Extended Preclinical Safety, Efficacy and Stability Testing of a Live-attenuated Chikungunya Vaccine Candidate

Chikungunya: Evolutionary history and recent epidemic spread

(2015) Scott C. Weaver et al.   ANTIVIRAL RESEARCH

Chikungunya Virus and the Global Spread of a Mosquito-Borne Disease

(2015) Scott C. Weaver et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chikungunya Vaccine Candidate Is Highly Attenuated and Protects Nonhuman Primates Against Telemetrically Monitored Disease Following a Single Dose

(2014) C. J. Roy et al.   JOURNAL OF INFECTIOUS DISEASES

Chikungunya in the Americas

(2014) Isabelle Leparc-Goffart et al.   LANCET

Deliberate Attenuation of Chikungunya Virus by Adaptation to Heparan Sulfate-Dependent Infectivity: A Model for Rational Arboviral Vaccine Design

(2014) Christina L. Gardner et al.   PLoS Neglected Tropical Diseases

A Novel Live-Attenuated Vaccine Candidate for Mayaro Fever

(2014) William J. Weise et al.   PLoS Neglected Tropical Diseases

Stable, High-Level Expression of Reporter Proteins from Improved Alphavirus Expression Vectors To Track Replication and Dissemination during Encephalitic and Arthritogenic Disease

(2013) C. Sun et al.   JOURNAL OF VIROLOGY

Deciphering the protective role of adaptive immunity to CHIKV/IRES a novel candidate vaccine against Chikungunya in the A129 mouse model

(2013) Haiyan Chu et al.   VACCINE

A recombinant measles vaccine expressing chikungunya virus-like particles is strongly immunogenic and protects mice from lethal challenge with chikungunya virus

(2013) Samantha Brandler et al.   VACCINE

IRES-based Venezuelan equine encephalitis vaccine candidate elicits protective immunity in mice

(2013) Shannan L. Rossi et al.   VIROLOGY

IRES-driven Expression of the Capsid Protein of the Venezuelan Equine Encephalitis Virus TC-83 Vaccine Strain Increases Its Attenuation and Safety

(2013) Mathilde Guerbois et al.   PLoS Neglected Tropical Diseases

Chikungunya virus and prospects for a vaccine

(2012) Scott C Weaver et al.   Expert Review of Vaccines

Attenuation of Chikungunya Virus Vaccine Strain 181/Clone 25 Is Determined by Two Amino Acid Substitutions in the E2 Envelope Glycoprotein

(2012) R. Gorchakov et al.   JOURNAL OF VIROLOGY

Cross-protective immunity against o‘nyong-nyong virus afforded by a novel recombinant chikungunya vaccine

(2012) Charalambos D. Partidos et al.   VACCINE

A vaccine candidate for eastern equine encephalitis virus based on IRES-mediated attenuation

(2012) Jyotsna Pandya et al.   VACCINE

Interferon-alpha/beta deficiency greatly exacerbates arthritogenic disease in mice infected with wild-type chikungunya virus but not with the cell culture-adapted live-attenuated 181/25 vaccine candidate

(2012) Christina L. Gardner et al.   VIROLOGY

Probing the attenuation and protective efficacy of a candidate chikungunya virus vaccine in mice with compromised interferon (IFN) signaling

(2011) Charalambos D. Partidos et al.   VACCINE

Novel Chikungunya Vaccine Candidate with an IRES-Based Attenuation and Host Range Alteration Mechanism

(2011) Kenneth Plante et al.   PLoS Pathogens

Glycoprotein organization of Chikungunya virus particles revealed by X-ray crystallography

(2010) James E. Voss et al.   NATURE

A virus-like particle vaccine for epidemic Chikungunya virus protects nonhuman primates against infection

(2010) Wataru Akahata et al.   NATURE MEDICINE

Estimating Chikungunya prevalence in La Réunion Island outbreak by serosurveys: Two methods for two critical times of the epidemic

(2008) Patrick Gérardin et al.   BMC INFECTIOUS DISEASES

Serious acute chikungunya virus infection requiring intensive care during the reunion island outbreak in 2005–2006*

(2008) Jérôme Lemant et al.   CRITICAL CARE MEDICINE

A Mouse Model for Chikungunya: Young Age and Inefficient Type-I Interferon Signaling Are Risk Factors for Severe Disease

(2008) Thérèse Couderc et al.   PLoS Pathogens

IRES-dependent replication of Venezuelan equine encephalitis virus makes it highly attenuated and incapable of replicating in mosquito cells

(2008) Eugenia Volkova et al.   VIROLOGY

Clinical burden of chikungunya virus infection

(2007) Benjamin Queyriaux et al.   LANCET INFECTIOUS DISEASES