Lysosomal ion channels involved in cellular entry and uncoating of enveloped viruses: Implications for therapeutic strategies against SARS-CoV-2

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

Trypsin promotes porcine deltacoronavirus mediating cell-to-cell fusion in a cell type-dependent manner

(2020) Yue-Lin Yang et al.   Emerging Microbes & Infections

The lysosome: A potential juncture between SARS‐CoV‐2 infectivity and Niemann‐Pick disease type C, with therapeutic implications

(2020) Rami A. Ballout et al.   FASEB JOURNAL

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

(2020) Xiuyuan Ou et al.   Nature Communications

Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function

(2020) Susanne Gerndt et al.   eLife

Could the Inhibition of Endo-Lysosomal Two-Pore Channels (TPCs) by the Natural Flavonoid Naringenin Represent an Option to Fight SARS-CoV-2 Infection?

(2020) Antonio Filippini et al.   Frontiers in Microbiology

Identification of potassium and calcium channel inhibitors as modulators of polyomavirus endosomal trafficking

(2020) Samuel J. Dobson et al.   ANTIVIRAL RESEARCH

Could an endo-lysosomal ion channel be the Achilles heel of SARS-CoV2?

(2020) Christian Grimm et al.   CELL CALCIUM

Porcine deltacoronavirus enters cells via two pathways: A protease-mediated one at the cell surface and another facilitated by cathepsins in the endosome

(2019) Jialin Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR

(2019) Xiaoli Zhang et al.   PLOS BIOLOGY

Cellular entry and uncoating of naked and quasi-enveloped human hepatoviruses

(2019) Efraín E Rivera-Serrano et al.   eLife

NAADP Receptors

(2019) Antony Galione   Cold Spring Harbor Perspectives in Biology

Lysosomal Potassium Channels: Potential Roles in Lysosomal Function and Neurodegenerative Diseases

(2018) Xinghua Feng et al.   CNS & Neurological Disorders-Drug Targets

Potassium is a trigger for conformational change in the fusion spike of an enveloped RNA virus

(2018) Emma K. Punch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel

(2018) Ji She et al.   NATURE

Autophagy during viral infection — a double-edged sword

(2018) Younho Choi et al.   NATURE REVIEWS MICROBIOLOGY

CLC Chloride Channels and Transporters: Structure, Function, Physiology, and Disease

(2018) Thomas J. Jentsch et al.   PHYSIOLOGICAL REVIEWS

Ebola virus requires phosphatidylinositol (3,5) bisphosphate production for efficient viral entry

(2018) Shirley Qiu et al.   VIROLOGY

Mucolipin-2 Cation Channel Increases Trafficking Efficiency of Endocytosed Viruses

(2018) Nicholas Rinkenberger et al.   mBio

Bunyavirus requirement for endosomal K+ reveals new roles of cellular ion channels during infection

(2018) Samantha Hover et al.   PLoS Pathogens

Release and uptake mechanisms of vesicular Ca2+ stores

(2018) Junsheng Yang et al.   Protein & Cell

NAADP-dependent Ca2+ signaling regulates Middle East respiratory syndrome-coronavirus pseudovirus translocation through the endolysosomal system

(2018) Gihan S. Gunaratne et al.   CELL CALCIUM

Two-pore channels open up

(2018) Sandip Patel   NATURE

Mining of Ebola virus entry inhibitors identifies approved drugs as two-pore channel pore blockers

(2018) Christopher J. Penny et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Lysosomal Ion Channels as Decoders of Cellular Signals

(2018) Ping Li et al.   TRENDS IN BIOCHEMICAL SCIENCES

A voltage-dependent K+channel in the lysosome is required for refilling lysosomal Ca2+stores

(2017) Wuyang Wang et al.   JOURNAL OF CELL BIOLOGY

Characterization of the Quasi-Enveloped Hepatitis E Virus Particles Released by the Cellular Exosomal Pathway

(2017) Shigeo Nagashima et al.   JOURNAL OF VIROLOGY

Redistribution of Endosomal Membranes to the African Swine Fever Virus Replication Site

(2017) Miguel Cuesta-Geijo et al.   Viruses-Basel

An Endosomal NAADP-Sensitive Two-Pore Ca 2+ Channel Regulates ER-Endosome Membrane Contact Sites to Control Growth Factor Signaling

(2017) Bethan S. Kilpatrick et al.   Cell Reports

The phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infection

(2017) Elizabeth A. Nelson et al.   PLoS Neglected Tropical Diseases

High lumenal chloride in the lysosome is critical for lysosome function

(2017) Kasturi Chakraborty et al.   eLife

Recombinant tandem of pore-domains in a Weakly Inward rectifying K+ channel 2 (TWIK2) forms active lysosomal channels

(2017) Nicole Bobak et al.   Scientific Reports

The Lysosome as a Regulatory Hub

(2016) Rushika M. Perera et al.   Annual Review of Cell and Developmental Biology

The position of lysosomes within the cell determines their luminal pH

(2016) Danielle E. Johnson et al.   JOURNAL OF CELL BIOLOGY

The lysosome as a command-and-control center for cellular metabolism

(2016) Chun-Yan Lim et al.   JOURNAL OF CELL BIOLOGY

Isolated pores dissected from human two-pore channel 2 are functional

(2016) Christopher J. Penny et al.   Scientific Reports

Structure, Function, and Evolution of Coronavirus Spike Proteins

(2016) Fang Li   Annual Review of Virology

Lysosomal Physiology

(2015) Haoxing Xu et al.   Annual Review of Physiology

Lysosomal calcium regulates autophagy

(2015) Diego L Medina et al.   Autophagy

TMEM175 Is an Organelle K + Channel Regulating Lysosomal Function

(2015) Chunlei Cang et al.   CELL

BK Channels Alleviate Lysosomal Storage Diseases by Providing Positive Feedback Regulation of Lysosomal Ca2+ Release

(2015) Qi Cao et al.   DEVELOPMENTAL CELL

Modulation of Potassium Channels Inhibits Bunyavirus Infection

(2015) Samantha Hover et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ebolavirus Glycoprotein Directs Fusion through NPC1 + Endolysosomes

(2015) James A. Simmons et al.   JOURNAL OF VIROLOGY

Requirement for Chloride Channel Function during the Hepatitis C Virus Life Cycle

(2015) Zsofia Igloi et al.   JOURNAL OF VIROLOGY

Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment

(2015) Yasuteru Sakurai et al.   SCIENCE

Vaccinia Virus Infection Requires Maturation of Macropinosomes

(2015) Zaira Rizopoulos et al.   TRAFFIC

Inhibition of herpes simplex virus type 1 entry by chloride channel inhibitors tamoxifen and NPPB

(2014) Kai Zheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ebolavirus Entry Requires a Compact Hydrophobic Fist at the Tip of the Fusion Loop

(2014) S. M. Gregory et al.   JOURNAL OF VIROLOGY

Stepwise Priming by Acidic pH and a High K+ Concentration Is Required for Efficient Uncoating of Influenza A Virus Cores after Penetration

(2014) S. Stauffer et al.   JOURNAL OF VIROLOGY

The voltage-gated sodium channel TPC1 confers endolysosomal excitability

(2014) Chunlei Cang et al.   Nature Chemical Biology

Lassa virus entry requires a trigger-induced receptor switch

(2014) L. T. Jae et al.   SCIENCE

Two-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels

(2014) T. Rahman et al.   Science Signaling

Two-pore channels (TPCs): Current controversies

(2013) Anthony J. Morgan et al.   BIOESSAYS

mTOR Regulates Lysosomal ATP-Sensitive Two-Pore Na+ Channels to Adapt to Metabolic State

(2013) Chunlei Cang et al.   CELL

Regulation of membrane trafficking by signalling on endosomal and lysosomal membranes

(2013) Xinran Li et al.   JOURNAL OF PHYSIOLOGY-LONDON

A pathogenic picornavirus acquires an envelope by hijacking cellular membranes

(2013) Zongdi Feng et al.   NATURE

Live cell imaging of viral entry

(2013) Eileen Sun et al.   Current Opinion in Virology

TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes

(2012) Xiang Wang et al.   CELL

Ebola virus entry requires the host-programmed recognition of an intracellular receptor

(2012) Emily Happy Miller et al.   EMBO JOURNAL

Endosomal Maturation, Rab7 GTPase and Phosphoinositides in African Swine Fever Virus Entry

(2012) Miguel A. Cuesta-Geijo et al.   PLoS One

Amino acids and mTORC1: from lysosomes to disease

(2012) Alejo Efeyan et al.   TRENDS IN MOLECULAR MEDICINE

Lysosomal Acidification Mechanisms

(2011) Joseph A. Mindell   Annual Review of Physiology

Molecular mechanisms of endolysosomal Ca2+signalling in health and disease

(2011) Anthony J. Morgan et al.   BIOCHEMICAL JOURNAL

Domain assembly of NAADP-gated two-pore channels

(2011) Dev Churamani et al.   BIOCHEMICAL JOURNAL

Photoaffinity Labeling of Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Targets in Mammalian Cells

(2011) Yaping Lin-Moshier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Photoaffinity Labeling of High Affinity Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-Binding Proteins in Sea Urchin Egg

(2011) Timothy F. Walseth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection

(2011) Marceline Côté et al.   NATURE

Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

(2011) Jan E. Carette et al.   NATURE

Structure and function of the complete internal fusion loop from Ebolavirus glycoprotein 2

(2011) S. M. Gregory et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Late-penetrating viruses

(2011) Pierre-Yves Lozach et al.   Current Opinion in Virology

Virus Entry by Endocytosis

(2010) Jason Mercer et al.   Annual Review of Biochemistry

Ion flux and the function of endosomes and lysosomes: pH is just the start

(2010) Cameron C. Scott et al.   BIOESSAYS

A cation counterflux supports lysosomal acidification

(2010) Benjamin E. Steinberg et al.   JOURNAL OF CELL BIOLOGY

PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

(2010) Xian-ping Dong et al.   Nature Communications

Cellular Entry of Ebola Virus Involves Uptake by a Macropinocytosis-Like Mechanism and Subsequent Trafficking through Early and Late Endosomes

(2010) Mohammad F. Saeed et al.   PLoS Pathogens

Ebolavirus Is Internalized into Host Cells via Macropinocytosis in a Viral Glycoprotein-Dependent Manner

(2010) Asuka Nanbo et al.   PLoS Pathogens

Identification of novel cellular targets for therapeutic intervention against Ebola virus infection by siRNA screening

(2009) Andrey A. Kolokoltsov et al.   DRUG DEVELOPMENT RESEARCH

Ebolavirusglycoprotein structure and mechanism of entry

(2009) Jeffrey E Lee et al.   Future Virology

Activating Mutations of the TRPML1 Channel Revealed by Proline-scanning Mutagenesis

(2009) Xian-ping Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NAADP mobilizes calcium from acidic organelles through two-pore channels

(2009) Peter J. Calcraft et al.   NATURE

Human host factors required for influenza virus replication

(2009) Renate König et al.   NATURE

SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway

(2008) Hongliang Wang et al.   CELL RESEARCH

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

(2008) Michael Degtyarev et al.   JOURNAL OF CELL BIOLOGY

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

(2008) Xian-Ping Dong et al.   NATURE

The Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes

(2008) Austin R. Graves et al.   NATURE

Mechanisms of membrane fusion: disparate players and common principles

(2008) Sascha Martens et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY