Molecular mechanisms of endolysosomal Ca2+signalling in health and disease

Two distinct calcium pools in the endoplasmic reticulum of HEK-293T cells

(2011) Francisco J. Aulestia et al.   BIOCHEMICAL JOURNAL

NAADP links histamine H1 receptors to secretion of von Willebrand factor in human endothelial cells

(2011) B. Esposito et al.   BLOOD

Sea urchin eggs in the acid reign

(2011) Anthony J. Morgan   CELL CALCIUM

Aberrant Ca2+ signalling through acidic calcium stores in pancreatic acinar cells

(2011) O.H. Petersen et al.   CELL CALCIUM

Vacuolar Ca2+ uptake

(2011) Jon K. Pittman   CELL CALCIUM

Acidic calcium stores of Saccharomyces cerevisiae

(2011) Kyle W. Cunningham   CELL CALCIUM

Mucolipin-3 Regulates Luminal Calcium, Acidification, and Membrane Fusion in the Endosomal Pathway

(2011) Benjamin Lelouvier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient Receptor Potential Mucolipin 1 (TRPML1) and Two-pore Channels Are Functionally Independent Organellar Ion Channels

(2011) Soichiro Yamaguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclic Adenosine Diphosphate Ribose Activates Ryanodine Receptors, whereas NAADP Activates Two-pore Domain Channels

(2011) Oluseye A. Ogunbayo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STIM1 and STIM2 Are Located in the Acidic Ca2+Stores and Associates with Orai1 upon Depletion of the Acidic Stores in Human Platelets

(2011) Hanene Zbidi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TPC1 – SV Channels Gain Shape

(2011) Rainer Hedrich et al.   Molecular Plant

TheArabidopsisIntracellular Na+/H+Antiporters NHX5 and NHX6 Are Endosome Associated and Necessary for Plant Growth and Development

(2011) Elias Bassil et al.   PLANT CELL

In situ Measurement of the Electrical Potential Across the Lysosomal Membrane Using FRET

(2011) Mirkka Koivusalo et al.   TRAFFIC

Calcium- and polyphosphate-containing acidic granules of sea urchin eggs are similar to acidocalcisomes, but are not the targets for NAADP

(2010) Isabela B. Ramos et al.   BIOCHEMICAL JOURNAL

Manipulation of the host by pathogens to survive the lysosome

(2010) Paul R. Pryor et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mucolipidosis type IV and the mucolipins

(2010) Gideon Bach et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Endolysosomal calcium regulation and disease

(2010) Emyr Lloyd-Evans et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

NAADP as an intracellular messenger regulating lysosomal calcium-release channels

(2010) Antony Galione et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Regulation and Isoform Function of the V-ATPases

(2010) Masashi Toei et al.   BIOCHEMISTRY

Ion flux and the function of endosomes and lysosomes: pH is just the start

(2010) Cameron C. Scott et al.   BIOESSAYS

Use of granzyme B-based fluorescent protein reporters to monitor granzyme distribution and granule integrity in live cells

(2010) Catherina H. Bird et al.   BIOLOGICAL CHEMISTRY

Two-pore channels: Regulation by NAADP and customized roles in triggering calcium signals

(2010) Sandip Patel et al.   CELL CALCIUM

ClC-3—A Granular Anion Transporter Involved in Insulin Secretion?

(2010) Thomas J. Jentsch et al.   Cell Metabolism

Response to Jentsch et al.

(2010) Erik Renström   Cell Metabolism

Purified TPC Isoforms Form NAADP Receptors with Distinct Roles for Ca2+ Signaling and Endolysosomal Trafficking

(2010) Margarida Ruas et al.   CURRENT BIOLOGY

Cytosolic pH is a second messenger for glucose and regulates the PKA pathway through V-ATPase

(2010) Reinhard Dechant et al.   EMBO JOURNAL

Chloride channels of intracellular membranes

(2010) John C. Edwards et al.   FEBS LETTERS

TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADP

(2010) Michael X. Zhu et al.   FEBS LETTERS

Mucolipins: Intracellular TRPML1-3 channels

(2010) Xiping Cheng et al.   FEBS LETTERS

Deviant Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-mediated Ca2+Signaling upon Lysosome Proliferation

(2010) George D. Dickinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Generation of Cyclic ADP-ribose and Nicotinic Acid Adenine Dinucleotide Phosphate by CD38 for Ca2+Signaling in Interleukin-8-treated Lymphokine-activated Killer Cells

(2010) So-Young Rah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PKA Regulates Vacuolar H+-ATPase Localization and Activity via Direct Phosphorylation of the A Subunit in Kidney Cells

(2010) Rodrigo Alzamora et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An NAADP-gated Two-pore Channel Targeted to the Plasma Membrane Uncouples Triggering from Amplifying Ca2+Signals

(2010) Eugen Brailoiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Calcium-mobilizing Messenger Nicotinic Acid Adenine Dinucleotide Phosphate Participates in Sperm Activation by Mediating the Acrosome Reaction

(2010) Sridhar R. Vasudevan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acidic NAADP-sensitive Calcium Stores in the Endothelium

