Metastasis: crosstalk between tissue mechanics and tumour cell plasticity

p120-catenin-dependent collective brain infiltration by glioma cell networks

(2020) Pavlo G. Gritsenko et al.   NATURE CELL BIOLOGY

Publisher Correction: Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties

(2020) Tito Panciera et al.   NATURE MATERIALS

Vimentin Intermediate Filaments as Potential Target for Cancer Treatment

(2020) Katerina Strouhalova et al.   Cancers

LOXL2 Expression Status Is Correlated With Molecular Characterizations of Cervical Carcinoma and Associated With Poor Cancer Survival via Epithelial-Mesenchymal Transition (EMT) Phenotype

(2020) Canhui Cao et al.   Frontiers in Oncology

Guidelines and definitions for research on epithelial–mesenchymal transition

(2020) Jing Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Desmoplasia and Biophysics in Pancreatic Ductal Adenocarcinoma

(2020) Francesco Di Maggio et al.   PANCREAS

Cell–cell adhesion and 3D matrix confinement determine jamming transitions in breast cancer invasion

(2020) Olga Ilina et al.   NATURE CELL BIOLOGY

Gain Fat—Lose Metastasis: Converting Invasive Breast Cancer Cells into Adipocytes Inhibits Cancer Metastasis

(2019) Dana Ishay-Ronen et al.   CANCER CELL

Author Correction: Hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability

(2019) Toni Celià-Terrassa et al.   Nature Communications

Energetic regulation of coordinated leader–follower dynamics during collective invasion of breast cancer cells

(2019) Jian Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells

(2019) Cornelia Kröger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamically stiffened matrix promotes malignant transformation of mammary epithelial cells via collective mechanical signaling

(2019) Matthew G. Ondeck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer cells in the tumor core exhibit spatially coordinated migration patterns

(2019) Ralitza Staneva et al.   JOURNAL OF CELL SCIENCE

Integrins, CAFs and Mechanical Forces in the Progression of Cancer

(2019) Imjoo Jang et al.   Cancers

Unjamming overcomes kinetic and proliferation arrest in terminally differentiated cells and promotes collective motility of carcinoma

(2019) Andrea Palamidessi et al.   NATURE MATERIALS

Integrins as biomechanical sensors of the microenvironment

(2019) Jenny Z. Kechagia et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The role of proteases in epithelial-to-mesenchymal cell transitions in cancer

(2019) Julia Mitschke et al.   CANCER AND METASTASIS REVIEWS

E-cadherin is required for metastasis in multiple models of breast cancer

(2019) Veena Padmanaban et al.   NATURE

A Tale of Two States: Normal and Transformed, With and Without Rigidity Sensing

(2019) Michael Sheetz   Annual Review of Cell and Developmental Biology

Differential Contributions of Pre- and Post-EMT Tumor Cells in Breast Cancer Metastasis

(2019) Ana Rita Lourenco et al.   CANCER RESEARCH

Higher matrix stiffness as an independent initiator triggers epithelial-mesenchymal transition and facilitates HCC metastasis

(2019) Yinying Dong et al.   Journal of Hematology & Oncology

Metabolic changes in tumor cells and tumor-associated macrophages: A mutual relationship

(2018) Romana T. Netea-Maier et al.   CANCER LETTERS

The ‘endocytic matrix reloaded’ and its impact on the plasticity of migratory strategies

(2018) Sara Sigismund et al.   CURRENT OPINION IN CELL BIOLOGY

EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration

(2018) Nicole M. Aiello et al.   DEVELOPMENTAL CELL

Intravital microscopy of collective invasion plasticity in breast cancer

(2018) Olga Ilina et al.   Disease Models & Mechanisms

Epithelial-mesenchymal transition softens head and neck cancer cells to facilitate migration in 3D environments

(2018) Yin-Quan Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mechanisms and impact of altered tumour mechanics

(2018) Hamid Mohammadi et al.   NATURE CELL BIOLOGY

From jamming to collective cell migration through a boundary induced transition

(2018) Oleksandr Chepizhko et al.   Soft Matter

Hypoxia Pathway Proteins As Central Mediators of Metabolism in the Tumor Cells and Their Microenvironment

(2018) Sundary Sormendi et al.   Frontiers in Immunology

YAP/TAZ Activation as a Target for Treating Metastatic Cancer

(2018) Janine Warren et al.   Cancers

Defining the Role of Solid Stress and Matrix Stiffness in Cancer Cell Proliferation and Metastasis

(2018) Maria Kalli et al.   Frontiers in Oncology

Identification of the tumour transition states occurring during EMT

(2018) Ievgenia Pastushenko et al.   NATURE

Hybrid epithelial/mesenchymal phenotypes promote metastasis and therapy resistance across carcinomas

(2018) Mohit Kumar Jolly et al.   PHARMACOLOGY & THERAPEUTICS

Role of Extracellular Matrix in Development and Cancer Progression

(2018) Cameron Walker et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

YAP/TAZ Signaling as a Molecular Link between Fibrosis and Cancer

(2018) Satoshi Noguchi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Matrix stiffness mechanically conditions EMT and migratory behavior of oral squamous cell carcinoma

(2018) Bibiana F. Matte et al.   JOURNAL OF CELL SCIENCE

Inter- and intra-tumoral heterogeneity in cancer-associated fibroblasts of human pancreatic ductal adenocarcinoma

(2018) Cindy Neuzillet et al.   JOURNAL OF PATHOLOGY

EMT Transition States during Tumor Progression and Metastasis

(2018) Ievgenia Pastushenko et al.   TRENDS IN CELL BIOLOGY

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

(2017) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Jamming transitions in cancer

(2017) Linda Oswald et al.   JOURNAL OF PHYSICS D-APPLIED PHYSICS

Numb prevents a complete epithelial–mesenchymal transition by modulating Notch signalling

(2017) Federico Bocci et al.   Journal of the Royal Society Interface

EMT and MET: necessary or permissive for metastasis?

(2017) Mohit Kumar Jolly et al.   Molecular Oncology

Upholding a role for EMT in breast cancer metastasis

(2017) Xin Ye et al.   NATURE

Upholding a role for EMT in pancreatic cancer metastasis

(2017) Nicole M. Aiello et al.   NATURE

Mechanoreciprocity in cell migration

(2017) Sjoerd van Helvert et al.   NATURE CELL BIOLOGY

The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer

(2017) Angela M. Krebs et al.   NATURE CELL BIOLOGY

Endocytic reawakening of motility in jammed epithelia

(2017) Chiara Malinverno et al.   NATURE MATERIALS

Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells

(2017) Brian Bierie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue Force Programs Cell Fate and Tumor Aggression

(2017) Jason J. Northey et al.   Cancer Discovery

Tissue elasticity properties as biomarkers for prostate cancer

(2017) Kenneth Hoyt et al.   Cancer Biomarkers

Plasticity of Cell Migration In Vivo and In Silico

(2016) Veronika te Boekhorst et al.   Annual Review of Cell and Developmental Biology

Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy

(2016) Hong Jiang et al.   NATURE MEDICINE

ZEB1 induces LOXL2-mediated collagen stabilization and deposition in the extracellular matrix to drive lung cancer invasion and metastasis

(2016) D H Peng et al.   ONCOGENE

Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters

(2016) Kevin J. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

Stability of the hybrid epithelial/mesenchymal phenotype

(2016) Mohit Kumar Jolly et al.   Oncotarget

Tumor-induced remote ECM network orientation steers angiogenesis

(2016) Hayri E. Balcioglu et al.   Scientific Reports

Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity

(2016) Evelyne Beerling et al.   Cell Reports

Mechanotransduction in cancer

(2016) LiKang Chin et al.   Current Opinion in Chemical Engineering

Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration

(2015) I. Acerbi et al.   Integrative Biology

Dense fibrillar collagen is a potent inducer of invadopodia via a specific signaling network

(2015) Vira V. Artym et al.   JOURNAL OF CELL BIOLOGY

An epigenetically distinct breast cancer cell subpopulation promotes collective invasion

(2015) Jill M. Westcott et al.   JOURNAL OF CLINICAL INVESTIGATION

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

(2015) Xiaofeng Zheng et al.   NATURE

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

(2015) Kari R. Fischer et al.   NATURE

A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity

(2015) Bartlomiej Waclaw et al.   NATURE

Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway

(2015) Spencer C. Wei et al.   NATURE CELL BIOLOGY

Unjamming and cell shape in the asthmatic airway epithelium

(2015) Jin-Ah Park et al.   NATURE MATERIALS

Stemness of the hybrid Epithelial/Mesenchymal State in Breast Cancer and Its Association with Poor Survival

(2015) Anne Grosse-Wilde et al.   PLoS One

The ZEB1/miR-200c feedback loop regulates invasion via actin interacting proteins MYLK and TKS5

(2015) Vignesh Sundararajan et al.   Oncotarget

Mesenchymal Cancer Cell-Stroma Crosstalk Promotes Niche Activation, Epithelial Reversion, and Metastatic Colonization

(2015) Yaiza del Pozo Martin et al.   Cell Reports

Cell jamming: Collective invasion of mesenchymal tumor cells imposed by tissue confinement

(2014) Anna Haeger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis

(2014) Nicola Aceto et al.   CELL

Nuclear Deformability Constitutes a Rate-Limiting Step During Cell Migration in 3-D Environments

(2014) Patricia M. Davidson et al.   Cellular and Molecular Bioengineering

In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity

(2014) Sei Kuriyama et al.   JOURNAL OF CELL BIOLOGY

Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival

(2014) Takamasa Harada et al.   JOURNAL OF CELL BIOLOGY

TGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion

(2014) Lukas D. Osborne et al.   MOLECULAR BIOLOGY OF THE CELL

Extracellular matrix density promotes EMT by weakening cell–cell adhesions

(2014) Sandeep Kumar et al.   Molecular BioSystems

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

 1 Integrin Inhibition Elicits a Prometastatic Switch Through the TGF -miR-200-ZEB Network in E-Cadherin-Positive Triple-Negative Breast Cancer

(2014) H. H. Truong et al.   Science Signaling

Stromally Derived Lysyl Oxidase Promotes Metastasis of Transforming Growth Factor- -Deficient Mouse Mammary Carcinomas

(2013) M. W. Pickup et al.   CANCER RESEARCH

Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program

(2013) Kevin J. Cheung et al.   CELL

Epidermal Snail expression drives skin cancer initiation and progression through enhanced cytoprotection, epidermal stem/progenitor cell expansion and enhanced metastatic potential

(2013) B De Craene et al.   CELL DEATH AND DIFFERENTIATION

Integrin signaling in control of tumor growth and progression

(2013) Jiangling Xiong et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

(2013) Katarina Wolf et al.   JOURNAL OF CELL BIOLOGY

Prevalence and heterogeneity of circulating tumour cells in metastatic cutaneous melanoma

(2013) Leila Khoja et al.   MELANOMA RESEARCH

Minimization of thermodynamic costs in cancer cell invasion

(2013) L. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells

(2013) M. A. Nieto   SCIENCE

Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

(2013) M. Yu et al.   SCIENCE

Spatiotemporal Regulation of Epithelial-Mesenchymal Transition Is Essential for Squamous Cell Carcinoma Metastasis

(2012) Jeff H. Tsai et al.   CANCER CELL

Matrix rigidity regulates a switch between TGF-β1–induced apoptosis and epithelial–mesenchymal transition

(2012) Jennifer L. Leight et al.   MOLECULAR BIOLOGY OF THE CELL

Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK

(2012) A-M Baker et al.   ONCOGENE

Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

(2012) T. Stylianopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Why the stroma matters in breast cancer

(2012) Matthew W. Conklin et al.   Cell Adhesion & Migration

Twist1-Induced Invadopodia Formation Promotes Tumor Metastasis

(2011) Mark A. Eckert et al.   CANCER CELL

Snail2 is an Essential Mediator of Twist1-Induced Epithelial Mesenchymal Transition and Metastasis

(2011) E. Casas et al.   CANCER RESEARCH

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

(2011) Peter Friedl et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Tracking the intermediate stages of epithelial-mesenchymal transition in epithelial stem cells and cancer

(2011) Nicole Vincent Jordan et al.   CELL CYCLE

Distinct Types of Tumor-Initiating Cells Form Human Colon Cancer Tumors and Metastases

(2011) Sebastian M. Dieter et al.   Cell Stem Cell

Physiological type I collagen organization induces the formation of a novel class of linear invadosomes

(2011) Amélie Juin et al.   MOLECULAR BIOLOGY OF THE CELL

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Analysis of Epithelial and Mesenchymal Markers in Ovarian Cancer Reveals Phenotypic Heterogeneity and Plasticity

(2011) Robert Strauss et al.   PLoS One

Hypoxia, inflammation, and the tumor microenvironment in metastatic disease

(2010) Elizabeth C. Finger et al.   CANCER AND METASTASIS REVIEWS

Determinants of leader cells in collective cell migration

(2010) Antoine A. Khalil et al.   Integrative Biology

Epithelial-Mesenchymal Transition in Cancer: Parallels Between Normal Development and Tumor Progression

(2010) Douglas S. Micalizzi et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Autocrine TGF-  and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts

(2010) Y. Kojima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Forcing form and function: biomechanical regulation of tumor evolution

(2010) Hongmei Yu et al.   TRENDS IN CELL BIOLOGY

Epithelial-Mesenchymal Transition

(2009) Michael W. Klymkowsky et al.   AMERICAN JOURNAL OF PATHOLOGY

Mechanics, malignancy, and metastasis: The force journey of a tumor cell

(2009) Sanjay Kumar et al.   CANCER AND METASTASIS REVIEWS

14-3-3ζ Cooperates with ErbB2 to Promote Ductal Carcinoma In Situ Progression to Invasive Breast Cancer by Inducing Epithelial-Mesenchymal Transition

(2009) Jing Lu et al.   CANCER CELL

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression

(2009) D. L. Gibbons et al.   GENES & DEVELOPMENT

Plasticity of cell migration: a multiscale tuning model

(2009) Peter Friedl et al.   JOURNAL OF CELL BIOLOGY

Adhesion signaling - crosstalk between integrins, Src and Rho

(2009) S. Huveneers et al.   JOURNAL OF CELL SCIENCE

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Circulating tumour tissue fragments in patients with pulmonary metastasis of clear cell renal cell carcinoma

(2009) Gursah Kats-Ugurlu et al.   JOURNAL OF PATHOLOGY

Collective cell migration in morphogenesis, regeneration and cancer

(2009) Peter Friedl et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Contact Guidance Mediated Three-Dimensional Cell Migration is Regulated by Rho/ROCK-Dependent Matrix Reorganization

(2008) Paolo P. Provenzano et al.   BIOPHYSICAL JOURNAL

Induction of EMT by Twist Proteins as a Collateral Effect of Tumor-Promoting Inactivation of Premature Senescence

(2008) Stéphane Ansieau et al.   CANCER CELL

Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

(2008) Jing Yang et al.   DEVELOPMENTAL CELL