Novel insights into the treatment of SARS-CoV-2 infection: An overview of current clinical trials

Structure analysis of the receptor binding of 2019-nCoV

(2020) Yun Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Angiotensin receptor blockers as tentative SARS‐CoV‐2 therapeutics

(2020) David Gurwitz   DRUG DEVELOPMENT RESEARCH

Coronavirus infections and immune responses

(2020) Geng Li et al.   JOURNAL OF MEDICAL VIROLOGY

Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2

(2020) Zhixin Liu et al.   JOURNAL OF MEDICAL VIROLOGY

SARS-CoV-2 infection in children: Transmission dynamics and clinical characteristics

(2020) Qing Cao et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS

(2020) Yushun Wan et al.   JOURNAL OF VIROLOGY

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Therapeutic options for the 2019 novel coronavirus (2019-nCoV)

(2020) Guangdi Li et al.   NATURE REVIEWS DRUG DISCOVERY

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission

(2020) Xintian Xu et al.   Science China-Life Sciences

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

Role of Melatonin in the Regulation of Pain

(2020) Shanshan Xie et al.   Journal of Pain Research

Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations

(2020) Yanan Cao et al.   Cell Discovery

Immune response to SARS‐CoV‐2 and mechanisms of immunopathological changes in COVID‐19

(2020) Ahmet Kursat Azkur et al.   ALLERGY

A potential role for integrins in host cell entry by SARS-CoV-2

(2020) Christian JA Sigrist et al.   ANTIVIRAL RESEARCH

Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China

(2020) Chuan Qin et al.   CLINICAL INFECTIOUS DISEASES

Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial

(2020) Philippe Gautret et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma

(2020) Chenguang Shen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Recent advances in nanotechnology-based drug delivery systems for the kidney

(2020) Fatemeh Oroojalian et al.   JOURNAL OF CONTROLLED RELEASE

The potential chemical structure of anti‐SARS‐CoV‐2 RNA‐dependent RNA polymerase

(2020) Jrhau Lung et al.   JOURNAL OF MEDICAL VIROLOGY

Detection of antibodies against SARS-CoV-2 in patients with COVID-19

(2020) Zhe Du et al.   JOURNAL OF MEDICAL VIROLOGY

Potential therapeutic agents against COVID-19

(2020) Chih-Chia Lu et al.   Journal of the Chinese Medical Association

How will country-based mitigation measures influence the course of the COVID-19 epidemic?

(2020) Roy M Anderson et al.   LANCET

A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19

(2020) Bin Cao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structure of mouse coronavirus spike protein complexed with receptor reveals mechanism for viral entry

(2020) Jian Shang et al.   PLoS Pathogens

Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases

(2020) Cynthia Liu et al.   ACS Central Science

Molecular immune pathogenesis and diagnosis of COVID-19

(2020) Xiaowei Li et al.   Journal of Pharmaceutical Analysis

COVID-19: Melatonin as a potential adjuvant treatment

(2020) Rui Zhang et al.   LIFE SCIENCES

COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses

(2020) Muhammad Adnan Shereen et al.   Journal of Advanced Research

From SARS to COVID-19: A previously unknown SARS- related coronavirus (SARS-CoV-2) of pandemic potential infecting humans – Call for a One Health approach

(2020) Mohamed E. El Zowalaty et al.   One Health

Evolution of the COVID-19 vaccine development landscape

(2020) Tung Thanh Le et al.   NATURE REVIEWS DRUG DISCOVERY

Innate and Adaptive Immune Memory: an Evolutionary Continuum in the Host’s Response to Pathogens

(2019) Mihai G. Netea et al.   Cell Host & Microbe

From SARS to MERS, Thrusting Coronaviruses into the Spotlight

(2019) Zhiqi Song et al.   Viruses-Basel

Middle East Respiratory Syndrome Vaccine Candidates: Cautious Optimism

(2019) Craig Schindewolf et al.   Viruses-Basel

Synthesis and evaluation of injectable thermosensitive penta‐block copolymer hydrogel (PNIPAAm‐PCL‐PEG‐PCL‐PNIPAAm) and star‐shaped poly(CL─CO─LA)‐b‐PEG for wound healing applications

(2019) Fatemeh Oroojalian et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mesenchymal Stem Cells Reconditioned in Their Own Serum Exhibit Augmented Therapeutic Properties in the Setting of Acute Respiratory Distress Syndrome

(2019) Amy L. Xu et al.   Stem Cells Translational Medicine

Overexpression of IL-10 Enhances the Efficacy of Human Umbilical-Cord-Derived Mesenchymal Stromal Cells in E. coli Pneumosepsis

(2019) Mirjana Jerkic et al.   Journal of Clinical Medicine

New Nucleoside Analogues for the Treatment of Hemorrhagic Fever Virus Infections

(2019) Erik De Clercq   Chemistry-An Asian Journal

Recent Advances in the Vaccine Development Against Middle East Respiratory Syndrome-Coronavirus

(2019) Chean Yeah Yong et al.   Frontiers in Microbiology

Comparison of DNA and mRNA vaccines against cancer

(2019) Zohreh Jahanafrooz et al.   DRUG DISCOVERY TODAY

Recent advances on HIV DNA vaccines development: Stepwise improvements to clinical trials

(2019) Tayebeh Rezaei et al.   JOURNAL OF CONTROLLED RELEASE

Recent Progress in Vaccine Development Against Chikungunya Virus

(2019) Shan Gao et al.   Frontiers in Microbiology

Effects of AANAT overexpression on the inflammatory responses and autophagy activity in the cellular and transgenic animal levels

(2018) Guoshi Liu et al.   Autophagy

An innovative immunosensor for ultrasensitive detection of breast cancer specific carbohydrate (CA 15-3) in unprocessed human plasma and MCF-7 breast cancer cell lysates using gold nanospear electrochemically assembled onto thiolated graphene quantum dots

(2018) Mohammad Hasanzadeh et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Distinguishing the Effects of Inhaled Nitric Oxide and Lung Recruitment in Pediatric Acute Respiratory Distress Syndrome

(2018) Hiromi Miyoshi et al.   Pediatric Critical Care Medicine

Recent trends in rapid detection of influenza infections by bio and nanobiosensor

(2018) Soodabeh Hassanpour et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Heterologous prime–boost vaccination with adenoviral vector and protein nanoparticles induces both Th1 and Th2 responses against Middle East respiratory syndrome coronavirus

(2018) Seo-Yeon Jung et al.   VACCINE

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

(2018) Maria L. Agostini et al.   mBio

Applications of nanoparticle systems in drug delivery technology

(2018) Syed A.A. Rizvi et al.   SAUDI PHARMACEUTICAL JOURNAL

Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis

(2018) Robert N. Kirchdoerfer et al.   Scientific Reports

Flavivirus Receptors: Diversity, Identity, and Cell Entry

(2018) Mathilde Laureti et al.   Frontiers in Immunology

Tetraspanins: Architects of viral entry and exit platforms

(2018) Michael P. Hantak et al.   JOURNAL OF VIROLOGY

Estimating the cost of vaccine development against epidemic infectious diseases: a cost minimisation study

(2018) Dimitrios Gouglas et al.   Lancet Global Health

Effects of human umbilical cord blood mononuclear cells on respiratory system mechanics in a murine model of neonatal lung injury

(2017) David R. Mills et al.   EXPERIMENTAL LUNG RESEARCH

Transplantation of Menstrual Blood-Derived Mesenchymal Stem Cells Promotes the Repair of LPS-Induced Acute Lung Injury

(2017) Bingyu Xiang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Middle East Respiratory Syndrome

(2017) Yaseen M. Arabi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nanomaterial-based biosensors for detection of pathogenic virus

(2017) Ahad Mokhtarzadeh et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

MERS-CoV spike nanoparticles protect mice from MERS-CoV infection

(2017) Christopher M. Coleman et al.   VACCINE

Therapeutic Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Acute Lung Injury Mice

(2017) Hua Zhu et al.   Scientific Reports

Vaccines for emerging infectious diseases: Lessons from MERS coronavirus and Zika virus

(2017) Joel N. Maslow   Human Vaccines & Immunotherapeutics

Recent advances in co-delivery systems based on polymeric nanoparticle for cancer treatment

(2017) Maryam Afsharzadeh et al.   Artificial Cells Nanomedicine and Biotechnology

The mechanisms of sudden-onset type adverse reactions to oseltamivir

(2016) R. Hama et al.   ACTA NEUROLOGICA SCANDINAVICA

Role of the ACE2/Angiotensin 1–7 Axis of the Renin–Angiotensin System in Heart Failure

(2016) Vaibhav B. Patel et al.   CIRCULATION RESEARCH

Genetically modified mesenchymal stromal cells in cancer therapy

(2016) Elizabeth K. Sage et al.   CYTOTHERAPY

Vaccines for the prevention against the threat of MERS-CoV

(2016) Lanying Du et al.   Expert Review of Vaccines

Airway Memory CD4 + T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses

(2016) Jincun Zhao et al.   IMMUNITY

A synthetic consensus anti-Spike protein DNA vaccine induces protective immunity against Middle East Respiratory Syndrome Coronavirus in non-human primates

(2016) K. Muthumani et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Whole-Inactivated and Virus-Like Particle Vaccine Strategies for Chikungunya Virus

(2016) Adam D. DeZure et al.   JOURNAL OF INFECTIOUS DISEASES

Graphene quantum dot as an electrically conductive material toward low potential detection: a new platform for interface science

(2016) Mohammad Hasanzadeh et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS

Zika virus cell tropism in the developing human brain and inhibition by azithromycin

(2016) Hanna Retallack et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SARS-like WIV1-CoV poised for human emergence

(2016) Vineet D. Menachery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo

(2016) Michael C. W. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Principles of Virus Uncoating: Cues and the Snooker Ball

(2016) Yohei Yamauchi et al.   TRAFFIC

Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines

(2016) Lanying Du et al.   Nature Communications

Azithromycin induces anti-viral effects in cultured bronchial epithelial cells from COPD patients

(2016) Mandy Menzel et al.   Scientific Reports

Structure, Function, and Evolution of Coronavirus Spike Proteins

(2016) Fang Li   Annual Review of Virology

How, with whom and when: an overview of CD147-mediated regulatory networks influencing matrix metalloproteinase activity

(2015) G. D. Grass et al.   BIOSCIENCE REPORTS

Antibacterial effect of mesenchymal stem cells againstEscherichia coliis mediated by secretion of beta- defensin- 2 via toll- like receptor 4 signalling

(2015) Dong Kyung Sung et al.   CELLULAR MICROBIOLOGY

Middle East Respiratory Syndrome Coronavirus: Another Zoonotic Betacoronavirus Causing SARS-Like Disease

(2015) Jasper F. W. Chan et al.   CLINICAL MICROBIOLOGY REVIEWS

Synthetic and Biological Vesicular Nano-Carriers Designed for Gene Delivery

(2015) Fatemeh Soltani et al.   CURRENT PHARMACEUTICAL DESIGN

Middle East respiratory syndrome: current status and future prospects for vaccine development

(2015) Lanying Du et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Early Administration of Azithromycin and Prevention of Severe Lower Respiratory Tract Illnesses in Preschool Children With a History of Such Illnesses

(2015) Leonard B. Bacharier et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Passive Immunotherapy with Dromedary Immune Serum in an Experimental Animal Model for Middle East Respiratory Syndrome Coronavirus Infection

(2015) Jincun Zhao et al.   JOURNAL OF VIROLOGY

Host cell proteases: Critical determinants of coronavirus tropism and pathogenesis

(2015) Jean Kaoru Millet et al.   VIRUS RESEARCH

Dynamics of Virus-Receptor Interactions in Virus Binding, Signaling, and Endocytosis

(2015) Steeve Boulant et al.   Viruses-Basel

Reply to “Statins may decrease the Fatality Rate of MERS Infection”

(2015) Allison L. Totura et al.   mBio

Evaluation of candidate vaccine approaches for MERS-CoV

(2015) Lingshu Wang et al.   Nature Communications

Extended Preclinical Safety, Efficacy and Stability Testing of a Live-attenuated Chikungunya Vaccine Candidate

(2015) Kenneth S Plante et al.   PLoS Neglected Tropical Diseases

In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome

(2015) Oscar E. Simonson et al.   Stem Cells Translational Medicine

Evaluation of Ebola Virus Inhibitors for Drug Repurposing

(2015) Peter B. Madrid et al.   ACS Infectious Diseases

Continuous and Discontinuous RNA Synthesis in Coronaviruses

(2015) Isabel Sola et al.   Annual Review of Virology

The Comparative Efficacy and Safety of the Angiotensin Receptor Blockers in the Management of Hypertension and Other Cardiovascular Diseases

(2014) Hazel Mae A. Abraham et al.   DRUG SAFETY

Medical nanoparticles for next generation drug delivery to the lungs

(2014) S. H. van Rijt et al.   EUROPEAN RESPIRATORY JOURNAL

Right or Left: The Role of Nanoparticles in Pulmonary Diseases

(2014) Xuefei Lu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Use of Genetically Modified Mesenchymal Stem Cells to Treat Neurodegenerative Diseases

(2014) Robert Wyse et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Development of nucleic acid vaccines: use of self-amplifying RNA in lipid nanoparticles

(2014) Alicia Rodriguez-Gascon et al.   International Journal of Nanomedicine

Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein

(2014) Jean Kaoru Millet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice

(2014) Christopher M. Coleman et al.   VACCINE

Therapeutic Potential and Mechanisms of Action of Mesenchymal Stromal Cells for Acute Respiratory Distress Syndrome

(2014) Gerard Curley et al.   Current Stem Cell Research & Therapy

Nanomedicines for Inflammatory Arthritis: Head-to-Head Comparison of Glucocorticoid-Containing Polymers, Micelles, and Liposomes

(2013) Lingdong Quan et al.   ACS Nano

Receptor recognition and cross-species infections of SARS coronavirus

(2013) Fang Li   ANTIVIRAL RESEARCH

Middle East Respiratory Syndrome Coronavirus Spike Protein Delivered by Modified Vaccinia Virus Ankara Efficiently Induces Virus-Neutralizing Antibodies

(2013) F. Song et al.   JOURNAL OF VIROLOGY

Novel Inhibitors of Severe Acute Respiratory Syndrome Coronavirus Entry That Act by Three Distinct Mechanisms

(2013) A. O. Adedeji et al.   JOURNAL OF VIROLOGY

Inhibition of NF- B-Mediated Inflammation in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice Increases Survival

(2013) M. L. DeDiego et al.   JOURNAL OF VIROLOGY

Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Announcement of the Coronavirus Study Group

(2013) R. J. de Groot et al.   JOURNAL OF VIROLOGY

Prone Positioning in Severe Acute Respiratory Distress Syndrome

(2013) Claude Guérin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Keratinocyte Growth Factor Gene Delivery via Mesenchymal Stem Cells Protects against Lipopolysaccharide-Induced Acute Lung Injury in Mice

(2013) Jie Chen et al.   PLoS One

Network Analysis of Transcriptional Responses Induced by Mesenchymal Stem Cell Treatment of Experimental Sepsis

(2012) Claudia C. dos Santos et al.   AMERICAN JOURNAL OF PATHOLOGY

A hexapeptide of the receptor-binding domain of SARS corona virus spike protein blocks viral entry into host cells via the human receptor ACE2

(2012) Anna-Winona Struck et al.   ANTIVIRAL RESEARCH

Inhaled Nitric Oxide Therapy Fails to Improve Outcome in Experimental Severe Influenza

(2012) Ilyse Darwish et al.   International Journal of Medical Sciences

A facile inhibitor screening of SARS coronavirus N protein using nanoparticle-based RNA oligonucleotide

(2012) Changhyun Roh   International Journal of Nanomedicine

Mechanisms of Host Receptor Adaptation by Severe Acute Respiratory Syndrome Coronavirus

(2012) Kailang Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The acute respiratory distress syndrome

(2012) Michael A. Matthay et al.   JOURNAL OF CLINICAL INVESTIGATION

Mesenchymal stem cells enhance survival and bacterial clearance in murineEscherichia colipneumonia

(2012) Naveen Gupta et al.   THORAX

Ready, Set, Fuse! The Coronavirus Spike Protein and Acquisition of Fusion Competence

(2012) Taylor Heald-Sargent et al.   Viruses-Basel

Mechanisms of Coronavirus Cell Entry Mediated by the Viral Spike Protein

(2012) Sandrine Belouzard et al.   Viruses-Basel

Human Coronaviruses: Insights into Environmental Resistance and Its Influence on the Development of New Antiseptic Strategies

(2012) Chloé Geller et al.   Viruses-Basel

Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response

(2011) I. Glowacka et al.   JOURNAL OF VIROLOGY

Human-Leukocyte Antigen Class I Cw 1502 and Class II DR 0301 Genotypes Are Associated with Resistance to Severe Acute Respiratory Syndrome (SARS) Infection

(2011) Sheng-Fan Wang et al.   VIRAL IMMUNOLOGY

Angiotensin-Converting Enzyme 2: The First Decade

(2011) Nicola E. Clarke et al.   International Journal of Hypertension

Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patients

(2010) Thida Ong et al.   CRITICAL CARE MEDICINE

Angiotensin-converting enzyme 2 is a key modulator of the renin–angiotensin system in cardiovascular and renal disease

(2010) Chris Tikellis et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Mechanisms of viral entry: sneaking in the front door

(2010) Jennifer A. Thorley et al.   PROTOPLASMA

Label-Free, Electrical Detection of the SARS Virus N-Protein with Nanowire Biosensors Utilizing Antibody Mimics as Capture Probes

(2009) Fumiaki N. Ishikawa et al.   ACS Nano

Human Umbilical Cord Mesenchymal Stem Cells Reduce Fibrosis of Bleomycin-Induced Lung Injury

(2009) Yuben Moodley et al.   AMERICAN JOURNAL OF PATHOLOGY

The spike protein of SARS-CoV — a target for vaccine and therapeutic development

(2009) Lanying Du et al.   NATURE REVIEWS MICROBIOLOGY

Boosted expression of the SARS-CoV nucleocapsid protein in tobacco and its immunogenicity in mice

(2009) Nuoyan Zheng et al.   VACCINE

Peptide Nanoparticles as Novel Immunogens: Design and Analysis of a Prototypic Severe Acute Respiratory Syndrome Vaccine

(2008) Tais A. P. F. Pimentel et al.   Chemical Biology & Drug Design

Structures and Mechanisms of Viral Membrane Fusion Proteins: Multiple Variations on a Common Theme

(2008) Judith M. White et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Vaccines to prevent severe acute respiratory syndrome coronavirus-induced disease

(2007) Luis Enjuanes et al.   VIRUS RESEARCH