(2010) G. Cristina Brailoiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ecto-enzyme CD38 Is a Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Synthase That Couples Receptor Activation to Ca2+Mobilization from Lysosomes in Pancreatic Acinar Cells

(2010) François Cosker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TPC2 Proteins Mediate Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)- and Agonist-evoked Contractions of Smooth Muscle

(2010) Nezahat Tugba Durlu-Kandilci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Vacuolar Proton-translocating ATPase Activity and Assembly by Extracellular pH

(2010) Theodore T. Diakov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TPC2 Is a Novel NAADP-sensitive Ca2+Release Channel, Operating as a Dual Sensor of Luminal pH and Ca2+

(2010) Samantha J. Pitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Two-pore Channel 2 (TPCN2)-mediated Ca2+Currents in Isolated Lysosomes

(2010) Michael Schieder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Topology of NAADP-sensitive Two-pore Channels and Their Regulation by N-linked Glycosylation

(2010) Robert Hooper et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vacuolar Cation/H+Antiporters ofSaccharomyces cerevisiae

(2010) Olivier Cagnac et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Direct and Indirect Effectors of the Transient Receptor Potential Melastatin 2 (TRPM2) Cation Channel

(2010) Balázs Tóth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A cation counterflux supports lysosomal acidification

(2010) Benjamin E. Steinberg et al.   JOURNAL OF CELL BIOLOGY

The Na+/H+ exchanger Nhx1p regulates the initiation of Saccharomyces cerevisiae vacuole fusion

(2010) Q.-S. Qiu et al.   JOURNAL OF CELL SCIENCE

A Functional Role for Nicotinic Acid Adenine Dinucleotide Phosphate in Oxytocin-Mediated Contraction of Uterine Smooth Muscle from Rat

(2010) P. K. Aley et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

TRPM2: a multifunctional ion channel for calcium signalling

(2010) Adriana Sumoza-Toledo et al.   JOURNAL OF PHYSIOLOGY-LONDON

Degeneration of an Intracellular Ion Channel in the Primate Lineage by Relaxation of Selective Constraints

(2010) X. Cai et al.   MOLECULAR BIOLOGY AND EVOLUTION

The Arf-like GTPase Arl8 Mediates Delivery of Endocytosed Macromolecules to Lysosomes in Caenorhabditis elegans

(2010) Isei Nakae et al.   MOLECULAR BIOLOGY OF THE CELL

The Sodium/Proton Exchanger NHE8 Regulates Late Endosomal Morphology and Function

(2010) Scott P. Lawrence et al.   MOLECULAR BIOLOGY OF THE CELL

Simultaneous intracellular chloride and pH measurements using a GFP-based sensor

(2010) Daniele Arosio et al.   NATURE METHODS

AtNHX3 is a vacuolar K+/H+ antiporter required for low-potassium tolerance in Arabidopsis thaliana

(2010) HUA LIU et al.   PLANT CELL AND ENVIRONMENT

Nicotinic acid adenine dinucleotide phosphate regulates skeletal muscle differentiation via action at two-pore channels

(2010) P. K. Aley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unique characteristics of Ca2+ homeostasis of the trans-Golgi compartment

(2010) V. Lissandron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysosomal Pathology and Osteopetrosis upon Loss of H+-Driven Lysosomal Cl- Accumulation

(2010) S. Weinert et al.   SCIENCE

Endosomal Chloride-Proton Exchange Rather Than Chloride Conductance Is Crucial for Renal Endocytosis

(2010) G. Novarino et al.   SCIENCE

Planar Patch Clamp Approach to Characterize Ionic Currents from Intact Lysosomes

(2010) M. Schieder et al.   Science Signaling

Lipids on Trial: The Search for the Offending Metabolite in Niemann-Pick type C Disease

(2010) Emyr Lloyd-Evans et al.   TRAFFIC

Acidic calcium stores open for business: expanding the potential for intracellular Ca2+ signaling

(2010) Sandip Patel et al.   TRENDS IN CELL BIOLOGY

PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

(2010) Xian-ping Dong et al.   Nature Communications

The epidemiology of progressive intellectual and neurological deterioration in childhood

(2009) C. Verity et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Ca2+ transfer from the ER to mitochondria: When, how and why

(2009) Rosario Rizzuto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mechanisms and consequences of impaired lipid trafficking in Niemann–Pick type C1-deficient mammalian cells

(2009) Barbara Karten et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Niemann–Pick C2 (NPC2) and intracellular cholesterol trafficking

(2009) Judith Storch et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Suppression of Sulfonylurea- and Glucose-Induced Insulin Secretion In Vitro and In Vivo in Mice Lacking the Chloride Transport Protein ClC-3

(2009) Dai-Qing Li et al.   Cell Metabolism

The Granular Chloride Channel ClC-3 Is Permissive for Insulin Secretion

(2009) Ludmila V. Deriy et al.   Cell Metabolism

Second Messenger Signaling: Multiple Receptors for NAADP

(2009) Andreas H. Guse   CURRENT BIOLOGY

CD38-mediated Ca2+Signaling Contributes to Angiotensin II-induced Activation of Hepatic Stellate Cells

(2009) Seon-Young Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of the Penta-EF-hand Protein ALG-2 as a Ca2+-dependent Interactor of Mucolipin-1

(2009) Silvia Vergarajauregui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unimpaired Lysosomal Acidification in Respiratory Epithelial Cells in Cystic Fibrosis

(2009) Peter M. Haggie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Ancestral Deuterostome Family of Two-pore Channels Mediates Nicotinic Acid Adenine Dinucleotide Phosphate-dependent Calcium Release from Acidic Organelles

(2009) Eugen Brailoiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling

(2009) Eugen Brailoiu et al.   JOURNAL OF CELL BIOLOGY

Inhibitors of V-ATPases: old and new players

(2009) M. Huss et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

NAADP mobilizes calcium from acidic organelles through two-pore channels

(2009) Peter J. Calcraft et al.   NATURE

Identification of a chemical probe for NAADP by virtual screening

(2009) Edmund Naylor et al.   Nature Chemical Biology

Genetically encoded FRET sensors to monitor intracellular Zn2+ homeostasis

(2009) Jan L Vinkenborg et al.   NATURE METHODS

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

(2009) Paul Saftig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mucolipidosis Type IV: The Effect of Increased Lysosomal pH on the Abnormal Lysosomal Storage

(2009) Aviram Kogot-Levin et al.   PEDIATRIC RESEARCH

The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca2+ release channels

(2009) Antony Galione et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The two-pore channel TPCN2 mediates NAADP-dependent Ca2+-release from lysosomal stores

(2009) Xiangang Zong et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Calcium Pumps in Health and Disease

(2009) Marisa Brini et al.   PHYSIOLOGICAL REVIEWS

Thefou2mutation in the major vacuolar cation channel TPC1 confers tolerance to inhibitory luminal calcium

(2009) Diana Beyhl et al.   PLANT JOURNAL

TRPM2 Functions as a Lysosomal Ca2+-Release Channel in   Cells

(2009) I. Lange et al.   Science Signaling

Function, structure and regulation of the vacuolar (H+)-ATPases

(2008) Kevin C. Jefferies et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

NAADP-mediated channel ‘chatter’ in neurons of the rat medulla oblongata

(2008) G. Cristina Brailoiu et al.   BIOCHEMICAL JOURNAL

Structure and regulation of the vacuolar ATPases

(2008) Daniel J. Cipriano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Sorting of lysosomal proteins

(2008) Thomas Braulke et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Lysosomes co-localize with ryanodine receptor subtype 3 to form a trigger zone for calcium signalling by NAADP in rat pulmonary arterial smooth muscle

(2008) Nicholas P. Kinnear et al.   CELL CALCIUM

Ca2+ Signaling Occurs via Second Messenger Release from Intraorganelle Synthesis Sites

(2008) Lianne C. Davis et al.   CURRENT BIOLOGY

An Expanded Biological Repertoire for Ins(3,4,5,6)P4 through its Modulation of ClC-3 Function

(2008) Jennifer Mitchell et al.   CURRENT BIOLOGY

The V-type H+-ATPase in vesicular trafficking: targeting, regulation and function

(2008) Vladimir Marshansky et al.   CURRENT OPINION IN CELL BIOLOGY

Neuraminidase 1 Is a Negative Regulator of Lysosomal Exocytosis

(2008) Gouri Yogalingam et al.   DEVELOPMENTAL CELL

Generation of Nicotinic Acid Adenine Dinucleotide Phosphate and Cyclic ADP-Ribose by Glucagon-Like Peptide-1 Evokes Ca2+ Signal That Is Essential for Insulin Secretion in Mouse Pancreatic Islets

(2008) B.-J. Kim et al.   DIABETES

Calcium dynamics in bovine adrenal medulla chromaffin cell secretory granules

(2008) Jaime SantoDomingo et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Intravesicular Calcium Release Mediates the Motion and Exocytosis of Secretory Organelles

(2008) Marcial Camacho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRP-ML1 functions as a lysosomal NAADP-sensitive Ca2+ release channel in coronary arterial myocytes

(2008) Fan Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The co-presence of Na+/Ca2+-K+exchanger and Na+/Ca2+exchanger in bovine adrenal chromaffin cells

(2008) Chien-Yuan Pan et al.   JOURNAL OF NEUROCHEMISTRY

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

(2008) Xian-Ping Dong et al.   NATURE

The Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes

(2008) Austin R. Graves et al.   NATURE

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE

An H+ P-ATPase on the tonoplast determines vacuolar pH and flower colour

(2008) Walter Verweij et al.   NATURE CELL BIOLOGY

Two newly identified genetic determinants of pigmentation in Europeans

(2008) Patrick Sulem et al.   NATURE GENETICS

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

(2008) Emyr Lloyd-Evans et al.   NATURE MEDICINE

Intracellular Calcium Release from Human Platelets: Different Messengers for Multiple Stores

(2008) Isaac Jardín et al.   TRENDS IN CARDIOVASCULAR MEDICINE