Vaccines for emerging infectious diseases: Lessons from MERS coronavirus and Zika virus

Adaptive Immune Responses to Zika Virus Are Important for Controlling Virus Infection and Preventing Infection in Brain and Testes

(2017) Clayton W. Winkler et al.   JOURNAL OF IMMUNOLOGY

Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ça Suffit!)

(2017) Ana Maria Henao-Restrepo et al.   LANCET

Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination

(2017) Norbert Pardi et al.   NATURE

A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models

(2017) Chao Shan et al.   NATURE MEDICINE

Zika Virus Infection and Associated Neurologic Disorders in Brazil

(2017) Wanderson K. de Oliveira et al.   NEW ENGLAND JOURNAL OF MEDICINE

Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity

(2017) Susana V. Bardina et al.   SCIENCE

MERS-CoV spike nanoparticles protect mice from MERS-CoV infection

(2017) Christopher M. Coleman et al.   VACCINE

Vaccine development for emerging virulent infectious diseases

(2017) Joel N. Maslow   VACCINE

DNA vaccine encoding Middle East respiratory syndrome coronavirus S1 protein induces protective immune responses in mice

(2017) Hang Chi et al.   VACCINE

Viral and serological kinetics in Zika virus-infected patients in South Korea

(2017) Young Eui Jeong et al.   Virology Journal

Immunogenicity of Candidate MERS-CoV DNA Vaccines Based on the Spike Protein

(2017) Sawsan S. Al-amri et al.   Scientific Reports

Zika Virus Antagonizes Type I Interferon Responses during Infection of Human Dendritic Cells

(2017) James R. Bowen et al.   PLoS Pathogens

Vertical Transmission of Zika Virus in Aedes aegypti Mosquitoes

(2016) Saravanan Thangamani et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling

(2016) Alesha Grant et al.   Cell Host & Microbe

Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy

(2016) Qiming Liang et al.   Cell Stem Cell

Zika Virus: Implications for Public Health

(2016) Daniele Focosi et al.   CLINICAL INFECTIOUS DISEASES

Congenital cerebral malformations and dysfunction in fetuses and newborns following the 2013 to 2014 Zika virus epidemic in French Polynesia

(2016) Marianne Besnard et al.   Eurosurveillance

High specificity of a novel Zika virus ELISA in European patients after exposure to different flaviviruses

(2016) Daniela Huzly et al.   Eurosurveillance

Viral load kinetics of Zika virus in plasma, urine and saliva in a couple returning from Martinique, French West Indies

(2016) Camille Fourcade et al.   JOURNAL OF CLINICAL VIROLOGY

Characterization of dengue virus infections in a sample of patients suggests unique clinical, immunological, and virological profiles that impact on the diagnosis of dengue and dengue hemorrhagic fever

(2016) Thamarasi Senaratne et al.   JOURNAL OF MEDICAL VIROLOGY

Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study

(2016) Van-Mai Cao-Lormeau et al.   LANCET

Structural basis of potent Zika–dengue virus antibody cross-neutralization

(2016) Giovanna Barba-Spaeth et al.   NATURE

Vaccine protection against Zika virus from Brazil

(2016) Rafael A. Larocca et al.   NATURE

Zika virus infection damages the testes in mice

(2016) Jennifer Govero et al.   NATURE

Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus

(2016) Wanwisa Dejnirattisai et al.   NATURE IMMUNOLOGY

A roadmap for MERS-CoV research and product development: report from a World Health Organization consultation

(2016) Kayvon Modjarrad et al.   NATURE MEDICINE

Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate

(2016) Kristina M Adams Waldorf et al.   NATURE MEDICINE

Prolonged Shedding of Zika Virus Associated with Congenital Infection

(2016) Danielle B.L. Oliveira et al.   NEW ENGLAND JOURNAL OF MEDICINE

Zika Virus Infection in Pregnant Women in Rio de Janeiro

(2016) Patrícia Brasil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Zika Virus and the Guillain–Barré Syndrome — Case Series from Seven Countries

(2016) Thais dos Santos et al.   NEW ENGLAND JOURNAL OF MEDICINE

Zika Virus Associated with Meningoencephalitis

(2016) Guillaume Carteaux et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prolonged Detection of Zika Virus RNA in Pregnant Women

(2016) Dana Meaney-Delman et al.   OBSTETRICS AND GYNECOLOGY

Rapid development of a DNA vaccine for Zika virus

(2016) K. A. Dowd et al.   SCIENCE

Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys

(2016) P. Abbink et al.   SCIENCE

Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection

(2016) K. Stettler et al.   SCIENCE

Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines

(2016) Lanying Du et al.   Nature Communications

A theoretical estimate of the risk of microcephaly during pregnancy with Zika virus infection

(2016) Hiroshi Nishiura et al.   Epidemics

Differential Susceptibilities of Aedes aegypti and Aedes albopictus from the Americas to Zika Virus

(2016) Thais Chouin-Carneiro et al.   PLoS Neglected Tropical Diseases

Rapid Detection Strategies for the Global Threat of Zika Virus: Current State, New Hypotheses, and Limitations

(2016) Shruti Shukla et al.   Frontiers in Microbiology

Comparison of Test Results for Zika Virus RNA in Urine, Serum, and Saliva Specimens from Persons with Travel-Associated Zika Virus Disease — Florida, 2016

(2016) Andrea M. Bingham et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Hearing Loss in Infants with Microcephaly and Evidence of Congenital Zika Virus Infection — Brazil, November 2015–May 2016

(2016) Mariana C. Leal et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Likely Sexual Transmission of Zika Virus from a Man with No Symptoms of Infection — Maryland, 2016

(2016) Richard B. Brooks et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Preventative Vaccines for Zika Virus Outbreak: Preliminary Evaluation

(2016) Eun Kim et al.   EBioMedicine

Pushing Forward With Zika Vaccines

(2016) Richard B. Kennedy   EBioMedicine

In vivo protection against ZIKV infection and pathogenesis through passive antibody transfer and active immunisation with a prMEnv DNA vaccine

(2016) Karuppiah Muthumani et al.   npj Vaccines

Animal models of Middle East respiratory syndrome coronavirus infection

(2015) Neeltje van Doremalen et al.   ANTIVIRAL RESEARCH

Viral Shedding and Antibody Response in 37 Patients With Middle East Respiratory Syndrome Coronavirus Infection

(2015) Victor M. Corman et al.   CLINICAL INFECTIOUS DISEASES

Detection of Zika virus in saliva

(2015) Didier Musso et al.   JOURNAL OF CLINICAL VIROLOGY

Middle East Respiratory Syndrome Coronavirus Superspreading Event Involving 81 Persons, Korea 2015

(2015) Myoung-don Oh et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Characterization and Demonstration of the Value of a Lethal Mouse Model of Middle East Respiratory Syndrome Coronavirus Infection and Disease

(2015) Xinrong Tao et al.   JOURNAL OF VIROLOGY

A Highly Immunogenic and Protective Middle East Respiratory Syndrome Coronavirus Vaccine Based on a Recombinant Measles Virus Vaccine Platform

(2015) Anna H. Malczyk et al.   JOURNAL OF VIROLOGY

Protective Efficacy of Recombinant Modified Vaccinia Virus Ankara Delivering Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein

(2015) Asisa Volz et al.   JOURNAL OF VIROLOGY

Generation of a Transgenic Mouse Model of Middle East Respiratory Syndrome Coronavirus Infection and Disease

(2015) Anurodh Shankar Agrawal et al.   JOURNAL OF VIROLOGY

Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection

(2015) Kristen E. Pascal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A synthetic consensus anti–spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates

(2015) Karuppiah Muthumani et al.   Science Translational Medicine

Zika: another sexually transmitted infection?

(2015) Andrés M Patiño-Barbosa et al.   SEXUALLY TRANSMITTED INFECTIONS

Dromedary Camels and the Transmission of Middle East Respiratory Syndrome Coronavirus (MERS-CoV)

(2015) M. G. Hemida et al.   Transboundary and Emerging Diseases

Intratracheal exposure of common marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/2012 isolates does not result in lethal disease

(2015) Reed F. Johnson et al.   VIROLOGY

Prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Abu Dhabi Emirate, United Arab Emirates

(2015) Mohammed F. Yusof et al.   VIRUS GENES

Receptor-binding domain-based subunit vaccines against MERS-CoV

(2015) Naru Zhang et al.   VIRUS RESEARCH

Evaluation of candidate vaccine approaches for MERS-CoV

(2015) Lingshu Wang et al.   Nature Communications

Multi-Organ Damage in Human Dipeptidyl Peptidase 4 Transgenic Mice Infected with Middle East Respiratory Syndrome-Coronavirus

(2015) Guangyu Zhao et al.   PLoS One

Clinical Course and Outcomes of Critically Ill Patients With Middle East Respiratory Syndrome Coronavirus Infection

