Scaffolds that mimic antigen-presenting cells enable ex vivo expansion of primary T cells

The effect of surface modification of mesoporous silica micro-rod scaffold on immune cell activation and infiltration

(2016) Weiwei Aileen Li et al.   BIOMATERIALS

CD19 CAR–T cells of defined CD4+:CD8+ composition in adult B cell ALL patients

(2016) Cameron J. Turtle et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting of cancer neoantigens with donor-derived T cell receptor repertoires

(2016) E. Stronen et al.   SCIENCE

Enrichment and Expansion with Nanoscale Artificial Antigen Presenting Cells for Adoptive Immunotherapy

(2015) Karlo Perica et al.   ACS Nano

Versatile click alginate hydrogels crosslinked via tetrazine–norbornene chemistry

(2015) Rajiv M. Desai et al.   BIOMATERIALS

Isolation of neoantigen-specific T cells from tumor and peripheral lymphocytes

(2015) Cyrille J. Cohen et al.   JOURNAL OF CLINICAL INVESTIGATION

T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

(2015) Daniel W Lee et al.   LANCET

Adoptive cell transfer as personalized immunotherapy for human cancer

(2015) S. A. Rosenberg et al.   SCIENCE

Adoptive cellular therapy: A race to the finish line

(2015) Carl H. June et al.   Science Translational Medicine

Biodegradable Nanoellipsoidal Artificial Antigen Presenting Cells for Antigen Specific T-Cell Activation

(2015) Randall A. Meyer et al.   Small

Polymer-Based Synthetic Dendritic Cells for Tailoring Robust and Multifunctional T Cell Responses

(2014) Subhra Mandal et al.   ACS Chemical Biology

Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy

(2014) Jaeyun Kim et al.   NATURE BIOTECHNOLOGY

A carbon nanotube–polymer composite for T-cell therapy

(2014) Tarek R. Fadel et al.   Nature Nanotechnology

Antigen-specific activation and cytokine-facilitated expansion of naive, human CD8+ T cells

(2014) Matthias Wölfl et al.   Nature Protocols

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

(2014) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Towards efficient cancer immunotherapy: advances in developing artificial antigen-presenting cells

(2014) Loek J. Eggermont et al.   TRENDS IN BIOTECHNOLOGY

Allogeneic lymphocyte-licensed DCs expand T cells with improved antitumor activity and resistance to oxidative stress and immunosuppressive factors

(2014) Chuan Jin et al.   Molecular Therapy-Methods & Clinical Development

Particle shape dependence of CD8+ T cell activation by artificial antigen presenting cells

(2013) Joel C. Sunshine et al.   BIOMATERIALS

Bioorthogonal Copper-Free Click Chemistry In Vivo for Tumor-Targeted Delivery of Nanoparticles

(2012) Heebeom Koo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

HLA Anchor Optimization of the Melan-A-HLA-A2 Epitope within a Long Peptide Is Required for Efficient Cross-Priming of Human Tumor-Reactive T Cells

(2012) J.-M. Chauvin et al.   JOURNAL OF IMMUNOLOGY

Functional single-cell analysis of T-cell activation by supported lipid bilayer-tethered ligands on arrays of nanowells

(2012) Alexis J. Torres et al.   LAB ON A CHIP

Induction of potent anti-tumor responses while eliminating systemic side effects via liposome-anchored combinatorial immunotherapy

(2011) Brandon Kwong et al.   BIOMATERIALS

Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias

(2011) R. J. Brentjens et al.   BLOOD

The immunological synapse: a cause or consequence of T-cell receptor triggering?

(2011) Balbino Alarcón et al.   IMMUNOLOGY

An Artificial Antigen-presenting Cell with Paracrine Delivery of IL-2 Impacts the Magnitude and Direction of the T Cell Response

(2011) Erin R. Steenblock et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Artificial Antigen-Presenting Cells for Use in Adoptive Immunotherapy

(2010) Cameron J. Turtle et al.   CANCER JOURNAL

Membrane-Mediated Effect on Ion Channels Induced by the Anesthetic Drug Ketamine

(2010) Hansjörg Jerabek et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Comparison of anti-CD3 and anti-CD28-coated beads with soluble anti-CD3 for expanding human T cells: Differing impact on CD8 T cell phenotype and responsiveness to restimulation

(2010) Yixin Li et al.   Journal of Translational Medicine

Stability and Liquid-Liquid Phase Separation in Mixed Saturated Lipid Bilayers

(2009) Gabriel S. Longo et al.   BIOPHYSICAL JOURNAL

Manufacturing Validation of Biologically Functional T Cells Targeted to CD19 Antigen for Autologous Adoptive Cell Therapy

(2009) Daniel Hollyman et al.   JOURNAL OF IMMUNOTHERAPY

Asymmetric Structural Features in Single Supported Lipid Bilayers Containing Cholesterol and GM1 Resolved with Synchrotron X-Ray Reflectivity

(2008) Christian Reich et al.   BIOPHYSICAL JOURNAL

The effect of artificial antigen-presenting cells with preclustered anti-CD28/-CD3/-LFA-1 monoclonal antibodies on the induction of ex vivo expansion of functional human antitumor T cells

(2008) R. Zappasodi et al.   HAEMATOLOGICA

A Comprehensive Platform for Ex Vivo T-cell Expansion Based on Biodegradable Polymeric Artificial Antigen-presenting Cells

(2008) Erin R Steenblock et al.   MOLECULAR THERAPY

Enhanced Cellular Activation with Single Walled Carbon Nanotube Bundles Presenting Antibody Stimuli

(2008) Tarek R. Fadel et al.   NANO LETTERS

Treatment of Metastatic Melanoma with Autologous CD4+ T Cells against NY-ESO-1

(2008) Naomi N. Hunder et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tuning lipid mixtures to induce or suppress domain formation across leaflets of unsupported asymmetric bilayers

(2008) M. D. Collins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA