From SARS to MERS, Thrusting Coronaviruses into the Spotlight

Enhanced protection in mice induced by immunization with inactivated whole viruses compare to spike protein of middle east respiratory syndrome coronavirus

(2018) Yao Deng et al.   Emerging Microbes & Infections

Current understanding of middle east respiratory syndrome coronavirus infection in human and animal models

(2018) Yanqun Wang et al.   Journal of Thoracic Disease

Origin and evolution of pathogenic coronaviruses

(2018) Jie Cui et al.   NATURE REVIEWS MICROBIOLOGY

High Prevalence of MERS-CoV Infection in Camel Workers in Saudi Arabia

(2018) Abeer N. Alshukairi et al.   mBio

Human Neutralizing Monoclonal Antibody Inhibition of Middle East Respiratory Syndrome Coronavirus Replication in the Common Marmoset

(2017) Zhe Chen et al.   JOURNAL OF INFECTIOUS DISEASES

Permissivity of Dipeptidyl Peptidase 4 Orthologs to Middle East Respiratory Syndrome Coronavirus Is Governed by Glycosylation and Other Complex Determinants

(2017) Kayla M. Peck et al.   JOURNAL OF VIROLOGY

Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice

(2017) Kun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MERS, SARS and other coronaviruses as causes of pneumonia

(2017) Yudong Yin et al.   RESPIROLOGY

The recombinant N-terminal domain of spike proteins is a potential vaccine against Middle East respiratory syndrome coronavirus (MERS-CoV) infection

(2017) Lan Jiaming et al.   VACCINE

Rapid development of vaccines against emerging pathogens: The replication-deficient simian adenovirus platform technology

(2017) Sarah C. Gilbert et al.   VACCINE

DNA vaccine encoding Middle East respiratory syndrome coronavirus S1 protein induces protective immune responses in mice

(2017) Hang Chi et al.   VACCINE

Immunogenicity of Candidate MERS-CoV DNA Vaccines Based on the Spike Protein

(2017) Sawsan S. Al-amri et al.   Scientific Reports

Comparative pathology of rhesus macaque and common marmoset animal models with Middle East respiratory syndrome coronavirus

(2017) Pin Yu et al.   PLoS One

Dipeptidyl Peptidase 4 Distribution in the Human Respiratory Tract

(2016) David K. Meyerholz et al.   AMERICAN JOURNAL OF PATHOLOGY

MERS-CoV spike protein: a key target for antivirals

(2016) Lanying Du et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Airway Memory CD4 + T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses

(2016) Jincun Zhao et al.   IMMUNITY

Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)

(2016) Nan Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protective T Cell Responses Featured by Concordant Recognition of Middle East Respiratory Syndrome Coronavirus–Derived CD8+T Cell Epitopes and Host MHC

(2016) William J. Liu et al.   JOURNAL OF IMMUNOLOGY

Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels

(2016) W. Widagdo et al.   JOURNAL OF VIROLOGY

Recombinant Receptor-Binding Domains of Multiple Middle East Respiratory Syndrome Coronaviruses (MERS-CoVs) Induce Cross-Neutralizing Antibodies against Divergent Human and Camel MERS-CoVs and Antibody Escape Mutants

(2016) Wanbo Tai et al.   JOURNAL OF VIROLOGY

SARS and MERS: recent insights into emerging coronaviruses

(2016) Emmie de Wit et al.   NATURE REVIEWS MICROBIOLOGY

MERS-CoV vaccine candidates in development: The current landscape

(2016) Kayvon Modjarrad   VACCINE

Immunodominant SARS Coronavirus Epitopes in Humans Elicited both Enhancing and Neutralizing Effects on Infection in Non-human Primates

(2016) Qidi Wang et al.   ACS Infectious Diseases

MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2

(2016) Man-Lung Yeung et al.   Nature Microbiology

A mouse model for MERS coronavirus-induced acute respiratory distress syndrome

(2016) Adam S. Cockrell et al.   Nature Microbiology

Protease inhibitors targeting coronavirus and filovirus entry

(2015) Yanchen Zhou et al.   ANTIVIRAL RESEARCH

A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein

(2015) Yan Li et al.   CELL RESEARCH

Epidemiological investigation of MERS-CoV spread in a single hospital in South Korea, May to June 2015*

(2015) H Y Park et al.   Eurosurveillance

Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways

(2015) Hin Chu et al.   JOURNAL OF INFECTIOUS DISEASES

Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset

(2015) Jasper Fuk-Woo Chan et al.   JOURNAL OF INFECTIOUS DISEASES

Asymptomatic Middle East Respiratory Syndrome Coronavirus Infection in Rabbits

(2015) Bart L. Haagmans et al.   JOURNAL OF VIROLOGY

Middle East respiratory syndrome

(2015) Alimuddin Zumla et al.   LANCET

Spatiotemporal interplay of severe acute respiratory syndrome coronavirus and respiratory mucosal cells drives viral dissemination in rhesus macaques

(2015) L Liu et al.   Mucosal Immunology

A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence

(2015) Vineet D Menachery et al.   NATURE MEDICINE

2014 MERS-CoV Outbreak in Jeddah — A Link to Health Care Facilities

(2015) Ikwo K. Oboho et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus

(2015) Davide Corti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels

(2015) B. L. Haagmans et al.   SCIENCE

Intratracheal exposure of common marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/2012 isolates does not result in lethal disease

(2015) Reed F. Johnson et al.   VIROLOGY

Evaluation of candidate vaccine approaches for MERS-CoV

(2015) Lingshu Wang et al.   Nature Communications

Recombinant Receptor Binding Domain Protein Induces Partial Protective Immunity in Rhesus Macaques Against Middle East Respiratory Syndrome Coronavirus Challenge

(2015) Jiaming Lan et al.   EBioMedicine

Multi-Organ Damage in Human Dipeptidyl Peptidase 4 Transgenic Mice Infected with Middle East Respiratory Syndrome-Coronavirus

(2015) Guangyu Zhao et al.   PLoS One

Clinical Course and Outcomes of Critically Ill Patients With Middle East Respiratory Syndrome Coronavirus Infection

(2014) Yaseen M. Arabi et al.   ANNALS OF INTERNAL MEDICINE

Hospital-Associated Outbreak of Middle East Respiratory Syndrome Coronavirus: A Serologic, Epidemiologic, and Clinical Description

(2014) Mohammad Mousa Al-Abdallat et al.   CLINICAL INFECTIOUS DISEASES

An Observational, Laboratory-Based Study of Outbreaks of Middle East Respiratory Syndrome Coronavirus in Jeddah and Riyadh, Kingdom of Saudi Arabia, 2014

(2014) C. Drosten et al.   CLINICAL INFECTIOUS DISEASES

Current advancements and potential strategies in the development of MERS-CoV vaccines

(2014) Naru Zhang et al.   Expert Review of Vaccines

Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia

(2014) Mustafa Saad et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

T Cell Responses to Whole SARS Coronavirus in Humans

(2014) C. K.-f. Li et al.   JOURNAL OF IMMUNOLOGY

Host Species Restriction of Middle East Respiratory Syndrome Coronavirus through Its Receptor, Dipeptidyl Peptidase 4

(2014) N. van Doremalen et al.   JOURNAL OF VIROLOGY

Receptor Variation and Susceptibility to Middle East Respiratory Syndrome Coronavirus Infection

(2014) A. Barlan et al.   JOURNAL OF VIROLOGY

Receptor Recognition Mechanisms of Coronaviruses: a Decade of Structural Studies

(2014) Fang Li   JOURNAL OF VIROLOGY

Mouse Dipeptidyl Peptidase 4 Is Not a Functional Receptor for Middle East Respiratory Syndrome Coronavirus Infection

(2014) A. S. Cockrell et al.   JOURNAL OF VIROLOGY

A Conformation-Dependent Neutralizing Monoclonal Antibody Specifically Targeting Receptor-Binding Domain in Middle East Respiratory Syndrome Coronavirus Spike Protein

(2014) L. Du et al.   JOURNAL OF VIROLOGY

Evidence for Camel-to-Human Transmission of MERS Coronavirus

(2014) Esam I. Azhar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rapid generation of a mouse model for Middle East respiratory syndrome

(2014) Jincun Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunogenicity of an adenoviral-based Middle East Respiratory Syndrome coronavirus vaccine in BALB/c mice

(2014) Eun Kim et al.   VACCINE

Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response

(2014) Hin Chu et al.   VIROLOGY

Middle East Respiratory Syndrome Coronavirus Infection in Dromedary Camels in Saudi Arabia

(2014) A. N. Alagaili et al.   mBio

Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor

(2014) Lu Lu et al.   Nature Communications

Infection with MERS-CoV Causes Lethal Pneumonia in the Common Marmoset

(2014) Darryl Falzarano et al.   PLoS Pathogens

Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4

(2013) Nianshuang Wang et al.   CELL RESEARCH

Therapeutic Options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) – possible lessons from a systematic review of SARS-CoV therapy

(2013) Hisham Momattin et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus

(2013) C. M. Coleman et al.   JOURNAL OF GENERAL VIROLOGY

Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment

(2013) S. K. P. Lau et al.   JOURNAL OF GENERAL VIROLOGY

Interferon-  and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays

(2013) B. J. Hart et al.   JOURNAL OF GENERAL VIROLOGY

An Animal Model of MERS Produced by Infection of Rhesus Macaques With MERS Coronavirus

(2013) Y. Yao et al.   JOURNAL OF INFECTIOUS DISEASES

Active Replication of Middle East Respiratory Syndrome Coronavirus and Aberrant Induction of Inflammatory Cytokines and Chemokines in Human Macrophages: Implications for Pathogenesis

(2013) Jie Zhou et al.   JOURNAL OF INFECTIOUS DISEASES

Complete Protection against Severe Acute Respiratory Syndrome Coronavirus-Mediated Lethal Respiratory Disease in Aged Mice by Immunization with a Mouse-Adapted Virus Lacking E Protein

(2013) C. Fett et al.   JOURNAL OF VIROLOGY

Adenosine Deaminase Acts as a Natural Antagonist for Dipeptidyl Peptidase 4-Mediated Entry of the Middle East Respiratory Syndrome Coronavirus

(2013) V. S. Raj et al.   JOURNAL OF VIROLOGY

Middle East Respiratory Syndrome Coronavirus Infection Mediated by the Transmembrane Serine Protease TMPRSS2

(2013) Kazuya Shirato et al.   JOURNAL OF VIROLOGY

Structure of the Fusion Core and Inhibition of Fusion by a Heptad Repeat Peptide Derived from the S Protein of Middle East Respiratory Syndrome Coronavirus

(2013) J. Gao et al.   JOURNAL OF VIROLOGY

Tropism of and Innate Immune Responses to the Novel Human Betacoronavirus Lineage C Virus in Human Ex Vivo Respiratory Organ Cultures

(2013) R. W. Y. Chan et al.   JOURNAL OF VIROLOGY

Identification of a Receptor-Binding Domain in the S Protein of the Novel Human Coronavirus Middle East Respiratory Syndrome Coronavirus as an Essential Target for Vaccine Development

(2013) L. Du et al.   JOURNAL OF VIROLOGY

Crystal Structure of the Receptor-Binding Domain from Newly Emerged Middle East Respiratory Syndrome Coronavirus

(2013) Y. Chen et al.   JOURNAL OF VIROLOGY

The Spike Protein of the Emerging Betacoronavirus EMC Uses a Novel Coronavirus Receptor for Entry, Can Be Activated by TMPRSS2, and Is Targeted by Neutralizing Antibodies

(2013) S. Gierer et al.   JOURNAL OF VIROLOGY

Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study

(2013) Abdullah Assiri et al.   LANCET INFECTIOUS DISEASES

Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor

(2013) Xing-Yi Ge et al.   NATURE

Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26

(2013) Guangwen Lu et al.   NATURE

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

(2013) V. Stalin Raj et al.   NATURE

Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV–infected rhesus macaques

(2013) Darryl Falzarano et al.   NATURE MEDICINE

A decade after SARS: strategies for controlling emerging coronaviruses

(2013) Rachel L. Graham et al.   NATURE REVIEWS MICROBIOLOGY

Hospital Outbreak of Middle East Respiratory Syndrome Coronavirus

(2013) Abdullah Assiri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pneumonia from Human Coronavirus in a Macaque Model

(2013) Vincent J. Munster et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Does Not Replicate in Syrian Hamsters

(2013) Emmie de Wit et al.   PLoS One

Engineering a Replication-Competent, Propagation-Defective Middle East Respiratory Syndrome Coronavirus as a Vaccine Candidate

(2013) F. Almazan et al.   mBio

A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease

(2012) Rachel L Graham et al.   NATURE MEDICINE

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-related increases in PGD2 expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice

(2011) Jincun Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Fully Human Monoclonal Antibody Directed to Proteolytic Cleavage Site in Severe Acute Respiratory Syndrome (SARS) Coronavirus S Protein Neutralizes the Virus in a Rhesus Macaque SARS Model

(2011) Tohru Miyoshi-Akiyama et al.   JOURNAL OF INFECTIOUS DISEASES

Molecular Determinants of Severe Acute Respiratory Syndrome Coronavirus Pathogenesis and Virulence in Young and Aged Mouse Models of Human Disease

(2011) M. Frieman et al.   JOURNAL OF VIROLOGY

A Double-Inactivated Severe Acute Respiratory Syndrome Coronavirus Vaccine Provides Incomplete Protection in Mice and Induces Increased Eosinophilic Proinflammatory Pulmonary Response upon Challenge

(2011) M. Bolles et al.   JOURNAL OF VIROLOGY

Epithelial Cells Lining Salivary Gland Ducts Are Early Target Cells of Severe Acute Respiratory Syndrome Coronavirus Infection in the Upper Respiratory Tracts of Rhesus Macaques

(2011) L. Liu et al.   JOURNAL OF VIROLOGY

Effects of respiratory syncytial virus infection and major basic protein derived from eosinophils in pulmonary alveolar epithelial cells (A549)

(2010) Taisei Ishioka et al.   CELL BIOLOGY INTERNATIONAL

T Cell Responses Are Required for Protection from Clinical Disease and for Virus Clearance in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice

(2010) J. Zhao et al.   JOURNAL OF VIROLOGY

Procyanidins and butanol extract of Cinnamomi Cortex inhibit SARS-CoV infection

(2009) Min Zhuang et al.   ANTIVIRAL RESEARCH

SARS vaccines: where are we?

(2009) Rachel L Roper et al.   Expert Review of Vaccines

The spike protein of SARS-CoV — a target for vaccine and therapeutic development

(2009) Lanying Du et al.   NATURE REVIEWS MICROBIOLOGY

Evasion by Stealth: Inefficient Immune Activation Underlies Poor T Cell Response and Severe Disease in SARS-CoV-Infected Mice

(2009) Jincun Zhao et al.   PLoS Pathogens

Severe acute respiratory syndrome vaccine efficacy in ferrets: whole killed virus and adenovirus-vectored vaccines

(2008) R. H. See et al.   JOURNAL OF GENERAL VIROLOGY

Structural Basis for Potent Cross-Neutralizing Human Monoclonal Antibody Protection against Lethal Human and Zoonotic Severe Acute Respiratory Syndrome Coronavirus Challenge

(2008) B. Rockx et al.   JOURNAL OF VIROLOGY

Engineering attenuated virus vaccines by controlling replication fidelity

(2008) Marco Vignuzzi et al.   NATURE MEDICINE

Pathology of Experimental SARS Coronavirus Infection in Cats and Ferrets

(2008) J. M. A. van den Brand et al.   VETERINARY PATHOLOGY

An immunosuppressed Syrian golden hamster model for SARS-CoV infection

(2008) Scott R. Schaecher et al.   VIROLOGY

Rhesus angiotensin converting enzyme 2 supports entry of severe acute respiratory syndrome coronavirus in Chinese macaques

(2008) Yunxin Chen et al.   VIROLOGY

MyD88 Is Required for Protection from Lethal Infection with a Mouse-Adapted SARS-CoV

(2008) Timothy Sheahan et al.   PLoS Pathogens

Pathogenetic mechanisms of severe acute respiratory syndrome

(2007) Yong Guo et al.   VIRUS RESEARCH

Vaccines to prevent severe acute respiratory syndrome coronavirus-induced disease

(2007) Luis Enjuanes et al.   VIRUS RESEARCH