Cell surface glycosaminoglycans exacerbate plasma membrane perturbation induced by the islet amyloid polypeptide

Cofactor-mediated amyloidogenesis

(2019) Jillian Madine   BIOSCIENCE REPORTS

Glycosaminoglycans Induce Amyloid Self-Assembly of a Peptide Hormone by Concerted Secondary and Quaternary Conformational Transitions

(2019) Mathew Sebastiao et al.   BIOCHEMISTRY

Identification of a hinge residue controlling islet amyloid polypeptide self-assembly and cytotoxicity

(2019) Elizabeth Godin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetic and Conformational Insights into Islet Amyloid Polypeptide Self-Assembly Using a Biarsenical Fluorogenic Probe

(2018) Noé Quittot et al.   BIOCONJUGATE CHEMISTRY

The role of heparan sulfates in protein aggregation and their potential impact on neurodegeneration

(2018) Auriane Maïza et al.   FEBS LETTERS

RAGE binds preamyloid IAPP intermediates and mediates pancreatic β cell proteotoxicity

(2018) Andisheh Abedini et al.   JOURNAL OF CLINICAL INVESTIGATION

Conformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid

(2018) Melissa Birol et al.   Nature Communications

Neuroprotective Activities of Heparin, Heparinase III, and Hyaluronic Acid on the Aβ42-Treated Forebrain Spheroids Derived from Human Stem Cells

(2018) Julie Bejoy et al.   ACS Biomaterials-Science & Engineering

Neuroprotective Activities of Heparin, Heparinase III, and Hyaluronic Acid on the Aβ42-Treated Forebrain Spheroids Derived from Human Stem Cells

(2018) Julie Bejoy et al.   ACS Biomaterials Science & Engineering

Cell surface proteoglycan-mediated uptake and accumulation of the Alzheimer's disease peptide Aβ(1–42)

(2018) Emelie Wesén et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism

(2017) Abhisek Mukherjee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The β-cell assassin: IAPP cytotoxicity

(2017) Daniel Raleigh et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity

(2017) Pascal Krotee et al.   eLife

Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type

(2017) Elisabet Ihse et al.   Scientific Reports

Extracellular matrix structure

(2016) Achilleas D. Theocharis et al.   ADVANCED DRUG DELIVERY REVIEWS

Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics

(2016) Andisheh Abedini et al.   eLife

Molecular Structure, Membrane Interactions, and Toxicity of the Islet Amyloid Polypeptide in Type 2 Diabetes Mellitus

(2016) Lucie Caillon et al.   Journal of Diabetes Research

Amyloid Formation in Human Islets Is Enhanced by Heparin and Inhibited by Heparinase

(2015) K. J. Potter et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Heparan Sulfate Proteoglycans Are Important for Islet Amyloid Formation and Islet Amyloid Polypeptide-induced Apoptosis

(2015) Marie E. Oskarsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fiber-Dependent and -Independent Toxicity of Islet Amyloid Polypeptide

(2014) Diana E. Schlamadinger et al.   BIOPHYSICAL JOURNAL

Amyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetes

(2014) Jinyoung Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Human IAPP–induced pancreatic β cell toxicity and its regulation by autophagy

(2014) Nayumi Shigihara et al.   JOURNAL OF CLINICAL INVESTIGATION

New insights into the roles of sulfated glycosaminoglycans in islet amyloid polypeptide amyloidogenesis and cytotoxicity

(2013) Carole Anne De Carufel et al.   BIOPOLYMERS

Mechanisms of islet amyloidosis toxicity in type 2 diabetes

(2013) Andisheh Abedini et al.   FEBS LETTERS

Distinct Internalization Pathways of Human Amylin Monomers and Its Cytotoxic Oligomers in Pancreatic Cells

(2013) Saurabh Trikha et al.   PLoS One

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A common landscape for membrane-active peptides

(2013) Nicholas B. Last et al.   PROTEIN SCIENCE

Deletion of Fas protects islet beta cells from cytotoxic effects of human islet amyloid polypeptide

(2012) Y. J. Park et al.   DIABETOLOGIA

Amyloid Formation in Heterogeneous Environments: Islet Amyloid Polypeptide Glycosaminoglycan Interactions

(2012) Hui Wang et al.   JOURNAL OF MOLECULAR BIOLOGY

Elucidating membrane structure and protein behavior using giant plasma membrane vesicles

(2012) Erdinc Sezgin et al.   Nature Protocols

Membrane Disruption and Early Events in the Aggregation of the Diabetes Related Peptide IAPP from a Molecular Perspective

(2011) Jeffrey R. Brender et al.   ACCOUNTS OF CHEMICAL RESEARCH

β-Cell Loss and β-Cell Apoptosis in Human Type 2 Diabetes Are Related to Islet Amyloid Deposition

(2011) Catherine A. Jurgens et al.   AMERICAN JOURNAL OF PATHOLOGY

Heparin Binds 8 kDa Gelsolin Cross-β-Sheet Oligomers and Accelerates Amyloidogenesis by Hastening Fibril Extension

(2011) James P. Solomon et al.   BIOCHEMISTRY

Sulfated Glycosaminoglycans Accelerate Transthyretin Amyloidogenesis by Quaternary Structural Conversion

(2011) Steve Bourgault et al.   BIOCHEMISTRY

Glycosaminoglycans, Protein Aggregation and Neurodegeneration

(2011) Dulce Papy-Garcia et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Exendin-4 increases islet amyloid deposition but offsets the resultant beta cell toxicity in human islet amyloid polypeptide transgenic mouse islets

(2011) K. Aston-Mourney et al.   DIABETOLOGIA

Concentration-dependent transitions govern the subcellular localization of islet amyloid polypeptide

(2011) Mazin Magzoub et al.   FASEB JOURNAL

Mechanism of Amylin Fibrillization Enhancement by Heparin

(2011) Suman Jha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monitoring and Inhibition of Insulin Fibrillation by a Small Organic Fluorogen with Aggregation-Induced Emission Characteristics

(2011) Yuning Hong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective role of p62-positive cytoplasmic inclusions

(2010) J F Rivera et al.   CELL DEATH AND DIFFERENTIATION

Comparison of aggregation enhancement and inhibition as strategies for reducing the cytotoxicity of the aortic amyloid polypeptide medin

(2010) Jillian Madine et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Heparan sulfate mediates amyloid-beta internalization and cytotoxicity

(2010) Elina Sandwall et al.   GLYCOBIOLOGY

Thioflavine T interaction with synthetic Alzheimer's disease β-amyloid peptides: Detection of amyloid aggregation in solution

(2010) Harry Levine   PROTEIN SCIENCE

Requirements for Receptor Engagement during Infection by Adenovirus Complexed with Blood Coagulation Factor X

(2010) Angela C. Bradshaw et al.   PLoS Pathogens

Evidence for Proteotoxicity in β Cells in Type 2 Diabetes

(2009) Tatyana Gurlo et al.   AMERICAN JOURNAL OF PATHOLOGY

Membrane permeabilization by Islet Amyloid Polypeptide

(2009) Maarten F.M. Engel   CHEMISTRY AND PHYSICS OF LIPIDS

Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress

(2009) R. L. Hull et al.   DIABETOLOGIA

Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer Hypothesis

(2008) Leena Haataja et al.   ENDOCRINE REVIEWS

Extrinsic Fluorescent Dyes as Tools for Protein Characterization

(2008) Andrea Hawe et al.   PHARMACEUTICAL RESEARCH

Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane

(2008) M. F. M. Engel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA