Fucoxanthin, a Marine-Derived Carotenoid from Brown Seaweeds and Microalgae: A Promising Bioactive Compound for Cancer Therapy

Nrf1 Is Endowed with a Dominant Tumor-Repressing Effect onto the Wnt/β-Catenin-Dependent and Wnt/β-Catenin-Independent Signaling Networks in the Human Liver Cancer

(2020) Jiayu Chen et al.   Oxidative Medicine and Cellular Longevity

Pro-oxidant Actions of Carotenoids in Triggering Apoptosis of Cancer Cells: A Review of Emerging Evidence

(2020) Juhyun Shin et al.   Antioxidants

Fucoxanthin inhibits tumour-related lymphangiogenesis and growth of breast cancer

(2019) Jia Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Rat Glioma Cell-Based Functional Characterization of Anti-Stress and Protein Deaggregation Activities in the Marine Carotenoids, Astaxanthin and Fucoxanthin

(2019) Sajal Afzal et al.   Marine Drugs

Induction of Apoptosis in Human Glioma Cells by Fucoxanthin via Triggering of ROS-Mediated Oxidative Damage and Regulation of MAPKs and PI3K–AKT Pathways

(2019) Hua-lian Wu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Preventive Effects of the Marine Microalga Phaeodactylum tricornutum, Used as a Food Supplement, on Risk Factors Associated with Metabolic Syndrome in Wistar Rats

(2019) Claire Mayer et al.   Nutrients

Fucoxanthin and Rosmarinic Acid Combination Has Anti-Inflammatory Effects through Regulation of NLRP3 Inflammasome in UVB-Exposed HaCaT Keratinocytes

(2019) Azahara Rodríguez-Luna et al.   Marine Drugs

Marine Carotenoid Fucoxanthin Possesses Anti-Metastasis Activity: Molecular Evidence

(2019) Sukant Garg et al.   Marine Drugs

Fucoxanthin, a Marine Xanthophyll Isolated From Conticribra weissflogii ND-8: Preventive Anti-Inflammatory Effect in a Mouse Model of Sepsis

(2019) Jingqian Su et al.   Frontiers in Pharmacology

The Molecular Mechanism of Epithelial–Mesenchymal Transition for Breast Carcinogenesis

(2019) Chia-Jung Li et al.   Biomolecules

BIRC5/Survivin is a novel ATG12–ATG5 conjugate interactor and an autophagy-induced DNA damage suppressor in human cancer and mouse embryonic fibroblast cells

(2019) Tzu-Yu Lin et al.   Autophagy

DNA repair inhibitors to enhance radiotherapy: Progresses and limitations

(2019) S. Ferreira et al.   Cancer Radiotherapie

Seaweed Secondary Metabolites with Beneficial Health Effects: An Overview of Successes in In Vivo Studies and Clinical Trials

(2019) Gonçalo P. Rosa et al.   Marine Drugs

Cytotoxic activity of fucoxanthin, alone and in combination with the cancer drugs imatinib and doxorubicin, in CML cell lines

(2018) Tânia Patrícia Almeida et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Low-dose doxorubicin with carotenoids selectively alters redox status and upregulates oxidative stress-mediated apoptosis in breast cancer cells

(2018) Kariyappa Vijay et al.   FOOD AND CHEMICAL TOXICOLOGY

Effects of fucoxanthin on autophagy and apoptosis in SGC-7901cells and the mechanism

(2018) Yue Zhu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Fucoxanthin and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Synergistically Promotes Apoptosis of Human Cervical Cancer Cells by Targeting PI3K/Akt/NF-κB Signaling Pathway

(2018) Ye Jin et al.   MEDICAL SCIENCE MONITOR

Anti-Oxidant and Fucoxanthin Contents of Brown Alga Ishimozuku (Sphaerotrichia divaricata) from the West Coast of Aomori, Japan

(2018) Hayato Maeda et al.   Marine Drugs

Degradation of Fucoxanthin to Elucidate the Relationship between the Fucoxanthin Molecular Structure and Its Antiproliferative Effect on Caco-2 Cells

(2018) Shiro Komba et al.   Marine Drugs

DNA repair pathways and cisplatin resistance: an intimate relationship

(2018) CR Rocha et al.   Clinics

Fucoxanthin potentiates anoikis in colon mucosa and prevents carcinogenesis in AOM/DSS model mice

(2018) Masaru Terasaki et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Malaysian brown seaweeds Sargassum siliquosum and Sargassum polycystum : Low density lipoprotein (LDL) oxidation, angiotensin converting enzyme (ACE), α-amylase, and α-glucosidase inhibition activities

(2017) Hemlatha Nagappan et al.   FOOD RESEARCH INTERNATIONAL

Anticancer effects of seaweed compounds fucoxanthin and phloroglucinol, alone and in combination with 5-fluorouracil in colon cells

(2017) Eduarda Lopes-Costa et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Dual Biological Functions of a Cytoprotective Effect and Apoptosis Induction by Bioavailable Marine Carotenoid Fucoxanthinol through Modulation of the Nrf2 Activation in RAW264.7 Macrophage Cells

(2017) Junsei Taira et al.   Marine Drugs

Antitumor Effects of Laminaria Extract Fucoxanthin on Lung Cancer

(2017) ChengHan Mei et al.   Marine Drugs

Induction of Anoikis in Human Colorectal Cancer Cells by Fucoxanthinol

(2017) Masaru Terasaki et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Carotenoids Database: structures, chemical fingerprints and distribution among organisms

(2017) Junko Yabuzaki   Database-The Journal of Biological Databases and Curation

Fucoxanthin production by heterokont microalgae

(2017) Maria Petrushkina et al.   Algal Research-Biomass Biofuels and Bioproducts

Metastatic colonization by circulating tumour cells

(2016) Joan Massagué et al.   NATURE

Fucoxanthin Activates Apoptosis via Inhibition of PI3K/Akt/mTOR Pathway and Suppresses Invasion and Migration by Restriction of p38-MMP-2/9 Pathway in Human Glioblastoma Cells

(2016) Yugang Liu et al.   NEUROCHEMICAL RESEARCH

Anti-Neuroinflammatory Effects of Fucoxanthin via Inhibition of Akt/NF-κB and MAPKs/AP-1 Pathways and Activation of PKA/CREB Pathway in Lipopolysaccharide-Activated BV-2 Microglial Cells

(2016) Dong Zhao et al.   NEUROCHEMICAL RESEARCH

Role of Antioxidants and Natural Products in Inflammation

(2016) Palanisamy Arulselvan et al.   Oxidative Medicine and Cellular Longevity

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Low-molecular-weight fucoidan and high-stability fucoxanthin from brown seaweed exert prebiotics and anti-inflammatory activities in Caco-2 cells

(2016) Pai-An Hwang et al.   Food & Nutrition Research

Production of fucoxanthin-rich fraction (FxRF) from a diatom, Chaetoceros calcitrans (Paulsen) Takano 1968

(2015) Su Chern Foo et al.   Algal Research-Biomass Biofuels and Bioproducts

Zeaxanthin Inhibits Hypoxia-Induced VEGF Secretion by RPE Cells through Decreased Protein Levels of Hypoxia-Inducible Factors-1α

(2015) Richard Rosen et al.   Biomed Research International

Fucoxanthin induces growth arrest and apoptosis in human bladder cancer T24 cells by up-regulation of p21 and down-regulation of mortalin

(2014) Linbo Wang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Inhibitory effects of fucoxanthinol on the viability of human breast cancer cell lines MCF-7 and MDA-MB-231 are correlated with modulation of the NF-kappaB pathway

(2014) Arlette Rwigemera et al.   CELL BIOLOGY AND TOXICOLOGY

Regulation of virus-induced inflammatory response by Dunaliella salina alga extract in macrophages

(2014) Hui-Wen Lin et al.   FOOD AND CHEMICAL TOXICOLOGY

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fucoxanthin induces apoptosis in human cervical cancer cell line HeLa via PI3K/Akt pathway

(2014) Guoliu Ye et al.   TUMOR BIOLOGY

Essential role of autophagy in fucoxanthin-induced cytotoxicity to human epithelial cervical cancer HeLa cells

(2013) Li-li Hou et al.   ACTA PHARMACOLOGICA SINICA

Marine algal fucoxanthin inhibits the metastatic potential of cancer cells

(2013) Tae-Wook Chung et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Modulation of platelet aggregation-related eicosanoid production by dietary F-fucoidan from brown alga Laminaria japonica in human subjects

(2013) Rendong Ren et al.   BRITISH JOURNAL OF NUTRITION

Fucoxanthin Extractions of Brown Seaweeds and Analysis of Their Lipid Fraction in Methanol

(2013) Irwandi JASWIR et al.   FOOD SCIENCE AND TECHNOLOGY RESEARCH

Anticancer effects of marine carotenoids, fucoxanthin and its deacetylated product, fucoxanthinol, on osteosarcoma

(2013) TAKAYOSHI ROKKAKU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Isolation of Fucoxanthin and Highly Unsaturated Monogalactosyldiacylglycerol from Brown Alga Fucus evanescens C Agardh and In Vitro Investigation of Their Antitumor Activity

(2013) Tatiana I. Imbs et al.   MARINE BIOTECHNOLOGY

Production, Characterization, and Antioxidant Activity of Fucoxanthin from the Marine Diatom Odontella aurita

(2013) Song Xia et al.   Marine Drugs

Fucoxanthin Enhances Cisplatin-Induced Cytotoxicity via NFκB-Mediated Pathway and Downregulates DNA Repair Gene Expression in Human Hepatoma HepG2 Cells

(2013) Cheng-Ling Liu et al.   Marine Drugs

Marine algal carotenoids inhibit angiogenesis by down-regulating FGF-2-mediated intracellular signals in vascular endothelial cells

(2013) Ponesakki Ganesan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Determination of fucoxanthin isomers in microalgae (Isochrysissp.) by high-performance liquid chromatography coupled with diode-array detector multistage mass spectrometry coupled with positive electrospray ionization

(2013) Pasquale Crupi et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet?

(2013) L. M. Coussens et al.   SCIENCE

A Potential Commercial Source of Fucoxanthin Extracted from the Microalga Phaeodactylum tricornutum

(2012) Sang Min Kim et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Topoisomerase degradation, DSB repair, p53 and IAPs in cancer cell resistance to camptothecin-like topoisomerase I inhibitors

(2012) Maja T. Tomicic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Inhibition of tumor growth in vitro and in vivo by fucoxanthin against melanoma B16F10 cells

(2012) Kil-Nam Kim et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Anti-inflammatory effect of fucoxanthin derivatives isolated from Sargassum siliquastrum in lipopolysaccharide-stimulated RAW 264.7 macrophage

(2012) Soo-Jin Heo et al.   FOOD AND CHEMICAL TOXICOLOGY

Isolation of fucoxanthin from edible brown algae by microwave-assisted extraction coupled with high-speed countercurrent chromatography

(2012) Xiaohua Xiao et al.   JOURNAL OF SEPARATION SCIENCE

Fucoxanthin as a major carotenoid in Isochrysis aff. galbana: Characterization of extraction for commercial application

(2012) Sang Min Kim et al.   Journal of the Korean Society for Applied Biological Chemistry

In Vivo Induction of Apoptosis by Fucoxanthin, a Marine Carotenoid, Associated with Down-Regulating STAT3/EGFR Signaling in Sarcoma 180 (S180) Xenografts-Bearing Mice

(2012) Jun Wang et al.   Marine Drugs

Anti-neoplastic effects of fucoxanthin and its deacetylated product, fucoxanthinol, on Burkitt’s and Hodgkin’s lymphoma cells

(2012) SENJI TAFUKU et al.   ONCOLOGY REPORTS

Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters

(2012) Safaa Yehia Eid et al.   PHYTOMEDICINE

Siphonaxanthin, a marine carotenoid from green algae, effectively induces apoptosis in human leukemia (HL-60) cells

(2011) Ponesakki Ganesan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Pharmacokinetics of fucoxanthinol in human plasma after the oral administration of kombu extract

(2011) Takashi Hashimoto et al.   BRITISH JOURNAL OF NUTRITION

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Carotenoids in Algae: Distributions, Biosyntheses and Functions

(2011) Shinichi Takaichi   Marine Drugs

Fucoxanthin and its deacetylated product, fucoxanthinol, induce apoptosis of primary effusion lymphomas

(2010) Kei Yamamoto et al.   CANCER LETTERS

Effects of fucoxanthin on proliferation and apoptosis in human gastric adenocarcinoma MGC-803 cells via JAK/STAT signal pathway

(2010) Rui-xue Yu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Evaluation of anti-inflammatory effect of fucoxanthin isolated from brown algae in lipopolysaccharide-stimulated RAW 264.7 macrophages

(2010) Soo-Jin Heo et al.   FOOD AND CHEMICAL TOXICOLOGY

Comparative Antioxidant Activity of Edible Japanese Brown Seaweeds

(2010) M.K. Widjaja-Adhi Airanthi et al.   JOURNAL OF FOOD SCIENCE

Study on the microalgal pigments extraction process: Performance of microwave assisted extraction

(2010) Virginie Pasquet et al.   PROCESS BIOCHEMISTRY

Fucoxanthin induces apoptosis in human leukemia HL-60 cells through a ROS-mediated Bcl-xL pathway

(2010) Kil-Nam Kim et al.   TOXICOLOGY IN VITRO

Implication of mitogen-activated protein kinase in the induction of G1 cell cycle arrest and gadd45 expression by the carotenoid fucoxanthin in human cancer cells

(2009) Yoshiko Satomi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Inhibition of proliferation of a hepatoma cell line by fucoxanthin in relation to cell cycle arrest and enhanced gap junctional intercellular communication

(2009) Cheng-Ling Liu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The effects of Xanthigen™in the weight management of obese premenopausal women with non-alcoholic fatty liver disease and normal liver fat

(2009) M. Abidov et al.   DIABETES OBESITY & METABOLISM

Commercial-scale Preparation of Biofunctional Fucoxanthin from Waste Parts of Brown Sea Algae Laminalia japonica

(2009) Kazuki KANAZAWA et al.   FOOD SCIENCE AND TECHNOLOGY RESEARCH

Single and repeated oral dose toxicity study of fucoxanthin (FX), a marine carotenoid, in mice

(2009) Fumiaki Beppu et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Bioavailability and metabolism of fucoxanthin in rats: structural characterization of metabolites by LC-MS (APCI)

(2009) Ravi Kumar Sangeetha et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Growth inhibition of human hepatic carcinoma HepG2 cells by fucoxanthin is associated with down-regulation of cyclin D

(2008) Swadesh K. Das et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Low bioavailability of dietary epoxyxanthophylls in humans

(2008) Akira Asai et al.   BRITISH JOURNAL OF NUTRITION

Antiadult T-cell leukemia effects of brown algae fucoxanthin and its deacetylated product, fucoxanthinol

(2008) Chie Ishikawa et al.   INTERNATIONAL JOURNAL OF CANCER

Toxicity and Antioxidant Activity in Vitro and in Vivo of TwoFucus vesiculosusExtracts

(2008) M. C. Zaragozá et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Protective effect of fucoxanthin isolated from Sargassum siliquastrum on UV-B induced cell damage

(2008) Soo-Jin Heo et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Induction of Autophagy during Extracellular Matrix Detachment Promotes Cell Survival

(2007) Christopher Fung et al.   MOLECULAR BIOLOGY OF THE CELL