Stiffness Sensing in Cells and Tissues

Mechanosensitivity of Cancer Cells in Contact with Soft Substrates Using AFM

(2018) Yara Abidine et al.   BIOPHYSICAL JOURNAL

Controlling Cellular Volume via Mechanical and Physical Properties of Substrate

(2018) Kenan Xie et al.   BIOPHYSICAL JOURNAL

Reduced substrate stiffness promotes M2-like macrophage activation and enhances peroxisome proliferator-activated receptor γ expression

(2018) Takayuki Okamoto et al.   EXPERIMENTAL CELL RESEARCH

Regulation of ATP utilization during metastatic cell migration by collagen architecture

(2018) Matthew R. Zanotelli et al.   MOLECULAR BIOLOGY OF THE CELL

Comparison of non-invasive assessment of liver fibrosis in patients with alpha1-antitrypsin deficiency using magnetic resonance elastography (MRE), acoustic radiation force impulse (ARFI) Quantification, and 2D-shear wave elastography (2D-SWE)

(2018) Rolf Reiter et al.   PLoS One

LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration

(2018) Elvira Infante et al.   Nature Communications

The Roles of Matrix Stiffness and ß-Catenin Signaling in Endothelial-to-Mesenchymal Transition of Aortic Valve Endothelial Cells

(2018) Aileen Zhong et al.   Cardiovascular Engineering and Technology

Cancer cells’ ability to mechanically adjust to extracellular matrix stiffness correlates with their invasive potential

(2018) Lena Wullkopf et al.   MOLECULAR BIOLOGY OF THE CELL

Cell Membranes Resist Flow

(2018) Zheng Shi et al.   CELL

Divergent immune responses to synthetic and biological scaffolds

(2018) Kaitlyn Sadtler et al.   BIOMATERIALS

Membrane tension controls adhesion positioning at the leading edge of cells

(2017) Bruno Pontes et al.   JOURNAL OF CELL BIOLOGY

Opposite Effects of Mechanical Action of Fluid Flow on Proangiogenic Factor Secretion From Human Adipose-Derived Stem Cells With and Without Oxidative Stress

(2017) Beatriz Bravo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Substrate Stiffness Combined with Hepatocyte Growth Factor Modulates Endothelial Cell Behavior

(2016) Hao Chang et al.   BIOMACROMOLECULES

Actomyosin Cortical Mechanical Properties in Nonadherent Cells Determined by Atomic Force Microscopy

(2016) Alexander X. Cartagena-Rivera et al.   BIOPHYSICAL JOURNAL

Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis

(2016) Xiaobo Wang et al.   Cell Metabolism

Endothelial directed collective migration depends on substrate stiffness via localized myosin contractility and cell-matrix interactions

(2016) Adam Charles Canver et al.   JOURNAL OF BIOMECHANICS

Chondrocyte Morphology in Stiff and Soft Agarose Gels and the Influence of Fetal Calf Serum

(2016) Asima Karim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mechanosensing is critical for axon growth in the developing brain

(2016) David E Koser et al.   NATURE NEUROSCIENCE

Matrix stiffening promotes a tumor vasculature phenotype

(2016) Francois Bordeleau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell motility regulation on a stepped micro pillar array device (SMPAD) with a discrete stiffness gradient

(2016) Sujin Lee et al.   Soft Matter

Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration

(2016) Alba Diz-Muñoz et al.   PLOS BIOLOGY

Collagen Matrix Density Drives the Metabolic Shift in Breast Cancer Cells

(2016) Brett A. Morris et al.   EBioMedicine

Modeling universal dynamics of cell spreading on elastic substrates

(2015) Houfu Fan et al.   Biomechanics and Modeling in Mechanobiology

Active Biochemical Regulation of Cell Volume and a Simple Model of Cell Tension Response

(2015) Jiaxiang Tao et al.   BIOPHYSICAL JOURNAL

Local VE-cadherin mechanotransduction triggers long-ranged remodeling of endothelial monolayers

(2015) A. K. Barry et al.   JOURNAL OF CELL SCIENCE

Three-dimensional matrix fiber alignment modulates cell migration and MT1-MMP utility by spatially and temporally directing protrusions

(2015) Stephanie I. Fraley et al.   Scientific Reports

CD44-Mediated Adhesion to Hyaluronic Acid Contributes to Mechanosensing and Invasive Motility

(2014) Yushan Kim et al.   MOLECULAR CANCER RESEARCH

Liposome adhesion generates traction stress

(2014) Michael P. Murrell et al.   Nature Physics

Compression stiffening of brain and its effect on mechanosensing by glioma cells

(2014) Katarzyna Pogoda et al.   NEW JOURNAL OF PHYSICS

Fibroblasts probe substrate rigidity with filopodia extensions before occupying an area

(2014) Stephanie Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Augmentation of integrin-mediated mechanotransduction by hyaluronic acid

(2013) Anant Chopra et al.   BIOMATERIALS

The effect of time-dependent deformation of viscoelastic hydrogels on myogenic induction and Rac1 activity in mesenchymal stem cells

(2013) Andrew R. Cameron et al.   BIOMATERIALS

Arterial Stiffening Precedes Systolic Hypertension in Diet-Induced Obesity

(2013) Robert M. Weisbrod et al.   HYPERTENSION

Substrate Stiffness Regulates Cellular Uptake of Nanoparticles

(2013) Changjin Huang et al.   NANO LETTERS

Cellular mechanoadaptation to substrate mechanical properties: contributions of substrate stiffness and thickness to cell stiffness measurements using AFM

(2013) Shirish Vichare et al.   Soft Matter

The effect of growth factor environment on fibroblast morphological response to substrate stiffness

(2012) Frederick Grinnell et al.   BIOMATERIALS

The effect of substrate modulus on the growth and function of matrix-embedded endothelial cells

(2012) Sylaja Murikipudi et al.   BIOMATERIALS

Membrane Tension Maintains Cell Polarity by Confining Signals to the Leading Edge during Neutrophil Migration

(2012) Andrew R. Houk et al.   CELL

Molecular Basis of Arterial Stiffening: Role of Glycation – A Mini-Review

(2012) David R. Sell et al.   GERONTOLOGY

The influence of substrate creep on mesenchymal stem cell behaviour and phenotype

(2011) Andrew. R. Cameron et al.   BIOMATERIALS

The control of chromosome segregation during mitosis in epithelial cells by substrate elasticity

(2011) Leyla Kocgozlu et al.   BIOMATERIALS

Substrate Viscosity Enhances Correlation in Epithelial Sheet Movement

(2011) Michael Murrell et al.   BIOPHYSICAL JOURNAL

Biochemical and mechanical extracellular matrix properties dictate mammary epithelial cell motility and assembly

(2011) Olga Shebanova et al.   Biotechnology Journal

Reprogramming cardiomyocyte mechanosensing by crosstalk between integrins and hyaluronic acid receptors

(2011) Anant Chopra et al.   JOURNAL OF BIOMECHANICS

Mechanical Force Affects Expression of an In Vitro Metastasis-Like Phenotype in HCT-8 Cells

(2010) Xin Tang et al.   BIOPHYSICAL JOURNAL

Pericellular Conditions Regulate Extent of Cell-Mediated Compaction of Collagen Gels

(2010) Mark D. Stevenson et al.   BIOPHYSICAL JOURNAL

How deeply cells feel: methods for thin gels

(2010) Amnon Buxboim et al.   JOURNAL OF PHYSICS-CONDENSED MATTER

Matrix Rigidity Regulates Cancer Cell Growth and Cellular Phenotype

(2010) Robert W. Tilghman et al.   PLoS One

Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture

(2010) P. M. Gilbert et al.   SCIENCE

Glutamine addiction: a new therapeutic target in cancer

(2010) David R. Wise et al.   TRENDS IN BIOCHEMICAL SCIENCES

Filamin A Is Essential for Active Cell Stiffening but not Passive Stiffening under External Force

(2009) K.E. Kasza et al.   BIOPHYSICAL JOURNAL

Absence of Filamin A Prevents Cells from Responding to Stiffness Gradients on Gels Coated with Collagen but not Fibronectin

(2009) Fitzroy J. Byfield et al.   BIOPHYSICAL JOURNAL

The motility of normal and cancer cells in response to the combined influence of the substrate rigidity and anisotropic microstructure

(2008) Tzvetelina Tzvetkova-Chevolleau et al.   BIOMATERIALS

Cell-Cell Mechanical Communication through Compliant Substrates

(2008) Cynthia A. Reinhart-King et al.   BIOPHYSICAL JOURNAL