(2014) Yaseen M. Arabi et al.   ANNALS OF INTERNAL MEDICINE

Bat Origins of MERS-CoV Supported by Bat Coronavirus HKU4 Usage of Human Receptor CD26

(2014) Qihui Wang et al.   Cell Host & Microbe

Rapid spread of emerging Zika virus in the Pacific area

(2014) D. Musso et al.   CLINICAL MICROBIOLOGY AND INFECTION

Evidence of perinatal transmission of Zika virus, French Polynesia, December 2013 and February 2014

(2014) M Besnard et al.   Eurosurveillance

Zika virus infection complicated by Guillain-Barré syndrome – case report, French Polynesia, December 2013

(2014) E Oehler et al.   Eurosurveillance

Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012

(2014) Ziad A. Memish et al.   Influenza and Other Respiratory Viruses

Virus-Specific Memory CD8 T Cells Provide Substantial Protection from Lethal Severe Acute Respiratory Syndrome Coronavirus Infection

(2014) R. Channappanavar et al.   JOURNAL OF VIROLOGY

Host Species Restriction of Middle East Respiratory Syndrome Coronavirus through Its Receptor, Dipeptidyl Peptidase 4

(2014) N. van Doremalen et al.   JOURNAL OF VIROLOGY

Receptor Variation and Susceptibility to Middle East Respiratory Syndrome Coronavirus Infection

(2014) A. Barlan et al.   JOURNAL OF VIROLOGY

Transmission of MERS-Coronavirus in Household Contacts

(2014) Christian Drosten et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evidence for Camel-to-Human Transmission of MERS Coronavirus

(2014) Esam I. Azhar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evidence for Camel-to-Human Transmission of MERS Coronavirus

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

Zika Virus Emergence in Mosquitoes in Southeastern Senegal, 2011

(2014) Diawo Diallo et al.   PLoS One

Tailoring Subunit Vaccine Immunity with Adjuvant Combinations and Delivery Routes Using the Middle East Respiratory Coronavirus (MERS-CoV) Receptor-Binding Domain as an Antigen

(2014) Jiaming Lan et al.   PLoS One

Receptor usage and cell entry of bat coronavirus HKU4 provide insight into bat-to-human transmission of MERS coronavirus

(2014) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunogenicity of an adenoviral-based Middle East Respiratory Syndrome coronavirus vaccine in BALB/c mice

(2014) Eun Kim et al.   VACCINE

Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice

(2014) Christopher M. Coleman et al.   VACCINE

Spread, Circulation, and Evolution of the Middle East Respiratory Syndrome Coronavirus

(2014) M. Cotten et al.   mBio

Aedes hensilli as a Potential Vector of Chikungunya and Zika Viruses

(2014) Jeremy P. Ledermann et al.   PLoS Neglected Tropical Diseases

Infection with MERS-CoV Causes Lethal Pneumonia in the Common Marmoset

(2014) Darryl Falzarano et al.   PLoS Pathogens

A Shorter Time Interval Between First and Second Dengue Infections Is Associated With Protection From Clinical Illness in a School-based Cohort in Thailand

(2013) Kathryn B. Anderson et al.   JOURNAL OF INFECTIOUS DISEASES

Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission

(2013) Benoit Guery et al.   LANCET

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

(2013) V. Stalin Raj et al.   NATURE

Hospital Outbreak of Middle East Respiratory Syndrome Coronavirus

(2013) Abdullah Assiri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hospital-Associated Middle East Respiratory Syndrome Coronavirus Infections

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in Humans

(2012) S. van Boheemen et al.   mBio

Lack of Peripheral Memory B Cell Responses in Recovered Patients with Severe Acute Respiratory Syndrome: A Six-Year Follow-Up Study

(2011) F. Tang et al.   JOURNAL OF IMMUNOLOGY

A Double-Inactivated Severe Acute Respiratory Syndrome Coronavirus Vaccine Provides Incomplete Protection in Mice and Induces Increased Eosinophilic Proinflammatory Pulmonary Response upon Challenge

(2011) M. Bolles et al.   JOURNAL OF VIROLOGY

T Cell Responses Are Required for Protection from Clinical Disease and for Virus Clearance in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice

(2010) J. Zhao et al.   JOURNAL OF VIROLOGY

Zika Virus Outbreak on Yap Island, Federated States of Micronesia

(2009) Mark R. Duffy et al.   NEW ENGLAND JOURNAL OF MEDICINE