Molecular Structure, Membrane Interactions, and Toxicity of the Islet Amyloid Polypeptide in Type 2 Diabetes Mellitus

Inhibition of islet amyloid polypeptide fibril formation by selenium-containing phycocyanin and prevention of beta cell apoptosis

(2014) Xiaoling Li et al.   BIOMATERIALS

Defining the Molecular Basis of Amyloid Inhibitors: Human Islet Amyloid Polypeptide–Insulin Interactions

(2014) Anna C. Susa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evaluation of membrane models and their composition for islet amyloid polypeptide-membrane aggregation

(2013) Lucie Caillon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Macromolecular Crowding as a Suppressor of Human IAPP Fibril Formation and Cytotoxicity

(2013) Janine Seeliger et al.   PLoS One

Binding of Islet Amyloid Polypeptide to Supported Lipid Bilayers and Amyloid Aggregation at the Membranes

(2012) Kenji Sasahara et al.   BIOCHEMISTRY

Phosphatidylethanolamine Enhances Amyloid Fiber-Dependent Membrane Fragmentation

(2012) Michele F. M. Sciacca et al.   BIOCHEMISTRY

Ionic Strength Effects on Amyloid Formation by Amylin Are a Complicated Interplay among Debye Screening, Ion Selectivity, and Hofmeister Effects

(2012) Peter J. Marek et al.   BIOCHEMISTRY

Role of Aromatic Interactions in Amyloid Formation by Islet Amyloid Polypeptide

(2012) Ling-Hsien Tu et al.   BIOCHEMISTRY

Deletion of Fas protects islet beta cells from cytotoxic effects of human islet amyloid polypeptide

(2012) Y. J. Park et al.   DIABETOLOGIA

Structural Properties of EGCG-Induced, Nontoxic Alzheimer's Disease Aβ Oligomers

(2012) Juan Miguel Lopez del Amo et al.   JOURNAL OF MOLECULAR BIOLOGY

The Polyphenol EGCG Inhibits Amyloid Formation Less Efficiently at Phospholipid Interfaces than in Bulk Solution

(2012) Maarten F. M. Engel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Morin hydrate inhibits amyloid formation by islet amyloid polypeptide and disaggregates amyloid fibers

(2012) Harris Noor et al.   PROTEIN SCIENCE

Mutations That Replace Aromatic Side Chains Promote Aggregation of the Alzheimer’s Aβ Peptide

(2011) Anne H. Armstrong et al.   BIOCHEMISTRY

Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment

(2011) Ravi Prakash Reddy Nanga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A mechanistic approach for islet amyloid polypeptide aggregation to develop anti-amyloidogenic agents for type-2 diabetes

(2011) Ejaz Ahmad et al.   BIOCHIMIE

cJUN N-terminal kinase (JNK) activation mediates islet amyloid-induced beta cell apoptosis in cultured human islet amyloid polypeptide transgenic mouse islets

(2011) S. L. Subramanian et al.   DIABETOLOGIA

IL-1 Blockade Attenuates Islet Amyloid Polypeptide-Induced Proinflammatory Cytokine Release and Pancreatic Islet Graft Dysfunction

(2011) C. Westwell-Roper et al.   JOURNAL OF IMMUNOLOGY

Low pH Acts as Inhibitor of Membrane Damage Induced by Human Islet Amyloid Polypeptide

(2011) Lucie Khemtémourian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Probing small molecule binding to amyloid fibrils

(2011) Alexander K. Buell et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

Potent Kinetic Stabilizers That Prevent Transthyretin-Mediated Cardiomyocyte Proteotoxicity

(2011) M. M. Alhamadsheh et al.   Science Translational Medicine

The effect of curcumin on human islet amyloid polypeptide misfolding and toxicity

(2010) Marie Daval et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

The Flavanol (−)-Epigallocatechin 3-Gallate Inhibits Amyloid Formation by Islet Amyloid Polypeptide, Disaggregates Amyloid Fibrils, and Protects Cultured Cells against IAPP-Induced Toxicity

(2010) Fanling Meng et al.   BIOCHEMISTRY

The N-terminal fragment of human islet amyloid polypeptide is non-fibrillogenic in the presence of membranes and does not cause leakage of bilayers of physiologically relevant lipid composition

(2010) Lucie Khemtémourian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Suppression of IAPP fibrillation at anionic lipid membranes via IAPP-derived amyloid inhibitors and insulin

(2010) Daniel Sellin et al.   BIOPHYSICAL CHEMISTRY

Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective role of p62-positive cytoplasmic inclusions

(2010) J F Rivera et al.   CELL DEATH AND DIFFERENTIATION

Differences between amyloid toxicity in alpha and beta cells in human and mouse islets and the role of caspase-3

(2010) E. Law et al.   DIABETOLOGIA

The role of the disulfide bond in the interaction of islet amyloid polypeptide with membranes

(2010) Lucie Khemtémourian et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Aβ42 Neurotoxicity Is Mediated by Ongoing Nucleated Polymerization Process Rather than by Discrete Aβ42 Species

(2010) Asad Jan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

(2010) Jan Bieschke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired Processing of Human Pro-Islet Amyloid Polypeptide Is Not a Causative Factor for Fibril Formation or Membrane Damage in Vitro

(2009) Lucie Khemtémourian et al.   BIOCHEMISTRY

The Ability of Rodent Islet Amyloid Polypeptide To Inhibit Amyloid Formation by Human Islet Amyloid Polypeptide Has Important Implications for the Mechanism of Amyloid Formation and the Design of Inhibitors

(2009) Ping Cao et al.   BIOCHEMISTRY

Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis

(2009) S. Zraika et al.   DIABETOLOGIA

Insulin is a kinetic but not a thermodynamic inhibitor of amylin aggregation

(2009) Wei Cui et al.   FEBS Journal

Calcium-activated Calpain-2 Is a Mediator of Beta Cell Dysfunction and Apoptosis in Type 2 Diabetes

(2009) Chang-jiang Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic α-Helix Structure of Micelle-bound Human Amylin

(2009) Sharadrao M. Patil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

(−)-Epigallocatechin-3-Gallate (EGCG) Maintains κ-Casein in Its Pre-Fibrillar State without Redirecting Its Aggregation Pathway

(2009) Sean A. Hudson et al.   JOURNAL OF MOLECULAR BIOLOGY

Amylin Proprotein Processing Generates Progressively More Amyloidogenic Peptides that Initially Sample the Helical State†

(2008) Isaac T. Yonemoto et al.   BIOCHEMISTRY

Structures of Rat and Human Islet Amyloid Polypeptide IAPP1−19in Micelles by NMR Spectroscopy†

(2008) Ravi Prakash Reddy Nanga et al.   BIOCHEMISTRY

Rifampicin Does Not Prevent Amyloid Fibril Formation by Human Islet Amyloid Polypeptide but Does Inhibit Fibril Thioflavin-T Interactions: Implications for Mechanistic Studies of β-Cell Death†

(2008) Fanling Meng et al.   BIOCHEMISTRY

Recent Insights in Islet Amyloid Polypeptide-Induced Membrane Disruption and Its Role inβ-Cell Death in Type 2 Diabetes Mellitus

(2008) Lucie Khemtémourian et al.   Experimental Diabetes Research

Annular Protofibrils Are a Structurally and Functionally Distinct Type of Amyloid Oligomer

(2008) Rakez Kayed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid Aggregation on Lipid Bilayers and Its Impact on Membrane Permeability

(2008) Ran Friedman et al.   JOURNAL OF MOLECULAR BIOLOGY

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane

(2008) M. F. M. Engel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atomic structure of the cross-β spine of islet amyloid polypeptide (amylin)

(2008) Jed J.W. Wiltzius et al.   PROTEIN SCIENCE

Interaction of membrane-bound islet amyloid polypeptide with soluble and crystalline insulin

(2008) Jefferson D. Knight et al.   PROTEIN SCIENCE

Contribution of the intrinsic disulfide to the assembly mechanism of islet amyloid

(2004) Bon W. Koo et al.   PROTEIN SCIENCE