphosphate receptor
Categories
Funding
- U.S. National Institutes of Health [AI-108222, AI-104120]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, Brazil [13/50624-0]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [13/50624-0] Funding Source: FAPESP
Ask authors/readers for more resources
Calcium ion (Ca2+) is an important second messenger in trypanosomatids and essential for their survival although prolonged high intracellular Ca2+ levels lead to cell death. As other eukaiyotic cells, trypanosomes use two sources of Ca2+ for generating signals: Ca2+ release from intracellular stores and Ca2+ entry across the plasma membrane. Ca2+ release from intracellular stores is controlled by the inositol 1,4,5-trisphosphate receptor (IP3R) that is located in acidocalcisomes, acidic organelles that are the primary Ca2+ reservoir in these cells. A plasma membrane Ca2+-ATPase controls the cytosolic Ca2+ levels and a number of pumps and exchangers are responsible for Ca2+ uptake and release from intracellular compartments. The trypanosomatid genomes contain a wide variety of signaling and regulatory proteins that bind Ca2+ as well as many Ca2+-binding proteins that await further characterization. The mitochondrial Ca2+ transporters of trypanosomatids have an important role in the regulation of cell bioenergetics and flagellar Ca2+ appears to have roles in sensing the environment. In trypanosomatids in which an intracellular life cycle is present, Ca2+ signaling is important for host cell invasion. (C) 2014 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available