A voltage-dependent K+channel in the lysosome is required for refilling lysosomal Ca2+stores

An Endosomal NAADP-Sensitive Two-Pore Ca 2+ Channel Regulates ER-Endosome Membrane Contact Sites to Control Growth Factor Signaling

(2017) Bethan S. Kilpatrick et al.   Cell Reports

The formation and function of ER-endosome membrane contact sites

(2016) Emily R. Eden   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Vicenistatin induces early endosome-derived vacuole formation in mammalian cells

(2016) Yuko Nishiyama et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Endolysosomes Are the Principal Intracellular Sites of Acid Hydrolase Activity

(2016) Nicholas A. Bright et al.   CURRENT BIOLOGY

The position of lysosomes within the cell determines their luminal pH

(2016) Danielle E. Johnson et al.   JOURNAL OF CELL BIOLOGY

The endoplasmic reticulum, not the pH gradient, drives calcium refilling of lysosomes

(2016) Abigail G Garrity et al.   eLife

Lysosomal Physiology

(2015) Haoxing Xu et al.   Annual Review of Physiology

Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts

(2015) Bei-Bei Chu et al.   CELL

TMEM175 Is an Organelle K + Channel Regulating Lysosomal Function

(2015) Chunlei Cang et al.   CELL

BK Channels Alleviate Lysosomal Storage Diseases by Providing Positive Feedback Regulation of Lysosomal Ca2+ Release

(2015) Qi Cao et al.   DEVELOPMENTAL CELL

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

Structure and function of ER membrane contact sites with other organelles

(2015) Melissa J. Phillips et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation

(2015) Wuyang Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling

(2015) Y. Zhou et al.   SCIENCE

Function and dysfunction of two-pore channels

(2015) Sandip Patel   Science Signaling

Function and dysfunction of two-pore channels

(2015) Sandip Patel   Science Signaling

PIKfyve, a Class III Lipid Kinase, Is Required for TLR-Induced Type I IFN Production via Modulation of ATF3

(2014) X. Cai et al.   JOURNAL OF IMMUNOLOGY

Nuclear BK channels regulate gene expression via the control of nuclear calcium signaling

(2014) Boxing Li et al.   NATURE NEUROSCIENCE

Lysosome Transport as a Function of Lysosome Diameter

(2014) Debjyoti Bandyopadhyay et al.   PLoS One

Pharmacological consequences of the coexpression of BK channel α and auxiliary β subunits

(2014) Yolima P. Torres et al.   Frontiers in Physiology

Inhibition of the autophagic flux by salinomycin in breast cancer stem-like/progenitor cells interferes with their maintenance

(2013) Wen Yue et al.   Autophagy

mitoBKCa is encoded by the Kcnma1 gene, and a splicing sequence defines its mitochondrial location

(2013) H. Singh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of the modulation of BK potassium channel complexes with different auxiliary subunit compositions by the omega-3 fatty acid DHA

(2013) T. Hoshi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes

(2012) Xiang Wang et al.   CELL

Structure-Activity Analysis of Niclosamide Reveals Potential Role for Cytoplasmic pH in Control of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling

(2012) Bruno D. Fonseca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular BKCa(iBKCa) channels

(2012) Harpreet Singh et al.   JOURNAL OF PHYSIOLOGY-LONDON

Orai-STIM-mediated Ca2+ release from secretory granules revealed by a targeted Ca2+ and pH probe

(2012) E. J. Dickson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic activation of BK currents in vivo generates bidirectional effects on neuronal excitability

(2012) J. R. Montgomery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release

(2012) Dongbiao Shen et al.   Nature Communications

Lysosomal Acidification Mechanisms

(2011) Joseph A. Mindell   Annual Review of Physiology

Molecular mechanisms of endolysosomal Ca2+signalling in health and disease

(2011) Anthony J. Morgan et al.   BIOCHEMICAL JOURNAL

In situ Measurement of the Electrical Potential Across the Lysosomal Membrane Using FRET

(2011) Mirkka Koivusalo et al.   TRAFFIC

Aberrant Ca2+ handling in lysosomal storage disorders

(2010) Kirill Kiselyov et al.   CELL CALCIUM

Block of mouse Slo1 and Slo3 K+channels by CTX, IbTX, TEA, 4-AP and quinidine

(2010) Qiong-Yao Tang et al.   Channels

A cation counterflux supports lysosomal acidification

(2010) Benjamin E. Steinberg et al.   JOURNAL OF CELL BIOLOGY

LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium

(2010) Jiusheng Yan et al.   NATURE

Structure of the Human BK Channel Ca2+-Activation Apparatus at 3.0 A Resolution

(2010) P. Yuan et al.   SCIENCE

PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

(2010) Xian-ping Dong et al.   Nature Communications

Ultrastructural characterization of giant endosomes induced by GTPase-deficient Rab5

(2009) Catherine Sem Wegener et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Voltage-Gated Ion Channels in Human Pancreatic  -Cells: Electrophysiological Characterization and Role in Insulin Secretion

(2008) M. Braun et al.   DIABETES

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

(2008) Xian-Ping Dong et al.   NATURE

Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domains

(2008) Huanghe Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY