Durotaxis: The Hard Path from In Vitro to In Vivo

Spatial mapping of tissue properties in vivo reveals a 3D stiffness gradient in the mouse limb bud

(2020) Min Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Durotaxis

(2020) Raimon Sunyer et al.   CURRENT BIOLOGY

Electric Fields at Breast Cancer and Cancer Cell Collective Galvanotaxis

(2020) Kan Zhu et al.   Scientific Reports

Rapid Homeostatic Turnover of Embryonic ECM during Tissue Morphogenesis

(2020) Yutaka Matsubayashi et al.   DEVELOPMENTAL CELL

Magnetic Micromanipulation for In Vivo Measurement of Stiffness Heterogeneity and Anisotropy in the Mouse Mandibular Arch

(2020) Min Zhu et al.   Research

Cell Shape and Durotaxis Explained from Cell-Extracellular Matrix Forces and Focal Adhesion Dynamics

(2020) Elisabeth G. Rens et al.   iScience

Durotaxis by Human Cancer Cells

(2019) Brian J. DuChez et al.   BIOPHYSICAL JOURNAL

Rapid changes in tissue mechanics regulate cell behaviour in the developing embryonic brain

(2019) Amelia J Thompson et al.   eLife

In vivo topology converts competition for cell-matrix adhesion into directional migration

(2019) Fernanda Bajanca et al.   Nature Communications

Oscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch

(2019) Hirotaka Tao et al.   Nature Communications

Membrane Tension Orchestrates Rear Retraction in Matrix-Directed Cell Migration

(2019) Joseph H.R. Hetmanski et al.   DEVELOPMENTAL CELL

Mechanosensing during directed cell migration requires dynamic actin polymerization at focal adhesions

(2019) Julieann I. Puleo et al.   JOURNAL OF CELL BIOLOGY

Mechanisms of 3D cell migration

(2019) Kenneth M. Yamada et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stiffness Sensing in Cells and Tissues

(2019) Paul A. Janmey et al.   PHYSIOLOGICAL REVIEWS

A hybrid computational model for collective cell durotaxis

(2018) Jorge Escribano et al.   Biomechanics and Modeling in Mechanobiology

FAK controls the mechanical activation of YAP, a transcriptional regulator required for durotaxis

(2018) Dariusz Lachowski et al.   FASEB JOURNAL

Water content, not stiffness, dominates Brillouin spectroscopy measurements in hydrated materials

(2018) Pei-Jung Wu et al.   NATURE METHODS

The mechanical microenvironment regulates ovarian cancer cell morphology, migration, and spheroid disaggregation

(2018) Andrew J. McKenzie et al.   Scientific Reports

Tissue stiffening coordinates morphogenesis by triggering collective cell migration in vivo

(2018) Elias H. Barriga et al.   NATURE

A fluid-to-solid jamming transition underlies vertebrate body axis elongation

(2018) Alessandro Mongera et al.   NATURE

Curvotaxis directs cell migration through cell-scale curvature landscapes

(2018) Laurent Pieuchot et al.   Nature Communications

Supracellular contraction at the rear of neural crest cell groups drives collective chemotaxis

(2018) Adam Shellard et al.   SCIENCE

Extracellular matrix type modulates cell migration on mechanical gradients

(2017) Christopher D. Hartman et al.   EXPERIMENTAL CELL RESEARCH

Evaluating biomechanical properties of murine embryos using Brillouin microscopy and optical coherence tomography

(2017) Raksha Raghunathan et al.   JOURNAL OF BIOMEDICAL OPTICS

Enzyme-Induced Matrix Softening Regulates Hepatocarcinoma Cancer Cell Phenotypes

(2017) Youyun Liang et al.   MACROMOLECULAR BIOSCIENCE

A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion

(2017) Anna Labernadie et al.   NATURE CELL BIOLOGY

Mechanoreciprocity in cell migration

(2017) Sjoerd van Helvert et al.   NATURE CELL BIOLOGY

Persistence-Driven Durotaxis: Generic, Directed Motility in Rigidity Gradients

(2017) Elizaveta A. Novikova et al.   PHYSICAL REVIEW LETTERS

Stem cell migration and mechanotransduction on linear stiffness gradient hydrogels

(2017) William J. Hadden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shifting the optimal stiffness for cell migration

(2017) Benjamin L. Bangasser et al.   Nature Communications

Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane

(2017) Alexandros Glentis et al.   Nature Communications

Biphasic Dependence of Glioma Survival and Cell Migration on CD44 Expression Level

(2017) Rebecca L. Klank et al.   Cell Reports

Substrate Rigidity Controls Activation and Durotaxis in Pancreatic Stellate Cells

(2017) Dariusz Lachowski et al.   Scientific Reports

Strain Stiffening of Fibrillar Collagen during Individual and Collective Cell Migration Identified by AFM Nanoindentation

(2016) Sjoerd van Helvert et al.   ACS Applied Materials & Interfaces

Focal Adhesion–Independent Cell Migration

(2016) Ewa K. Paluch et al.   Annual Review of Cell and Developmental Biology

Cell migration and organization in three-dimensional in vitro culture driven by stiffness gradient

(2016) Danielle Joaquin et al.   BIOTECHNOLOGY AND BIOENGINEERING

Self-generated chemotactic gradients—cells steering themselves

(2016) Luke Tweedy et al.   CURRENT OPINION IN CELL BIOLOGY

Measuring forces and stressesin situin living tissues

(2016) Kaoru Sugimura et al.   DEVELOPMENT

Collective epithelial cell sheet adhesion and migration on polyelectrolyte multilayers with uniform and gradients of compliance

(2016) Jessica S. Martinez et al.   EXPERIMENTAL CELL RESEARCH

In vivo quantification of spatially varying mechanical properties in developing tissues

(2016) Friedhelm Serwane et al.   NATURE METHODS

Mechanosensing is critical for axon growth in the developing brain

(2016) David E Koser et al.   NATURE NEUROSCIENCE

The front and rear of collective cell migration

(2016) Roberto Mayor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Vascular smooth muscle cell durotaxis depends on extracellular matrix composition

(2016) Christopher D. Hartman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collective cell durotaxis emerges from long-range intercellular force transmission

(2016) R. Sunyer et al.   SCIENCE

CNS Cell Distribution and Axon Orientation Determine Local Spinal Cord Mechanical Properties

(2015) David E. Koser et al.   BIOPHYSICAL JOURNAL

Assessment of elasticity of colorectal cancer tissue, clinical utility, pathological and phenotypical relevance

(2015) Shingo Kawano et al.   CANCER SCIENCE

Collective Cell Motility Promotes Chemotactic Prowess and Resistance to Chemorepulsion

(2015) Gema Malet-Engra et al.   CURRENT BIOLOGY

Asymmetric cell convergence-driven zebrafish fin bud initiation and pre-pattern requires Tbx5a control of a mesenchymal Fgf signal

(2015) Q. Mao et al.   DEVELOPMENT

Anisotropic stress orients remodelling of mammalian limb bud ectoderm

(2015) Kimberly Lau et al.   NATURE CELL BIOLOGY

Integration of actin dynamics and cell adhesion by a three-dimensional, mechanosensitive molecular clutch

(2015) Lindsay B. Case et al.   NATURE CELL BIOLOGY

Collective cell migration: guidance principles and hierarchies

(2015) Anna Haeger et al.   TRENDS IN CELL BIOLOGY

Microglia mechanics: immune activation alters traction forces and durotaxis

(2015) Lars Bollmann et al.   Frontiers in Cellular Neuroscience

Local 3D matrix microenvironment regulates cell migration through spatiotemporal dynamics of contractility-dependent adhesions

(2015) Andrew D. Doyle et al.   Nature Communications

Substrate stress relaxation regulates cell spreading

(2015) Ovijit Chaudhuri et al.   Nature Communications

A Simple Force-Motion Relation for Migrating Cells Revealed by Multipole Analysis of Traction Stress

(2014) Hirokazu Tanimoto et al.   BIOPHYSICAL JOURNAL

Micro-composite substrates for the study of cell-matrix mechanical interactions

(2014) Pen-hsiu Grace Chao et al.   Journal of the Mechanical Behavior of Biomedical Materials

Steering cell migration: lamellipodium dynamics and the regulation of directional persistence

(2014) Matthias Krause et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Physical influences of the extracellular environment on cell migration

(2014) Guillaume Charras et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Focal Adhesion-Localized CdGAP Regulates Matrix Rigidity Sensing and Durotaxis

(2014) Duncan B. Wormer et al.   PLoS One

Fibroblasts probe substrate rigidity with filopodia extensions before occupying an area

(2014) Stephanie Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrix

(2014) R. J. Petrie et al.   SCIENCE

Vertebrate Limb Bud Formation Is Initiated by Localized Epithelial-to-Mesenchymal Transition

(2014) J. Gros et al.   SCIENCE

A peptide functionalized poly(ethylene glycol) (PEG) hydrogel for investigating the influence of biochemical and biophysical matrix properties on tumor cell migration

(2014) Samir P. Singh et al.   Biomaterials Science

Combined Effects of PEG Hydrogel Elasticity and Cell-Adhesive Coating on Fibroblast Adhesion and Persistent Migration

(2013) Dimitris Missirlis et al.   BIOMACROMOLECULES

Determinants of Maximal Force Transmission in a Motor-Clutch Model of Cell Traction in a Compliant Microenvironment

(2013) Benjamin L. Bangasser et al.   BIOPHYSICAL JOURNAL

Mesenchymal stem cell durotaxis depends on substrate stiffness gradient strength

(2013) Ludovic G. Vincent et al.   Biotechnology Journal

Vascular fibrosis in atherosclerosis

(2013) Tao-Hua Lan et al.   CARDIOVASCULAR PATHOLOGY

Master Equation-Based Analysis of a Motor-Clutch Model for Cell Traction Force

(2013) Benjamin L. Bangasser et al.   Cellular and Molecular Bioengineering

Substrates with Engineered Step Changes in Rigidity Induce Traction Force Polarity and Durotaxis

(2013) Mark T. Breckenridge et al.   Cellular and Molecular Bioengineering

Mechanical guidance of cell migration: lessons from chemotaxis

(2013) Pere Roca-Cusachs et al.   CURRENT OPINION IN CELL BIOLOGY

Interstitial Dendritic Cell Guidance by Haptotactic Chemokine Gradients

(2013) M. Weber et al.   SCIENCE

The alignment and fusion assembly of adipose-derived stem cells on mechanically patterned matrices

(2012) Yu Suk Choi et al.   BIOMATERIALS

Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration

(2012) Sergey V. Plotnikov et al.   CELL

Membrane Tension Maintains Cell Polarity by Confining Signals to the Leading Edge during Neutrophil Migration

(2012) Andrew R. Houk et al.   CELL

Crawling from soft to stiff matrix polarizes the cytoskeleton and phosphoregulates myosin-II heavy chain

(2012) Matthew Raab et al.   JOURNAL OF CELL BIOLOGY

In vivo Brillouin optical microscopy of the human eye

(2012) Giuliano Scarcelli et al.   OPTICS EXPRESS

Evidence of a large-scale mechanosensing mechanism for cellular adaptation to substrate stiffness

(2012) L. Trichet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elasticity boundary conditions required for cell mechanotaxis on microelastically-patterned gels

(2011) Takahito Kawano et al.   BIOMATERIALS

Focal Adhesion Kinase Stabilizes the Cytoskeleton

(2011) Ben Fabry et al.   BIOPHYSICAL JOURNAL

Calcium gradients underlying cell migration

(2011) Chaoliang Wei et al.   CURRENT OPINION IN CELL BIOLOGY

Stiffness Gradients Mimicking In Vivo Tissue Variation Regulate Mesenchymal Stem Cell Fate

(2011) Justin R. Tse et al.   PLoS One

Oriented cell motility and division underlie early limb bud morphogenesis

(2010) L. A. Wyngaarden et al.   DEVELOPMENT

Collective Chemotaxis Requires Contact-Dependent Cell Polarity

(2010) Eric Theveneau et al.   DEVELOPMENTAL CELL

Vinculin Facilitates Cell Invasion into Three-dimensional Collagen Matrices

(2010) Claudia T. Mierke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Understanding eukaryotic chemotaxis: a pseudopod-centred view

(2010) Robert H. Insall   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Guiding Neuronal Cell Migrations

(2010) O. Marin et al.   Cold Spring Harbor Perspectives in Biology

Vascular Smooth Muscle Cell Durotaxis Depends on Substrate Stiffness Gradient Strength

(2009) Brett C. Isenberg et al.   BIOPHYSICAL JOURNAL

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Vascular endothelial growth factor (VEGF) regulates cranial neural crest migration in vivo

(2009) Rebecca McLennan et al.   DEVELOPMENTAL BIOLOGY

Random versus directionally persistent cell migration

(2009) Ryan J. Petrie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Spatially controlled hydrogel mechanics to modulate stem cell interactions

(2009) Ross A. Marklein et al.   Soft Matter

Rho-Kinase Phosphorylates PAR-3 and Disrupts PAR Complex Formation

(2008) Masanori Nakayama et al.   DEVELOPMENTAL CELL

Durotaxis as an elastic stability phenomenon

(2008) Konstantinos A. Lazopoulos et al.   JOURNAL OF BIOMECHANICS

Traction Dynamics of Filopodia on Compliant Substrates

(2008) C. E. Chan et al.   SCIENCE

Non-invasive measurement of brain viscoelasticity using magnetic resonance elastography

(2007) Ingolf Sack et al.   NMR IN BIOMEDICINE