Ready, Set, Fuse! The Coronavirus Spike Protein and Acquisition of Fusion Competence

Mechanisms of Host Receptor Adaptation by Severe Acute Respiratory Syndrome Coronavirus

(2012) Kailang Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane-Anchored Serine Proteases in Vertebrate Cell and Developmental Biology

(2011) Roman Szabo et al.   Annual Review of Cell and Developmental Biology

Fully Human Monoclonal Antibody Directed to Proteolytic Cleavage Site in Severe Acute Respiratory Syndrome (SARS) Coronavirus S Protein Neutralizes the Virus in a Rhesus Macaque SARS Model

(2011) Tohru Miyoshi-Akiyama et al.   JOURNAL OF INFECTIOUS DISEASES

Cleavage and Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by Human Airway Trypsin-Like Protease

(2011) S. Bertram et al.   JOURNAL OF VIROLOGY

Anti-Severe Acute Respiratory Syndrome Coronavirus Spike Antibodies Trigger Infection of Human Immune Cells via a pH- and Cysteine Protease-Independent Fc R Pathway

(2011) M. Jaume et al.   JOURNAL OF VIROLOGY

Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response

(2011) I. Glowacka et al.   JOURNAL OF VIROLOGY

A Virus-Binding Hot Spot on Human Angiotensin-Converting Enzyme 2 Is Critical for Binding of Two Different Coronaviruses

(2011) K. Wu et al.   JOURNAL OF VIROLOGY

Structure and function of the complete internal fusion loop from Ebolavirus glycoprotein 2

(2011) S. M. Gregory et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of mouse coronavirus receptor-binding domain complexed with its murine receptor

(2011) G. Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subcellular location and topology of severe acute respiratory syndrome coronavirus envelope protein

(2011) Jose L. Nieto-Torres et al.   VIROLOGY

Inhibition of lung serine proteases in mice: a potentially new approach to control influenza infection

(2011) Mahmoud M Bahgat et al.   Virology Journal

A Single Asparagine-Linked Glycosylation Site of the Severe Acute Respiratory Syndrome Coronavirus Spike Glycoprotein Facilitates Inhibition by Mannose-Binding Lectin through Multiple Mechanisms

(2010) Y. Zhou et al.   JOURNAL OF VIROLOGY

A Transmembrane Serine Protease Is Linked to the Severe Acute Respiratory Syndrome Coronavirus Receptor and Activates Virus Entry

(2010) A. Shulla et al.   JOURNAL OF VIROLOGY

Efficient Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by the Transmembrane Protease TMPRSS2

(2010) S. Matsuyama et al.   JOURNAL OF VIROLOGY

The Hydrophobic Domain of Infectious Bronchitis Virus E Protein Alters the Host Secretory Pathway and Is Important for Release of Infectious Virus

(2010) T. R. Ruch et al.   JOURNAL OF VIROLOGY

Cleavage of Influenza Virus Hemagglutinin by Airway Proteases TMPRSS2 and HAT Differs in Subcellular Localization and Susceptibility to Protease Inhibitors

(2010) E. Bottcher-Friebertshauser et al.   JOURNAL OF VIROLOGY

Inhibition of Influenza Virus Infection in Human Airway Cell Cultures by an Antisense Peptide-Conjugated Morpholino Oligomer Targeting the Hemagglutinin-Activating Protease TMPRSS2

(2010) E. Bottcher-Friebertshauser et al.   JOURNAL OF VIROLOGY

Novel Type II Transmembrane Serine Proteases, MSPL and TMPRSS13, Proteolytically Activate Membrane Fusion Activity of the Hemagglutinin of Highly Pathogenic Avian Influenza Viruses and Induce Their Multicycle Replication

(2010) Y. Okumura et al.   JOURNAL OF VIROLOGY

A Small-Molecule Oxocarbazate Inhibitor of Human Cathepsin L Blocks Severe Acute Respiratory Syndrome and Ebola Pseudotype Virus Infection into Human Embryonic Kidney 293T cells

(2010) P. P. Shah et al.   MOLECULAR PHARMACOLOGY

Pathogenesis of neurotropic murine coronavirus is multifactorial

(2010) Judith M. Phillips et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

HIV Enters Cells via Endocytosis and Dynamin-Dependent Fusion with Endosomes

(2009) Kosuke Miyauchi et al.   CELL

Role of Spike Protein Endodomains in Regulating Coronavirus Entry

(2009) Ana Shulla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two-Step Conformational Changes in a Coronavirus Envelope Glycoprotein Mediated by Receptor Binding and Proteolysis

(2009) S. Matsuyama et al.   JOURNAL OF VIROLOGY

Broad-Spectrum In Vitro Activity and In Vivo Efficacy of the Antiviral Protein Griffithsin against Emerging Viruses of the Family Coronaviridae

(2009) B. R. O'Keefe et al.   JOURNAL OF VIROLOGY

Proteolytic Activation of the 1918 Influenza Virus Hemagglutinin

(2009) C. Chaipan et al.   JOURNAL OF VIROLOGY

Proteolytic Activation of the Spike Protein at a Novel RRRR/S Motif Is Implicated in Furin-Dependent Entry, Syncytium Formation, and Infectivity of Coronavirus Infectious Bronchitis Virus in Cultured Cells

(2009) Y. Yamada et al.   JOURNAL OF VIROLOGY

Characterization of a Highly Conserved Domain within the Severe Acute Respiratory Syndrome Coronavirus Spike Protein S2 Domain with Characteristics of a Viral Fusion Peptide

(2009) I. G. Madu et al.   JOURNAL OF VIROLOGY

The spike protein of SARS-CoV — a target for vaccine and therapeutic development

(2009) Lanying Du et al.   NATURE REVIEWS MICROBIOLOGY

Cleavage of the SARS Coronavirus Spike Glycoprotein by Airway Proteases Enhances Virus Entry into Human Bronchial Epithelial Cells In Vitro

(2009) Yiu-Wing Kam et al.   PLoS One

Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor

(2009) K. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites

(2009) S. Belouzard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a minimal peptide derived from heptad repeat (HR) 2 of spike protein of SARS-CoV and combination of HR1-derived peptides as fusion inhibitors

(2008) I-Jung Liu et al.   ANTIVIRAL RESEARCH

Importance of SARS-CoV spike protein Trp-rich region in viral infectivity

(2008) Yanning Lu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of the Prefusion and Transition States of Severe Acute Respiratory Syndrome Coronavirus S2-HR2†

(2008) Susanna McReynolds et al.   BIOCHEMISTRY

SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway

(2008) Hongliang Wang et al.   CELL RESEARCH

Clathrin- and caveolae-independent entry of feline infectious peritonitis virus in monocytes depends on dynamin

(2008) E. Van Hamme et al.   JOURNAL OF GENERAL VIROLOGY

Entry from the Cell Surface of Severe Acute Respiratory Syndrome Coronavirus with Cleaved S Protein as Revealed by Pseudotype Virus Bearing Cleaved S Protein

(2008) R. Watanabe et al.   JOURNAL OF VIROLOGY

Cathepsin L Functionally Cleaves the Severe Acute Respiratory Syndrome Coronavirus Class I Fusion Protein Upstream of Rather than Adjacent to the Fusion Peptide

(2008) B. J. Bosch et al.   JOURNAL OF VIROLOGY

Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice

(2008) M. M. Becker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA