Identification of a hinge residue controlling islet amyloid polypeptide self-assembly and cytotoxicity

Site-specific detection of protein secondary structure using 2D IR dihedral indexing: a proposed assembly mechanism of oligomeric hIAPP

(2018) Michał Maj et al.   Chemical Science

Conformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid

(2018) Melissa Birol et al.   Nature Communications

The β-cell assassin: IAPP cytotoxicity

(2017) Daniel Raleigh et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

A Free Energy Barrier Caused by the Refolding of an Oligomeric Intermediate Controls the Lag Time of Amyloid Formation by hIAPP

(2017) Arnaldo L. Serrano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate

(2017) Diana C Rodriguez Camargo et al.   eLife

Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity

(2017) Pascal Krotee et al.   eLife

Proline and lysine residues provide modulatory switches in amyloid formation: Insights from prion protein

(2016) Allison Kraus   Prion

Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics

(2016) Andisheh Abedini et al.   eLife

Delineating the Role of Helical Intermediates in Natively Unfolded Polypeptide Amyloid Assembly and Cytotoxicity

(2015) Carole Anne De Carufel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Monitoring C-Peptide Storage and Secretion in Islet β-Cells In Vitro and In Vivo

(2015) Shuaishuai Zhu et al.   DIABETES

Probing the Sources of the Apparent Irreproducibility of Amyloid Formation: Drastic Changes in Kinetics and a Switch in Mechanism Due to Micellelike Oligomer Formation at Critical Concentrations of IAPP

(2015) Jeffrey R. Brender et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Mechanistic Contributions of Biological Cofactors in Islet Amyloid Polypeptide Amyloidogenesis

(2015) Phuong Trang Nguyen et al.   Journal of Diabetes Research

Toxicity of Protein Oligomers Is Rationalized by a Function Combining Size and Surface Hydrophobicity

(2014) Benedetta Mannini et al.   ACS Chemical Biology

The Role of Stable α-Synuclein Oligomers in the Molecular Events Underlying Amyloid Formation

(2014) Nikolai Lorenzen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

New insights into the roles of sulfated glycosaminoglycans in islet amyloid polypeptide amyloidogenesis and cytotoxicity

(2013) Carole Anne De Carufel et al.   BIOPOLYMERS

Islet amyloid: From fundamental biophysics to mechanisms of cytotoxicity

(2013) Ping Cao et al.   FEBS LETTERS

Mechanisms of islet amyloidosis toxicity in type 2 diabetes

(2013) Andisheh Abedini et al.   FEBS LETTERS

Ion Mobility Spectrometry–Mass Spectrometry Defines the Oligomeric Intermediates in Amylin Amyloid Formation and the Mode of Action of Inhibitors

(2013) Lydia M. Young et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient  -sheet

(2013) L. E. Buchanan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Islet amyloid polypeptide toxicity and membrane interactions

(2013) P. Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Aromatic Interactions in Amyloid Formation by Islet Amyloid Polypeptide

(2012) Ling-Hsien Tu et al.   BIOCHEMISTRY

Membrane Disruption and Early Events in the Aggregation of the Diabetes Related Peptide IAPP from a Molecular Perspective

(2011) Jeffrey R. Brender et al.   ACCOUNTS OF CHEMICAL RESEARCH

Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment

(2011) Ravi Prakash Reddy Nanga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Fibril Structure of Human Islet Amyloid Polypeptide

(2011) Sahar Bedrood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

Role of amino acid hydrophobicity, aromaticity, and molecular volume on IAPP(20-29) amyloid self-assembly

(2011) Todd M. Doran et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Selection for Nonamyloidogenic Mutants of Islet Amyloid Polypeptide (IAPP) Identifies an Extended Region for Amyloidogenicity

(2010) Ayano Fox et al.   BIOCHEMISTRY

The Interplay of Catalysis and Toxicity by Amyloid Intermediates on Lipid Bilayers: Insights from Type II Diabetes

(2009) James A. Hebda et al.   Annual Review of Biophysics

Dynamic α-Helix Structure of Micelle-bound Human Amylin

(2009) Sharadrao M. Patil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular and Conformational Determinants of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) for Activation of the PAC1 Receptor

(2009) Steve Bourgault et al.   JOURNAL OF MEDICINAL CHEMISTRY

Helix Stabilization Precedes Aqueous and Bilayer-Catalyzed Fiber Formation in Islet Amyloid Polypeptide

(2009) Jessica A. Williamson et al.   JOURNAL OF MOLECULAR BIOLOGY

A critical assessment of the role of helical intermediates in amyloid formation by natively unfolded proteins and polypeptides

(2009) A. Abedini et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Structures of Rat and Human Islet Amyloid Polypeptide IAPP1−19in Micelles by NMR Spectroscopy†

(2008) Ravi Prakash Reddy Nanga et al.   BIOCHEMISTRY

Amyloid Fiber Formation and Membrane Disruption are Separate Processes Localized in Two Distinct Regions of IAPP, the Type-2-Diabetes-Related Peptide

(2008) Jeffrey R. Brender et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amide inequivalence in the fibrillar assembly of islet amyloid polypeptide

(2008) Bon W. Koo et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Contribution of the intrinsic disulfide to the assembly mechanism of islet amyloid

(2004) Bon W. Koo et al.   PROTEIN SCIENCE