Unraveling the mechanobiology of immune cells

Cytoskeletal tension actively sustains the migratory T‐cell synaptic contact

(2020) Sudha Kumari et al.   EMBO JOURNAL

Molecular regulation of TLR signaling in health and disease: mechano-regulation of macrophages and TLR signaling

(2020) Erika J Gruber et al.   Innate Immunity

Mechanotransduction in T Cell Development, Differentiation and Function

(2020) Muaz Rushdi et al.   Cells

Mapping the stochastic sequence of individual ligand-receptor binding events to cellular activation: T cells act on the rare events

(2019) Jenny J. Y. Lin et al.   Science Signaling

Cytoskeletal Control of Antigen-Dependent T Cell Activation

(2019) Huw Colin-York et al.   Cell Reports

Mechano-regulation of Peptide-MHC Class I Conformations Determines TCR Antigen Recognition

(2019) Peng Wu et al.   MOLECULAR CELL

Biophysical regulation of macrophages in health and disease

(2019) Vijaykumar S. Meli et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Material stiffness influences the polarization state, function and migration mode of macrophages

(2019) Rukmani Sridharan et al.   Acta Biomaterialia

Integrins and Their Role in Immune Cell Adhesion

(2019) Michael L. Dustin   CELL

Mechanobiology of Macrophages: How Physical Factors Coregulate Macrophage Plasticity and Phagocytosis

(2019) Nikhil Jain et al.   Annual Review of Biomedical Engineering

Augmentation of T-Cell Activation by Oscillatory Forces and Engineered Antigen-Presenting Cells

(2019) Fatemeh S. Majedi et al.   NANO LETTERS

Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity

(2019) Angel G. Solis et al.   NATURE

Mechanosensing through immunoreceptors

(2019) Cheng Zhu et al.   NATURE IMMUNOLOGY

T cell activation and immune synapse organization respond to the microscale mechanics of structured surfaces

(2019) Weiyang Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of 3D cell migration

(2019) Kenneth M. Yamada et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cryoprotectant enables structural control of porous scaffolds for exploration of cellular mechano-responsiveness in 3D

(2019) Shumeng Jiang et al.   Nature Communications

Reduced substrate stiffness promotes M2-like macrophage activation and enhances peroxisome proliferator-activated receptor γ expression

(2018) Takayuki Okamoto et al.   EXPERIMENTAL CELL RESEARCH

Human T Cell Development, Localization, and Function throughout Life

(2018) Brahma V. Kumar et al.   IMMUNITY

Cutting Edge: Piezo1 Mechanosensors Optimize Human T Cell Activation

(2018) Chinky Shiu Chen Liu et al.   JOURNAL OF IMMUNOLOGY

Interstitial Flow Promotes Macrophage Polarization toward an M2 Phenotype

(2018) Ran Li et al.   MOLECULAR BIOLOGY OF THE CELL

Scaffolds that mimic antigen-presenting cells enable ex vivo expansion of primary T cells

(2018) Alexander S Cheung et al.   NATURE BIOTECHNOLOGY

Rewiring T-cell responses to soluble factors with chimeric antigen receptors

(2018) ZeNan L Chang et al.   Nature Chemical Biology

Real-time fluorescence and deformability cytometry

(2018) Philipp Rosendahl et al.   NATURE METHODS

Mechanogenetics for the remote and noninvasive control of cancer immunotherapy

(2018) Yijia Pan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

αβ T Cell Receptor Mechanosensing Forces out Serial Engagement

(2018) Yinnian Feng et al.   TRENDS IN IMMUNOLOGY

Durable Interactions of T Cells with T Cell Receptor Stimuli in the Absence of a Stable Immunological Synapse

(2018) Viveka Mayya et al.   Cell Reports

Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding

(2018) Leah V. Sibener et al.   CELL

T Cells on Engineered Substrates: The Impact of TCR Clustering Is Enhanced by LFA-1 Engagement

(2018) Emmanuelle Benard et al.   Frontiers in Immunology

Stress hormone signaling through β-adrenergic receptors regulates macrophage mechanotype and function

(2018) Tae-Hyung Kim et al.   FASEB JOURNAL

A TCR mechanotransduction signaling loop induces negative selection in the thymus

(2018) Jinsung Hong et al.   NATURE IMMUNOLOGY

Spatial confinement downsizes the inflammatory response of macrophages

(2018) Nikhil Jain et al.   NATURE MATERIALS

Cell engineering with microfluidic squeezing preserves functionality of primary immune cells in vivo

(2018) Tia DiTommaso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Mechanotransduction and Tension in T Cell Function

(2018) Jérémie Rossy et al.   Frontiers in Immunology

Improving T Cell Expansion with a Soft Touch

(2017) Lester H. Lambert et al.   NANO LETTERS

Mechanobiology of YAP and TAZ in physiology and disease

(2017) Tito Panciera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Instructing Human Macrophage Polarization by Stiffness and Glycosaminoglycan Functionalization in 3D Collagen Networks

(2017) Markus Friedemann et al.   Advanced Healthcare Materials

Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity

(2017) Michael Saitakis et al.   eLife

Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing

(2016) Roshni Basu et al.   CELL

Biologic-free mechanically induced muscle regeneration

(2016) Christine A. Cezar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue Stiffness Dictates Development, Homeostasis, and Disease Progression

(2015) Andrew M Handorf et al.   Organogenesis

Accumulation of Dynamic Catch Bonds between TCR and Agonist Peptide-MHC Triggers T Cell Signaling

(2014) Baoyu Liu et al.   CELL

Physical and mechanical regulation of macrophage phenotype and function

(2014) Frances Y. McWhorter et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy

(2014) Jaeyun Kim et al.   NATURE BIOTECHNOLOGY

Mechanotransduction and extracellular matrix homeostasis

(2014) Jay D. Humphrey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Appreciating force and shape — the rise of mechanotransduction in cell biology

(2014) Thomas Iskratsch et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Actin polymerization as a key innate immune effector mechanism to controlSalmonellainfection

(2014) Si Ming Man et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Advances in high-throughput single-cell microtechnologies

(2013) Westbrook M Weaver et al.   CURRENT OPINION IN BIOTECHNOLOGY

Modulation of macrophage phenotype by cell shape

(2013) F. Y. McWhorter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrodynamic stretching of single cells for large population mechanical phenotyping

(2012) D. R. Gossett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Adrenergic-regulated phosphorylation of the skeletal muscle CaV1.1 channel in the fight-or-flight response

(2010) M. A. Emrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interstitial fluid pressure in tumors: therapeutic barrier and biomarker of angiogenesis

(2008) Sarah Jane Lunt et al.   Future Oncology