Journal
TRENDS IN PARASITOLOGY
Volume 28, Issue 1, Pages 31-37Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2011.10.007
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Funding
- National Institutes of Health [A1068647, A1077538]
- Grant Agency of the Czech Republic [204/09/1667]
- Ministry of Education of the Czech Republic [6007665801]
- Praemium Academiae
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The ability of mitochondria to take up Ca2+ was discovered 50 years ago. This calcium uptake, through a mitochondrial calcium uniporter (MCU), is important not only for the regulation of cellular ATP concentration but also for more complex pathways such as shaping Ca2+ signals and the activation of programmed cell death. The molecular nature of the uniporter remained unknown for decades. By a comparative study of mitochondrial protein profiles of organisms lacking or possessing MCU, such as yeast in the former case and vertebrates and trypanosomes in the latter, two groups recently found the protein that possesses all the characteristics of the MCU. These results add another success story to the already substantial contributions of trypanosomes to mammalian biochemistry.
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