Interaction of human IAPP and Aβ1-42 aggravated the AD-related pathology and impaired the cognition in mice

Opposite changes in APP processing and human Aβ levels in rats carrying either a protective or a pathogenic APP mutation

(2020) Marc D Tambini et al.   eLife

Intramitochondrial proteostasis is directly coupled to α-synuclein and amyloid β 1-42 pathologies

(2020) Janin Lautenschläger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

(2020) Erik C. B. Johnson et al.   NATURE MEDICINE

Islet Amyloid Polypeptide: A Partner in Crime With Aβ in the Pathology of Alzheimer's Disease

(2020) Ana F. Raimundo et al.   Frontiers in Molecular Neuroscience

20(S)-protopanaxadiol promotes the migration, proliferation and differentiation of neural stem cells by targeting GSK-3β in the Wnt/GSK-3β/β-catenin pathway

(2019) Kai Li Lin et al.   Journal of Ginseng Research

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

Azadirachtin inhibits amyloid formation, disaggregates pre-formed fibrils and protects pancreatic β-cells from human islet amyloid polypeptide/amylin-induced cytotoxicity

(2019) Richa Dubey et al.   BIOCHEMICAL JOURNAL

Interplay between Alzheimer’s disease and global glucose metabolism revealed by the metabolic profile alterations of pancreatic tissue and serum in APP/PS1 transgenic mice

(2019) Xia Liu et al.   ACTA PHARMACOLOGICA SINICA

The db mutation improves memory in younger mice in a model of Alzheimer's disease

(2019) Le Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease

(2019) Tomoko Wakabayashi et al.   Molecular Neurodegeneration

Antagonistic Activity of Naphthoquinone-Based Hybrids toward Amyloids Associated with Alzheimer’s Disease and Type-2 Diabetes

(2019) Ashim Paul et al.   ACS Chemical Neuroscience

A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease

(2019) Sung Hoon Baik et al.   Cell Metabolism

Type 2 diabetes: a multifaceted disease

(2019) Ewan R. Pearson   DIABETOLOGIA

Amylin as a potential link between type 2 diabetes and alzheimer disease

(2019) Ivan Martinez‐Valbuena et al.   ANNALS OF NEUROLOGY

High-Fat Diet Increases Amylin Accumulation in the Hippocampus and Accelerates Brain Aging in hIAPP Transgenic Mice

(2019) Xiao-Xia Xi et al.   Frontiers in Aging Neuroscience

Islet Amyloid Polypeptide Promotes Amyloid-Beta Aggregation by Binding-Induced Helix-Unfolding of the Amyloidogenic Core

(2018) Xinwei Ge et al.   ACS Chemical Neuroscience

Role of microglia-neuron interactions in diabetic encephalopathy

(2018) Yuan Liu et al.   AGEING RESEARCH REVIEWS

Amyloid growth and membrane damage: Current themes and emerging perspectives from theory and experiments on Aβ and hIAPP

(2018) Michele F.M. Sciacca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A novel GLP-1/GIP/Gcg triagonist reduces cognitive deficits and pathology in the 3xTg mouse model of Alzheimer's disease

(2018) Tian Li et al.   HIPPOCAMPUS

Fluoxetine Inhibits Natural Decay of Long-Term Memory via Akt/GSK-3β Signaling

(2018) Jee Hyun Yi et al.   MOLECULAR NEUROBIOLOGY

Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications

(2018) Geert Jan Biessels et al.   Nature Reviews Endocrinology

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

(2018) Steven E. Arnold et al.   Nature Reviews Neurology

Genetically reducing mTOR signaling rescues central insulin dysregulation in a mouse model of Alzheimer's disease

(2018) Antonella Caccamo et al.   NEUROBIOLOGY OF AGING

Review: Relationship of type 2 diabetes to human brain pathology

(2018) J. J. Pruzin et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

GLP-1 receptor agonists downregulate aberrant GnT-III expression in Alzheimer's disease models through the Akt/GSK-3β/β-catenin signaling

(2018) Ying Wang et al.   NEUROPHARMACOLOGY

Data-driven modeling of mitochondrial dysfunction in Alzheimer's disease

(2018) Patrick Toglia et al.   CELL CALCIUM

Type 2 Diabetes Mellitus and Alzheimer’s Disease: Role of Insulin Signalling and Therapeutic Implications

(2018) Andrea Tumminia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondria as central regulators of neural stem cell fate and cognitive function

(2018) Mireille Khacho et al.   NATURE REVIEWS NEUROSCIENCE

Alzheimer's disease

(2017) C. A. Lane et al.   EUROPEAN JOURNAL OF NEUROLOGY

Amyloid-β and islet amyloid pathologies link Alzheimer’s disease and type 2 diabetes in a transgenic model

(2017) Nadeeja Wijesekara et al.   FASEB JOURNAL

The Link between Type 2 Diabetes and Neurodegeneration: Roles for Amyloid-β, Amylin, and Tau Proteins

(2017) Prashant Bharadwaj et al.   JOURNAL OF ALZHEIMERS DISEASE

Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors

(2017) Pascal Krotee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Islet inflammation in type 2 diabetes and physiology

(2017) Kosei Eguchi et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypothalamic stem cells control ageing speed partly through exosomal miRNAs

(2017) Yalin Zhang et al.   NATURE

Agmatine ameliorates type 2 diabetes induced-Alzheimer's disease-like alterations in high-fat diet-fed mice via reactivation of blunted insulin signalling

(2017) Somang Kang et al.   NEUROPHARMACOLOGY

Inflammation, Stem Cells, and the Aging Hypothalamus

(2017) Andrew R. Mendelsohn et al.   REJUVENATION RESEARCH

Dianxianning improved amyloid β-induced pathological characteristics partially through DAF-2/DAF-16 insulin like pathway in transgenic C. elegans

(2017) Dejuan Zhi et al.   Scientific Reports

Impaired Hippocampal Glutamate and Glutamine Metabolism in the db/db Mouse Model of Type 2 Diabetes Mellitus

(2017) Jens Velde Andersen et al.   NEURAL PLASTICITY

Nectin-3 modulates the structural plasticity of dentate granule cells and long-term memory

(2017) X-X Wang et al.   Translational Psychiatry

Molecular Understanding of Aβ-hIAPP Cross-Seeding Assemblies on Lipid Membranes

(2016) Mingzhen Zhang et al.   ACS Chemical Neuroscience

Energy metabolism and inflammation in brain aging and Alzheimer’s disease

(2016) Fei Yin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glucose Transporters in Brain: In Health and in Alzheimer’s Disease

(2016) Leszek Szablewski   JOURNAL OF ALZHEIMERS DISEASE

Dihydropyridine Derivatives Modulate Heat Shock Responses and have a Neuroprotective Effect in a Transgenic Mouse Model of Alzheimer’s Disease

(2016) Ágnes Kasza et al.   JOURNAL OF ALZHEIMERS DISEASE

Progressive Neuronal Pathology and Synaptic Loss Induced by Prediabetes and Type 2 Diabetes in a Mouse Model of Alzheimer’s Disease

(2016) Juan Jose Ramos-Rodriguez et al.   MOLECULAR NEUROBIOLOGY

Long-term central pathology and cognitive impairment are exacerbated in a mixed model of Alzheimer’s disease and type 2 diabetes

(2016) Carmen Infante-Garcia et al.   PSYCHONEUROENDOCRINOLOGY

In Vivo Seeding and Cross-Seeding of Localized Amyloidosis

(2015) Marie E. Oskarsson et al.   AMERICAN JOURNAL OF PATHOLOGY

Alzheimer's disease and type 2 diabetes-related alterations in brain mitochondria, autophagy and synaptic markers

(2015) Cristina Carvalho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Central vascular disease and exacerbated pathology in a mixed model of type 2 diabetes and Alzheimer's disease

(2015) Juan Jose Ramos-Rodriguez et al.   PSYCHONEUROENDOCRINOLOGY

Rutin inhibits amylin-induced neurocytotoxicity and oxidative stress

(2015) Xiao-Lin Yu et al.   Food & Function

Islet Amyloid Polypeptide (IAPP): A Second Amyloid in Alzheimer's Disease

(2014) Janelle Fawver et al.   Current Alzheimer Research

β-amyloid Peptides and Amyloid Plaques in Alzheimer’s Disease

(2014) Gunnar K. Gouras et al.   Neurotherapeutics

Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: Implications for diagnostic and therapeutic strategies

(2013) Zhichun Chen et al.   PROGRESS IN NEUROBIOLOGY

Thy1-hAPPLond/Swe+mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function

(2012) Mehrdad Faizi et al.   Brain and Behavior

Remodelling of biological parameters during human ageing: evidence for complex regulation in longevity and in type 2 diabetes

(2011) Liana Spazzafumo et al.   AGE

β-Amyloid protein (Aβ) and human amylin regulation of apoptotic genes occurs through the amylin receptor

(2011) Jack H. Jhamandas et al.   APOPTOSIS

Interaction between Amyloid Beta Peptide and an Aggregation Blocker Peptide Mimicking Islet Amyloid Polypeptide

(2011) Nasrollah Rezaei-Ghaleh et al.   PLoS One

Encephalopathies: the emerging diabetic complications

(2010) Anders A. F. Sima   ACTA DIABETOLOGICA

Quiescent and Active Hippocampal Neural Stem Cells with Distinct Morphologies Respond Selectively to Physiological and Pathological Stimuli and Aging

(2010) Sebastian Lugert et al.   Cell Stem Cell

Aging of the subventricular zone neural stem cell niche: evidence for quiescence-associated changes between early and mid-adulthood

(2010) M. Bouab et al.   NEUROSCIENCE

Aβ and human amylin share a common toxicity pathwayviamitochondrial dysfunction

(2010) Yun-An Lim et al.   PROTEOMICS